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Items: 1 to 50 of 80

1.

Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study.

Kühn T, Stepien M, López-Nogueroles M, Machado AD, Sookthai D, Johnson T, Roca M, Hüsing A, Maldonado SG, Cross AJ, Murphy N, Freisling H, Rinaldi S, Scalbert A, Fedirco V, Severi G, Boutron-Ruault MC, Mancini FR, Sowah SA, Boeing H, Jakszyn P, Sánchez MJ, Merino S, Colorado-Yohar S, Barricarte A, Khaw KT, Schmidt JA, Perez-Cornago A, Trichopoulou A, Karakatsani A, Thriskos P, Palli D, Agnoli C, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita B, van Gils CH, Heath A, Gunter MJ, Riboli E, Lahoz A, Jenab M, Kaaks R.

J Natl Cancer Inst. 2019 Aug 21. pii: djz166. doi: 10.1093/jnci/djz166. [Epub ahead of print]

PMID:
31435679
2.

CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC.

Becker JH, Gao Y, Soucheray M, Pulido I, Kikuchi E, Rodríguez ML, Gandhi R, Lafuente-Sanchis A, Aupí M, Alcácer Fernández-Coronado J, Martín-Martorell P, Cremades A, Galbis-Caravajal JM, Alcácer J, Christensen CL, Simms P, Hess A, Asahina H, Kahle MP, Al-Shahrour F, Borgia JA, Lahoz A, Insa A, Juan O, Jänne PA, Wong KK, Carretero J, Shimamura T.

Cancer Res. 2019 Sep 1;79(17):4439-4452. doi: 10.1158/0008-5472.CAN-19-0024. Epub 2019 Jul 4.

PMID:
31273063
3.

LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics.

Alcoriza-Balaguer MI, García-Cañaveras JC, López A, Conde I, Juan O, Carretero J, Lahoz A.

Anal Chem. 2019 Jan 2;91(1):836-845. doi: 10.1021/acs.analchem.8b03409. Epub 2018 Dec 13.

PMID:
30500173
4.

Early radiological response as predictor of overall survival in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor mutations.

Salvador-Coloma C, Lorente D, Palanca S, Simarro J, Mancheño N, Sandoval J, Lahoz A, Juan Ó.

J Thorac Dis. 2018 Mar;10(3):1386-1393. doi: 10.21037/jtd.2018.02.30.

5.

RpeakChrom: Novel R package for the automated characterization and optimization of column efficiency in high-performance liquid chromatography analysis.

Peris-Díaz MD, Alcoriza-Balaguer MI, García-Cañaveras JC, Santonja F, Sentandreu E, Lahoz A.

Electrophoresis. 2017 Nov;38(22-23):2985-2995. doi: 10.1002/elps.201700180. Epub 2017 Jul 26.

PMID:
28665035
6.

A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis.

García-Cañaveras JC, Peris-Díaz MD, Alcoriza-Balaguer MI, Cerdán-Calero M, Donato MT, Lahoz A.

Electrophoresis. 2017 Sep;38(18):2331-2340. doi: 10.1002/elps.201700079. Epub 2017 Jun 8.

PMID:
28512733
7.

Galectin-3 as a marker of interstitial atrial remodelling involved in atrial fibrillation.

Hernández-Romero D, Vílchez JA, Lahoz Á, Romero-Aniorte AI, Jover E, García-Alberola A, Jara-Rubio R, Martínez CM, Valdés M, Marín F.

Sci Rep. 2017 Jan 12;7:40378. doi: 10.1038/srep40378.

8.

cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.

Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Marín MP, Lahoz A, Millán JM, Rodrigo R.

PLoS One. 2016 Nov 18;11(11):e0166717. doi: 10.1371/journal.pone.0166717. eCollection 2016.

9.

Xenobiotic metabolism in differentiated human bronchial epithelial cells.

Boei JJWA, Vermeulen S, Klein B, Hiemstra PS, Verhoosel RM, Jennen DGJ, Lahoz A, Gmuender H, Vrieling H.

Arch Toxicol. 2017 May;91(5):2093-2105. doi: 10.1007/s00204-016-1868-7. Epub 2016 Oct 13.

10.

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.

García-Cañaveras JC, Castell JV, Donato MT, Lahoz A.

Sci Rep. 2016 Jun 6;6:27239. doi: 10.1038/srep27239.

11.

Reply.

Hervás D, Lahoz A.

Liver Transpl. 2016 Jun;22(6):861. doi: 10.1002/lt.24408. No abstract available.

12.

Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells.

García-Cañaveras JC, López S, Castell JV, Donato MT, Lahoz A.

Anal Bioanal Chem. 2016 Feb;408(4):1217-30. doi: 10.1007/s00216-015-9227-8. Epub 2016 Jan 14.

PMID:
26769129
13.

Von Willebrand factor is associated with atrial fibrillation development in ischaemic patients after cardiac surgery.

Hernández-Romero D, Lahoz Á, Roldan V, Jover E, Romero-Aniorte AI, Martinez CM, Jara-Rubio R, Arribas JM, Garcia-Alberola A, Cánovas S, Valdés M, Marín F.

Europace. 2016 Sep;18(9):1328-34. doi: 10.1093/europace/euv354. Epub 2015 Nov 12.

PMID:
26566941
14.

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells.

García-Cañaveras JC, Jiménez N, Gómez-Lechón MJ, Castell JV, Donato MT, Lahoz A.

Electrophoresis. 2015 Sep;36(18):2294-2302. doi: 10.1002/elps.201500095. Epub 2015 Jul 22.

PMID:
26031481
15.

TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.

Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, Barbier-Torres L, Lahoz A, Parés A, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, Beraza N.

Lab Invest. 2015 Feb;95(2):223-36. doi: 10.1038/labinvest.2014.151. Epub 2014 Dec 22.

16.

Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species.

García-Cañaveras JC, Donato MT, Lahoz A.

Methods Mol Biol. 2014;1198:233-47. doi: 10.1007/978-1-4939-1258-2_15.

PMID:
25270933
17.

A score model for the continuous grading of early allograft dysfunction severity.

Pareja E, Cortes M, Hervás D, Mir J, Valdivieso A, Castell JV, Lahoz A.

Liver Transpl. 2015 Jan;21(1):38-46. doi: 10.1002/lt.23990. Epub 2014 Nov 24.

18.

In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS.

Carretero A, León Z, García-Cañaveras JC, Zaragoza A, Gómez-Lechón MJ, Donato MT, Lahoz A.

Anal Bioanal Chem. 2014 Sep;406(22):5465-76. doi: 10.1007/s00216-014-7983-5. Epub 2014 Jun 27.

PMID:
24969468
19.

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.

Jetten MJ, Claessen SM, Dejong CH, Lahoz A, Castell JV, van Delft JH, Kleinjans JC.

Toxicology. 2014 Sep 2;323:61-9. doi: 10.1016/j.tox.2014.06.007. Epub 2014 Jun 17.

PMID:
24949552
20.

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction.

Cortes M, Pareja E, García-Cañaveras JC, Donato MT, Montero S, Mir J, Castell JV, Lahoz A.

J Hepatol. 2014 Sep;61(3):564-74. doi: 10.1016/j.jhep.2014.04.023. Epub 2014 May 2.

PMID:
24798621
21.

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

Benet M, Moya M, Donato MT, Lahoz A, Hervás D, Guzmán C, Gómez-Lechón MJ, Castell JV, Jover R.

Arch Toxicol. 2014 Apr;88(4):967-82. doi: 10.1007/s00204-014-1197-7. Epub 2014 Jan 28.

PMID:
24469900
22.

Feedback regulation of SIN by Etd1 and Rho1 in fission yeast.

Alcaide-Gavilán M, Lahoz A, Daga RR, Jimenez J.

Genetics. 2014 Feb;196(2):455-70. doi: 10.1534/genetics.113.155218. Epub 2013 Dec 13.

23.

High-sensitivity troponin T as a biomarker for the development of atrial fibrillation after cardiac surgery.

Hernández-Romero D, Vílchez JA, Lahoz Á, Romero-Aniorte AI, Orenes-Piñero E, Caballero L, Jara-Rubio R, Arribas JM, García-Alberola A, Valdés M, Lip GY, Marín F.

Eur J Cardiothorac Surg. 2014 Apr;45(4):733-8. doi: 10.1093/ejcts/ezt488. Epub 2013 Oct 25.

PMID:
24163361
24.

Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model.

Solberg R, Escobar J, Arduini A, Torres-Cuevas I, Lahoz A, Sastre J, Saugstad OD, Vento M, Kuligowski J, Quintás G.

PLoS One. 2013 Jun 18;8(6):e66540. doi: 10.1371/journal.pone.0066540. Print 2013.

25.

Metabolomic changes in the rat retina after optic nerve crush.

Agudo-Barriuso M, Lahoz A, Nadal-Nicolás FM, Sobrado-Calvo P, Piquer-Gil M, Díaz-Llopis M, Vidal-Sanz M, Mullor JL.

Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4249-59. doi: 10.1167/iovs.12-11451.

PMID:
23696609
26.

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).

Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R.

J Proteome Res. 2013 Jun 7;12(6):2732-41. doi: 10.1021/pr400085n. Epub 2013 May 15.

PMID:
23641669
27.

Mammalian cell metabolomics: experimental design and sample preparation.

León Z, García-Cañaveras JC, Donato MT, Lahoz A.

Electrophoresis. 2013 Oct;34(19):2762-75. doi: 10.1002/elps.201200605. Epub 2013 May 13. Review.

PMID:
23436493
28.

A tumor suppressor role for srGAP3 in mammary epithelial cells.

Lahoz A, Hall A.

Oncogene. 2013 Oct;32(40):4854-60. doi: 10.1038/onc.2012.489. Epub 2012 Oct 29.

PMID:
23108406
29.

An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.

Lahoz A, Vilà MR, Fabre M, Miquel JM, Rivas M, Maines J, Castell JV, Gómez-Lechón MJ.

Toxicol In Vitro. 2013 Jun;27(4):1410-5. doi: 10.1016/j.tiv.2012.08.001. Epub 2012 Aug 13.

PMID:
22910125
30.

K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.

Magudia K, Lahoz A, Hall A.

J Cell Biol. 2012 Jul 23;198(2):185-94. doi: 10.1083/jcb.201202108.

31.

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A.

J Lipid Res. 2012 Oct;53(10):2231-41. doi: 10.1194/jlr.D028803. Epub 2012 Jul 19.

32.

Successful ultrasound guidance for transversus abdominis plane blocks improves postoperative analgesia after open appendicectomy in children.

Reinoso-Barbero F, Población G, Builes LM, Castro LE, Lahoz AI.

Eur J Anaesthesiol. 2012 Aug;29(8):402-4. doi: 10.1097/EJA.0b013e328353570e. No abstract available.

PMID:
22488336
33.

Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.

Tolosa L, Pinto S, Donato MT, Lahoz A, Castell JV, O'Connor JE, Gómez-Lechón MJ.

Toxicol Sci. 2012 May;127(1):187-98. doi: 10.1093/toxsci/kfs083. Epub 2012 Feb 13.

PMID:
22331495
34.

[Infant mortality in a third level paediatric hospital. therapeutic effort limitation, clinical-pathological agreement and diagnostic accuracy].

Alonso Villán E, Pérez Rodríguez J, Rodríguez JI, Ruiz JA, del Cerro MJ, Hierro L, García Pose A, Aroca A, Asensio A, García-Miguel P, Soto C, del Diego JI, Díaz C, Iglesias A, Lahoz A, Rodríguez I.

An Pediatr (Barc). 2012 Jun;76(6):343-9. doi: 10.1016/j.anpedi.2011.09.025. Epub 2011 Nov 25. Spanish.

35.

Evaluation of cytochrome P450 activities in human hepatocytes in vitro.

Gómez-Lechón MJ, Lahoz A, Castell JV, Donato MT.

Methods Mol Biol. 2012;806:87-97. doi: 10.1007/978-1-61779-367-7_7.

PMID:
22057447
36.

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.

Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R.

Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.

37.

A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A.

J Proteome Res. 2011 Oct 7;10(10):4825-34. doi: 10.1021/pr200629p. Epub 2011 Sep 6.

PMID:
21830829
38.

Novel antihypertensive hexa- and heptapeptides with ACE-inhibiting properties: from the in vitro ACE assay to the spontaneously hypertensive rat.

Ruiz-Giménez P, Marcos JF, Torregrosa G, Lahoz A, Fernández-Musoles R, Valles S, Alborch E, Manzanares P, Salom JB.

Peptides. 2011 Jul;32(7):1431-8. doi: 10.1016/j.peptides.2011.05.013. Epub 2011 May 14.

PMID:
21605609
39.

Exploring mass spectrometry suitability to examine human liver graft metabonomic profiles.

Cortés M, Pareja E, Castell JV, Moya A, Mir J, Lahoz A.

Transplant Proc. 2010 Oct;42(8):2953-8. doi: 10.1016/j.transproceed.2010.07.049.

PMID:
20970580
40.

Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Lahoz A, Alcaide-Gavilán M, Daga RR, Jimenez J.

Genetics. 2010 Dec;186(4):1261-70. doi: 10.1534/genetics.110.121368. Epub 2010 Sep 27.

42.

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.

Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A.

Drug Metab Dispos. 2010 Sep;38(9):1449-55. doi: 10.1124/dmd.110.033605. Epub 2010 May 25.

PMID:
20501911
43.

In vitro evaluation of potential hepatotoxicity induced by drugs.

Gómez-Lechón MJ, Lahoz A, Gombau L, Castell JV, Donato MT.

Curr Pharm Des. 2010 Jun;16(17):1963-77. Review.

PMID:
20236064
44.

Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.

Donato MT, Montero S, Castell JV, Gómez-Lechón MJ, Lahoz A.

Anal Bioanal Chem. 2010 Mar;396(6):2251-63. doi: 10.1007/s00216-009-3441-1. Epub 2010 Feb 10.

PMID:
20145913
45.

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.

Anthérieu S, Chesné C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A, Uusitalo J, Guguen-Guillouzo C, Guillouzo A.

Drug Metab Dispos. 2010 Mar;38(3):516-25. doi: 10.1124/dmd.109.030197. Epub 2009 Dec 17.

PMID:
20019244
46.

Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor.

Bonora-Centelles A, Donato MT, Lahoz A, Pareja E, Mir J, Castell JV, Gómez-Lechón MJ.

Cell Transplant. 2010;19(1):21-8. doi: 10.3727/096368909X474267.

PMID:
19796502
47.

Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes.

Bonora-Centelles A, Jover R, Mirabet V, Lahoz A, Carbonell F, Castell JV, Gómez-Lechón MJ.

Cell Transplant. 2009;18(12):1319-40. doi: 10.3727/096368909X12483162197321. Epub 2009 Aug 5.

PMID:
19660180
48.

Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.

Lahoz A, Donato MT, Picazo L, Castell JV, Gómez-Lechón MJ.

Drug Metab Lett. 2008 Aug;2(3):205-9.

PMID:
19356095
49.

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH.

Drug Metab Dispos. 2009 Jun;37(6):1305-11. doi: 10.1124/dmd.108.025775. Epub 2009 Feb 27.

PMID:
19251822
50.

Functional assessment of the quality of human hepatocyte preparations for cell transplantation.

Donato MT, Lahoz A, Montero S, Bonora A, Pareja E, Mir J, Castell JV, Gómez-Lechón MJ.

Cell Transplant. 2008;17(10-11):1211-9.

PMID:
19181215

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