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Items: 1 to 50 of 148

1.

Phytochrome Evolution in 3D: Deletion, Duplication, and Diversification.

Rockwell NC, Lagarias JC.

New Phytol. 2019 Oct 8. doi: 10.1111/nph.16240. [Epub ahead of print] Review.

PMID:
31595505
2.

Conservation and diversity in the secondary forward photodynamics of red/green cyanobacteriochromes.

Jenkins AJ, Gottlieb SM, Chang CW, Hayer RJ, Martin SS, Lagarias JC, Larsen DS.

Photochem Photobiol Sci. 2019 Oct 9;18(10):2539-2552. doi: 10.1039/c9pp00295b.

PMID:
31528964
3.

Structural Characterization of Agonist Binding to an A3 Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments.

Stamatis D, Lagarias P, Barkan K, Vrontaki E, Ladds G, Kolocouris A.

J Med Chem. 2019 Oct 10;62(19):8831-8846. doi: 10.1021/acs.jmedchem.9b01164. Epub 2019 Sep 27.

PMID:
31502843
4.

The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers.

Musharrafieh R, Lagarias PI, Ma C, Tan GS, Kolocouris A, Wang J.

Mol Pharmacol. 2019 Aug;96(2):148-157. doi: 10.1124/mol.119.116640. Epub 2019 Jun 7.

PMID:
31175183
5.

LOF and GOF Alleles Shed Light on the Molecular Basis of phyB Signaling in Plants.

Hu W, Lagarias JC.

Plant Cell. 2019 Jul;31(7):1400-1401. doi: 10.1105/tpc.19.00373. Epub 2019 May 13. No abstract available.

6.

Reverse Photodynamics of the Noncanonical Red/Green NpR3784 Cyanobacteriochrome from Nostoc punctiforme.

Kirpich JS, Gottlieb SM, Chang CW, Kim PW, Martin SS, Lagarias JC, Larsen DS.

Biochemistry. 2019 May 7;58(18):2307-2317. doi: 10.1021/acs.biochem.8b01275. Epub 2019 Apr 29.

PMID:
30977638
7.

Forward Photodynamics of the Noncanonical Red/Green NpR3784 Cyanobacteriochrome from Nostoc punctiforme.

Kirpich JS, Gottlieb SM, Chang CW, Kim PW, Martin SS, Lagarias JC, Larsen DS.

Biochemistry. 2019 May 7;58(18):2297-2306. doi: 10.1021/acs.biochem.8b01274. Epub 2019 Apr 22.

PMID:
30973006
8.

Phototaxis in a wild isolate of the cyanobacterium Synechococcus elongatus.

Yang Y, Lam V, Adomako M, Simkovsky R, Jakob A, Rockwell NC, Cohen SE, Taton A, Wang J, Lagarias JC, Wilde A, Nobles DR, Brand JJ, Golden SS.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12378-E12387. doi: 10.1073/pnas.1812871115. Epub 2018 Dec 14.

9.

Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells.

Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS, Gan F, Bryant DA, Lagarias JC.

J Biol Chem. 2018 Sep 7;293(36):13850. doi: 10.1074/jbc.AAC118.005397. No abstract available.

10.

Molecular Dynamics Simulations on the Bioactive Molecule of hIAPP22-29 (NFGAILSS) and Rational Drug Design.

Lagarias P, Elkhou Y, Vedad J, Konstantinidi A, Profit AA, Kellici TF, Kolocouris A, Desamero RZB, Mavromoustakos T.

Methods Mol Biol. 2018;1824:1-16. doi: 10.1007/978-1-4939-8630-9_1.

PMID:
30039398
11.

Protonation Heterogeneity Modulates the Ultrafast Photocycle Initiation Dynamics of Phytochrome Cph1.

Kirpich JS, Mix LT, Martin SS, Rockwell NC, Lagarias JC, Larsen DS.

J Phys Chem Lett. 2018 Jun 21;9(12):3454-3462. doi: 10.1021/acs.jpclett.8b01133. Epub 2018 Jun 11.

12.

Noncanonical Photodynamics of the Orange/Green Cyanobacteriochrome Power Sensor NpF2164g7 from the PtxD Phototaxis Regulator of Nostoc punctiforme.

Kirpich JS, Chang CW, Madsen D, Gottlieb SM, Martin SS, Rockwell NC, Lagarias JC, Larsen DS.

Biochemistry. 2018 May 8;57(18):2636-2648. doi: 10.1021/acs.biochem.7b01252. Epub 2018 Apr 23.

PMID:
29633829
13.

Correlating structural and photochemical heterogeneity in cyanobacteriochrome NpR6012g4.

Lim S, Yu Q, Gottlieb SM, Chang CW, Rockwell NC, Martin SS, Madsen D, Lagarias JC, Larsen DS, Ames JB.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4387-4392. doi: 10.1073/pnas.1720682115. Epub 2018 Apr 9.

14.

Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells.

Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS, Gan F, Bryant DA, Lagarias JC.

J Biol Chem. 2018 Jun 1;293(22):8473-8483. doi: 10.1074/jbc.RA118.002258. Epub 2018 Apr 9. Erratum in: J Biol Chem. 2018 Sep 7;293(36):13850.

15.

Discovery of Novel Adenosine Receptor Antagonists through a Combined Structure- and Ligand-Based Approach Followed by Molecular Dynamics Investigation of Ligand Binding Mode.

Lagarias P, Vrontaki E, Lambrinidis G, Stamatis D, Convertino M, Ortore G, Mavromoustakos T, Klotz KN, Kolocouris A.

J Chem Inf Model. 2018 Apr 23;58(4):794-815. doi: 10.1021/acs.jcim.7b00455. Epub 2018 Mar 19.

PMID:
29485875
16.

Bilin-Dependent Photoacclimation in Chlamydomonas reinhardtii.

Wittkopp TM, Schmollinger S, Saroussi S, Hu W, Zhang W, Fan Q, Gallaher SD, Leonard MT, Soubeyrand E, Basset GJ, Merchant SS, Grossman AR, Duanmu D, Lagarias JC.

Plant Cell. 2017 Nov;29(11):2711-2726. doi: 10.1105/tpc.17.00149. Epub 2017 Oct 30.

17.

Light-Regulated Synthesis of Cyclic-di-GMP by a Bidomain Construct of the Cyanobacteriochrome Tlr0924 (SesA) without Stable Dimerization.

Blain-Hartung M, Rockwell NC, Lagarias JC.

Biochemistry. 2017 Nov 21;56(46):6145-6154. doi: 10.1021/acs.biochem.7b00734. Epub 2017 Nov 8.

PMID:
29072834
18.

Designing brighter near-infrared fluorescent proteins: insights from structural and biochemical studies.

Baloban M, Shcherbakova DM, Pletnev S, Pletnev VZ, Lagarias JC, Verkhusha VV.

Chem Sci. 2017 Jun 1;8(6):4546-4557. doi: 10.1039/c7sc00855d. Epub 2017 May 4.

19.

Ferredoxin-dependent bilin reductases in eukaryotic algae: Ubiquity and diversity.

Rockwell NC, Lagarias JC.

J Plant Physiol. 2017 Oct;217:57-67. doi: 10.1016/j.jplph.2017.05.022. Epub 2017 May 31.

20.

Phytochrome diversification in cyanobacteria and eukaryotic algae.

Rockwell NC, Lagarias JC.

Curr Opin Plant Biol. 2017 Jun;37:87-93. doi: 10.1016/j.pbi.2017.04.003. Epub 2017 Apr 23. Review.

21.

Algal light sensing and photoacclimation in aquatic environments.

Duanmu D, Rockwell NC, Lagarias JC.

Plant Cell Environ. 2017 Nov;40(11):2558-2570. doi: 10.1111/pce.12943. Epub 2017 May 11. Review.

22.

The phycocyanobilin chromophore of streptophyte algal phytochromes is synthesized by HY2.

Rockwell NC, Martin SS, Li FW, Mathews S, Lagarias JC.

New Phytol. 2017 May;214(3):1145-1157. doi: 10.1111/nph.14422. Epub 2017 Jan 20.

23.

There and Back Again: Loss and Reacquisition of Two-Cys Photocycles in Cyanobacteriochromes.

Rockwell NC, Martin SS, Lagarias JC.

Photochem Photobiol. 2017 May;93(3):741-754. doi: 10.1111/php.12708.

PMID:
28055111
24.

Cyanobacteriochrome Photoreceptors Lacking the Canonical Cys Residue.

Fushimi K, Rockwell NC, Enomoto G, Ni-Ni-Win, Martin SS, Gan F, Bryant DA, Ikeuchi M, Lagarias JC, Narikawa R.

Biochemistry. 2016 Dec 20;55(50):6981-6995. Epub 2016 Dec 9.

PMID:
27935696
25.

A Tightly Regulated Genetic Selection System with Signaling-Active Alleles of Phytochrome B.

Hu W, Lagarias JC.

Plant Physiol. 2017 Jan;173(1):366-375. doi: 10.1104/pp.16.01345. Epub 2016 Nov 23.

26.

Identification of Cyanobacteriochromes Detecting Far-Red Light.

Rockwell NC, Martin SS, Lagarias JC.

Biochemistry. 2016 Jul 19;55(28):3907-19. doi: 10.1021/acs.biochem.6b00299. Epub 2016 Jul 2.

PMID:
27295035
27.

1H, 13C, and 15N chemical shift assignments of cyanobacteriochrome NpR6012g4 in the green-absorbing photoproduct state.

Lim S, Yu Q, Rockwell NC, Martin SS, Lagarias JC, Ames JB.

Biomol NMR Assign. 2016 Apr;10(1):157-61. doi: 10.1007/s12104-015-9657-4. Epub 2015 Nov 4.

28.

Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging.

Berlin S, Carroll EC, Newman ZL, Okada HO, Quinn CM, Kallman B, Rockwell NC, Martin SS, Lagarias JC, Isacoff EY.

Nat Methods. 2015 Sep;12(9):852-8. doi: 10.1038/nmeth.3480. Epub 2015 Jul 13.

29.

A Constitutively Active Allele of Phytochrome B Maintains Circadian Robustness in the Absence of Light.

Jones MA, Hu W, Litthauer S, Lagarias JC, Harmer SL.

Plant Physiol. 2015 Sep;169(1):814-25. doi: 10.1104/pp.15.00782. Epub 2015 Jul 8.

30.

Characterization of Red/Green Cyanobacteriochrome NpR6012g4 by Solution Nuclear Magnetic Resonance Spectroscopy: A Hydrophobic Pocket for the C15-E,anti Chromophore in the Photoproduct.

Rockwell NC, Martin SS, Lim S, Lagarias JC, Ames JB.

Biochemistry. 2015 Jun 23;54(24):3772-83. doi: 10.1021/acs.biochem.5b00438. Epub 2015 Jun 5.

PMID:
25989712
31.

Characterization of Red/Green Cyanobacteriochrome NpR6012g4 by Solution Nuclear Magnetic Resonance Spectroscopy: A Protonated Bilin Ring System in Both Photostates.

Rockwell NC, Martin SS, Lim S, Lagarias JC, Ames JB.

Biochemistry. 2015 Apr 28;54(16):2581-600. doi: 10.1021/bi501548t. Epub 2015 Apr 14.

PMID:
25843271
32.

Identification of DXCF cyanobacteriochrome lineages with predictable photocycles.

Rockwell NC, Martin SS, Lagarias JC.

Photochem Photobiol Sci. 2015 May;14(5):929-41. doi: 10.1039/c4pp00486h.

PMID:
25738434
33.

Conservation and diversity in the primary forward photodynamics of red/green cyanobacteriochromes.

Gottlieb SM, Kim PW, Chang CW, Hanke SJ, Hayer RJ, Rockwell NC, Martin SS, Lagarias JC, Larsen DS.

Biochemistry. 2015 Feb 3;54(4):1028-42. doi: 10.1021/bi5012755. Epub 2015 Jan 20.

PMID:
25545467
34.

NpR3784 is the prototype for a distinctive group of red/green cyanobacteriochromes using alternative Phe residues for photoproduct tuning.

Rockwell NC, Martin SS, Gan F, Bryant DA, Lagarias JC.

Photochem Photobiol Sci. 2015 Feb;14(2):258-69. doi: 10.1039/c4pp00336e.

PMID:
25342233
35.

Marine algae and land plants share conserved phytochrome signaling systems.

Duanmu D, Bachy C, Sudek S, Wong CH, Jiménez V, Rockwell NC, Martin SS, Ngan CY, Reistetter EN, van Baren MJ, Price DC, Wei CL, Reyes-Prieto A, Lagarias JC, Worden AZ.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15827-32. doi: 10.1073/pnas.1416751111. Epub 2014 Sep 29.

36.

Extensive remodeling of a cyanobacterial photosynthetic apparatus in far-red light.

Gan F, Zhang S, Rockwell NC, Martin SS, Lagarias JC, Bryant DA.

Science. 2014 Sep 12;345(6202):1312-7. doi: 10.1126/science.1256963. Epub 2014 Aug 21.

37.

Phytochrome C plays a major role in the acceleration of wheat flowering under long-day photoperiod.

Chen A, Li C, Hu W, Lau MY, Lin H, Rockwell NC, Martin SS, Jernstedt JA, Lagarias JC, Dubcovsky J.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10037-44. doi: 10.1073/pnas.1409795111. Epub 2014 Jun 24.

38.

Heterogeneous photodynamics of the pfr state in the cyanobacterial phytochrome Cph1.

Kim PW, Rockwell NC, Martin SS, Lagarias JC, Larsen DS.

Biochemistry. 2014 Jul 22;53(28):4601-11. doi: 10.1021/bi5005359. Epub 2014 Jul 8.

39.

Optically Guided Photoactivity: Coordinating Tautomerization, Photoisomerization, Inhomogeneity, and Reactive Intermediates within the RcaE Cyanobacteriochrome.

Gottlieb SM, Chang CW, Martin SS, Rockwell NC, Lagarias JC, Larsen DS.

J Phys Chem Lett. 2014 May 1;5(9):1527-33. doi: 10.1021/jz500378n. Epub 2014 Apr 14.

PMID:
26270091
40.

Conserved phenylalanine residues are required for blue-shifting of cyanobacteriochrome photoproducts.

Rockwell NC, Martin SS, Gulevich AG, Lagarias JC.

Biochemistry. 2014 May 20;53(19):3118-30. doi: 10.1021/bi500037a. Epub 2014 May 6.

PMID:
24766217
41.

Photoconversion changes bilin chromophore conjugation and protein secondary structure in the violet/orange cyanobacteriochrome NpF2164g3' [corrected].

Lim S, Rockwell NC, Martin SS, Dallas JL, Lagarias JC, Ames JB.

Photochem Photobiol Sci. 2014 Jun;13(6):951-62. doi: 10.1039/c3pp50442e. Erratum in: Photochem Photobiol Sci. 2014 Sep;13(9):1360.

42.

Dynamic inhomogeneity in the photodynamics of cyanobacterial phytochrome Cph1.

Kim PW, Rockwell NC, Martin SS, Lagarias JC, Larsen DS.

Biochemistry. 2014 May 6;53(17):2818-26. doi: 10.1021/bi500108s. Epub 2014 Apr 21.

43.

Eukaryotic algal phytochromes span the visible spectrum.

Rockwell NC, Duanmu D, Martin SS, Bachy C, Price DC, Bhattacharya D, Worden AZ, Lagarias JC.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3871-6. doi: 10.1073/pnas.1401871111. Epub 2014 Feb 24. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E1051.

44.

Primary and secondary photodynamics of the violet/orange dual-cysteine NpF2164g3 cyanobacteriochrome domain from Nostoc punctiforme.

Gottlieb SM, Kim PW, Corley SC, Madsen D, Hanke SJ, Chang CW, Rockwell NC, Martin SS, Lagarias JC, Larsen DS.

Biochemistry. 2014 Feb 18;53(6):1029-40. doi: 10.1021/bi4015538. Epub 2014 Feb 3.

PMID:
24437620
45.

Primary endosymbiosis and the evolution of light and oxygen sensing in photosynthetic eukaryotes.

Rockwell NC, Lagarias JC, Bhattacharya D.

Front Ecol Evol. 2014;2(66). doi: 10.3389/fevo.2014.00066.

46.

Primary photodynamics of the green/red-absorbing photoswitching regulator of the chromatic adaptation E domain from Fremyella diplosiphon.

Gottlieb SM, Kim PW, Rockwell NC, Hirose Y, Ikeuchi M, Lagarias JC, Larsen DS.

Biochemistry. 2013 Nov 19;52(46):8198-208. doi: 10.1021/bi400946q. Epub 2013 Nov 7.

PMID:
24147541
47.

Unraveling the Primary Isomerization Dynamics in Cyanobacterial Phytochrome Cph1 with Multi-pulse Manipulations.

Kim PW, Rockwell NC, Freer LH, Chang CW, Martin SS, Lagarias JC, Larsen DS.

J Phys Chem Lett. 2013 Jul 20;4(16):2605-2609.

48.

His74 conservation in the bilin reductase PcyA family reflects an important role in protein-substrate structure and dynamics.

Kabasakal BV, Gae DD, Li J, Lagarias JC, Koehl P, Fisher AJ.

Arch Biochem Biophys. 2013 Sep 15;537(2):233-42. doi: 10.1016/j.abb.2013.07.021. Epub 2013 Aug 2.

49.

¹H, ¹⁵N, and ¹³C chemical shift assignments of cyanobacteriochrome NpF2164g3 in the photoproduct state.

Lim S, Rockwell NC, Martin SS, Lagarias JC, Ames JB.

Biomol NMR Assign. 2014 Oct;8(2):259-62. doi: 10.1007/s12104-013-9496-0. Epub 2013 Jun 9.

50.

Reactive ground-state pathways are not ubiquitous in red/green cyanobacteriochromes.

Chang CW, Gottlieb SM, Kim PW, Rockwell NC, Lagarias JC, Larsen DS.

J Phys Chem B. 2013 Sep 26;117(38):11229-38. doi: 10.1021/jp402112u. Epub 2013 Jun 19.

PMID:
23725062

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