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Items: 32

1.

The pan-cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia.

Chang WH, Lai AG.

Ann N Y Acad Sci. 2019 Jul;1448(1):65-82. doi: 10.1111/nyas.14170. Epub 2019 Jun 19.

PMID:
31215667
2.

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia.

Chang WH, Lai AG.

DNA Repair (Amst). 2019 Jun;78:142-153. doi: 10.1016/j.dnarep.2019.04.008. Epub 2019 Apr 24.

PMID:
31054516
3.
4.

Pan-cancer genomic amplifications underlie a WNT hyperactivation phenotype associated with stem cell-like features leading to poor prognosis.

Chang WH, Lai AG.

Transl Res. 2019 Jun;208:47-62. doi: 10.1016/j.trsl.2019.02.008. Epub 2019 Apr 22.

PMID:
31028732
5.
6.

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.

Wing PA, Davenne T, Wettengel J, Lai AG, Zhuang X, Chakraborty A, D'Arienzo V, Kramer C, Ko C, Harris JM, Schreiner S, Higgs M, Roessler S, Parish JL, Protzer U, Balfe P, Rehwinkel J, McKeating JA.

Life Sci Alliance. 2019 Mar 27;2(2). pii: e201900355. doi: 10.26508/lsa.201900355. Print 2019 Apr.

7.

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication.

Zhuang X, Magri A, Hill M, Lai AG, Kumar A, Rambhatla SB, Donald CL, Lopez-Clavijo AF, Rudge S, Pinnick K, Chang WH, Wing PAC, Brown R, Qin X, Simmonds P, Baumert TF, Ray D, Loudon A, Balfe P, Wakelam M, Butterworth S, Kohl A, Jopling CL, Zitzmann N, McKeating JA.

Nat Commun. 2019 Jan 22;10(1):377. doi: 10.1038/s41467-019-08299-7.

8.

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers.

Chang WH, Forde D, Lai AG.

J Transl Med. 2019 Jan 9;17(1):14. doi: 10.1186/s12967-019-1775-9.

9.

Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.

Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.

Elife. 2019 Jan 7;8. pii: e44851. doi: 10.7554/eLife.44851.

10.

Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.

Govek SP, Bonnefous C, Julien JD, Nagasawa JY, Kahraman M, Lai AG, Douglas KL, Aparicio AM, Darimont BD, Grillot KL, Joseph JD, Kaufman JA, Lee KJ, Lu N, Moon MJ, Prudente RY, Sensintaffar J, Rix PJ, Hager JH, Smith ND.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):367-372. doi: 10.1016/j.bmcl.2018.12.042. Epub 2018 Dec 19.

PMID:
30587451
11.

Comparative genomic analysis of crustacean hyperglycemic hormone (CHH) neuropeptide genes across diverse crustacean species.

Chang WH, Lai AG.

F1000Res. 2018 Jan 23;7:100. doi: 10.12688/f1000research.13732.1. eCollection 2018.

12.

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen.

Lai AG, Forde D, Chang WH, Yuan F, Zhuang X, Orbegozo Rubio C, Song CX, McKeating JA.

Wellcome Open Res. 2018 Sep 26;3:126. doi: 10.12688/wellcomeopenres.14839.1. eCollection 2018.

13.

Daytime variation in hepatitis C virus replication kinetics following liver transplant.

Zhuang X, Lai AG, McKeating JA, Rowe I, Balfe P.

Version 2. Wellcome Open Res. 2018 Sep 20 [revised 2018 Jan 1];3:96. doi: 10.12688/wellcomeopenres.14696.2. eCollection 2018.

14.

Mixed evolutionary origins of endogenous biomass-depolymerizing enzymes in animals.

Chang WH, Lai AG.

BMC Genomics. 2018 Jun 20;19(1):483. doi: 10.1186/s12864-018-4861-0.

15.

A TALE of shrimps: Genome-wide survey of homeobox genes in 120 species from diverse crustacean taxa.

Chang WH, Lai AG.

F1000Res. 2018 Jan 17;7:71. doi: 10.12688/f1000research.13636.1. eCollection 2018.

16.

Genome-wide analyses of the bHLH superfamily in crustaceans: reappraisal of higher-order groupings and evidence for lineage-specific duplications.

Chang WH, Lai AG.

R Soc Open Sci. 2018 Mar 14;5(3):172433. doi: 10.1098/rsos.172433. eCollection 2018 Mar.

17.

EvoRegen in animals: Time to uncover deep conservation or convergence of adult stem cell evolution and regenerative processes.

Lai AG, Aboobaker AA.

Dev Biol. 2018 Jan 15;433(2):118-131. doi: 10.1016/j.ydbio.2017.10.010. Epub 2017 Nov 30. Review.

18.

Interplay between circadian clock and viral infection.

Zhuang X, Rambhatla SB, Lai AG, McKeating JA.

J Mol Med (Berl). 2017 Dec;95(12):1283-1289. doi: 10.1007/s00109-017-1592-7. Epub 2017 Sep 30. Review.

19.

The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells.

Lai AG, Kosaka N, Abnave P, Sahu S, Aboobaker AA.

Dev Biol. 2018 Jan 15;433(2):218-226. doi: 10.1016/j.ydbio.2017.07.023. Epub 2017 Jul 28.

20.

Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species.

Lai AG, Aboobaker AA.

BMC Genomics. 2017 May 18;18(1):389. doi: 10.1186/s12864-017-3769-4.

21.

The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.

Lai AG, Pouchkina-Stantcheva N, Di Donfrancesco A, Kildisiute G, Sahu S, Aboobaker AA.

BMC Evol Biol. 2017 Apr 26;17(1):107. doi: 10.1186/s12862-017-0949-4.

22.

The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion.

Kao D, Lai AG, Stamataki E, Rosic S, Konstantinides N, Jarvis E, Di Donfrancesco A, Pouchkina-Stancheva N, Sémon M, Grillo M, Bruce H, Kumar S, Siwanowicz I, Le A, Lemire A, Eisen MB, Extavour C, Browne WE, Wolff C, Averof M, Patel NH, Sarkies P, Pavlopoulos A, Aboobaker A.

Elife. 2016 Nov 16;5. pii: e20062. doi: 10.7554/eLife.20062.

23.

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.

Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.

Elife. 2016 Jul 13;5. pii: e15828. doi: 10.7554/eLife.15828. Erratum in: Elife. 2019 Jan 07;8:.

24.

Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft.

Govek SP, Nagasawa JY, Douglas KL, Lai AG, Kahraman M, Bonnefous C, Aparicio AM, Darimont BD, Grillot KL, Joseph JD, Kaufman JA, Lee KJ, Lu N, Moon MJ, Prudente RY, Sensintaffar J, Rix PJ, Hager JH, Smith ND.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5163-7. doi: 10.1016/j.bmcl.2015.09.074. Epub 2015 Oct 3.

PMID:
26463130
25.

Could ROS signals drive tissue-specific clocks?

Schippers JH, Lai AG, Mueller-Roeber B, Dijkwel PP.

Transcription. 2013 Sep-Dec;4(5):206-8. No abstract available.

26.

CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses.

Lai AG, Doherty CJ, Mueller-Roeber B, Kay SA, Schippers JH, Dijkwel PP.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17129-34. doi: 10.1073/pnas.1209148109. Epub 2012 Oct 1.

27.

Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

Rowbottom MW, Faraoni R, Chao Q, Campbell BT, Lai AG, Setti E, Ezawa M, Sprankle KG, Abraham S, Tran L, Struss B, Gibney M, Armstrong RC, Gunawardane RN, Nepomuceno RR, Valenta I, Hua H, Gardner MF, Cramer MD, Gitnick D, Insko DE, Apuy JL, Jones-Bolin S, Ghose AK, Herbertz T, Ator MA, Dorsey BD, Ruggeri B, Williams M, Bhagwat S, James J, Holladay MW.

J Med Chem. 2012 Feb 9;55(3):1082-105. doi: 10.1021/jm2009925. Epub 2012 Jan 23.

PMID:
22168626
28.

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.

Holladay MW, Campbell BT, Rowbottom MW, Chao Q, Sprankle KG, Lai AG, Abraham S, Setti E, Faraoni R, Tran L, Armstrong RC, Gunawardane RN, Gardner MF, Cramer MD, Gitnick D, Ator MA, Dorsey BD, Ruggeri BR, Williams M, Bhagwat SS, James J.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5342-6. doi: 10.1016/j.bmcl.2011.07.019. Epub 2011 Jul 14.

PMID:
21807507
29.

Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of Arabidopsis thaliana.

Lai AG, Denton-Giles M, Mueller-Roeber B, Schippers JH, Dijkwel PP.

Genome Biol Evol. 2011;3:627-40. doi: 10.1093/gbe/evr038. Epub 2011 May 27.

30.

Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.

Chao Q, Sprankle KG, Grotzfeld RM, Lai AG, Carter TA, Velasco AM, Gunawardane RN, Cramer MD, Gardner MF, James J, Zarrinkar PP, Patel HK, Bhagwat SS.

J Med Chem. 2009 Dec 10;52(23):7808-16. doi: 10.1021/jm9007533.

PMID:
19754199
31.

Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.

Patel HK, Grotzfeld RM, Lai AG, Mehta SA, Milanov ZV, Chao Q, Sprankle KG, Carter TA, Velasco AM, Fabian MA, James J, Treiber DK, Lockhart DJ, Zarrinkar PP, Bhagwat SS.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5182-5. doi: 10.1016/j.bmcl.2009.07.024. Epub 2009 Jul 9.

PMID:
19646870
32.

A small molecule-kinase interaction map for clinical kinase inhibitors.

Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, Lélias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ.

Nat Biotechnol. 2005 Mar;23(3):329-36. Epub 2005 Feb 13.

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