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Items: 29

1.

Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.

Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard AD, Jenkins SL, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark NR, Jones MR, Kou Y, Goff T, Woodland H, Amaral FMR, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bausela XB, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dishuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Dae Devlin T, Pérez-García V, Ma'ayan A.

Nat Commun. 2016 Sep 26;7:12846. doi: 10.1038/ncomms12846.

2.

Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.

Bolton HA, Zhu E, Terry AM, Guy TV, Koh WP, Tan SY, Power CA, Bertolino P, Lahl K, Sparwasser T, Shklovskaya E, Fazekas de St Groth B.

J Clin Invest. 2015 Sep;125(9):3627-41. doi: 10.1172/JCI76031. Epub 2015 Aug 24.

3.

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production.

Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R.

J Immunol. 2015 Aug 15;195(4):1753-62. doi: 10.4049/jimmunol.1400658. Epub 2015 Jul 13.

4.

Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid.

Zeng R, Bscheider M, Lahl K, Lee M, Butcher EC.

Mucosal Immunol. 2016 Jan;9(1):183-93. doi: 10.1038/mi.2015.50. Epub 2015 Jul 1.

5.

Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.

Mayer CT, Lahl K, Milanez-Almeida P, Watts D, Dittmer U, Fyhrquist N, Huehn J, Kopf M, Kretschmer K, Rouse B, Sparwasser T.

Immun Inflamm Dis. 2014 Nov;2(3):162-5. doi: 10.1002/iid3.33. Epub 2014 Oct 26.

6.

Orphan chemoattractant receptor GPR15 mediates dendritic epidermal T-cell recruitment to the skin.

Lahl K, Sweere J, Pan J, Butcher E.

Eur J Immunol. 2014 Sep;44(9):2577-81. doi: 10.1002/eji.201444628. Epub 2014 Jun 24.

7.

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.

Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC.

Nat Immunol. 2014 Jan;15(1):98-108. doi: 10.1038/ni.2768. Epub 2013 Dec 1.

8.

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.

Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T.

PLoS Pathog. 2013;9(9):e1003648. doi: 10.1371/journal.ppat.1003648. Epub 2013 Sep 26.

9.

Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses.

Deal EM, Lahl K, Narváez CF, Butcher EC, Greenberg HB.

J Clin Invest. 2013 Jun;123(6):2464-74. doi: 10.1172/JCI60945. Epub 2013 May 1.

10.

The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model.

Lehtimäki S, Savinko T, Lahl K, Sparwasser T, Wolff H, Lauerma A, Alenius H, Fyhrquist N.

J Invest Dermatol. 2012 Dec;132(12):2744-51. doi: 10.1038/jid.2012.212. Epub 2012 Jun 28.

11.

Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.

Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, Pachynski R, Nguyen L, Ghodsi A, Adler S, Butcher EC.

Immunity. 2012 Mar 23;36(3):438-50. doi: 10.1016/j.immuni.2012.01.017.

12.

Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection.

Cervantes-Barragán L, Firner S, Bechmann I, Waisman A, Lahl K, Sparwasser T, Thiel V, Ludewig B.

J Immunol. 2012 Apr 15;188(8):3678-85. doi: 10.4049/jimmunol.1102422. Epub 2012 Mar 9.

13.

Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis.

Fyhrquist N, Lehtimäki S, Lahl K, Savinko T, Lappeteläinen AM, Sparwasser T, Wolff H, Lauerma A, Alenius H.

J Invest Dermatol. 2012 Jun;132(6):1672-80. doi: 10.1038/jid.2012.40. Epub 2012 Mar 8.

14.

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.

Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H, Stockinger B.

Nat Immunol. 2011 Oct 9;12(11):1071-7. doi: 10.1038/ni.2133.

15.

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.

Beyer M, Thabet Y, Müller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schönfeld EA, Böttcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL.

Nat Immunol. 2011 Aug 14;12(9):898-907. doi: 10.1038/ni.2084.

16.

Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells.

Weiss EM, Schmidt A, Vobis D, Garbi N, Lahl K, Mayer CT, Sparwasser T, Ludwig A, Suri-Payer E, Oberle N, Krammer PH.

J Immunol. 2011 Aug 15;187(4):1684-91. doi: 10.4049/jimmunol.1002321. Epub 2011 Jul 11.

17.

CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.

Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, Sparwasser T.

Eur J Immunol. 2011 Mar;41(3):716-25. doi: 10.1002/eji.201040913. Epub 2011 Feb 11.

18.

IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.

Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, DePinho RA, Basta S, Ohashi PS, Mak TW.

Cell. 2011 Feb 18;144(4):601-13. doi: 10.1016/j.cell.2011.01.011. Epub 2011 Feb 3.

19.

In vivo depletion of FoxP3+ Tregs using the DEREG mouse model.

Lahl K, Sparwasser T.

Methods Mol Biol. 2011;707:157-72. doi: 10.1007/978-1-61737-979-6_10.

PMID:
21287334
20.

Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.

Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J, Sparwasser T.

Cancer Res. 2010 Oct 15;70(20):7788-99. doi: 10.1158/0008-5472.CAN-10-1736. Epub 2010 Oct 5.

21.

Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation.

Baru AM, Hartl A, Lahl K, Krishnaswamy JK, Fehrenbach H, Yildirim AO, Garn H, Renz H, Behrens GM, Sparwasser T.

Eur J Immunol. 2010 Aug;40(8):2259-66. doi: 10.1002/eji.200939972. Erratum in: Eur J Immunol. 2010 Sep;40(9):2655.

22.

FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.

Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T, Probst HC, van den Broek M.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):199-203. doi: 10.1073/pnas.0910620107. Epub 2009 Dec 15.

23.

Immunostimulatory RNA blocks suppression by regulatory T cells.

Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S.

J Immunol. 2010 Jan 15;184(2):939-46. doi: 10.4049/jimmunol.0901245. Epub 2009 Dec 4.

24.

Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice.

Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, deRoos P, Rudensky A, Sparwasser T.

J Immunol. 2009 Dec 15;183(12):7631-4. doi: 10.4049/jimmunol.0804308.

25.

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.

Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T.

J Immunol. 2009 Nov 1;183(9):5662-72. doi: 10.4049/jimmunol.0803762. Epub 2009 Oct 7.

26.

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.

Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW.

Nat Med. 2009 May;15(5):528-36. doi: 10.1038/nm.1953. Epub 2009 Apr 26. Erratum in: Nat Med. 2009 Jul;15(7):819.

PMID:
19396174
27.

DC activated via dectin-1 convert Treg into IL-17 producers.

Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, Reis e Sousa C.

Eur J Immunol. 2008 Dec;38(12):3274-81. doi: 10.1002/eji.200838950.

28.

Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity.

Heit A, Gebhardt F, Lahl K, Neuenhahn M, Schmitz F, Anderl F, Wagner H, Sparwasser T, Busch DH, Kastenmüller K.

Eur J Immunol. 2008 Jun;38(6):1585-97. doi: 10.1002/eji.200737966.

29.

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.

Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann A, Wagner H, Huehn J, Sparwasser T.

J Exp Med. 2007 Jan 22;204(1):57-63. Epub 2007 Jan 2.

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