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Items: 1 to 50 of 301

1.

Effects of Maternal Fructose Intake on Perinatal ER-Stress: A Defective XBP1s Nuclear Translocation Affects the ER-stress Resolution.

Rodrigo S, Panadero MI, Fauste E, Rodríguez L, Roglans N, Álvarez-Millán JJ, Otero P, Laguna JC, Bocos C.

Nutrients. 2019 Aug 17;11(8). pii: E1935. doi: 10.3390/nu11081935.

2.

Quality of life improvement with allergen immunotherapy treatment in patients with rhinoconjunctivitis in real life conditions. Results of an observational prospective study (ÍCARA).

Cuesta-Herranz J, Laguna JJ, Mielgo R, Pérez-Camo I, Callejo AM, Begoña L, Gomez MC, Madariaga B, Martinez A.

Eur Ann Allergy Clin Immunol. 2019 Sep 16;51(5). doi: 10.23822/EurAnnACI.1764-1489.104. Epub 2019 Jul 9.

3.

Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations.

Garvey LH, Dewachter P, Hepner DL, Mertes PM, Voltolini S, Clarke R, Cooke P, Garcez T, Guttormsen AB, Ebo DG, Hopkins PM, Khan DA, Kopac P, Krøigaard M, Laguna JJ, Marshall S, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Savic S, Scherer K, Takazawa T, Volcheck GW, Kolawole H.

Br J Anaesth. 2019 Jul;123(1):e50-e64. doi: 10.1016/j.bja.2019.04.044. Epub 2019 May 24.

PMID:
31130272
4.

Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation.

Gastaminza G, Ruiz-Canela M, Andrés-López B, Barasona Villarejo MJ, Cabañas R, García-Núñez I, Goikoetxea MJ, Laguna JJ, Lobera T, López-San Martín M, Martín-Lázaro J, Mielgo-Ballesteros R, Moreno E, Moya-Quesada MDC, Ortega-Rodríguez N, Rojas-Perez-Ezquerra P, Rosado A, Salas M, Sánchez-Morillas L, Vila-Albelda C, Corominas M.

J Allergy Clin Immunol Pract. 2019 May 24. pii: S2213-2198(19)30472-6. doi: 10.1016/j.jaip.2019.05.017. [Epub ahead of print]

PMID:
31129076
5.

Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions.

Hopkins PM, Cooke PJ, Clarke RC, Guttormsen AB, Platt PR, Dewachter P, Ebo DG, Garcez T, Garvey LH, Hepner DL, Khan DA, Kolawole H, Kopac P, Krøigaard M, Laguna JJ, Marshall SD, Mertes PM, Rose MA, Sabato V, Savic LC, Savic S, Takazawa T, Volcheck GW, Voltolini S, Sadleir PHM.

Br J Anaesth. 2019 Jul;123(1):e29-e37. doi: 10.1016/j.bja.2019.02.029. Epub 2019 Apr 24.

PMID:
31029409
6.

The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status.

Garvey LH, Ebo DG, Krøigaard M, Savic S, Clarke R, Cooke P, Dewachter P, Garcez T, Guttormsen AB, Hopkins PM, Hepner DL, Khan DA, Kolawole H, Kopac P, Marshall S, Mertes PM, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Scherer K, Takazawa T, Volcheck GW, Voltolini S, Laguna JJ.

Br J Anaesth. 2019 Jul;123(1):e126-e134. doi: 10.1016/j.bja.2019.03.018. Epub 2019 Apr 23. Review.

PMID:
31027914
7.

An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions.

Garvey LH, Ebo DG, Mertes PM, Dewachter P, Garcez T, Kopac P, Laguna JJ, Chiriac AM, Terreehorst I, Voltolini S, Scherer K.

Allergy. 2019 Apr 9. doi: 10.1111/all.13820. [Epub ahead of print]

PMID:
30964555
8.

Comparative epidemiology of suspected perioperative hypersensitivity reactions.

Mertes PM, Ebo DG, Garcez T, Rose M, Sabato V, Takazawa T, Cooke PJ, Clarke RC, Dewachter P, Garvey LH, Guttormsen AB, Hepner DL, Hopkins PM, Khan DA, Kolawole H, Kopac P, Krøigaard M, Laguna JJ, Marshall SD, Platt PR, Sadleir PHM, Savic LC, Savic S, Volcheck GW, Voltolini S.

Br J Anaesth. 2019 Jul;123(1):e16-e28. doi: 10.1016/j.bja.2019.01.027. Epub 2019 Mar 4. Review.

PMID:
30916015
9.

Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations.

Savic LC, Khan DA, Kopac P, Clarke RC, Cooke PJ, Dewachter P, Ebo DG, Garcez T, Garvey LH, Guttormsen AB, Hopkins PM, Hepner DL, Kolawole H, Krøigaard M, Laguna JJ, Marshall SD, Mertes PM, Platt PR, Rose MA, Sabato V, Sadleir PHM, Savic S, Takazawa T, Voltolini S, Volcheck GW.

Br J Anaesth. 2019 Jul;123(1):e82-e94. doi: 10.1016/j.bja.2019.01.026. Epub 2019 Mar 11. Review.

PMID:
30916014
10.

Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.

Dewachter P, Kopac P, Laguna JJ, Mertes PM, Sabato V, Volcheck GW, Cooke PJ.

Br J Anaesth. 2019 Jul;123(1):e65-e81. doi: 10.1016/j.bja.2019.01.020. Epub 2019 Mar 13. Review.

PMID:
30916009
11.

mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars.

Sangüesa G, Roglans N, Baena M, Velázquez AM, Laguna JC, Alegret M.

Int J Mol Sci. 2019 Mar 5;20(5). pii: E1117. doi: 10.3390/ijms20051117. Review.

12.

Assessment of the bacterial viability of chlorine- and quaternary ammonium compounds-treated Lactobacillus cells via a multi-method approach.

Olszewska MA, Nynca A, Białobrzewski I, Kocot AM, Łaguna J.

J Appl Microbiol. 2019 Apr;126(4):1070-1080. doi: 10.1111/jam.14208. Epub 2019 Feb 20.

PMID:
30664312
13.

NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs.

Doña I, Barrionuevo E, Salas M, Laguna JJ, Agúndez J, García-Martín E, Bogas G, Perkins JR, Cornejo-García JA, Torres MJ.

Sci Rep. 2018 Nov 12;8(1):16710. doi: 10.1038/s41598-018-34668-1.

14.

Chronic Liquid Fructose, but not Glucose, Supplementation Selectively Induces Visceral Adipose Tissue Leptin Resistance and Hypertrophy in Female Sprague-Dawley Rats.

Sangüesa G, Roglans N, Montañés JC, Baena M, Velázquez AM, Sánchez RM, Alegret M, Laguna JC.

Mol Nutr Food Res. 2018 Nov;62(22):e1800777. doi: 10.1002/mnfr.201800777. Epub 2018 Oct 11.

PMID:
30260587
15.

Differential effects of high consumption of fructose or glucose on mesenteric arterial function in female rats.

Shaligram S, Sangüesa G, Akther F, Alegret M, Laguna JC, Rahimian R.

J Nutr Biochem. 2018 Jul;57:136-144. doi: 10.1016/j.jnutbio.2018.03.021. Epub 2018 Apr 3.

16.

Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague-Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression.

Sangüesa G, Montañés JC, Baena M, Sánchez RM, Roglans N, Alegret M, Laguna JC.

Eur J Nutr. 2019 Apr;58(3):1283-1297. doi: 10.1007/s00394-018-1654-9. Epub 2018 Mar 7.

PMID:
29516226
17.

Practical Guidelines for Perioperative Hypersensitivity Reactions.

Laguna JJ, Archilla J, Doña I, Corominas M, Gastaminza G, Mayorga C, Berjes-Gimeno P, Tornero P, Martin S, Planas A, Moreno E, Torres MJ.

J Investig Allergol Clin Immunol. 2018;28(4):216-232. doi: 10.18176/jiaci.0236. Epub 2018 Feb 7. Review.

18.

Impairment of Novel Object Recognition Memory and Brain Insulin Signaling in Fructose- but Not Glucose-Drinking Female Rats.

Sangüesa G, Cascales M, Griñán C, Sánchez RM, Roglans N, Pallàs M, Laguna JC, Alegret M.

Mol Neurobiol. 2018 Aug;55(8):6984-6999. doi: 10.1007/s12035-017-0863-1. Epub 2018 Jan 26.

PMID:
29372547
19.

Daily intake of Mucuna pruriens in advanced Parkinson's disease: A 16-week, noninferiority, randomized, crossover, pilot study.

Cilia R, Laguna J, Cassani E, Cereda E, Raspini B, Barichella M, Pezzoli G.

Parkinsonism Relat Disord. 2018 Apr;49:60-66. doi: 10.1016/j.parkreldis.2018.01.014. Epub 2018 Jan 11.

PMID:
29352722
20.

The Basophil Activation Test Can Be of Value for Diagnosing Immediate Allergic Reactions to Omeprazole.

Laguna JJ, Bogas G, Salas M, Mayorga C, Dionicio J, Gonzalez-Mendiola R, Ariza A, Fernández-Santamaría R, Olazabal I, Doña I, Fernandez TD, Torres MJ.

J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1628-1636.e2. doi: 10.1016/j.jaip.2017.12.001. Epub 2018 Jan 12.

PMID:
29339127
21.

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake.

Cedó L, Santos D, Roglans N, Julve J, Pallarès V, Rivas-Urbina A, Llorente-Cortes V, Laguna JC, Blanco-Vaca F, Escolà-Gil JC.

PLoS One. 2017 Dec 15;12(12):e0189834. doi: 10.1371/journal.pone.0189834. eCollection 2017.

22.

Use of the Basophil Activation Test May Reduce the Need for Drug Provocation in Amoxicillin-Clavulanic Allergy.

Salas M, Fernández-Santamaría R, Mayorga C, Barrionuevo E, Ariza A, Posadas T, Laguna JJ, Montañez MI, Molina N, Fernández TD, Torres MJ.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):1010-1018.e2. doi: 10.1016/j.jaip.2017.08.009. Epub 2017 Sep 28.

PMID:
28964705
23.

Expression of hepatic genes related to energy metabolism during the transition period of Holstein and F1 Holstein-Gir cows.

Laguna JG, Cardoso MS, Lima JA, Reis RB, Carvalho AU, Saturnino HM, Teixeira SMR.

J Dairy Sci. 2017 Dec;100(12):9861-9870. doi: 10.3168/jds.2016-12459. Epub 2017 Sep 28.

24.

Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study.

Cilia R, Laguna J, Cassani E, Cereda E, Pozzi NG, Isaias IU, Contin M, Barichella M, Pezzoli G.

Neurology. 2017 Aug 1;89(5):432-438. doi: 10.1212/WNL.0000000000004175. Epub 2017 Jul 5.

25.

Basophil Histamine Release Induced by Amoxicilloyl-poly-L-lysine Compared With Amoxicillin in Patients With IgE-Mediated Allergic Reactions to Amoxicillin.

Arribas F, Falkencrone S, Sola J, Gomez-Serranillos MP, Laguna JJ, Montañez MI, Fernandez TD, Rodríguez D, Pineda F, Skov PS, Mayorga C, Torres MJ.

J Investig Allergol Clin Immunol. 2017;27(6):356-362. doi: 10.18176/jiaci.0180. Epub 2017 Jun 19.

26.

Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis.

Montañez MI, Mayorga C, Bogas G, Barrionuevo E, Fernandez-Santamaria R, Martin-Serrano A, Laguna JJ, Torres MJ, Fernandez TD, Doña I.

Front Immunol. 2017 May 29;8:614. doi: 10.3389/fimmu.2017.00614. eCollection 2017. Review.

27.

Evolution of diagnostic approaches in betalactam hypersensitivity.

Fernandez TD, Mayorga C, Salas M, Barrionuevo E, Posadas T, Ariza A, Laguna JJ, Moreno E, Torres MJ, Doña I, Montañez MI.

Expert Rev Clin Pharmacol. 2017 Jun;10(6):671-683. doi: 10.1080/17512433.2017.1313110. Epub 2017 Apr 17. Review.

PMID:
28375040
28.

Patients Taking Amoxicillin-Clavulanic Can Become Simultaneously Sensitized to Both Drugs.

Salas M, Laguna JJ, Doña I, Barrionuevo E, Fernandez-Santamaría R, Ariza A, Perez-Inestrosa E, Mayorga C, Fernández TD, Torres MJ.

J Allergy Clin Immunol Pract. 2017 May - Jun;5(3):694-702.e3. doi: 10.1016/j.jaip.2017.02.007. Epub 2017 Mar 22.

PMID:
28342830
29.

The Addition of Liquid Fructose to a Western-Type Diet in LDL-R-/- Mice Induces Liver Inflammation and Fibrogenesis Markers without Disrupting Insulin Receptor Signalling after an Insulin Challenge.

Sangüesa G, Baena M, Hutter N, Montañés JC, Sánchez RM, Roglans N, Laguna JC, Alegret M.

Nutrients. 2017 Mar 15;9(3). pii: E278. doi: 10.3390/nu9030278.

30.

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.

Sangüesa G, Shaligram S, Akther F, Roglans N, Laguna JC, Rahimian R, Alegret M.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H289-H304. doi: 10.1152/ajpheart.00339.2016. Epub 2016 Dec 6.

31.

Liquid fructose in Western-diet-fed mice impairs liver insulin signaling and causes cholesterol and triglyceride loading without changing calorie intake and body weight.

Baena M, Sangüesa G, Hutter N, Beltrán JM, Sánchez RM, Roglans N, Alegret M, Laguna JC.

J Nutr Biochem. 2017 Feb;40:105-115. doi: 10.1016/j.jnutbio.2016.10.015. Epub 2016 Nov 2.

PMID:
27883935
32.

Clinical approach on challenge and desensitization procedures with aspirin in patients with ischemic heart disease and nonsteroidal anti-inflammatory drug hypersensitivity.

Cortellini G, Romano A, Santucci A, Barbaud A, Bavbek S, Bignardi D, Blanca M, Bonadonna P, Costantino MT, Laguna JJ, Lombardo C, Losappio LM, Makowska J, Nakonechna A, Quercia O, Pastorello EA, Patella V, Terreehorst I, Testi S, Cernadas JR; EAACI Drug Interest Group on Challenge and Desensitization Procedures with Aspirin in CAD, Dionicio Elera J, Lippolis D, Voltolini S, Grosseto D.

Allergy. 2017 Mar;72(3):498-506. doi: 10.1111/all.13068. Epub 2016 Nov 28.

PMID:
27732743
33.

Fructose during pregnancy provokes fetal oxidative stress: The key role of the placental heme oxygenase-1.

Rodrigo S, Rodríguez L, Otero P, Panadero MI, García A, Barbas C, Roglans N, Ramos S, Goya L, Laguna JC, Álvarez-Millán JJ, Bocos C.

Mol Nutr Food Res. 2016 Dec;60(12):2700-2711. doi: 10.1002/mnfr.201600193. Epub 2016 Oct 4.

PMID:
27545118
34.

Medical Observation Units and Emergency Department Collaboration: Improving Patient Throughput.

Gabele D, Bugais C, Laguna J.

J Nurs Adm. 2016 Jul-Aug;46(7-8):360-5. doi: 10.1097/NNA.0000000000000359.

PMID:
27379909
35.

Mucuna pruriens for Parkinson's disease: Low-cost preparation method, laboratory measures and pharmacokinetics profile.

Cassani E, Cilia R, Laguna J, Barichella M, Contin M, Cereda E, Isaias IU, Sparvoli F, Akpalu A, Budu KO, Scarpa MT, Pezzoli G.

J Neurol Sci. 2016 Jun 15;365:175-80. doi: 10.1016/j.jns.2016.04.001. Epub 2016 Apr 16.

36.

Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues.

Baena M, Sangüesa G, Dávalos A, Latasa MJ, Sala-Vila A, Sánchez RM, Roglans N, Laguna JC, Alegret M.

Sci Rep. 2016 May 19;6:26149. doi: 10.1038/srep26149.

37.

Drug allergy passport and other documentation for patients with drug hypersensitivity - An ENDA/EAACI Drug Allergy Interest Group Position Paper.

Brockow K, Aberer W, Atanaskovic-Markovic M, Bavbek S, Bircher A, Bilo B, Blanca M, Bonadonna P, Burbach G, Calogiuri G, Caruso C, Celik G, Cernadas J, Chiriac A, Demoly P, Oude Elberink JN, Fernandez J, Gomes E, Garvey LH, Gooi J, Gotua M, Grosber M, Kauppi P, Kvedariene V, Laguna JJ, Makowska JS, Mosbech H, Nakonechna A, Papadopolous NG, Ring J, Romano A, Rockmann H, Sargur R, Sedlackova L, Sigurdardottir S, Schnyder B, Storaas T, Torres M, Zidarn M, Terreehorst I.

Allergy. 2016 Nov;71(11):1533-1539. doi: 10.1111/all.12929. Epub 2016 Aug 14.

PMID:
27145347
38.

Liquid fructose in pregnancy exacerbates fructose-induced dyslipidemia in adult female offspring.

Rodríguez L, Panadero MI, Rodrigo S, Roglans N, Otero P, Álvarez-Millán JJ, Laguna JC, Bocos C.

J Nutr Biochem. 2016 Jun;32:115-22. doi: 10.1016/j.jnutbio.2016.02.013. Epub 2016 Mar 23.

PMID:
27142744
39.

In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper.

Mayorga C, Celik G, Rouzaire P, Whitaker P, Bonadonna P, Rodrigues-Cernadas J, Vultaggio A, Brockow K, Caubet JC, Makowska J, Nakonechna A, Romano A, Montañez MI, Laguna JJ, Zanoni G, Gueant JL, Oude Elberink H, Fernandez J, Viel S, Demoly P, Torres MJ; In vitro tests for Drug Allergy Task Force of EAACI Drug Interest Group.

Allergy. 2016 Aug;71(8):1103-34. doi: 10.1111/all.12886. Epub 2016 May 25.

PMID:
26991315
40.

Role of Histamine Release Test for the Evaluation of Patients with Immediate Hypersensitivity Reactions to Clavulanic Acid.

Pineda F, Ariza A, Mayorga C, Arribas F, González-Mendiola R, Blanca-López N, Davila G, Cabañes N, Canto G, Laguna JJ, Senent C, Stahl-Skov P, Palacios R, Blanca M, Torres MJ.

Int Arch Allergy Immunol. 2015;168(4):233-40. doi: 10.1159/000443274. Epub 2016 Feb 20.

41.

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.

Oussalah A, Mayorga C, Blanca M, Barbaud A, Nakonechna A, Cernadas J, Gotua M, Brockow K, Caubet JC, Bircher A, Atanaskovic M, Demoly P, K Tanno L, Terreehorst I, Laguna JJ, Romano A, Guéant JL; Task force ‘Genetic predictors of drug hypersensitivity’ of the European Network on Drug Allergy (ENDA) of EAACI.

Allergy. 2016 Apr;71(4):443-62. doi: 10.1111/all.12821. Epub 2016 Jan 29. Review.

PMID:
26678823
42.

The Importance of the Canonical Wnt Signaling Pathway in the Porcine Endometrial Stromal Stem/Progenitor Cells: Implications for Regeneration.

Bukowska J, Ziecik AJ, Laguna J, Gawronska-Kozak B, Bodek G.

Stem Cells Dev. 2015 Dec 15;24(24):2873-85. doi: 10.1089/scd.2015.0078. Epub 2015 Oct 28.

43.

Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease.

Ayuso P, Plaza-Serón Mdel C, Blanca-López N, Doña I, Campo P, Canto G, Laguna JJ, Bartra J, Soriano-Gomis V, Blanca M, Cornejo-García JA, Perkins JR.

Pharmacogenomics. 2015 Jul;16(8):825-39. doi: 10.2217/pgs.15.43. Epub 2015 Jun 12.

PMID:
26067486
44.

Fructose only in pregnancy provokes hyperinsulinemia, hypoadiponectinemia, and impaired insulin signaling in adult male, but not female, progeny.

Rodríguez L, Panadero MI, Roglans N, Otero P, Rodrigo S, Álvarez-Millán JJ, Laguna JC, Bocos C.

Eur J Nutr. 2016 Mar;55(2):665-674. doi: 10.1007/s00394-015-0886-1. Epub 2015 Mar 26.

PMID:
25808117
45.

Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice.

Ettcheto M, Petrov D, Pedrós I, de Lemos L, Pallàs M, Alegret M, Laguna JC, Folch J, Camins A.

Exp Gerontol. 2015 May;65:69-78. doi: 10.1016/j.exger.2015.03.010. Epub 2015 Mar 20.

PMID:
25797218
46.

Bolivian kindred with combined spinocerebellar ataxia types 2 and 10.

Baizabal-Carvallo JF, Xia G, Botros P, Laguna J, Ashizawa T, Jankovic J.

Acta Neurol Scand. 2015 Aug;132(2):139-42. doi: 10.1111/ane.12371. Epub 2015 Jan 28.

47.

Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight.

Laguna JC, Alegret M, Roglans N.

Nutrients. 2014 Dec 22;6(12):5933-54. doi: 10.3390/nu6125933. Review.

48.

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress.

Baena M, Sangüesa G, Hutter N, Sánchez RM, Roglans N, Laguna JC, Alegret M.

Biochim Biophys Acta. 2015 Feb;1851(2):107-16. doi: 10.1016/j.bbalip.2014.11.003. Epub 2014 Nov 9.

PMID:
25463011
49.

HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.

Guéant JL, Romano A, Cornejo-Garcia JA, Oussalah A, Chery C, Blanca-López N, Guéant-Rodriguez RM, Gaeta F, Rouyer P, Josse T, Canto G, Carmona FD, Bossini-Castillo L, Martin J, Laguna JJ, Fernandez J, Feo F, Ostrov DA, Plasencia PC, Mayorga C, Torres MJ, Blanca M.

J Allergy Clin Immunol. 2015 Jan;135(1):253-9. doi: 10.1016/j.jaci.2014.07.047. Epub 2014 Sep 12.

PMID:
25224099
50.

Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs.

Cornejo-García JA, Flores C, Plaza-Serón MC, Acosta-Herrera M, Blanca-López N, Doña I, Torres MJ, Mayorga C, Guéant-Rodríguez RM, Ayuso P, Fernández J, Laguna JJ, Agúndez JA, García-Martín E, Guéant JL, Canto G, Blanca M.

PLoS One. 2014 Mar 11;9(3):e90966. doi: 10.1371/journal.pone.0090966. eCollection 2014.

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