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Items: 38


The Neuropeptide Y Y2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y2 Activation Reduces Histaminergic and IL-31-Induced Itch.

Ma H, Gao T, Jakobsson JET, Weman HM, Xu B, Larhammar D, Lagerström MC.

J Pharmacol Exp Ther. 2020 Jan;372(1):73-82. doi: 10.1124/jpet.119.262584. Epub 2019 Nov 26.


Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition.

Freitag FB, Ahemaiti A, Jakobsson JET, Weman HM, Lagerström MC.

Sci Rep. 2019 Nov 12;9(1):16573. doi: 10.1038/s41598-019-52642-3.


Neuropeptide Y in itch regulation.

Jakobsson JET, Ma H, Lagerström MC.

Neuropeptides. 2019 Dec;78:101976. doi: 10.1016/j.npep.2019.101976. Epub 2019 Oct 13. Review.


Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin.

Magnúsdóttir EI, Grujic M, Roers A, Hartmann K, Pejler G, Lagerström MC.

Mol Pain. 2018 Jan-Dec;14:1744806918808161. doi: 10.1177/1744806918808161. Epub 2018 Oct 3.


The anti-inflammatory alkaloid aloperine in Chinese herbal medicine is potentially useful for management of pain and itch.

Gao T, Lagerström MC.

Scand J Pain. 2015 Jul 1;8(1):25-26. doi: 10.1016/j.sjpain.2015.04.025. No abstract available.


Sinomenine is a promising analgesic and antihyperalgesic for pain and hypersensitivity in rheumatoid arthritis.

Lagerström MC.

Scand J Pain. 2015 Apr 1;7(1):15-16. doi: 10.1016/j.sjpain.2015.01.002. No abstract available.


The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch.

Gao T, Ma H, Xu B, Bergman J, Larhammar D, Lagerström MC.

J Invest Dermatol. 2018 Nov;138(11):2405-2411. doi: 10.1016/j.jid.2018.05.008. Epub 2018 May 24.


Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.

Häring M, Zeisel A, Hochgerner H, Rinwa P, Jakobsson JET, Lönnerberg P, La Manno G, Sharma N, Borgius L, Kiehn O, Lagerström MC, Linnarsson S, Ernfors P.

Nat Neurosci. 2018 Jun;21(6):869-880. doi: 10.1038/s41593-018-0141-1. Epub 2018 Apr 23.


CGRPα within the Trpv1-Cre population contributes to visceral nociception.

Spencer NJ, Magnúsdóttir EI, Jakobsson JET, Kestell G, Chen BN, Morris D, Brookes SJ, Lagerström MC.

Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G188-G200. doi: 10.1152/ajpgi.00188.2017. Epub 2017 Sep 28.


Spinal cord interneurons expressing the gastrin-releasing peptide receptor convey itch through VGLUT2-mediated signaling.

Aresh B, Freitag FB, Perry S, Blümel E, Lau J, Franck MCM, Lagerström MC.

Pain. 2017 May;158(5):945-961. doi: 10.1097/j.pain.0000000000000861.


Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease.

Viereckel T, Dumas S, Smith-Anttila CJ, Vlcek B, Bimpisidis Z, Lagerström MC, Konradsson-Geuken Å, Wallén-Mackenzie Å.

Sci Rep. 2016 Oct 20;6:35203. doi: 10.1038/srep35203.


Identification of a Neuronal Receptor Controlling Anaphylaxis.

Rogoz K, Aresh B, Freitag FB, Pettersson H, Magnúsdóttir EI, Larsson Ingwall L, Haddadi Andersen H, Franck MC, Nagaraja C, Kullander K, Lagerström MC.

Cell Rep. 2016 Jan 12;14(2):370-9. doi: 10.1016/j.celrep.2015.12.033. Epub 2015 Dec 31.


VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents.

Rogoz K, Stjärne L, Kullander K, Lagerström MC.

PLoS One. 2015 Jan 23;10(1):e0116568. doi: 10.1371/journal.pone.0116568. eCollection 2015.


Synaptic changes induced by melanocortin signalling.

Caruso V, Lagerström MC, Olszewski PK, Fredriksson R, Schiöth HB.

Nat Rev Neurosci. 2014 Feb;15(2):98-110. Review.


Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia.

Rogoz K, Andersen HH, Kullander K, Lagerström MC.

Mol Pharmacol. 2014 Feb;85(2):322-34. doi: 10.1124/mol.113.089532. Epub 2013 Nov 25.


VGLUT2-dependent glutamatergic transmission in primary afferents is required for intact nociception in both acute and persistent pain modalities.

Rogoz K, Lagerström MC, Dufour S, Kullander K.

Pain. 2012 Jul;153(7):1525-36. doi: 10.1016/j.pain.2012.04.017. Epub 2012 May 25.


A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.

Lagerström MC, Rogoz K, Abrahamsen B, Lind AL, Olund C, Smith C, Mendez JA, Wallén-Mackenzie Å, Wood JN, Kullander K.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5789-94. doi: 10.1073/pnas.1013602108. Epub 2011 Mar 17.


Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain.

Zhao J, Yuan G, Cendan CM, Nassar MA, Lagerström MC, Kullander K, Gavazzi I, Wood JN.

Mol Pain. 2010 Nov 8;6:77. doi: 10.1186/1744-8069-6-77.


VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, Kullander K.

Neuron. 2010 Nov 4;68(3):529-42. doi: 10.1016/j.neuron.2010.09.016.


Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function.

Wallén-Mackenzie A, Nordenankar K, Fejgin K, Lagerström MC, Emilsson L, Fredriksson R, Wass C, Andersson D, Egecioglu E, Andersson M, Strandberg J, Lindhe O, Schiöth HB, Chergui K, Hanse E, Långström B, Fredriksson A, Svensson L, Roman E, Kullander K.

J Neurosci. 2009 Feb 18;29(7):2238-51. doi: 10.1523/JNEUROSCI.5851-08.2009.


The Secretin GPCRs descended from the family of Adhesion GPCRs.

Nordström KJ, Lagerström MC, Wallér LM, Fredriksson R, Schiöth HB.

Mol Biol Evol. 2009 Jan;26(1):71-84. doi: 10.1093/molbev/msn228. Epub 2008 Oct 8.


The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury.

Pickering C, Hägglund M, Szmydynger-Chodobska J, Marques F, Palha JA, Waller L, Chodobski A, Fredriksson R, Lagerström MC, Schiöth HB.

BMC Neurosci. 2008 Oct 3;9:97. doi: 10.1186/1471-2202-9-97.


Structural diversity of G protein-coupled receptors and significance for drug discovery.

Lagerström MC, Schiöth HB.

Nat Rev Drug Discov. 2008 Apr;7(4):339-57. doi: 10.1038/nrd2518. Review. Erratum in: Nat Rev Drug Discov. 2008 Jun;7(6):542.


The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells.

Lagerström MC, Rabe N, Haitina T, Kalnina I, Hellström AR, Klovins J, Kullander K, Schiöth HB.

J Neurochem. 2007 Feb;100(4):1129-42. Epub 2006 Dec 22.


The G protein-coupled receptor subset of the chicken genome.

Lagerström MC, Hellström AR, Gloriam DE, Larsson TP, Schiöth HB, Fredriksson R.

PLoS Comput Biol. 2006 Jun 2;2(6):e54.


The ancestry of the prolactin-releasing hormone precursor.

Lagerström MC, Fredriksson R, Bjarnadottir TK, Schiöth HB.

Ann N Y Acad Sci. 2005 Apr;1040:368-70. Review.


Expansion of the superfamily of G-protein-coupled receptors in chordates.

Fredriksson R, Lagerström MC, Schiöth HB.

Ann N Y Acad Sci. 2005 Apr;1040:89-94. Review.


Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.

Lagerström MC, Fredriksson R, Bjarnadóttir TK, Fridmanis D, Holmquist T, Andersson J, Yan YL, Raudsepp T, Zoorob R, Kukkonen JP, Lundin LG, Klovins J, Chowdhary BP, Postlethwait JH, Schiöth HB.

Genomics. 2005 Jun;85(6):688-703.


The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB.

Genomics. 2004 Jul;84(1):23-33.


Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes.

Haitina T, Klovins J, Andersson J, Fredriksson R, Lagerström MC, Larhammar D, Larson ET, Schiöth HB.

Biochem J. 2004 Jun 1;380(Pt 2):475-86.


Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.

Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB.

FEBS Lett. 2003 Nov 20;554(3):381-8.


High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3.

Lagerström MC, Klovins J, Fredriksson R, Fridmanis D, Haitina T, Ling MK, Berglund MM, Schiöth HB.

J Biol Chem. 2003 Dec 19;278(51):51521-6. Epub 2003 Sep 30.


Functional role, structure, and evolution of the melanocortin-4 receptor.

Schiöth HB, Lagerström MC, Watanobe H, Jonsson L, Vergoni AV, Ringholm A, Skarphedinsson JO, Skuladottir GV, Klovins J, Fredriksson R.

Ann N Y Acad Sci. 2003 Jun;994:74-83. Review.


The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB.

Mol Pharmacol. 2003 Jun;63(6):1256-72.


Association of feather colour with constitutively active melanocortin 1 receptors in chicken.

Ling MK, Lagerström MC, Fredriksson R, Okimoto R, Mundy NI, Takeuchi S, Schiöth HB.

Eur J Biochem. 2003 Apr;270(7):1441-9.


There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.

Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB.

Biochem Biophys Res Commun. 2003 Feb 14;301(3):725-34.


Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.

Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB.

FEBS Lett. 2002 Nov 20;531(3):407-14.

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