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Items: 1 to 50 of 199

1.

Immunological biomarkers for the development and progression of type 1 diabetes.

Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T.

Diabetologia. 2018 Sep 12. doi: 10.1007/s00125-018-4726-8. [Epub ahead of print] Review.

PMID:
30209538
2.

Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis.

Bhosale SD, Moulder R, Venäläinen MS, Koskinen JS, Pitkänen N, Juonala MT, Kähönen MAP, Lehtimäki TJ, Viikari JSA, Elo LL, Goodlett DR, Lahesmaa R, Raitakari OT.

Sci Rep. 2018 Jun 15;8(1):9209. doi: 10.1038/s41598-018-27265-9.

3.

snpEnrichR: analyzing co-localization of SNPs and their proxies in genomic regions.

Nousiainen K, Kanduri K, Ricaño-Ponce I, Wijmenga C, Lahesmaa R, Kumar V, Lähdesmäki H.

Bioinformatics. 2018 Jun 7. doi: 10.1093/bioinformatics/bty460. [Epub ahead of print]

PMID:
29878048
4.

Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.

Schmidt A, Marabita F, Kiani NA, Gross CC, Johansson HJ, Éliás S, Rautio S, Eriksson M, Fernandes SJ, Silberberg G, Ullah U, Bhatia U, Lähdesmäki H, Lehtiö J, Gomez-Cabrero D, Wiendl H, Lahesmaa R, Tegnér J.

BMC Biol. 2018 May 7;16(1):47. doi: 10.1186/s12915-018-0518-3.

5.

Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter.

Lund RJ, Osmala M, Malonzo M, Lukkarinen M, Leino A, Salmi J, Vuorikoski S, Turunen R, Vuorinen T, Akdis C, Lähdesmäki H, Lahesmaa R, Jartti T.

Allergy. 2018 Aug;73(8):1735-1740. doi: 10.1111/all.13473. Epub 2018 May 21.

6.

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.

Lietzén N, Cheng L, Moulder R, Siljander H, Laajala E, Härkönen T, Peet A, Vehtari A, Tillmann V, Knip M, Lähdesmäki H, Lahesmaa R.

Sci Rep. 2018 Apr 12;8(1):5883. doi: 10.1038/s41598-018-24019-5.

7.

Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells.

Ubaid Ullah, Andrabi SBA, Tripathi SK, Dirasantha O, Kanduri K, Rautio S, Gross CC, Lehtimäki S, Bala K, Tuomisto J, Bhatia U, Chakroborty D, Elo LL, Lähdesmäki H, Wiendl H, Rasool O, Lahesmaa R.

Cell Rep. 2018 Feb 20;22(8):2094-2106. doi: 10.1016/j.celrep.2018.01.070.

8.

Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors.

Mukherjee SP, Bondarenko O, Kohonen P, Andón FT, Brzicová T, Gessner I, Mathur S, Bottini M, Calligari P, Stella L, Kisin E, Shvedova A, Autio R, Salminen-Mankonen H, Lahesmaa R, Fadeel B.

Sci Rep. 2018 Jan 18;8(1):1115. doi: 10.1038/s41598-018-19521-9.

9.

Analysis of the plasma proteome using iTRAQ and TMT-based Isobaric labeling.

Moulder R, Bhosale SD, Goodlett DR, Lahesmaa R.

Mass Spectrom Rev. 2018 Sep;37(5):583-606. doi: 10.1002/mas.21550. Epub 2017 Nov 9. Review.

PMID:
29120501
10.

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL.

Diabetologia. 2018 Feb;61(2):381-388. doi: 10.1007/s00125-017-4460-7. Epub 2017 Nov 8.

PMID:
29119244
11.

Mapping architectural and transcriptional alterations in non-lesional and lesional epidermis in vitiligo.

Singh A, Gotherwal V, Junni P, Vijayan V, Tiwari M, Ganju P, Kumar A, Sharma P, Fatima T, Gupta A, Holla A, Kar HK, Khanna S, Thukral L, Malik G, Natarajan K, Gadgil CJ, Lahesmaa R, Natarajan VT, Rani R, Gokhale RS.

Sci Rep. 2017 Aug 29;7(1):9860. doi: 10.1038/s41598-017-10253-w.

12.

Mass Spectrometry-Based Serum Proteomics for Biomarker Discovery and Validation.

Bhosale SD, Moulder R, Kouvonen P, Lahesmaa R, Goodlett DR.

Methods Mol Biol. 2017;1619:451-466. doi: 10.1007/978-1-4939-7057-5_31.

PMID:
28674903
13.

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation.

Tripathi SK, Chen Z, Larjo A, Kanduri K, Nousiainen K, Äijo T, Ricaño-Ponce I, Hrdlickova B, Tuomela S, Laajala E, Salo V, Kumar V, Wijmenga C, Lähdesmäki H, Lahesmaa R.

Cell Rep. 2017 May 30;19(9):1888-1901. doi: 10.1016/j.celrep.2017.05.013.

14.

RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells.

Lund RJ, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R.

Stem Cell Reports. 2017 May 9;8(5):1442-1454. doi: 10.1016/j.stemcr.2017.04.016.

15.

DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer.

Lund RJ, Huhtinen K, Salmi J, Rantala J, Nguyen EV, Moulder R, Goodlett DR, Lahesmaa R, Carpén O.

Sci Rep. 2017 May 4;7(1):1469. doi: 10.1038/s41598-017-01624-4.

16.

Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells.

Nguyen EV, Huhtinen K, Goo YA, Kaipio K, Andersson N, Rantanen V, Hynninen J, Lahesmaa R, Carpen O, Goodlett DR.

Mol Cell Proteomics. 2017 Jul;16(7):1377-1392. doi: 10.1074/mcp.M116.058321. Epub 2017 Apr 28.

17.

AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis.

Li Z, Khan MM, Kuja-Panula J, Wang H, Chen Y, Guo D, Chen ZJ, Lahesmaa R, Rauvala H, Tian L.

Brain Behav Immun. 2017 May;62:110-123. doi: 10.1016/j.bbi.2017.01.009. Epub 2017 Feb 1.

PMID:
28119027
18.

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, Korsgren O, Lahesmaa R, Flodström-Tullberg M.

Sci Rep. 2016 Dec 21;6:39378. doi: 10.1038/srep39378.

19.

The progress and potential of proteomic biomarkers for type 1 diabetes in children.

Moulder R, Bhosale SD, Lahesmaa R, Goodlett DR.

Expert Rev Proteomics. 2017 Jan;14(1):31-41. doi: 10.1080/14789450.2017.1265449. Epub 2016 Dec 20. Review.

PMID:
27997253
20.

Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells.

Rahkonen N, Stubb A, Malonzo M, Edelman S, Emani MR, Närvä E, Lähdesmäki H, Ruohola-Baker H, Lahesmaa R, Lund R.

Stem Cell Res. 2016 Nov;17(3):498-503. doi: 10.1016/j.scr.2016.09.025. Epub 2016 Sep 24.

21.

Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.

Martinez-Bravo MJ, Wahlund CJ, Qazi KR, Moulder R, Lukic A, Rådmark O, Lahesmaa R, Grunewald J, Eklund A, Gabrielsson S.

J Allergy Clin Immunol. 2017 Apr;139(4):1186-1194. doi: 10.1016/j.jaci.2016.05.051. Epub 2016 Aug 23.

PMID:
27566455
22.

Early signs of disease in type 1 diabetes.

Moulder R, Lahesmaa R.

Pediatr Diabetes. 2016 Jul;17 Suppl 22:43-8. doi: 10.1111/pedi.12329. Review.

PMID:
27411436
23.

Activation of Plasmacytoid Dendritic Cells in Colon-Draining Lymph Nodes during Citrobacter rodentium Infection Involves Pathogen-Sensing and Inflammatory Pathways Distinct from Conventional Dendritic Cells.

Toivonen R, Kong L, Rasool O, Lund RJ, Lahesmaa R, Hänninen A.

J Immunol. 2016 Jun 1;196(11):4750-9. doi: 10.4049/jimmunol.1600235. Epub 2016 Apr 27.

24.

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.

Côme C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimentel JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Chen Z, Lahesmaa R, Westermarck J.

PLoS One. 2016 Apr 21;11(4):e0152996. doi: 10.1371/journal.pone.0152996. eCollection 2016.

25.

Comparative analysis of human and mouse transcriptomes of Th17 cell priming.

Tuomela S, Rautio S, Ahlfors H, Öling V, Salo V, Ullah U, Chen Z, Hämälistö S, Tripathi SK, Äijö T, Rasool O, Soueidan H, Wessels L, Stockinger B, Lähdesmäki H, Lahesmaa R.

Oncotarget. 2016 Mar 22;7(12):13416-28. doi: 10.18632/oncotarget.7963.

26.

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells.

Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Söderström M, Emani MR, Stubb A, Närvä E, Ghimire B, Laiho A, Järveläinen H, Lahesmaa R, Lähdesmäki H, Hawkins RD, Lund RJ.

Sci Rep. 2016 Feb 25;6:22190. doi: 10.1038/srep22190.

27.

Identification of global regulators of T-helper cell lineage specification.

Kanduri K, Tripathi S, Larjo A, Mannerström H, Ullah U, Lund R, Hawkins RD, Ren B, Lähdesmäki H, Lahesmaa R.

Genome Med. 2015 Nov 20;7:122. doi: 10.1186/s13073-015-0237-0.

28.

Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data.

Intosalmi J, Ahlfors H, Rautio S, Mannerstöm H, Chen ZJ, Lahesmaa R, Stockinger B, Lähdesmäki H.

BMC Syst Biol. 2015 Nov 17;9:81. doi: 10.1186/s12918-015-0223-6.

29.

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases.

Gustafsson M, Gawel DR, Alfredsson L, Baranzini S, Björkander J, Blomgran R, Hellberg S, Eklund D, Ernerudh J, Kockum I, Konstantinell A, Lahesmaa R, Lentini A, Liljenström HR, Mattson L, Matussek A, Mellergård J, Mendez M, Olsson T, Pujana MA, Rasool O, Serra-Musach J, Stenmarker M, Tripathi S, Viitala M, Wang H, Zhang H, Nestor CE, Benson M.

Sci Transl Med. 2015 Nov 11;7(313):313ra178. doi: 10.1126/scitranslmed.aad2722.

30.

New Insights and Biomarkers for Type 1 Diabetes: Review for Scandinavian Journal of Immunology.

Heinonen MT, Moulder R, Lahesmaa R.

Scand J Immunol. 2015 Sep;82(3):244-53. doi: 10.1111/sji.12338. Review.

31.

GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.

Heinonen MT, Laine AP, Söderhäll C, Gruzieva O, Rautio S, Melén E, Pershagen G, Lähdesmäki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R; Finnish Pediatric Diabetes Registry.

J Immunol. 2015 Jun 15;194(12):5885-94. doi: 10.4049/jimmunol.1500016. Epub 2015 May 11.

32.

The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency.

Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R.

Stem Cell Reports. 2015 Mar 10;4(3):519-28. doi: 10.1016/j.stemcr.2015.01.014. Epub 2015 Feb 19.

33.

Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells.

Laurila K, Autio R, Kong L, Närvä E, Hussein S, Otonkoski T, Lahesmaa R, Lähdesmäki H.

BioData Min. 2014 Dec 13;7(1):32. doi: 10.1186/s13040-014-0032-2. eCollection 2014.

34.

Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility.

Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R.

Diabetes. 2015 Jun;64(6):2265-78. doi: 10.2337/db14-0983. Epub 2015 Jan 23.

35.

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity.

Hrdlickova B, Kumar V, Kanduri K, Zhernakova DV, Tripathi S, Karjalainen J, Lund RJ, Li Y, Ullah U, Modderman R, Abdulahad W, Lähdesmäki H, Franke L, Lahesmaa R, Wijmenga C, Withoff S.

Genome Med. 2014 Oct 28;6(10):88. doi: 10.1186/s13073-014-0088-0. eCollection 2014.

36.

Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.

Heinonen MT, Kanduri K, Lähdesmäki HJ, Lahesmaa R, Henttinen TA.

Immunol Cell Biol. 2015 Feb;93(2):158-66. doi: 10.1038/icb.2014.86. Epub 2014 Oct 7.

37.

Standard of hygiene and immune adaptation in newborn infants.

Kallionpää H, Laajala E, Öling V, Härkönen T, Tillmann V, Dorshakova NV, Ilonen J, Lähdesmäki H, Knip M, Lahesmaa R; DIABIMMUNE Study Group.

Clin Immunol. 2014 Nov;155(1):136-47. doi: 10.1016/j.clim.2014.09.009. Epub 2014 Sep 22.

38.

Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels.

Kumar V, Gutierrez-Achury J, Kanduri K, Almeida R, Hrdlickova B, Zhernakova DV, Westra HJ, Karjalainen J, Ricaño-Ponce I, Li Y, Stachurska A, Tigchelaar EF, Abdulahad WH, Lähdesmäki H, Hofker MH, Zhernakova A, Franke L, Lahesmaa R, Wijmenga C, Withoff S.

Hum Mol Genet. 2015 Jan 15;24(2):397-409. doi: 10.1093/hmg/ddu453. Epub 2014 Sep 4.

PMID:
25190711
39.

Transcriptional and epigenetic regulation of T-helper lineage specification.

Tripathi SK, Lahesmaa R.

Immunol Rev. 2014 Sep;261(1):62-83. doi: 10.1111/imr.12204. Review.

40.

The regulation and role of c-FLIP in human Th cell differentiation.

Kyläniemi MK, Kaukonen R, Myllyviita J, Rasool O, Lahesmaa R.

PLoS One. 2014 Jul 14;9(7):e102022. doi: 10.1371/journal.pone.0102022. eCollection 2014.

41.

Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation.

Äijö T, Butty V, Chen Z, Salo V, Tripathi S, Burge CB, Lahesmaa R, Lähdesmäki H.

Bioinformatics. 2014 Jun 15;30(12):i113-20. doi: 10.1093/bioinformatics/btu274.

42.

Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.

Kelkka T, Kienhöfer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R.

Antioxid Redox Signal. 2014 Dec 1;21(16):2231-45. doi: 10.1089/ars.2013.5828. Epub 2014 Jul 29.

43.

Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae: Possible Role in the Entry into Its Host Cells.

Peñate Medina TA, Korhonen JT, Lahesmaa R, Puolakkainen M, Peñate Medina O, Kinnunen PK.

Interdiscip Perspect Infect Dis. 2014;2014:412827. doi: 10.1155/2014/412827. Epub 2014 Mar 13.

44.

Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity.

Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G, Oberste MS, Lahesmaa R, Pesu M, Hyöty H.

J Med Virol. 2014 Aug;86(8):1412-20. doi: 10.1002/jmv.23903. Epub 2014 Feb 20.

PMID:
24616040
45.

Gut-adipose tissue axis in hepatic fat accumulation in humans.

Munukka E, Pekkala S, Wiklund P, Rasool O, Borra R, Kong L, Ojanen X, Cheng SM, Roos C, Tuomela S, Alen M, Lahesmaa R, Cheng S.

J Hepatol. 2014 Jul;61(1):132-8. doi: 10.1016/j.jhep.2014.02.020. Epub 2014 Mar 5.

PMID:
24613361
46.

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B.

Nat Immunol. 2014 Apr;15(4):384-392. doi: 10.1038/ni.2843. Epub 2014 Mar 2.

47.

Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells.

Noisa P, Lund C, Kanduri K, Lund R, Lähdesmäki H, Lahesmaa R, Lundin K, Chokechuwattanalert H, Otonkoski T, Tuuri T, Raivio T.

J Cell Sci. 2014 May 1;127(Pt 9):2083-94. doi: 10.1242/jcs.145755. Epub 2014 Feb 25.

48.

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R.

Diabetes. 2014 Jul;63(7):2402-14. doi: 10.2337/db13-1775. Epub 2014 Feb 18.

49.

Early T helper cell programming of gene expression in human.

Tuomela S, Lahesmaa R.

Semin Immunol. 2013 Nov 15;25(4):282-90. doi: 10.1016/j.smim.2013.10.013. Epub 2013 Nov 16. Review.

50.

Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.

Närvä E, Pursiheimo JP, Laiho A, Rahkonen N, Emani MR, Viitala M, Laurila K, Sahla R, Lund R, Lähdesmäki H, Jaakkola P, Lahesmaa R.

PLoS One. 2013 Nov 13;8(11):e78847. doi: 10.1371/journal.pone.0078847. eCollection 2013.

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