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Items: 27

1.

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model.

Hendrikx JJ, Lagas JS, Song JY, Rosing H, Schellens JH, Beijnen JH, Rottenberg S, Schinkel AH.

Int J Cancer. 2016 Feb 1;138(3):758-69. doi: 10.1002/ijc.29812. Epub 2015 Sep 21.

2.

Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.

Hendrikx JJ, Lagas JS, Wagenaar E, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.

Br J Cancer. 2014 May 27;110(11):2669-76. doi: 10.1038/bjc.2014.222. Epub 2014 Apr 29.

3.

Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.

Hendrikx JJ, Lagas JS, Daling R, Hooijberg JH, Schellens JH, Beijnen JH, Brandjes DP, Huitema AD.

Basic Clin Pharmacol Toxicol. 2014 Nov;115(5):472-5. doi: 10.1111/bcpt.12251. Epub 2014 Apr 28.

4.

Taxanes: old drugs, new oral formulations.

Jibodh RA, Lagas JS, Nuijen B, Beijnen JH, Schellens JH.

Eur J Pharmacol. 2013 Oct 5;717(1-3):40-6. doi: 10.1016/j.ejphar.2013.02.058. Epub 2013 May 7. Review.

PMID:
23660368
5.

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

Hendrikx JJ, Lagas JS, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.

Int J Cancer. 2013 May 15;132(10):2439-47. doi: 10.1002/ijc.27912. Epub 2012 Nov 14.

6.

P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine.

Lagas JS, Damen CW, van Waterschoot RA, Iusuf D, Beijnen JH, Schinkel AH.

Mol Pharmacol. 2012 Oct;82(4):636-44. Epub 2012 Jul 5.

PMID:
22767610
7.

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

van Waterschoot RA, Lagas JS, Wagenaar E, Rosing H, Beijnen JH, Schinkel AH.

Int J Cancer. 2010 Dec 15;127(12):2959-64. doi: 10.1002/ijc.25279.

8.

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.

Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, Beijnen JH, Schinkel AH.

Int J Cancer. 2012 Jan 1;130(1):223-33. doi: 10.1002/ijc.26000. Epub 2011 Apr 7.

9.

Lethal morphine intoxication in a patient with a sickle cell crisis and renal impairment: case report and a review of the literature.

Lagas JS, Wagenaar JF, Huitema AD, Hillebrand MJ, Koks CH, Gerdes VE, Brandjes DP, Beijnen JH.

Hum Exp Toxicol. 2011 Sep;30(9):1399-403. doi: 10.1177/0960327110388962. Epub 2010 Nov 5.

PMID:
21056950
10.

Toxicokinetics of a dipyridamole (Persantin) intoxication: case report.

Lagas JS, Wilhelm AJ, Vos RM, van den Dool EJ, van der Heide Y, Huissoon S, Beijnen JH, Brandjes DP.

Hum Exp Toxicol. 2011 Jan;30(1):74-8. doi: 10.1177/0960327110368696. Epub 2010 Apr 7.

PMID:
20375123
11.

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.

Lagas JS, van Waterschoot RA, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.

Mol Cancer Ther. 2010 Feb;9(2):319-26. doi: 10.1158/1535-7163.MCT-09-0663. Epub 2010 Jan 26.

12.

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.

Lagas JS, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.

Mol Pharmacol. 2010 Apr;77(4):687-94. doi: 10.1124/mol.109.062364. Epub 2010 Jan 19.

PMID:
20086033
13.

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide.

Lagas JS, Fan L, Wagenaar E, Vlaming ML, van Tellingen O, Beijnen JH, Schinkel AH.

Clin Cancer Res. 2010 Jan 1;16(1):130-40. doi: 10.1158/1078-0432.CCR-09-1321. Epub 2009 Dec 22.

14.

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

van Waterschoot RA, Lagas JS, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Song JY, Rooswinkel RW, van Tellingen O, Rosing H, Beijnen JH, Schinkel AH.

Cancer Res. 2009 Dec 1;69(23):8996-9002. doi: 10.1158/0008-5472.CAN-09-2915. Epub 2009 Nov 17.

15.

Pharmacokinetic assessment of multiple ATP-binding cassette transporters: the power of combination knockout mice.

Lagas JS, Vlaming ML, Schinkel AH.

Mol Interv. 2009 Jun;9(3):136-45. doi: 10.1124/mi.9.3.7. Review.

PMID:
19592674
16.
17.

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.

Lagas JS, van Waterschoot RA, van Tilburg VA, Hillebrand MJ, Lankheet N, Rosing H, Beijnen JH, Schinkel AH.

Clin Cancer Res. 2009 Apr 1;15(7):2344-51. doi: 10.1158/1078-0432.CCR-08-2253. Epub 2009 Mar 10.

18.

Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice.

Vlaming ML, Lagas JS, Schinkel AH.

Adv Drug Deliv Rev. 2009 Jan 31;61(1):14-25. doi: 10.1016/j.addr.2008.08.007. Epub 2008 Dec 7. Review.

PMID:
19118589
19.

Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite.

Sparidans RW, Vlaming ML, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):269-76. doi: 10.1016/j.jchromb.2008.12.026. Epub 2008 Dec 24.

PMID:
19117812
20.

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.

Lagas JS, van der Kruijssen CM, van de Wetering K, Beijnen JH, Schinkel AH.

Drug Metab Dispos. 2009 Jan;37(1):129-36. doi: 10.1124/dmd.108.023200. Epub 2008 Oct 9.

PMID:
18845662
21.

Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma.

Sparidans RW, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):77-82. doi: 10.1016/j.jchromb.2008.07.012. Epub 2008 Jul 18.

PMID:
18674973
22.

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

Damen CW, Rosing H, Tibben MM, van Maanen MJ, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 1;868(1-2):102-9. doi: 10.1016/j.jchromb.2008.04.046. Epub 2008 May 10.

PMID:
18501686
23.

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.

Lagas JS, Sparidans RW, van Waterschoot RA, Wagenaar E, Beijnen JH, Schinkel AH.

Antimicrob Agents Chemother. 2008 Mar;52(3):1034-9. doi: 10.1128/AAC.01041-07. Epub 2008 Jan 14.

24.

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

van Waterschoot RA, van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH.

Mol Pharmacol. 2008 Mar;73(3):1029-36. Epub 2007 Dec 21.

25.

Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium.

Sparidans RW, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):200-10. Epub 2007 May 17.

PMID:
17544343
26.

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.

Lagas JS, Vlaming ML, van Tellingen O, Wagenaar E, Jansen RS, Rosing H, Beijnen JH, Schinkel AH.

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6125-32.

27.

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.

Vlaming ML, Mohrmann K, Wagenaar E, de Waart DR, Elferink RP, Lagas JS, van Tellingen O, Vainchtein LD, Rosing H, Beijnen JH, Schellens JH, Schinkel AH.

J Pharmacol Exp Ther. 2006 Jul;318(1):319-27. Epub 2006 Apr 12.

PMID:
16611851

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