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Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention.

Le Goff M, Le Ferrec E, Mayer C, Mimouni V, Lagadic-Gossmann D, Schoefs B, Ulmann L.

Biochimie. 2019 Dec;167:106-118. doi: 10.1016/j.biochi.2019.09.012. Epub 2019 Sep 20. Review.


PAHs increase the production of extracellular vesicles both in vitro in endothelial cells and in vivo in urines from rats.

Le Goff M, Lagadic-Gossmann D, Latour R, Podechard N, Grova N, Gauffre F, Chevance S, Burel A, Appenzeller BMR, Ulmann L, Sergent O, Le Ferrec E.

Environ Pollut. 2019 Dec;255(Pt 1):113171. doi: 10.1016/j.envpol.2019.113171. Epub 2019 Sep 10.


Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.

van Meteren N, Lagadic-Gossmann D, Chevanne M, Gallais I, Gobart D, Burel A, Bucher S, Grova N, Fromenty B, Appenzeller BMR, Chevance S, Gauffre F, Le Ferrec E, Sergent O.

Toxicol Sci. 2019 Jul 31. pii: kfz157. doi: 10.1093/toxsci/kfz157. [Epub ahead of print]


Disturbances in H+ dynamics during environmental carcinogenesis.

Lagadic-Gossmann D, Hardonnière K, Mograbi B, Sergent O, Huc L.

Biochimie. 2019 Aug;163:171-183. doi: 10.1016/j.biochi.2019.06.013. Epub 2019 Jun 20. Review.


Moderate chronic ethanol consumption exerts beneficial effects on nonalcoholic fatty liver in mice fed a high-fat diet: possible role of higher formation of triglycerides enriched in monounsaturated fatty acids.

Bucher S, Begriche K, Catheline D, Trak-Smayra V, Tiaho F, Coulouarn C, Pinon G, Lagadic-Gossmann D, Rioux V, Fromenty B.

Eur J Nutr. 2019 Jun 3. doi: 10.1007/s00394-019-02017-1. [Epub ahead of print]


Combustion Particle-Induced Changes in Calcium Homeostasis: A Contributing Factor to Vascular Disease?

Holme JA, Brinchmann BC, Le Ferrec E, Lagadic-Gossmann D, Øvrevik J.

Cardiovasc Toxicol. 2019 Jun;19(3):198-209. doi: 10.1007/s12012-019-09518-9. Review.


Organic chemicals from diesel exhaust particles affects intracellular calcium, inflammation and β-adrenoceptors in endothelial cells.

Brinchmann BC, Le Ferrec E, Podechard N, Lagadic-Gossmann D, Holme JA, Øvrevik J.

Toxicol Lett. 2019 Mar 1;302:18-27. doi: 10.1016/j.toxlet.2018.11.009. Epub 2018 Nov 29.


Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide.

Tête A, Gallais I, Imran M, Chevanne M, Liamin M, Sparfel L, Bucher S, Burel A, Podechard N, Appenzeller BMR, Fromenty B, Grova N, Sergent O, Lagadic-Gossmann D.

Free Radic Biol Med. 2018 Dec;129:323-337. doi: 10.1016/j.freeradbiomed.2018.09.042. Epub 2018 Sep 27.


Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene.

Brinchmann BC, Le Ferrec E, Bisson WH, Podechard N, Huitfeldt HS, Gallais I, Sergent O, Holme JA, Lagadic-Gossmann D, Øvrevik J.

Biochem Pharmacol. 2018 Dec;158:1-12. doi: 10.1016/j.bcp.2018.09.023. Epub 2018 Sep 22.


Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure.

Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B.

Oxid Med Cell Longev. 2018 Jul 26;2018:4396403. doi: 10.1155/2018/4396403. eCollection 2018.


Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae.

Imran M, Sergent O, Tête A, Gallais I, Chevanne M, Lagadic-Gossmann D, Podechard N.

Biomolecules. 2018 May 14;8(2). pii: E26. doi: 10.3390/biom8020026.


Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s).

Brinchmann BC, Skuland T, Rambøl MH, Szoke K, Brinchmann JE, Gutleb AC, Moschini E, Kubátová A, Kukowski K, Le Ferrec E, Lagadic-Gossmann D, Schwarze PE, Låg M, Refsnes M, Øvrevik J, Holme JA.

Part Fibre Toxicol. 2018 May 11;15(1):21. doi: 10.1186/s12989-018-0257-1.


Lipophilic Chemicals from Diesel Exhaust Particles Trigger Calcium Response in Human Endothelial Cells via Aryl Hydrocarbon Receptor Non-Genomic Signalling.

Brinchmann BC, Le Ferrec E, Podechard N, Lagadic-Gossmann D, Shoji KF, Penna A, Kukowski K, Kubátová A, Holme JA, Øvrevik J.

Int J Mol Sci. 2018 May 10;19(5). pii: E1429. doi: 10.3390/ijms19051429.


Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo.

Bucher S, Tête A, Podechard N, Liamin M, Le Guillou D, Chevanne M, Coulouarn C, Imran M, Gallais I, Fernier M, Hamdaoui Q, Robin MA, Sergent O, Fromenty B, Lagadic-Gossmann D.

Sci Rep. 2018 Apr 13;8(1):5963. doi: 10.1038/s41598-018-24403-1.


Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis.

Lévêque M, Penna A, Le Trionnaire S, Belleguic C, Desrues B, Brinchault G, Jouneau S, Lagadic-Gossmann D, Martin-Chouly C.

Sci Rep. 2018 Mar 9;8(1):4310. doi: 10.1038/s41598-018-22558-5.


Benzo(a)pyrene triggers desensitization of β2-adrenergic pathway.

Mayati A, Podechard N, Rineau M, Sparfel L, Lagadic-Gossmann D, Fardel O, Le Ferrec E.

Sci Rep. 2017 Jun 12;7(1):3262. doi: 10.1038/s41598-017-03646-4.


Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.

Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D.

Sci Rep. 2017 Mar 15;7(1):195. doi: 10.1038/s41598-017-00269-7.


Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism.

Hardonnière K, Huc L, Sergent O, Holme JA, Lagadic-Gossmann D.

Semin Cancer Biol. 2017 Apr;43:49-65. doi: 10.1016/j.semcancer.2017.01.001. Epub 2017 Jan 11. Review.


Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents.

Podechard N, Chevanne M, Fernier M, Tête A, Collin A, Cassio D, Kah O, Lagadic-Gossmann D, Sergent O.

J Appl Toxicol. 2017 Jun;37(6):732-746. doi: 10.1002/jat.3421. Epub 2016 Nov 28.


The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival.

Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D.

Sci Rep. 2016 Aug 4;6:30776. doi: 10.1038/srep30776.


The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility.

Monet M, Poët M, Tauzin S, Fouqué A, Cophignon A, Lagadic-Gossmann D, Vacher P, Legembre P, Counillon L.

Sci Rep. 2016 Jun 15;6:28008. doi: 10.1038/srep28008.


Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.

Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D.

Toxicol In Vitro. 2015 Oct;29(7):1597-608. doi: 10.1016/j.tiv.2015.06.010. Epub 2015 Jun 15.


Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Solhaug A, Torgersen ML, Holme JA, Lagadic-Gossmann D, Eriksen GS.

Toxicology. 2014 Dec 4;326:119-29. doi: 10.1016/j.tox.2014.10.009. Epub 2014 Oct 18.


AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells.

Øvrevik J, Låg M, Lecureur V, Gilot D, Lagadic-Gossmann D, Refsnes M, Schwarze PE, Skuland T, Becher R, Holme JA.

Cell Commun Signal. 2014 Jul 24;12:48. doi: 10.1186/s12964-014-0048-8.


Calcium signaling and β2-adrenergic receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS-2B cells.

Mayati A, Le Ferrec E, Holme JA, Fardel O, Lagadic-Gossmann D, Ovrevik J.

Toxicol In Vitro. 2014 Sep;28(6):1153-7. doi: 10.1016/j.tiv.2014.05.012. Epub 2014 Jun 4.


Cooperative interaction of benzo[a]pyrene and ethanol on plasma membrane remodeling is responsible for enhanced oxidative stress and cell death in primary rat hepatocytes.

Collin A, Hardonnière K, Chevanne M, Vuillemin J, Podechard N, Burel A, Dimanche-Boitrel MT, Lagadic-Gossmann D, Sergent O.

Free Radic Biol Med. 2014 Jul;72:11-22. doi: 10.1016/j.freeradbiomed.2014.03.029. Epub 2014 Mar 26.


Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway.

Dendelé B, Tekpli X, Hardonnière K, Holme JA, Debure L, Catheline D, Arlt VM, Nagy E, Phillips DH, Ovrebø S, Mollerup S, Poët M, Chevanne M, Rioux V, Dimanche-Boitrel MT, Sergent O, Lagadic-Gossmann D.

Chem Biol Interact. 2014 Jan 25;207:41-51. doi: 10.1016/j.cbi.2013.11.002. Epub 2013 Nov 15.


A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes.

Aliche-Djoudi F, Podechard N, Collin A, Chevanne M, Provost E, Poul M, Le Hégarat L, Catheline D, Legrand P, Dimanche-Boitrel MT, Lagadic-Gossmann D, Sergent O.

Food Chem Toxicol. 2013 Oct;60:286-96. doi: 10.1016/j.fct.2013.07.061. Epub 2013 Jul 29.


Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages.

Solhaug A, Holme JA, Haglund K, Dendele B, Sergent O, Pestka J, Lagadic-Gossmann D, Eriksen GS.

Toxicol Lett. 2013 May 10;219(1):8-17. doi: 10.1016/j.toxlet.2013.02.012. Epub 2013 Feb 27.


Role for membrane remodeling in cell death: implication for health and disease.

Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D.

Toxicology. 2013 Feb 8;304:141-57. doi: 10.1016/j.tox.2012.12.014. Epub 2012 Dec 31. Review.


TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.

Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, Samson M, Dimanche-Boitrel MT.

Cell Death Differ. 2012 Dec;19(12):2003-14. doi: 10.1038/cdd.2012.90. Epub 2012 Jul 20.


NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function.

Tekpli X, Huc L, Sergent O, Dendelé B, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D.

Cell Physiol Biochem. 2012;29(5-6):657-66. doi: 10.1159/000171027. Epub 2012 May 11.


Enniatin B-induced cell death and inflammatory responses in RAW 267.4 murine macrophages.

Gammelsrud A, Solhaug A, Dendelé B, Sandberg WJ, Ivanova L, Kocbach Bølling A, Lagadic-Gossmann D, Refsnes M, Becher R, Eriksen G, Holme JA.

Toxicol Appl Pharmacol. 2012 May 15;261(1):74-87. doi: 10.1016/j.taap.2012.03.014. Epub 2012 Mar 27.


On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry.

Pang V, Counillon L, Lagadic-Gossmann D, Poet M, Lacroix J, Sergent O, Khan R, Rauch C.

Cell Biochem Biophys. 2012 May;63(1):47-57. doi: 10.1007/s12013-012-9340-7.


Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.

Mayati A, Levoin N, Paris H, N'Diaye M, Courtois A, Uriac P, Lagadic-Gossmann D, Fardel O, Le Ferrec E.

J Biol Chem. 2012 Feb 3;287(6):4041-52. doi: 10.1074/jbc.M111.319970. Epub 2011 Dec 13.


Myristic acid increases dihydroceramide Δ4-desaturase 1 (DES1) activity in cultured rat hepatocytes.

Ezanno H, le Bloc'h J, Beauchamp E, Lagadic-Gossmann D, Legrand P, Rioux V.

Lipids. 2012 Feb;47(2):117-28. doi: 10.1007/s11745-011-3638-x. Epub 2011 Dec 3.


Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.

Dendelé B, Tekpli X, Sergent O, Dimanche-Boitrel MT, Holme JA, Huc L, Lagadic-Gossmann D.

Toxicol In Vitro. 2012 Feb;26(1):94-101. doi: 10.1016/j.tiv.2011.11.001. Epub 2011 Nov 12.


Physical and chemical modulation of lipid rafts by a dietary n-3 polyunsaturated fatty acid increases ethanol-induced oxidative stress.

Aliche-Djoudi F, Podechard N, Chevanne M, Nourissat P, Catheline D, Legrand P, Dimanche-Boitrel MT, Lagadic-Gossmann D, Sergent O.

Free Radic Biol Med. 2011 Dec 1;51(11):2018-30. doi: 10.1016/j.freeradbiomed.2011.08.031. Epub 2011 Sep 1.


Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells.

Podechard N, Tekpli X, Catheline D, Holme JA, Rioux V, Legrand P, Rialland M, Fardel O, Lagadic-Gossmann D, Lecureur V.

Toxicol Lett. 2011 Oct 30;206(3):289-99. doi: 10.1016/j.toxlet.2011.07.024. Epub 2011 Aug 18.


Importance of plasma membrane dynamics in chemical-induced carcinogenesis.

Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D.

Recent Pat Anticancer Drug Discov. 2011 Sep;6(3):347-53. doi: 10.2174/157489211796957784. Review.


RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.

Gilot D, Le Meur N, Giudicelli F, Le Vée M, Lagadic-Gossmann D, Théret N, Fardel O.

PLoS One. 2011 Mar 29;6(3):e18261. doi: 10.1371/journal.pone.0018261.


Nongenomic effects of cisplatin: acute inhibition of mechanosensitive transporters and channels without actin remodeling.

Milosavljevic N, Duranton C, Djerbi N, Puech PH, Gounon P, Lagadic-Gossmann D, Dimanche-Boitrel MT, Rauch C, Tauc M, Counillon L, Poët M.

Cancer Res. 2010 Oct 1;70(19):7514-22. doi: 10.1158/0008-5472.CAN-10-1253. Epub 2010 Sep 14.


Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway.

Gilot D, Giudicelli F, Lagadic-Gossmann D, Fardel O.

Chem Biol Interact. 2010 Dec 5;188(3):546-52. doi: 10.1016/j.cbi.2010.08.011. Epub 2010 Sep 9.


Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells.

Rebillard A, Jouan-Lanhouet S, Jouan E, Legembre P, Pizon M, Sergent O, Gilot D, Tekpli X, Lagadic-Gossmann D, Dimanche-Boitrel MT.

Eur J Cancer. 2010 May;46(8):1445-55. doi: 10.1016/j.ejca.2010.01.034. Epub 2010 Mar 4.


On some aspects of the thermodynamic of membrane recycling mediated by fluid phase endocytosis: evaluation of published data and perspectives.

Rauch C, Pluen A, Foster N, Loughna P, Mobasheri A, Lagadic-Gossmann D, Counillon L.

Cell Biochem Biophys. 2010 Apr;56(2-3):73-90. doi: 10.1007/s12013-009-9072-5.


3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells.

Landvik NE, Arlt VM, Nagy E, Solhaug A, Tekpli X, Schmeiser HH, Refsnes M, Phillips DH, Lagadic-Gossmann D, Holme JA.

Mutat Res. 2010 Feb 3;684(1-2):11-23. doi: 10.1016/j.mrfmmm.2009.11.004. Epub 2009 Nov 24.


Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.

Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, Legrand P, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D.

Toxicol Appl Pharmacol. 2010 Feb 15;243(1):68-76. doi: 10.1016/j.taap.2009.11.014. Epub 2009 Nov 17.


The B[a]P-increased intercellular communication via translocation of connexin-43 into gap junctions reduces apoptosis.

Tekpli X, Rivedal E, Gorria M, Landvik NE, Rissel M, Dimanche-Boitrel MT, Baffet G, Holme JA, Lagadic-Gossmann D.

Toxicol Appl Pharmacol. 2010 Jan 15;242(2):231-40. doi: 10.1016/j.taap.2009.10.012. Epub 2009 Oct 27.


Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells.

Asare N, Tekpli X, Rissel M, Solhaug A, Landvik N, Lecureur V, Podechard N, Brunborg G, Låg M, Lagadic-Gossmann D, Holme JA.

Mutagenesis. 2009 Nov;24(6):481-93. doi: 10.1093/mutage/gep032. Epub 2009 Aug 24.


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