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Items: 32


Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local.

Pauza CD, Liou ML, Lahusen T, Xiao L, Lapidus RG, Cairo C, Li H.

Front Immunol. 2018 Jun 8;9:1305. doi: 10.3389/fimmu.2018.01305. eCollection 2018. Review.


BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis.

Lahusen TJ, Kim SJ, Miao K, Huang Z, Xu X, Deng CX.

Oncogene. 2018 Apr;37(17):2343-2350. doi: 10.1038/s41388-018-0127-1. Epub 2018 Feb 14.


"DNA Binding Region" of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint.

Masuda T, Xu X, Dimitriadis EK, Lahusen T, Deng CX.

Int J Biol Sci. 2016 Jan 1;12(2):133-43. doi: 10.7150/ijbs.14242. eCollection 2016.


SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.

Wang RH, Lahusen TJ, Chen Q, Xu X, Jenkins LM, Leo E, Fu H, Aladjem M, Pommier Y, Appella E, Deng CX.

Int J Biol Sci. 2014 Nov 26;10(10):1193-202. doi: 10.7150/ijbs.11066. eCollection 2014.


SRT1720 induces lysosomal-dependent cell death of breast cancer cells.

Lahusen TJ, Deng CX.

Mol Cancer Ther. 2015 Jan;14(1):183-92. doi: 10.1158/1535-7163.MCT-14-0584. Epub 2014 Nov 19.


WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.

Vassilopoulos A, Tominaga Y, Kim HS, Lahusen T, Li B, Yu H, Gius D, Deng CX.

Oncogene. 2015 Jun 4;34(23):3023-35. doi: 10.1038/onc.2014.239. Epub 2014 Aug 4.


Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.

Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TJ, Bewley C, Deng CX.

J Biol Chem. 2014 Aug 29;289(35):24202-14. doi: 10.1074/jbc.M114.567552. Epub 2014 Jul 8.


Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.

Vazquez-Ortiz G, Chisholm C, Xu X, Lahusen TJ, Li C, Sakamuru S, Huang R, Thomas CJ, Xia M, Deng C.

Breast Cancer Res. 2014 Jun 24;16(3):R67. doi: 10.1186/bcr3682.


A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer.

Vassilopoulos A, Chisholm C, Lahusen T, Zheng H, Deng CX.

Oncogene. 2014 Nov 20;33(47):5477-82. doi: 10.1038/onc.2013.516. Epub 2013 Dec 9.


SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC.

Cancer Cell. 2013 Apr 15;23(4):450-63. doi: 10.1016/j.ccr.2013.02.024. Epub 2013 Apr 4.


Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.

Xiao C, Wang RH, Lahusen TJ, Park O, Bertola A, Maruyama T, Reynolds D, Chen Q, Xu X, Young HA, Chen WJ, Gao B, Deng CX.

J Biol Chem. 2012 Dec 7;287(50):41903-13. doi: 10.1074/jbc.M112.415182. Epub 2012 Oct 16.


SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, Deng CX.

Cancer Cell. 2011 Oct 18;20(4):487-99. doi: 10.1016/j.ccr.2011.09.004.


Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation.

Lee MH, Lahusen T, Wang RH, Xiao C, Xu X, Hwang YS, He WW, Shi Y, Deng CX.

Oncogene. 2012 Jan 5;31(1):116-27. doi: 10.1038/onc.2011.217. Epub 2011 Jun 13.


Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription.

Chien CD, Kirilyuk A, Li JV, Zhang W, Lahusen T, Schmidt MO, Oh AS, Wellstein A, Riegel AT.

J Biol Chem. 2011 Jul 29;286(30):26813-27. doi: 10.1074/jbc.M110.216200. Epub 2011 Jun 2.


SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, Jou W, Gius D, Deng CX.

J Biol Chem. 2010 Nov 19;285(47):36776-84. doi: 10.1074/jbc.M110.168039. Epub 2010 Sep 16.


BRCA1 affects global DNA methylation through regulation of DNMT1.

Shukla V, Coumoul X, Lahusen T, Wang RH, Xu X, Vassilopoulos A, Xiao C, Lee MH, Man YG, Ouchi M, Ouchi T, Deng CX.

Cell Res. 2010 Nov;20(11):1201-15. doi: 10.1038/cr.2010.128. Epub 2010 Sep 7.


Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

Kim HS, Xiao C, Wang RH, Lahusen T, Xu X, Vassilopoulos A, Vazquez-Ortiz G, Jeong WI, Park O, Ki SH, Gao B, Deng CX.

Cell Metab. 2010 Sep 8;12(3):224-36. doi: 10.1016/j.cmet.2010.06.009.


Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

Fishler T, Li YY, Wang RH, Kim HS, Sengupta K, Vassilopoulos A, Lahusen T, Xu X, Lee MH, Liu Q, Elledge SJ, Ried T, Deng CX.

Oncogene. 2010 Jul 15;29(28):4007-17. doi: 10.1038/onc.2010.163. Epub 2010 May 17.


The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.

Lahusen T, Henke RT, Kagan BL, Wellstein A, Riegel AT.

Breast Cancer Res Treat. 2009 Jul;116(2):225-37. doi: 10.1007/s10549-009-0405-2. Epub 2009 May 6. Review.


E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells.

Mani A, Oh AS, Bowden ET, Lahusen T, Lorick KL, Weissman AM, Schlegel R, Wellstein A, Riegel AT.

Cancer Res. 2006 Sep 1;66(17):8680-6.


Assays for cyclin-dependent kinase inhibitors.

Senderowicz AM, Lahusen T.

Methods Mol Med. 2003;85:39-48. Review. No abstract available.


Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.

Messmann RA, Ullmann CD, Lahusen T, Kalehua A, Wasfy J, Melillo G, Ding I, Headlee D, Figg WD, Sausville EA, Senderowicz AM.

Clin Cancer Res. 2003 Feb;9(2):562-70.


Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).

Patel V, Lahusen T, Leethanakul C, Igishi T, Kremer M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind JS, Senderowicz AM.

Clin Cancer Res. 2002 Nov;8(11):3549-60.


Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.

Sausville EA, Arbuck SG, Messmann R, Headlee D, Bauer KS, Lush RM, Murgo A, Figg WD, Lahusen T, Jaken S, Jing X, Roberge M, Fuse E, Kuwabara T, Senderowicz AM.

J Clin Oncol. 2001 Apr 15;19(8):2319-33.


Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.

Robey RW, Medina-PĂ©rez WY, Nishiyama K, Lahusen T, Miyake K, Litman T, Senderowicz AM, Ross DD, Bates SE.

Clin Cancer Res. 2001 Jan;7(1):145-52.


Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes.

Melillo G, Sausville EA, Cloud K, Lahusen T, Varesio L, Senderowicz AM.

Cancer Res. 1999 Nov 1;59(21):5433-7.


Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol.

Carlson B, Lahusen T, Singh S, Loaiza-Perez A, Worland PJ, Pestell R, Albanese C, Sausville EA, Senderowicz AM.

Cancer Res. 1999 Sep 15;59(18):4634-41.


Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target.

Sausville EA, Zaharevitz D, Gussio R, Meijer L, Louarn-Leost M, Kunick C, Schultz R, Lahusen T, Headlee D, Stinson S, Arbuck SG, Senderowicz A.

Pharmacol Ther. 1999 May-Jun;82(2-3):285-92. Review.


Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA.

Cancer Res. 1999 Jun 1;59(11):2566-9.

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