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Inferring Leading Interactions in the p53/Mdm2/Mdmx Circuit through Live-Cell Imaging and Modeling.

Heltberg ML, Chen SH, Jiménez A, Jambhekar A, Jensen MH, Lahav G.

Cell Syst. 2019 Dec 4. pii: S2405-4712(19)30386-2. doi: 10.1016/j.cels.2019.10.010. [Epub ahead of print]


The effect of dust storm particles on single human lung cancer cells.

Ardon-Dryer K, Mock C, Reyes J, Lahav G.

Environ Res. 2019 Nov 7:108891. doi: 10.1016/j.envres.2019.108891. [Epub ahead of print]


Usefulness of ultrasound and fine needle aspiration cytology of major salivary gland lesions.

Yariv O, Popovtzer A, Wasserzug O, Neiderman NC, Halperin D, Lahav Y, Lahav G, Yehuda M.

Am J Otolaryngol. 2020 Jan - Feb;41(1):102293. doi: 10.1016/j.amjoto.2019.102293. Epub 2019 Sep 10.


Management of Acute Mastoiditis With Immediate Needle Aspiration for Subperiosteal Abscess.

Bartov N, Lahav Y, Lahav G, Zloczower E, Katzenell U, Halperin D, Hilly O, Shoffel-Havakuk H.

Otol Neurotol. 2019 Jul;40(6):e612-e618. doi: 10.1097/MAO.0000000000002231.


Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Reyes J, Chen JY, Stewart-Ornstein J, Karhohs KW, Mock CS, Lahav G.

Mol Cell. 2019 Mar 21;73(6):1306. doi: 10.1016/j.molcel.2019.02.035. No abstract available.


The multiple mechanisms that regulate p53 activity and cell fate.

Hafner A, Bulyk ML, Jambhekar A, Lahav G.

Nat Rev Mol Cell Biol. 2019 Apr;20(4):199-210. doi: 10.1038/s41580-019-0110-x. Review.


Fully unsupervised symmetry-based mitosis detection in time-lapse cell microscopy.

Gilad T, Reyes J, Chen JY, Lahav G, Riklin Raviv T.

Bioinformatics. 2019 Aug 1;35(15):2644-2653. doi: 10.1093/bioinformatics/bty1034.


Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages.

Chakrabarti S, Paek AL, Reyes J, Lasick KA, Lahav G, Michor F.

Nat Commun. 2018 Dec 18;9(1):5372. doi: 10.1038/s41467-018-07788-5.


Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Reyes J, Chen JY, Stewart-Ornstein J, Karhohs KW, Mock CS, Lahav G.

Mol Cell. 2018 Aug 16;71(4):581-591.e5. doi: 10.1016/j.molcel.2018.06.031. Epub 2018 Jul 26. Erratum in: Mol Cell. 2019 Mar 21;73(6):1306.


A probabilistic approach to joint cell tracking and segmentation in high-throughput microscopy videos.

Arbelle A, Reyes J, Chen JY, Lahav G, Riklin Raviv T.

Med Image Anal. 2018 Jul;47:140-152. doi: 10.1016/ Epub 2018 Apr 22.


Leveraging and coping with uncertainty in the response of individual cells to therapy.

Reyes J, Lahav G.

Curr Opin Biotechnol. 2018 Jun;51:109-115. doi: 10.1016/j.copbio.2017.12.007. Epub 2017 Dec 27. Review.


Conservation and Divergence of p53 Oscillation Dynamics across Species.

Stewart-Ornstein J, Cheng HWJ, Lahav G.

Cell Syst. 2017 Oct 25;5(4):410-417.e4. doi: 10.1016/j.cels.2017.09.012. Epub 2017 Oct 18.


Integrating genomic information and signaling dynamics for efficient cancer therapy.

Stewart-Ornstein J, Lahav G.

Curr Opin Syst Biol. 2017 Feb;1:38-43. doi: 10.1016/j.coisb.2016.12.013. Epub 2016 Dec 19.


p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics.

Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML, Lahav G.

Nat Struct Mol Biol. 2017 Oct;24(10):840-847. doi: 10.1038/nsmb.3452. Epub 2017 Aug 21.


The puzzling interplay between p53 and Sp1.

Oppenheim A, Lahav G.

Aging (Albany NY). 2017 May 9;9(5):1355-1356. doi: 10.18632/aging.101238. No abstract available.


The Single-Cell Yin and Yang of Live Imaging and Transcriptomics.

Tsabar M, Lahav G.

Cell Syst. 2017 Apr 26;4(4):375-377. doi: 10.1016/j.cels.2017.04.001.


p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM.

Stewart-Ornstein J, Lahav G.

Sci Signal. 2017 Apr 25;10(476). pii: eaah6671. doi: 10.1126/scisignal.aah6671.


Two is better than one; toward a rational design of combinatorial therapy.

Chen SH, Lahav G.

Curr Opin Struct Biol. 2016 Dec;41:145-150. doi: 10.1016/ Epub 2016 Aug 10. Review.


p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression.

Drayman N, Ben-Nun-Shaul O, Butin-Israeli V, Srivastava R, Rubinstein AM, Mock CS, Elyada E, Ben-Neriah Y, Lahav G, Oppenheim A.

Oncotarget. 2016 Aug 16;7(33):52643-52660. doi: 10.18632/oncotarget.10769.


Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.

Paek AL, Liu JC, Loewer A, Forrester WC, Lahav G.

Cell. 2016 Apr 21;165(3):631-42. doi: 10.1016/j.cell.2016.03.025. Epub 2016 Apr 7.


Schedule-dependent interaction between anticancer treatments.

Chen SH, Forrester W, Lahav G.

Science. 2016 Mar 11;351(6278):1204-8. doi: 10.1126/science.aac5610. Epub 2016 Mar 10.


Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit.

Stewart-Ornstein J, Lahav G.

Cell Rep. 2016 Feb 23;14(7):1800-1811. doi: 10.1016/j.celrep.2016.01.045. Epub 2016 Feb 11.


Single-cell analysis of circadian dynamics in tissue explants.

Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G.

Mol Biol Cell. 2015 Nov 5;26(22):3940-5. doi: 10.1091/mbc.E15-06-0403. Epub 2015 Aug 12.


X-ray fluorescence-based differentiation of neck tissues in a bovine model: implications for potential intraoperative use.

Lahav G, Shilstein S, Shchemelinin S, Ikher S, Halperin D, Chechik R, Breskin A.

Phys Med. 2015 May;31(3):233-41. doi: 10.1016/j.ejmp.2015.01.012. Epub 2015 Feb 10.


Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.

Gaglia G, Lahav G.

Mol Syst Biol. 2014 Oct 24;10:753. doi: 10.15252/msb.20145168.


Stem cells: balancing resistance and sensitivity to DNA damage.

Liu JC, Lerou PH, Lahav G.

Trends Cell Biol. 2014 May;24(5):268-74. doi: 10.1016/j.tcb.2014.03.002. Epub 2014 Apr 7.


The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.

Loewer A, Karanam K, Mock C, Lahav G.

BMC Biol. 2013 Nov 19;11:114. doi: 10.1186/1741-7007-11-114.


Activation and control of p53 tetramerization in individual living cells.

Gaglia G, Guan Y, Shah JV, Lahav G.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15497-501. doi: 10.1073/pnas.1311126110. Epub 2013 Sep 4.


High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Letai A, Lerou PH, Lahav G.

Cell Stem Cell. 2013 Oct 3;13(4):483-91. doi: 10.1016/j.stem.2013.07.018. Epub 2013 Aug 15. Erratum in: Cell Stem Cell. 2013 Nov 7;13(5):634. Agarwal, Vishesh [corrected to Agrawal, Vishesh].


Signal transduction and signaling networks.

Ikeda F, Lahav G.

Mol Biol Cell. 2013 Mar;24(6):676. doi: 10.1091/mbc.E12-12-0877. No abstract available.


Encoding and decoding cellular information through signaling dynamics.

Purvis JE, Lahav G.

Cell. 2013 Feb 28;152(5):945-56. doi: 10.1016/j.cell.2013.02.005. Review.


Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.

Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.

Nature. 2013 Feb 28;494(7438):480-3. doi: 10.1038/nature11897.


Dynamics of the DNA damage response: insights from live-cell imaging.

Karanam K, Loewer A, Lahav G.

Brief Funct Genomics. 2013 Mar;12(2):109-17. doi: 10.1093/bfgp/els059. Epub 2013 Jan 4. Review.


Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

Karanam K, Kafri R, Loewer A, Lahav G.

Mol Cell. 2012 Jul 27;47(2):320-9. doi: 10.1016/j.molcel.2012.05.052.


Decoding the insulin signal.

Purvis JE, Lahav G.

Mol Cell. 2012 Jun 29;46(6):715-6. doi: 10.1016/j.molcel.2012.06.005.


p53 dynamics control cell fate.

Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G.

Science. 2012 Jun 15;336(6087):1440-4. doi: 10.1126/science.1218351.


Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.

Orth JD, Loewer A, Lahav G, Mitchison TJ.

Mol Biol Cell. 2012 Feb;23(4):567-76. doi: 10.1091/mbc.E11-09-0781. Epub 2011 Dec 14.


We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.

Loewer A, Lahav G.

Curr Opin Genet Dev. 2011 Dec;21(6):753-8. doi: 10.1016/j.gde.2011.09.010. Epub 2011 Oct 15. Review.


Suppressing variation in synthetic circuits.

Batchelor E, Lahav G.

Mol Syst Biol. 2011 Aug 2;7:520. doi: 10.1038/msb.2011.53. No abstract available.


Stimulus-dependent dynamics of p53 in single cells.

Batchelor E, Loewer A, Mock C, Lahav G.

Mol Syst Biol. 2011 May 10;7:488. doi: 10.1038/msb.2011.20.


Laryngeal syphilis: a case report.

Lahav G, Lahav Y, Ciobotaro P, Ziv N, Halperin D.

Arch Otolaryngol Head Neck Surg. 2011 Mar;137(3):294-7. doi: 10.1001/archoto.2011.16.


A synthetic-natural hybrid oscillator in human cells.

Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17047-52. doi: 10.1073/pnas.1005615107. Epub 2010 Sep 13.


Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.

Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG Jr, Harper JW, Wei W.

Cancer Cell. 2010 Aug 9;18(2):147-59. doi: 10.1016/j.ccr.2010.06.015.


Fourier analysis and systems identification of the p53 feedback loop.

Geva-Zatorsky N, Dekel E, Batchelor E, Lahav G, Alon U.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13550-5. doi: 10.1073/pnas.1001107107. Epub 2010 Jul 9.


Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

Loewer A, Batchelor E, Gaglia G, Lahav G.

Cell. 2010 Jul 9;142(1):89-100. doi: 10.1016/j.cell.2010.05.031.


How to survive and thrive in the mother-mentor marathon.

Lahav G.

Mol Cell. 2010 May 28;38(4):477-80. doi: 10.1016/j.molcel.2010.05.012.


Dysphagia and dysphonia in a patient with cancer.

Schattner A, Mate A, Lahav G, Adi M.

Am J Med Sci. 2009 Sep;338(3):236-7. doi: 10.1097/MAJ.0b013e3181a8c34a.


Cell growth and size homeostasis in proliferating animal cells.

Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW.

Science. 2009 Jul 10;325(5937):167-71. doi: 10.1126/science.1174294.


The ups and downs of p53: understanding protein dynamics in single cells.

Batchelor E, Loewer A, Lahav G.

Nat Rev Cancer. 2009 May;9(5):371-7. doi: 10.1038/nrc2604. Epub 2009 Apr 9. Review.


Distinct mechanisms act in concert to mediate cell cycle arrest.

Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):785-90. doi: 10.1073/pnas.0806196106. Epub 2009 Jan 12.

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