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Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.

Aaker JD, Elbaz B, Wu Y, Looney TJ, Zhang L, Lahn BT, Popko B.

ASN Neuro. 2016 Sep 28;8(5). pii: 1759091416670749. Print 2016 Oct.


TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.

Ke Q, Li W, Lai X, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q, Yang S, Xiang AP.

Cell Res. 2016 Sep;26(9):1048-61. doi: 10.1038/cr.2016.93. Epub 2016 Aug 9.


Distribution of the cytoskeletal protein, Nestin, in acute leukemia.

Du X, Yang XH, Wu YF, Liang J, Zhang J, Huang ZC, Zhu ZP, Lin W, Zou MX, Wen JY, Wu SJ, Guo R, Zhang XM, Lahn BT, He F, Xiang AP.

Biotech Histochem. 2015 Jul;90(5):384-94. doi: 10.3109/10520295.2014.988751. Epub 2015 Apr 3.


Nestin(+) kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury.

Jiang MH, Li G, Liu J, Liu L, Wu B, Huang W, He W, Deng C, Wang D, Li C, Lahn BT, Shi C, Xiang AP.

Biomaterials. 2015 May;50:56-66. doi: 10.1016/j.biomaterials.2015.01.029. Epub 2015 Feb 14.


Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.

Jiang MH, Cai B, Tuo Y, Wang J, Zang ZJ, Tu X, Gao Y, Su Z, Li W, Li G, Zhang M, Jiao J, Wan Z, Deng C, Lahn BT, Xiang AP.

Cell Res. 2014 Dec;24(12):1466-85. doi: 10.1038/cr.2014.149. Epub 2014 Nov 21.


Involvement of extracellular factors in maintaining self-renewal of neural stem cell by nestin.

Di CG, Xiang AP, Jia L, Liu JF, Lahn BT, Ma BF.

Neuroreport. 2014 Jul 9;25(10):782-7. doi: 10.1097/WNR.0000000000000177. Erratum in: Neuroreport. 2016 Mar 23;27(5):366.


Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA.

Cell Rep. 2014 Jan 16;6(1):231-244. doi: 10.1016/j.celrep.2013.11.044. Epub 2013 Dec 27.


Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells.

Looney TJ, Zhang L, Chen CH, Lee JH, Chari S, Mao FF, Pelizzola M, Zhang L, Lister R, Baker SW, Fernandes CJ, Gaetz J, Foshay KM, Clift KL, Zhang Z, Li WQ, Vallender EJ, Wagner U, Qin JY, Michelini KJ, Bugarija B, Park D, Aryee E, Stricker T, Zhou J, White KP, Ren B, Schroth GP, Ecker JR, Xiang AP, Lahn BT.

Genome Res. 2014 Feb;24(2):267-80. doi: 10.1101/gr.143891.112. Epub 2013 Dec 5.


Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells.

Chen F, Cai B, Gao Y, Yuan X, Cheng F, Wang T, Jiang M, Zhou Y, Lahn BT, Li W, Xiang AP.

Biomaterials. 2013 Feb;34(6):1701-11. doi: 10.1016/j.biomaterials.2012.11.018. Epub 2012 Dec 4.


Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.

Ostler KR, Yang Q, Looney TJ, Zhang L, Vasanthakumar A, Tian Y, Kocherginsky M, Raimondi SL, DeMaio JG, Salwen HR, Gu S, Chlenski A, Naranjo A, Gill A, Peddinti R, Lahn BT, Cohn SL, Godley LA.

Cancer Res. 2012 Sep 15;72(18):4714-23. doi: 10.1158/0008-5472.CAN-12-0886. Epub 2012 Jul 18.


Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming.

Foshay KM, Looney TJ, Chari S, Mao FF, Lee JH, Zhang L, Fernandes CJ, Baker SW, Clift KL, Gaetz J, Di CG, Xiang AP, Lahn BT.

Mol Cell. 2012 Apr 27;46(2):159-70. doi: 10.1016/j.molcel.2012.02.013. Epub 2012 Mar 22.


Protecting against wayward human induced pluripotent stem cells with a suicide gene.

Cheng F, Ke Q, Chen F, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W, Xiang AP.

Biomaterials. 2012 Apr;33(11):3195-204. doi: 10.1016/j.biomaterials.2012.01.023. Epub 2012 Jan 24.


Evidence for a critical role of gene occlusion in cell fate restriction.

Gaetz J, Clift KL, Fernandes CJ, Mao FF, Lee JH, Zhang L, Baker SW, Looney TJ, Foshay KM, Yu WH, Xiang AP, Lahn BT.

Cell Res. 2012 May;22(5):848-58. doi: 10.1038/cr.2011.190. Epub 2011 Nov 29.


PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells.

Yu WH, Li FG, Chen XY, Li JT, Wu YH, Huang LH, Wang Z, Li P, Wang T, Lahn BT, Xiang AP.

Int J Biochem Cell Biol. 2012 Feb;44(2):377-84. doi: 10.1016/j.biocel.2011.11.013. Epub 2011 Nov 23.


Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.

Song CX, Szulwach KE, Fu Y, Dai Q, Yi C, Li X, Li Y, Chen CH, Zhang W, Jian X, Wang J, Zhang L, Looney TJ, Zhang B, Godley LA, Hicks LM, Lahn BT, Jin P, He C.

Nat Biotechnol. 2011 Jan;29(1):68-72. doi: 10.1038/nbt.1732. Epub 2010 Dec 12.


Nestin is required for the proper self-renewal of neural stem cells.

Park D, Xiang AP, Mao FF, Zhang L, Di CG, Liu XM, Shao Y, Ma BF, Lee JH, Ha KS, Walton N, Lahn BT.

Stem Cells. 2010 Dec;28(12):2162-71. doi: 10.1002/stem.541.


The "occlusis" model of cell fate restriction.

Lahn BT.

Bioessays. 2011 Jan;33(1):13-20. doi: 10.1002/bies.201000090. Epub 2010 Oct 15.


A stem cell-based tool for small molecule screening in adipogenesis.

Qin J, Li WQ, Zhang L, Chen F, Liang WH, Mao FF, Zhang XM, Lahn BT, Yu WH, Xiang AP.

PLoS One. 2010 Sep 27;5(9):e13014. doi: 10.1371/journal.pone.0013014.


Multiple mesodermal lineage differentiation of Apodemus sylvaticus embryonic stem cells in vitro.

Wang T, Mao FF, Lai W, Li W, Yu W, Wang Z, Zhang L, Zhang J, Niu J, Zhang X, Lahn BT, Xiang AP.

BMC Cell Biol. 2010 Jun 19;11:42. doi: 10.1186/1471-2121-11-42.


Systematic comparison of constitutive promoters and the doxycycline-inducible promoter.

Qin JY, Zhang L, Clift KL, Hulur I, Xiang AP, Ren BZ, Lahn BT.

PLoS One. 2010 May 12;5(5):e10611. doi: 10.1371/journal.pone.0010611.


Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors.

Li W, Liu C, Qin J, Zhang L, Chen R, Chen J, Yu X, Wu G, Lahn BT, Fu Y, Xiang AP.

Cell Transplant. 2010;19(9):1181-93. doi: 10.3727/096368910X504469. Epub 2010 May 4.


Geometric cues for directing the differentiation of mesenchymal stem cells.

Kilian KA, Bugarija B, Lahn BT, Mrksich M.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4872-7. doi: 10.1073/pnas.0903269107. Epub 2010 Mar 1.


Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients.

Chen Z, Wang T, Luo H, Lai Y, Yang X, Li F, Lei Y, Su C, Zhang X, Lahn BT, Xiang AP.

Hum Pathol. 2010 May;41(5):737-44. doi: 10.1016/j.humpath.2009.10.018. Epub 2010 Feb 4.


Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test.

Chen R, Chen J, Cheng S, Qin J, Li W, Zhang L, Jiao H, Yu X, Zhang X, Lahn BT, Xiang AP.

Toxicol Mech Methods. 2010 Mar;20(3):112-8. doi: 10.3109/15376510903585450.


Generation of functional hepatocytes from mouse induced pluripotent stem cells.

Li W, Wang D, Qin J, Liu C, Zhang Q, Zhang X, Yu X, Lahn BT, Mao FF, Xiang AP.

J Cell Physiol. 2010 Mar;222(3):492-501. doi: 10.1002/jcp.22000.


Let's celebrate human genetic diversity.

Lahn BT, Ebenstein L.

Nature. 2009 Oct 8;461(7265):726-8. doi: 10.1038/461726a. No abstract available.


Chromatin analysis of occluded genes.

Lee JH, Gaetz J, Bugarija B, Fernandes CJ, Snyder GE, Bush EC, Lahn BT.

Hum Mol Genet. 2009 Jul 15;18(14):2567-74. doi: 10.1093/hmg/ddp188. Epub 2009 Apr 20.


The radial glia antibody RC2 recognizes a protein encoded by Nestin.

Park D, Xiang AP, Zhang L, Mao FF, Walton NM, Choi SS, Lahn BT.

Biochem Biophys Res Commun. 2009 May 8;382(3):588-92. doi: 10.1016/j.bbrc.2009.03.074. Epub 2009 Mar 18.


Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells.

Ke H, Wang P, Yu W, Liu X, Liu C, Yang F, Mao FF, Zhang L, Zhang X, Lahn BT, Xiang AP.

Differentiation. 2009 Mar;77(3):256-62. doi: 10.1016/j.diff.2008.09.021. Epub 2008 Dec 2.


Systematic identification of cis-silenced genes by trans complementation.

Lee JH, Bugarija B, Millan EJ, Walton NM, Gaetz J, Fernandes CJ, Yu WH, Mekel-Bobrov N, Vallender TW, Snyder GE, Xiang AP, Lahn BT.

Hum Mol Genet. 2009 Mar 1;18(5):835-46. doi: 10.1093/hmg/ddn409. Epub 2008 Dec 2.


Genetic basis of human brain evolution.

Vallender EJ, Mekel-Bobrov N, Lahn BT.

Trends Neurosci. 2008 Dec;31(12):637-44. doi: 10.1016/j.tins.2008.08.010. Epub 2008 Oct 8. Review.


Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells.

Peng Y, Chen Z, Yu W, Zhou Q, Xu L, Mao FF, Huang G, Zhang X, Li S, Lahn BT, Xiang AP.

Cell Biol Int. 2008 Oct;32(10):1265-71. doi: 10.1016/j.cellbi.2008.07.011. Epub 2008 Jul 23.


Isolation, characterization and gene modification of fetal neural stem/progenitor cells from cynomolgus monkey.

Wang P, Liu XM, Liu XM, Ma BF, Jia L, Wang D, Zhang XM, Yu XB, Lahn BT, Xiang AP.

Neuroreport. 2008 Mar 5;19(4):419-24. doi: 10.1097/WNR.0b013e3282f76136.


A genome-wide screen for noncoding elements important in primate evolution.

Bush EC, Lahn BT.

BMC Evol Biol. 2008 Jan 23;8:17. doi: 10.1186/1471-2148-8-17.


A genetic legacy from archaic Homo.

Hawks J, Cochran G, Harpending HC, Lahn BT.

Trends Genet. 2008 Jan;24(1):19-23. Epub 2007 Dec 3.


Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells.

Yu W, Chen Z, Zhang J, Zhang L, Ke H, Huang L, Peng Y, Zhang X, Li S, Lahn BT, Xiang AP.

Mol Cell Biochem. 2008 Mar;310(1-2):11-8. Epub 2007 Dec 2.


Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host.

Xiang AP, Mao FF, Li WQ, Park D, Ma BF, Wang T, Vallender TW, Vallender EJ, Zhang L, Lee J, Waters JA, Zhang XM, Yu XB, Li SN, Lahn BT.

Hum Mol Genet. 2008 Jan 1;17(1):27-37. Epub 2007 Oct 3.


Uncovering the mutation-fixation correlation in short lineages.

Vallender EJ, Lahn BT.

BMC Evol Biol. 2007 Sep 21;7:168.


Nestin expression in different tumours and its relevance to malignant grade.

Yang XH, Wu QL, Yu XB, Xu CX, Ma BF, Zhang XM, Li SN, Lahn BT, Xiang AP.

J Clin Pathol. 2008 Apr;61(4):467-73. Epub 2007 Sep 14.


Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.

Niemann S, Landers JE, Churchill MJ, Hosler B, Sapp P, Speed WC, Lahn BT, Kidd KK, Brown RH Jr, Hayashi Y.

Neurology. 2008 Feb 26;70(9):666-76. Epub 2007 Aug 8.


Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells.

Zhang AX, Yu WH, Ma BF, Yu XB, Mao FF, Liu W, Zhang JQ, Zhang XM, Li SN, Li MT, Lahn BT, Xiang AP.

Mol Cell Biochem. 2007 Oct;304(1-2):167-79. Epub 2007 May 26.


Mathematical models for the proliferation of neural stem/progenitor cells in clonogenic culture.

Ma BF, Liu XM, Zhang AX, Wang P, Zhang XM, Li SN, Lahn BT, Xiang AP.

Rejuvenation Res. 2007 Jun;10(2):205-14.


Establishment and characterization of two new human embryonic stem cell lines, SYSU-1 and SYSU-2.

Huang G, Li WQ, Chen R, Chen ZG, Zhang XM, Mao FX, Huang SL, Li SN, Lahn BT, Xiang AP.

Chin Med J (Engl). 2007 Apr 5;120(7):589-94.


Evolutionary and biomedical insights from the rhesus macaque genome.

Rhesus Macaque Genome Sequencing and Analysis Consortium, Gibbs RA, Rogers J, Katze MG, Bumgarner R, Weinstock GM, Mardis ER, Remington KA, Strausberg RL, Venter JC, Wilson RK, Batzer MA, Bustamante CD, Eichler EE, Hahn MW, Hardison RC, Makova KD, Miller W, Milosavljevic A, Palermo RE, Siepel A, Sikela JM, Attaway T, Bell S, Bernard KE, Buhay CJ, Chandrabose MN, Dao M, Davis C, Delehaunty KD, Ding Y, Dinh HH, Dugan-Rocha S, Fulton LA, Gabisi RA, Garner TT, Godfrey J, Hawes AC, Hernandez J, Hines S, Holder M, Hume J, Jhangiani SN, Joshi V, Khan ZM, Kirkness EF, Cree A, Fowler RG, Lee S, Lewis LR, Li Z, Liu YS, Moore SM, Muzny D, Nazareth LV, Ngo DN, Okwuonu GO, Pai G, Parker D, Paul HA, Pfannkoch C, Pohl CS, Rogers YH, Ruiz SJ, Sabo A, Santibanez J, Schneider BW, Smith SM, Sodergren E, Svatek AF, Utterback TR, Vattathil S, Warren W, White CS, Chinwalla AT, Feng Y, Halpern AL, Hillier LW, Huang X, Minx P, Nelson JO, Pepin KH, Qin X, Sutton GG, Venter E, Walenz BP, Wallis JW, Worley KC, Yang SP, Jones SM, Marra MA, Rocchi M, Schein JE, Baertsch R, Clarke L, Csürös M, Glasscock J, Harris RA, Havlak P, Jackson AR, Jiang H, Liu Y, Messina DN, Shen Y, Song HX, Wylie T, Zhang L, Birney E, Han K, Konkel MK, Lee J, Smit AF, Ullmer B, Wang H, Xing J, Burhans R, Cheng Z, Karro JE, Ma J, Raney B, She X, Cox MJ, Demuth JP, Dumas LJ, Han SG, Hopkins J, Karimpour-Fard A, Kim YH, Pollack JR, Vinar T, Addo-Quaye C, Degenhardt J, Denby A, Hubisz MJ, Indap A, Kosiol C, Lahn BT, Lawson HA, Marklein A, Nielsen R, Vallender EJ, Clark AG, Ferguson B, Hernandez RD, Hirani K, Kehrer-Sawatzki H, Kolb J, Patil S, Pu LL, Ren Y, Smith DG, Wheeler DA, Schenck I, Ball EV, Chen R, Cooper DN, Giardine B, Hsu F, Kent WJ, Lesk A, Nelson DL, O'brien WE, Prüfer K, Stenson PD, Wallace JC, Ke H, Liu XM, Wang P, Xiang AP, Yang F, Barber GP, Haussler D, Karolchik D, Kern AD, Kuhn RM, Smith KE, Zwieg AS.

Science. 2007 Apr 13;316(5822):222-34.


The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.

Mekel-Bobrov N, Posthuma D, Gilbert SL, Lind P, Gosso MF, Luciano M, Harris SE, Bates TC, Polderman TJ, Whalley LJ, Fox H, Starr JM, Evans PD, Montgomery GW, Fernandes C, Heutink P, Martin NG, Boomsma DI, Deary IJ, Wright MJ, de Geus EJ, Lahn BT.

Hum Mol Genet. 2007 Mar 15;16(6):600-8. Epub 2007 Jan 12.


What makes us human: revisiting an age-old question in the genomic era.

Mekel-Bobrov N, Lahn BT.

J Biomed Discov Collab. 2006 Nov 29;1:18.


Multiple independent origins of sex chromosomes in amniotes.

Vallender EJ, Lahn BT.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18031-2. Epub 2006 Nov 20. No abstract available.


Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.

Evans PD, Mekel-Bobrov N, Vallender EJ, Hudson RR, Lahn BT.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18178-83. Epub 2006 Nov 7.


The evolution of word composition in metazoan promoter sequence.

Bush EC, Lahn BT.

PLoS Comput Biol. 2006 Nov 3;2(11):e150. Epub 2006 Sep 28.


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