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Items: 20


Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.

Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH.

J Cell Biol. 2019 Jun 3;218(6):1799-1809. doi: 10.1083/jcb.201810061. Epub 2019 Apr 15.


Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.

Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH.

Blood. 2019 Jan 17;133(3):193-204. doi: 10.1182/blood-2018-06-856062. Epub 2018 Nov 15.


Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.

Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH.

Blood Adv. 2018 Sep 25;2(18):2358-2368. doi: 10.1182/bloodadvances.2018020487.


Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.

Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH.

J Cell Biol. 2018 Apr 2;217(4):1453-1465. doi: 10.1083/jcb.201707055. Epub 2018 Mar 13.


Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.

Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH.

J Exp Med. 2017 Nov 6;214(11):3331-3346. doi: 10.1084/jem.20171178. Epub 2017 Sep 28.


Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.

Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM.

J Immunol. 2017 May 1;198(9):3410-3415. doi: 10.4049/jimmunol.1601743. Epub 2017 Mar 27.


The Rap1-RIAM-talin axis of integrin activation and blood cell function.

Lagarrigue F, Kim C, Ginsberg MH.

Blood. 2016 Jul 28;128(4):479-87. doi: 10.1182/blood-2015-12-638700. Epub 2016 May 20. Review.


A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.

Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH.

Nat Commun. 2015 Sep 30;6:8492. doi: 10.1038/ncomms9492.


Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

Viaud J, Lagarrigue F, Ramel D, Allart S, Chicanne G, Ceccato L, Courilleau D, Xuereb JM, Pertz O, Payrastre B, Gaits-Iacovoni F.

Nat Commun. 2014 Jun 6;5:4080. doi: 10.1038/ncomms5080.


SnapShot: talin and the modular nature of the integrin adhesome.

Ye F, Lagarrigue F, Ginsberg MH.

Cell. 2014 Mar 13;156(6):1340-1340.e1. doi: 10.1016/j.cell.2014.02.048.


ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/CXCL8 production by keratinocytes through NF-κB activation.

Dejean E, Foisseau M, Lagarrigue F, Lamant L, Prade N, Marfak A, Delsol G, Giuriato S, Gaits-Iacovoni F, Meggetto F.

Blood. 2012 May 17;119(20):4698-707. doi: 10.1182/blood-2011-10-386011. Epub 2012 Mar 6.


Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

Ramel D, Lagarrigue F, Pons V, Mounier J, Dupuis-Coronas S, Chicanne G, Sansonetti PJ, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Sci Signal. 2011 Sep 20;4(191):ra61. doi: 10.1126/scisignal.2001619.


The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.

Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, Payrastre B, Tronchère H.

J Biol Chem. 2011 Sep 16;286(37):32105-14. doi: 10.1074/jbc.M111.227512. Epub 2011 Jul 7.


Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion.

Lagarrigue F, Dupuis-Coronas S, Ramel D, Delsol G, Tronchère H, Payrastre B, Gaits-Iacovoni F.

Cancer Res. 2010 Sep 1;70(17):6978-87. doi: 10.1158/0008-5472.CAN-10-0861. Epub 2010 Aug 10.


PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

Ramel D, Lagarrigue F, Dupuis-Coronas S, Chicanne G, Leslie N, Gaits-Iacovoni F, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):127-31. doi: 10.1016/j.bbrc.2009.06.139. Epub 2009 Jul 1.


Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.

Coronas S, Lagarrigue F, Ramel D, Chicanne G, Delsol G, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2008 Jul 25;372(2):351-5. doi: 10.1016/j.bbrc.2008.05.062. Epub 2008 May 22.


Multiresistant Enterobacter cloacae outbreak in an intensive care unit associated with therapeutic beds.

van der Mee-Marquet N, Girard S, Lagarrigue F, Leroux I, Voyer I, Bloc D, Besnier JM, Quentin R.

Crit Care. 2006 Feb;10(1):405.


Influence of infusion flow rates on central venous pressure measurements through multi-lumen central venous catheters in intensive care.

Lakhal K, Ferrandière M, Lagarrigue F, Mercier C, Fusciardi J, Laffon M.

Intensive Care Med. 2006 Mar;32(3):460-3. Epub 2006 Feb 14.


[Morbidity and mortality of acute pancreatitis. Prospective study in a French university hospital].

Karsenti D, Bourlier P, Dorval E, Scotto B, Giraudeau B, Lanotte R, de Calan L, Mesny J, Lagarrigue F, Metman E.

Presse Med. 2002 Apr 27;31(16):727-34. French.


Complete thrombolysis of mesenteric vein occlusion with recombinant tissue-type plasminogen activator.

Robin P, Gruel Y, Lang M, Lagarrigue F, Scotto JM.

Lancet. 1988 Jun 18;1(8599):1391. No abstract available.


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