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Items: 26

1.

Ephrins and Eph Receptor Signaling in Tissue Repair and Fibrosis.

Wu B, Rockel JS, Lagares D, Kapoor M.

Curr Rheumatol Rep. 2019 Apr 12;21(6):23. doi: 10.1007/s11926-019-0825-x. Review.

PMID:
30980212
2.

P311 in Scar Wars: Myofibroblasts Lost without Transforming Growth Factor β Translation.

Lagares D.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):139-140. doi: 10.1165/rcmb.2018-0255ED. No abstract available.

PMID:
30277809
3.

BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts.

Kuehl T, Lagares D.

Matrix Biol. 2018 Aug;68-69:94-105. doi: 10.1016/j.matbio.2018.01.020. Epub 2018 Jan 31. Review.

PMID:
29408011
4.

Matrix Stiffness: the Conductor of Organ Fibrosis.

Santos A, Lagares D.

Curr Rheumatol Rep. 2018 Jan 19;20(1):2. doi: 10.1007/s11926-018-0710-z. Review.

PMID:
29349703
5.

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM.

Sci Transl Med. 2017 Dec 13;9(420). pii: eaal3765. doi: 10.1126/scitranslmed.aal3765.

PMID:
29237758
6.

Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.

Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M.

Nat Med. 2017 Dec 7;23(12):1499. doi: 10.1038/nm1217-1499b.

PMID:
29216045
7.

The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.

Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):471-481. doi: 10.1165/rcmb.2017-0075OC.

8.

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.

Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M.

Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23. Erratum in: Nat Med. 2017 Dec 7;23 (12 ):1499.

9.

Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.

Sakai N, Chun J, Duffield JS, Lagares D, Wada T, Luster AD, Tager AM.

Kidney Int. 2017 Mar;91(3):628-641. doi: 10.1016/j.kint.2016.09.030. Epub 2016 Dec 4.

10.

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization.

Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kühnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD Jr, Ochs M, Tager AM.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):105-16. doi: 10.1165/rcmb.2015-0152OC.

11.

Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.

Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM.

FASEB J. 2016 Jun;30(6):2435-50. doi: 10.1096/fj.201500197R. Epub 2016 Mar 22.

12.

Fibrogenic Lung Injury Induces Non-Cell-Autonomous Fibroblast Invasion.

Ahluwalia N, Grasberger PE, Mugo BM, Feghali-Bostwick C, Pardo A, Selman M, Lagares D, Tager AM.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):831-42. doi: 10.1165/rcmb.2015-0040OC.

13.

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.

Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M.

Ann Rheum Dis. 2015 Mar;74(3):569-78. doi: 10.1136/annrheumdis-2014-205743. Epub 2015 Jan 8.

14.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12.

15.

A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis.

Busnadiego O, Loureiro-Álvarez J, Sandoval P, Lagares D, Dotor J, Pérez-Lozano ML, López-Armada MJ, Lamas S, López-Cabrera M, Rodríguez-Pascual F.

J Am Soc Nephrol. 2015 Jan;26(1):173-82. doi: 10.1681/ASN.2013070799. Epub 2014 Jul 10.

16.

Fibrosis--a lethal component of systemic sclerosis.

Ho YY, Lagares D, Tager AM, Kapoor M.

Nat Rev Rheumatol. 2014 Jul;10(7):390-402. doi: 10.1038/nrrheum.2014.53. Epub 2014 Apr 22. Review.

PMID:
24752182
17.

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.

Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, Lussier B, Roughley P, Lagares D, Pelletier JP, Martel-Pelletier J, Kapoor M.

Ann Rheum Dis. 2015 Jul;74(7):1432-40. doi: 10.1136/annrheumdis-2013-204599. Epub 2014 Mar 20.

PMID:
24651621
18.

LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling.

Busnadiego O, González-Santamaría J, Lagares D, Guinea-Viniegra J, Pichol-Thievend C, Muller L, Rodríguez-Pascual F.

Mol Cell Biol. 2013 Jun;33(12):2388-401. doi: 10.1128/MCB.00036-13. Epub 2013 Apr 9.

19.

Targeting focal adhesion kinase in fibrotic diseases.

Lagares D, Kapoor M.

BioDrugs. 2013 Feb;27(1):15-23. doi: 10.1007/s40259-012-0003-4. Review.

PMID:
23329396
20.

Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase.

Lagares D, Busnadiego O, García-Fernández RA, Lamas S, Rodríguez-Pascual F.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):834-42. doi: 10.1165/rcmb.2011-0446OC. Epub 2012 Sep 6.

PMID:
22962065
21.

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.

Lagares D, Busnadiego O, García-Fernández RA, Kapoor M, Liu S, Carter DE, Abraham D, Shi-Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM, Leask A, Lamas S, Rodríguez-Pascual F.

Arthritis Rheum. 2012 May;64(5):1653-64. doi: 10.1002/art.33482.

22.

Role of endothelin in the cardiovascular system.

Rodríguez-Pascual F, Busnadiego O, Lagares D, Lamas S.

Pharmacol Res. 2011 Jun;63(6):463-72. doi: 10.1016/j.phrs.2011.01.014. Epub 2011 Feb 4. Review.

PMID:
21296157
23.

Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis.

Lagares D, García-Fernández RA, Jiménez CL, Magán-Marchal N, Busnadiego O, Lamas S, Rodríguez-Pascual F.

Arthritis Rheum. 2010 Mar;62(3):878-89. doi: 10.1002/art.27307.

24.

Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability.

Rodríguez-Pascual F, Redondo-Horcajo M, Magán-Marchal N, Lagares D, Martínez-Ruiz A, Kleinert H, Lamas S.

Mol Cell Biol. 2008 Dec;28(23):7139-55. doi: 10.1128/MCB.01145-08. Epub 2008 Sep 22.

25.

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.

Ramírez de Molina A, Gallego-Ortega D, Sarmentero-Estrada J, Lagares D, Gómez Del Pulgar T, Bandrés E, García-Foncillas J, Lacal JC.

Int J Biochem Cell Biol. 2008;40(9):1753-63. doi: 10.1016/j.biocel.2008.01.013. Epub 2008 Jan 19.

PMID:
18296102
26.

New dental simulator for microsurgical training preliminary overview.

Gargallo JU, Rubio EA, Pérez JL, Lagares DT, Vázquez CC.

Med Oral Patol Oral Cir Bucal. 2007 Dec 1;12(8):E582-4.

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