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Influence of inflammasome pathway activation in macrophages on the matrix metalloproteinase expression of human hepatic stellate cells.

Robert S, Gicquel T, Bodin A, Fautrel A, Barreto E, Victoni T, Lagente V, Boichot E.

Int Immunopharmacol. 2019 Jul;72:12-20. doi: 10.1016/j.intimp.2019.03.060. Epub 2019 Apr 4.


Intestinally derived bacterial products stimulate development of nonalcoholic steatohepatitis.

Dornas W, Lagente V.

Pharmacol Res. 2019 Mar;141:418-428. doi: 10.1016/j.phrs.2019.01.026. Epub 2019 Jan 15. Review.


Ethanol upregulates the P2X7 purinergic receptor in human macrophages.

Le Daré B, Victoni T, Bodin A, Vlach M, Vene E, Loyer P, Lagente V, Gicquel T.

Fundam Clin Pharmacol. 2019 Feb;33(1):63-74. doi: 10.1111/fcp.12433. Epub 2018 Dec 3.


Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell.

Dornas W, Glaise D, Bodin A, Sharanek A, Burban A, Le Guillou D, Robert S, Dutertre S, Aninat C, Corlu A, Lagente V.

J Cell Physiol. 2018 Jan;234(1):122-133. doi: 10.1002/jcp.27175. Epub 2018 Sep 7.


Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo.

Oliveira da Silva C, Monte-Alto-Costa A, Renovato-Martins M, Viana Nascimento FJ, Dos Santos Valença S, Lagente V, Pôrto LC, Victoni T.

Int J Mol Sci. 2017 Sep 9;18(9). pii: E1940. doi: 10.3390/ijms18091940.


Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2.

Barroso MV, Cattani-Cavalieri I, de Brito-Gitirana L, Fautrel A, Lagente V, Schmidt M, Porto LC, Romana-Souza B, Valença SS, Lanzetti M.

Bioorg Med Chem. 2017 Oct 15;25(20):5557-5568. doi: 10.1016/j.bmc.2017.08.026. Epub 2017 Aug 19.


Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release.

Victoni T, Salvator H, Abrial C, Brollo M, Porto LCS, Lagente V, Naline E, Grassin-Delyle S, Devillier P.

Respir Res. 2017 Jun 21;18(1):126. doi: 10.1186/s12931-017-0613-y.


The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes.

Ondet T, Muscatelli-Groux B, Coulouarn C, Robert S, Gicquel T, Bodin A, Lagente V, Grimaud JA.

Clin Exp Pharmacol Physiol. 2017 Jul;44(7):827-838. doi: 10.1111/1440-1681.12765.


Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments.

Dornas WC, Cardoso LM, Silva M, Machado NL, Chianca DA Jr, Alzamora AC, Lima WG, Lagente V, Silva ME.

Sci Rep. 2017 Apr 11;7:46051. doi: 10.1038/srep46051.


Purinergic receptors: new targets for the treatment of gout and fibrosis.

Gicquel T, Le Daré B, Boichot E, Lagente V.

Fundam Clin Pharmacol. 2017 Apr;31(2):136-146. doi: 10.1111/fcp.12256. Epub 2016 Dec 30. Review.


Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis.

Robert S, Gicquel T, Victoni T, Valença S, Barreto E, Bailly-Maître B, Boichot E, Lagente V.

Biosci Rep. 2016 Jul 15;36(4). pii: e00360. doi: 10.1042/BSR20160107. Print 2016 Aug. Review.


Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1β or TNF-α Release from Human Hepatic Stellate Cells.

Robert S, Gicquel T, Bodin A, Lagente V, Boichot E.

PLoS One. 2016 Apr 5;11(4):e0153118. doi: 10.1371/journal.pone.0153118. eCollection 2016.


Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice.

Agra LC, Lins MP, da Silva Marques P, Smaniotto S, Bandeira de Melo C, Lagente V, Barreto E.

Eur J Pharmacol. 2016 Jun 5;780:232-42. doi: 10.1016/j.ejphar.2016.03.056. Epub 2016 Mar 30.


[The NLRP3 inflammasome: Physiopathology and therapeutic application].

Gicquel T, Robert S, Victoni T, Lagente V.

Presse Med. 2016 Apr;45(4 Pt 1):438-46. doi: 10.1016/j.lpm.2016.01.006. Epub 2016 Feb 12. French.


Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.

Victoni T, Gicquel T, Bodin A, Daude M, Tenor H, Valença S, Devillier P, Porto LC, Lagente V, Boichot E.

Int Immunopharmacol. 2016 Jan;30:1-8. doi: 10.1016/j.intimp.2015.11.019. Epub 2015 Nov 21.


Complete Genome Sequence of Noninvasive Streptococcus pyogenes M/emm28 Strain STAB10015, Isolated from a Child with Perianal Dermatitis in French Brittany.

de Andrade Barboza S, Meygret A, Vincent P, Moullec S, Soriano N, Lagente V, Minet J, Kayal S, Faili A.

Genome Announc. 2015 Jul 16;3(4). pii: e00806-15. doi: 10.1128/genomeA.00806-15.


IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.

Gicquel T, Robert S, Loyer P, Victoni T, Bodin A, Ribault C, Gleonnec F, Couillin I, Boichot E, Lagente V.

FASEB J. 2015 Oct;29(10):4162-73. doi: 10.1096/fj.14-267393. Epub 2015 Jun 26.


The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.

Cell Death Dis. 2015 Feb 5;6:e1629. doi: 10.1038/cddis.2014.576.


Full-Length Genome Sequence of Type M/emm83 Group A Streptococcus pyogenes Strain STAB1101, Isolated from Clustered Cases in Brittany.

Soriano N, Vincent P, Auger G, Cariou ME, Moullec S, Lagente V, Ygout JF, Kayal S, Faili A.

Genome Announc. 2015 Jan 22;3(1). pii: e01459-14. doi: 10.1128/genomeA.01459-14.


Complete Genome Sequence of Streptococcus pyogenes M/emm44 Strain STAB901, Isolated in a Clonal Outbreak in French Brittany.

Soriano N, Vincent P, Piau C, Moullec S, Gautier P, Lagente V, Faili A, Kayal S.

Genome Announc. 2014 Nov 20;2(6). pii: e01174-14. doi: 10.1128/genomeA.01174-14.


Closed Genome Sequence of Noninvasive Streptococcus pyogenes M/emm3 Strain STAB902.

Soriano N, Vincent P, Moullec S, Meygret A, Lagente V, Kayal S, Faili A.

Genome Announc. 2014 Aug 28;2(4). pii: e00792-14. doi: 10.1128/genomeA.00792-14.


Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.

Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.

Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.


Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.

Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valença S, Porto LC, Lagente V, Boichot E.

PLoS One. 2014 Jan 8;9(1):e85243. doi: 10.1371/journal.pone.0085243. eCollection 2014.


Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.

Lanzetti M, da Costa CA, Nesi RT, Barroso MV, Martins V, Victoni T, Lagente V, Pires KM, e Silva PM, Resende AC, Porto LC, Benjamim CF, Valença SS.

Free Radic Biol Med. 2012 Dec 1;53(11):1993-2001. doi: 10.1016/j.freeradbiomed.2012.09.015. Epub 2012 Sep 19.


Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma.

Chevalier E, Lagente V, Dupont M, Fargeau H, Palazzi X, Richard V, Dassaud M, Fric M, Coupe M, Carré C, Leduc S, Bernardelli P, Vergne F, Berna P, Bertrand CP.

Eur Respir J. 2012 Mar;39(3):582-8. doi: 10.1183/09031936.00102610. Epub 2011 Nov 16.


IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.

Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I.

PLoS One. 2011;6(8):e23185. doi: 10.1371/journal.pone.0023185. Epub 2011 Aug 16.


IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.

Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B.

J Immunol. 2009 Dec 15;183(12):8195-202. doi: 10.4049/jimmunol.0803154.


Role of matrix metalloproteinases in the inflammatory process of respiratory diseases.

Lagente V, Boichot E.

J Mol Cell Cardiol. 2010 Mar;48(3):440-4. doi: 10.1016/j.yjmcc.2009.09.017. Epub 2009 Oct 8. Review.


Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways.

Pruniaux MP, Lagente V, Ouaged M, Bertin B, Moreau F, Julien-Larose C, Rocher MN, Leportier C, Martin B, Bouget A, Dubuit JP, Burnouf C, Doherty AM, Bertrand CP.

Fundam Clin Pharmacol. 2010 Feb;24(1):73-82. doi: 10.1111/j.1472-8206.2009.00725.x. Epub 2009 Jul 24.


Effects of betamethasone on inflammation and emphysema induced by cadmium nebulisation in rats.

Fiévez L, Kirschvink N, Zhang WH, Lagente V, Lekeux P, Bureau F, Gustin P.

Eur J Pharmacol. 2009 Mar 15;606(1-3):210-4. doi: 10.1016/j.ejphar.2009.01.020. Epub 2009 Jan 25.


Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases.

Lagente V, Le Quement C, Boichot E.

Expert Opin Ther Targets. 2009 Mar;13(3):287-95. doi: 10.1517/14728220902751632 . Review.


Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.

Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I.

Am J Respir Crit Care Med. 2009 May 15;179(10):903-13. doi: 10.1164/rccm.200808-1274OC. Epub 2009 Feb 12.


Suppressive effects of nitric oxide-releasing prednisolone NCX-1015 on the allergic pleural eosinophil recruitment in rats.

Oliveira MS, de O Barreto E, Zamuner S, Pires AL, Ferreira TP, Cordeiro RS, Lagente V, Martins MA, Wallace JL, e Silva PM.

Clin Exp Allergy. 2008 Nov;38(11):1830-7. doi: 10.1111/j.1365-2222.2008.03083.x. Epub 2008 Aug 3.


The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke.

Le Quément C, Guénon I, Gillon JY, Valença S, Cayron-Elizondo V, Lagente V, Boichot E.

Br J Pharmacol. 2008 Jul;154(6):1206-15. doi: 10.1038/bjp.2008.180. Epub 2008 May 19.


MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.

Le Quément C, Guénon I, Gillon JY, Lagente V, Boichot E.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1076-84. doi: 10.1152/ajplung.00489.2007. Epub 2008 Apr 4.


Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.

Podechard N, Lecureur V, Le Ferrec E, Guenon I, Sparfel L, Gilot D, Gordon JR, Lagente V, Fardel O.

Toxicol Lett. 2008 Mar 15;177(2):130-7. doi: 10.1016/j.toxlet.2008.01.006. Epub 2008 Jan 19.


Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent.

Doz E, Noulin N, Boichot E, Guénon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I.

J Immunol. 2008 Jan 15;180(2):1169-78.


Oxidative stress is an important component of airway inflammation in mice exposed to cigarette smoke or lipopolysaccharide.

Lagente V, Planquois JM, Leclerc O, Schmidlin F, Bertrand CP.

Clin Exp Pharmacol Physiol. 2008 May;35(5-6):601-5. doi: 10.1111/j.1440-1681.2007.04848.x. Epub 2007 Dec 27.


Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways.

Nénan S, Boichot E, Planquois JM, Berna P, Hitier S, Bénard T, Lagente V, Bertrand CP.

Eur J Pharmacol. 2008 Jan 28;579(1-3):374-81. Epub 2007 Oct 25.


IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.

Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I.

J Clin Invest. 2007 Dec;117(12):3786-99.


Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice.

Benturquia N, Le Guen S, Canestrelli C, Lagente V, Apiou G, Roques BP, Noble F.

Neuroscience. 2007 Nov 9;149(3):477-86. Epub 2007 Aug 8.


Influence of early neutrophil depletion on MMPs/TIMP-1 balance in bleomycin-induced lung fibrosis.

Manoury B, Nénan S, Guénon I, Lagente V, Boichot E.

Int Immunopharmacol. 2007 Jul;7(7):900-11. Epub 2007 Mar 15.


Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchi.

Naline E, Höglund CO, Vincent F, Emonds-Alt X, Lagente V, Advenier C, Frossard N.

Eur J Pharmacol. 2007 Apr 10;560(2-3):206-11. Epub 2007 Jan 18.


Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat.

Nénan S, Lagente V, Planquois JM, Hitier S, Berna P, Bertrand CP, Boichot E.

Eur J Pharmacol. 2007 Mar 15;559(1):75-81. Epub 2006 Dec 12.


TIMP-1 is a key factor of fibrogenic response to bleomycin in mouse lung.

Manoury B, Caulet-Maugendre S, Guénon I, Lagente V, Boichot E.

Int J Immunopathol Pharmacol. 2006 Jul-Sep;19(3):471-87.


Arenicola marina extracellular hemoglobin: a new promising blood substitute.

Rousselot M, Delpy E, Drieu La Rochelle C, Lagente V, Pirow R, Rees JF, Hagege A, Le Guen D, Hourdez S, Zal F.

Biotechnol J. 2006 Mar;1(3):333-45.


Increased extracellular matrix metalloproteinase inducer (EMMPRIN) expression in pulmonary fibrosis.

Guillot S, Delaval P, Brinchault G, Caulet-Maugendre S, Depince A, Lena H, Delatour B, Lagente V, Martin-Chouly C.

Exp Lung Res. 2006 Mar-Apr;32(3-4):81-97.


Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice.

Leclerc O, Lagente V, Planquois JM, Berthelier C, Artola M, Eichholtz T, Bertrand CP, Schmidlin F.

Eur Respir J. 2006 Jun;27(6):1102-9. Epub 2006 Mar 1.


Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice.

Manoury B, Nenan S, Guenon I, Boichot E, Planquois JM, Bertrand CP, Lagente V.

J Inflamm (Lond). 2006 Feb 22;3:2.


Role of matrix metalloproteinases in the development of airway inflammation and remodeling.

Lagente V, Manoury B, Nénan S, Le Quément C, Martin-Chouly C, Boichot E.

Braz J Med Biol Res. 2005 Oct;38(10):1521-30. Epub 2005 Sep 6. Review.

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