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MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties.

Chopra N, Wang R, Maloney B, Nho K, Beck JS, Pourshafie N, Niculescu A, Saykin AJ, Rinaldi C, Counts SE, Lahiri DK.

Mol Psychiatry. 2020 Jan 15. doi: 10.1038/s41380-019-0610-2. [Epub ahead of print]


Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease.

Maloney B, Balaraman Y, Liu Y, Chopra N, Edenberg HJ, Kelsoe J, Nurnberger JI, Lahiri DK.

Sci Rep. 2019 Dec 4;9(1):18261. doi: 10.1038/s41598-019-54076-3.


Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs.

Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A, Robertson H, Jones T, Strasburger A, Williams A, Kurian SM, Lamb B, Shekhar A, Lahiri DK, Saykin AJ.

Mol Psychiatry. 2019 Dec 2. doi: 10.1038/s41380-019-0602-2. [Epub ahead of print]


Moon missions spark the human imagination.

Lahiri DK.

Science. 2019 Nov 1;366(6465):581. doi: 10.1126/science.aaz6067. No abstract available.


M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.

Konar A, Gupta R, Shukla RK, Maloney B, Khanna VK, Wadhwa R, Lahiri DK, Thakur MK.

Sci Rep. 2019 Sep 30;9(1):13990. doi: 10.1038/s41598-019-48238-6.


APPealing for a role in cellular iron efflux.

Lahiri DK, Maloney B, Wang R.

J Biol Chem. 2019 Jun 14;294(24):9365. doi: 10.1074/jbc.L119.009216. No abstract available.


Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD.

Lahiri DK.

Curr Alzheimer Res. 2019;16(4):279-280. doi: 10.2174/156720501604190424114752.


Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder.

Sokol DK, Maloney B, Westmark CJ, Lahiri DK.

Front Psychiatry. 2019 Apr 10;10:165. doi: 10.3389/fpsyt.2019.00165. eCollection 2019. Review.


Biological Hallmarks of Cancer in Alzheimer's Disease.

Nudelman KNH, McDonald BC, Lahiri DK, Saykin AJ.

Mol Neurobiol. 2019 Oct;56(10):7173-7187. doi: 10.1007/s12035-019-1591-5. Epub 2019 Apr 16. Review.


Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation.

Witek E, Hickman D, Lahiri DK, Srinivasan M.

Front Aging Neurosci. 2019 Jan 25;10:432. doi: 10.3389/fnagi.2018.00432. eCollection 2018.


Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta).

Duffy KB, Ray B, Lahiri DK, Tilmont EM, Tinkler GP, Herbert RL, Greig NH, Ingram DK, Ottinger MA, Mattison JA.

J Alzheimers Dis. 2019;68(1):115-126. doi: 10.3233/JAD-180487.


Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease.

Long JM, Maloney B, Rogers JT, Lahiri DK.

Mol Psychiatry. 2019 Mar;24(3):345-363. doi: 10.1038/s41380-018-0266-3. Epub 2018 Nov 23.


Nuclear factor-kappa B: Glucocorticoid-induced leucine zipper interface analogs suppress pathology in an Alzheimer's disease model.

Srinivasan M, Lahiri N, Thyagarajan A, Witek E, Hickman D, Lahiri DK.

Alzheimers Dement (N Y). 2018 May 24;4:488-498. doi: 10.1016/j.trci.2018.04.004. eCollection 2018.


Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.

Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, Ströbel P, Michalke B, Rogers JT.

J Neurochem. 2018 Dec;147(6):831-848. doi: 10.1111/jnc.14580. Epub 2018 Nov 19.


Understanding Healthy Protective Mechanisms Against Old Age.

Lahiri DK.

Curr Aging Sci. 2018;11(1):2-3. doi: 10.2174/187460981101180727124958. No abstract available.


Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis.

Maloney B, Bayon BL, Zawia NH, Lahiri DK.

Neurotoxicology. 2018 Sep;68:126-132. doi: 10.1016/j.neuro.2018.06.016. Epub 2018 Jul 5.


A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.

Konar A, Kumar A, Maloney B, Lahiri DK, Thakur MK.

Sci Rep. 2018 Jul 2;8(1):9928. doi: 10.1038/s41598-018-27640-6.


(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer's Disease.

Becker RE, Greig NH, Lahiri DK, Bledsoe J, Majercik S, Ballard C, Aarsland D, Schneider LS, Flanagan D, Govindarajan R, Sano M, Ferrucci L, Kapogiannis D.

Curr Alzheimer Res. 2018;15(9):883-891. doi: 10.2174/1567205015666180110120026. Review.


Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders.

Lahiri DK, Maloney B, Greig NH.

J Biol Chem. 2017 Dec 8;292(49):20353. doi: 10.1074/jbc.L117.000502. No abstract available.


When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author.

Lahiri DK, Maloney B, Sambamurti K.

Gene. 2017 Nov 30;635:46-47. doi: 10.1016/j.gene.2017.08.011. Epub 2017 Sep 6.


A cardinal sin when researching neuropsin/KLK8: Thou shalt validate antibodies.

Lahiri DK, Konar A, Thakur MK, Maloney B.

Alzheimers Dement. 2017 Sep;13(9):1068-1069. doi: 10.1016/j.jalz.2016.12.016. Epub 2017 Jul 18. No abstract available.


Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease.

Srinivasan M, Lahiri DK.

Mol Neurobiol. 2017 Dec;54(10):8063-8070. doi: 10.1007/s12035-016-0277-5. Epub 2016 Nov 26. Review.


Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells.

Srinivasan M, Bayon B, Chopra N, Lahiri DK.

PLoS One. 2016 Oct 20;11(10):e0160314. doi: 10.1371/journal.pone.0160314. eCollection 2016.


Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism.

Erickson CA, Ray B, Wink LK, Bayon BL, Pedapati EV, Shaffer R, Schaefer TL, Lahiri DK.

J Psychiatr Res. 2017 Jan;84:153-160. doi: 10.1016/j.jpsychires.2016.09.003. Epub 2016 Sep 9.


Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease.

Decourt B, Lahiri DK, Sabbagh MN.

Curr Alzheimer Res. 2017;14(4):412-425. doi: 10.2174/1567205013666160930110551. Review.


Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism.

Westmark CJ, Sokol DK, Maloney B, Lahiri DK.

Mol Psychiatry. 2016 Oct;21(10):1333-41. doi: 10.1038/mp.2016.134. Epub 2016 Aug 30. Review.


Analysis of peripheral amyloid precursor protein in Angelman Syndrome.

Erickson CA, Wink LK, Baindu B, Ray B, Schaefer TL, Pedapati EV, Lahiri DK.

Am J Med Genet A. 2016 Sep;170(9):2334-7. doi: 10.1002/ajmg.a.37811. Epub 2016 Jun 21.


Epigenetics of dementia: understanding the disease as a transformation rather than a state.

Maloney B, Lahiri DK.

Lancet Neurol. 2016 Jun;15(7):760-774. doi: 10.1016/S1474-4422(16)00065-X. Epub 2016 May 9. Review.


Potential for Stem Cells Therapy in Alzheimer's Disease: Do Neurotrophic Factors Play Critical Role?

Bali P, Lahiri DK, Banik A, Nehru B, Anand A.

Curr Alzheimer Res. 2017;14(2):208-220. Review.


Transgenerational latent early-life associated regulation unites environment and genetics across generations.

Lahiri DK, Maloney B, Bayon BL, Chopra N, White FA, Greig NH, Nurnberger JI.

Epigenomics. 2016 Mar;8(3):373-87. doi: 10.2217/epi.15.117. Epub 2016 Mar 7.


A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5.

Shah K, Lahiri DK.

Mol Neurobiol. 2017 Apr;54(3):2255-2268. doi: 10.1007/s12035-016-9792-7. Epub 2016 Mar 5. Review.


Editorial: Translational Alzheimer's Disease Research.

Huang Y, Lahiri DK.

Curr Alzheimer Res. 2016;13(3):214. No abstract available.


Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke.

Kim E, Woo MS, Qin L, Ma T, Beltran CD, Bao Y, Bailey JA, Corbett D, Ratan RR, Lahiri DK, Cho S.

J Neurosci. 2015 Nov 11;35(45):15113-26. doi: 10.1523/JNEUROSCI.2890-15.2015.


Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.

Sarkar S, Raymick J, Ray B, Lahiri DK, Paule MG, Schmued L.

Curr Alzheimer Res. 2015;12(9):837-46.


Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?

Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y, Mudher A, Padjen AL, Mukaetova-Ladinska E, Ihara M, Srivastava S, Padma Srivastava MV, Masters CL, Kalaria RN, Anand A.

J Alzheimers Dis. 2015;47(4):815-43. doi: 10.3233/JAD-150136. Review.


What is aging for? That remains the question.

Lahiri DK.

Curr Aging Sci. 2015;8(1):1. No abstract available.


What can triumphs and tribulations from drug research in Alzheimer's disease tell us about the development of psychotropic drugs in general?

Becker RE, Seeman MV, Greig NH, Lahiri DK.

Lancet Psychiatry. 2015 Aug;2(8):756-764. doi: 10.1016/S2215-0366(15)00214-X. Review.


Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains.

Balaraman Y, Lahiri DK, Nurnberger JI.

Mol Neuropsychiatry. 2015 May;1(1):23-35. doi: 10.1159/000371886. Epub 2015 Feb 20. Review.


View of excellent ROAD from the CAR.

Lahiri DK.

Curr Alzheimer Res. 2015;12(2):96-9. No abstract available.


Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis.

Srinivasan M, Lahiri DK.

Expert Opin Ther Targets. 2015 Apr;19(4):471-87. doi: 10.1517/14728222.2014.989834. Epub 2015 Feb 4. Review.


Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation.

Srinivasan M, Blackburn C, Lahiri DK.

Drug Des Devel Ther. 2014 Dec 3;8:2409-21. doi: 10.2147/DDDT.S59722. eCollection 2014.


Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.

Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K.

Curr Alzheimer Res. 2015;12(1):32-46.


Impact of acamprosate on plasma amyloid-β precursor protein in youth: a pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker.

Erickson CA, Ray B, Maloney B, Wink LK, Bowers K, Schaefer TL, McDougle CJ, Sokol DK, Lahiri DK.

J Psychiatr Res. 2014 Dec;59:220-8. doi: 10.1016/j.jpsychires.2014.07.011. Epub 2014 Aug 19.


Human primary mixed brain cultures: preparation, differentiation, characterization and application to neuroscience research.

Ray B, Chopra N, Long JM, Lahiri DK.

Mol Brain. 2014 Sep 16;7:63. doi: 10.1186/s13041-014-0063-0.


Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment.

Greig NH, Sambamurti K, Lahiri DK, Becker RE.

Ann Neurol. 2014 Oct;76(4):629-30. doi: 10.1002/ana.24254. Epub 2014 Sep 5. No abstract available.


Cdk5 activity in the brain - multiple paths of regulation.

Shah K, Lahiri DK.

J Cell Sci. 2014 Jun 1;127(Pt 11):2391-400. doi: 10.1242/jcs.147553. Review.


Role of early life exposure and environment on neurodegeneration: implications on brain disorders.

Modgil S, Lahiri DK, Sharma VL, Anand A.

Transl Neurodegener. 2014 Apr 29;3:9. doi: 10.1186/2047-9158-3-9. eCollection 2014. Review.

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