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Items: 33


Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.

Hata A, Lagna G.

Curr Opin Hematol. 2019 May;26(3):161-169. doi: 10.1097/MOH.0000000000000493.


Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.

Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A.

Commun Biol. 2018 Sep 24;1:149. doi: 10.1038/s42003-018-0152-1. eCollection 2018.


Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.

Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A.

Sci Signal. 2018 Jan 16;11(513). pii: eaan6831. doi: 10.1126/scisignal.aan6831.


Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.

Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A.

Nat Commun. 2017 Jul 25;8(1):128. doi: 10.1038/s41467-017-00137-y.


Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.

Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A.

Sci Signal. 2017 May 2;10(477). pii: eaai8133. doi: 10.1126/scisignal.aai8133.


Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A.

Sci Signal. 2016 Jun 7;9(431):ra58. doi: 10.1126/scisignal.aaf6060.


Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.

Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A.

EMBO J. 2013 Dec 11;32(24):3192-205. doi: 10.1038/emboj.2013.242. Epub 2013 Nov 12.


Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway.

Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A.

J Biol Chem. 2012 Nov 9;287(46):38656-64. doi: 10.1074/jbc.M112.390898. Epub 2012 Sep 17.


Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.

Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G.

J Biol Chem. 2012 Aug 10;287(33):28067-77. doi: 10.1074/jbc.M112.379487. Epub 2012 Jun 20.


Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A.

J Biol Chem. 2012 Feb 3;287(6):3976-86. doi: 10.1074/jbc.M111.303156. Epub 2011 Dec 9.


Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.

Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A.

Mol Cell Biol. 2011 Dec;31(23):4760-74. doi: 10.1128/MCB.05776-11. Epub 2011 Oct 3.


down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.

Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A.

J Biol Chem. 2011 Aug 12;286(32):28097-110. doi: 10.1074/jbc.M111.236950. Epub 2011 Jun 13.


The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.

Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A.

Mol Cell Biol. 2011 Feb;31(3):517-30. doi: 10.1128/MCB.00884-10. Epub 2010 Dec 6.


Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.

Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A.

Mol Cell. 2010 Aug 13;39(3):373-84. doi: 10.1016/j.molcel.2010.07.011.


Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.

Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A.

EMBO J. 2010 Feb 3;29(3):559-73. doi: 10.1038/emboj.2009.370. Epub 2009 Dec 17.


The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.

Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A.

J Biol Chem. 2009 May 8;284(19):13202-12. doi: 10.1074/jbc.M900282200. Epub 2009 Mar 5.


Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.

Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A.

J Biol Chem. 2009 Feb 6;284(6):3728-38. doi: 10.1074/jbc.M808788200. Epub 2008 Dec 15.


SMAD proteins control DROSHA-mediated microRNA maturation.

Davis BN, Hilyard AC, Lagna G, Hata A.

Nature. 2008 Jul 3;454(7200):56-61. doi: 10.1038/nature07086. Epub 2008 Jun 11.


Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.

Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A.

J Biol Chem. 2007 Dec 21;282(51):37244-55. Epub 2007 Oct 17.


A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.

Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A.

Mol Cell Biol. 2007 Aug;27(16):5776-89. Epub 2007 Jun 18.


BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.

Lagna G, Nguyen PH, Ni W, Hata A.

Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1059-67.


OAZ regulates bone morphogenetic protein signaling through Smad6 activation.

Ku M, Howard S, Ni W, Lagna G, Hata A.

J Biol Chem. 2006 Feb 24;281(8):5277-87. Epub 2005 Dec 22.


OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.

Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J.

Cell. 2000 Jan 21;100(2):229-40.


Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein beta TrCP.

Lagna G, Carnevali F, Marchioni M, Hemmati-Brivanlou A.

Mech Dev. 1999 Jan;80(1):101-6.


A molecular basis for Smad specificity.

Lagna G, Hemmati-Brivanlou A.

Dev Dyn. 1999 Mar;214(3):269-77.


Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A.

Genes Dev. 1998 Jan 15;12(2):186-97.


Use of dominant negative constructs to modulate gene expression.

Lagna G, Hemmati-Brivanlou A.

Curr Top Dev Biol. 1998;36:75-98. Review. No abstract available.


Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1.

Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A.

Development. 1997 Aug;124(16):3177-84.


Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

Hata A, Lo RS, Wotton D, Lagna G, Massagué J.

Nature. 1997 Jul 3;388(6637):82-7.


Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J.

Nature. 1996 Oct 31;383(6603):832-6.


Overlapping transcription by RNA polymerases II and III of the Xenopus TFIIIA gene in somatic cells.

Martinez E, Lagna G, Roeder RG.

J Biol Chem. 1994 Oct 14;269(41):25692-8.


Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC.

Lagna G, Kovelman R, Sukegawa J, Roeder RG.

Mol Cell Biol. 1994 May;14(5):3053-64.


HrpF, a human sequence-specific DNA-binding protein homologous to XrpFI, a Xenopus laevis oocyte transcription factor.

Lagna G, Loreni F, Beccari E, Carnevali F.

Nucleic Acids Res. 1990 Oct 11;18(19):5811-6.

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