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Items: 35

1.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA.

Nat Commun. 2017 Sep 5;8(1):430. doi: 10.1038/s41467-017-00572-x.

2.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

3.

A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screening.

Caballero I, Lafuente MJ, Gamo FJ, Cid C.

Anal Biochem. 2016 Aug 1;506:13-21. doi: 10.1016/j.ab.2016.04.013. Epub 2016 Apr 29.

PMID:
27133204
4.

New insights into host-parasite ubiquitin proteome dynamics in P. falciparum infected red blood cells using a TUBEs-MS approach.

Mata-Cantero L, Azkargorta M, Aillet F, Xolalpa W, LaFuente MJ, Elortza F, Carvalho AS, Martin-Plaza J, Matthiesen R, Rodriguez MS.

J Proteomics. 2016 Apr 29;139:45-59. doi: 10.1016/j.jprot.2016.03.004. Epub 2016 Mar 10.

PMID:
26972027
5.

Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives.

Chaparro MJ, Vidal J, Angulo-Barturen I, Bueno JM, Burrows J, Cammack N, Castañeda P, Colmenarejo G, Coterón JM, de Las Heras L, Fernández E, Ferrer S, Gabarró R, Gamo FJ, García M, Jiménez-Díaz MB, Lafuente MJ, León ML, Martínez MS, Minick D, Prats S, Puente M, Rueda L, Sandoval E, Santos-Villarejo A, Witty M, Calderón F.

ACS Med Chem Lett. 2014 Mar 26;5(6):657-61. doi: 10.1021/ml500015r. eCollection 2014 Jun 12.

6.

Magnetic isolation of Plasmodium falciparum schizonts iRBCs to generate a high parasitaemia and synchronized in vitro culture.

Mata-Cantero L, Lafuente MJ, Sanz L, Rodriguez MS.

Malar J. 2014 Mar 21;13:112. doi: 10.1186/1475-2875-13-112.

7.

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.

Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016.

8.

Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder.

Zhan L, Kerr JR, Lafuente MJ, Maclean A, Chibalina MV, Liu B, Burke B, Bevan S, Nasir J.

Neuropathol Appl Neurobiol. 2011 Feb;37(2):206-19. doi: 10.1111/j.1365-2990.2010.01128.x.

PMID:
20874815
9.

Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1.

Mas S, Lafuente MJ, Crescenti A, Trias M, Ballesta A, Molina R, Zheng S, Wiencke JK, Lafuente A.

Anticancer Res. 2007 Mar-Apr;27(2):1151-6.

10.

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Nan X, Hou J, Maclean A, Nasir J, Lafuente MJ, Shu X, Kriaucionis S, Bird A.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2709-14. Epub 2007 Feb 12.

11.

Induction of NAD(P)H quinone oxidoreductase by vegetables widely consumed in Catalonia, Spain.

Laso N, Mas S, Lafuente MJ, Llobet JM, Molina R, Ballesta A, Kensler TW, Lafuente A.

Nutr Cancer. 2005;52(1):49-58.

PMID:
16091004
12.

Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix.

Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, Nasir J, Bredesen DE.

Cell Death Differ. 2004 Oct;11(10):1066-75.

13.

Concentration of hydroxyproline in blood: a biological marker in occupational exposure to asbestos and its relationship with Pi*Z and Pi*S polymorphism in the alpha-1 antitrypsin gene.

Mas S, Casterad X, Laso N, Lafuente MJ, Panades R, Calleja A, Hernandez S, Turuguet D, Deulofeu R, Ballesta A, Ascaso C, Lafuente A.

Am J Ind Med. 2004 Feb;45(2):186-93.

PMID:
14748049
14.

Regulation of mature T lymphocyte proliferation and differentiation by Par-4.

Lafuente MJ, Martin P, Garcia-Cao I, Diaz-Meco MT, Serrano M, Moscat J.

EMBO J. 2003 Sep 15;22(18):4689-98.

15.

Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.

Garcia-Cao I, Lafuente MJ, Criado LM, Diaz-Meco MT, Serrano M, Moscat J.

EMBO Rep. 2003 Mar;4(3):307-12.

16.

Cancer, genes, and catechol estrogen metabolites.

Mas S, Laso N, Lafuente MJ, Lafuente A, Molina R, Ballesta A, Zheng S, Wiencke JK.

Int J Clin Oncol. 2003 Feb;8(1):65-6. No abstract available.

PMID:
12601547
17.

Glutathione S-transferase (GSTM1 and GSTT1)-dependent risk for colorectal cancer.

Laso N, Lafuente MJ, Mas S, Trias M, Ascaso C, Molina R, Ballesta A, Rodriguez F, Lafuente A.

Anticancer Res. 2002 Nov-Dec;22(6A):3399-403.

PMID:
12530094
18.

Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos.

Lafuente MJ, Casterad X, Laso N, Mas S, Panades R, Calleja A, Hernandez S, Turuguet D, Ballesta A, Ascaso C, Lafuente A.

Toxicol Lett. 2002 Nov 15;136(1):9-17.

PMID:
12368052
19.

Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability.

Poirey R, Despons L, Leh V, Lafuente MJ, Potier S, Souciet JL, Jauniaux JC.

Microbiology. 2002 Jul;148(Pt 7):2111-23.

PMID:
12101299
20.

The use erythrocyte glutathione as a predictive marker for malignant melanoma.

Moral A, Lafuente MJ, Lafuente A, Castel T, Balesta AM, Trias ML; MMM Group. Multidisciplinary Malignant Melanoma Group.

Anticancer Res. 2000 Nov-Dec;20(6C):4757-60.

PMID:
11205213
21.

Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors.

Zheng S, Chen P, McMillan A, Lafuente A, Lafuente MJ, Ballesta A, Trias M, Wiencke JK.

Carcinogenesis. 2000 Nov;21(11):2057-64.

PMID:
11062168
22.

NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.

Lafuente MJ, Casterad X, Trias M, Ascaso C, Molina R, Ballesta A, Zheng S, Wiencke JK, Lafuente A.

Carcinogenesis. 2000 Oct;21(10):1813-9.

PMID:
11023538
23.

Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.

Nasir J, Lafuente MJ, Duan K, Colomer V, Engelender S, Ingersoll R, Margolis RL, Ross CA, Hayden MR.

Gene. 2000 Aug 22;254(1-2):181-7.

PMID:
10974549
24.

Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiae.

Lafuente MJ, Gancedo C, Jauniaux JC, Gancedo JM.

Mol Microbiol. 2000 Jan;35(1):161-72.

25.
26.

Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer.

Wiencke JK, Zheng S, Lafuente A, Lafuente MJ, Grudzen C, Wrensch MR, Miike R, Ballesta A, Trias M.

Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):501-6.

27.

Limitations in the use of glutathione S-transferase P1 in urine as a marker for bladder cancer.

Lafuente A, Rodriguez A, Gibanel R, Lafuente MJ, Alonso M, Molina R, Ballesta A, Carretero P.

Anticancer Res. 1998 Sep-Oct;18(5B):3771-2.

PMID:
9854493
28.

Glutathione and glutathione S-transferases in human squamous cell carcinomas of the larynx and GSTM1 dependent risk.

Lafuente A, Maristany M, Arias C, Cuchi A, Lafuente MJ, Molina R, Ballesta A, Trasserra J.

Anticancer Res. 1998 Jan-Feb;18(1A):107-11.

PMID:
9568063
29.
31.
33.

DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames.

Casamayor A, Aldea M, Casas C, Herrero E, Gamo FJ, Lafuente MJ, Gancedo C, Ariño J.

Yeast. 1995 Oct;11(13):1281-8.

PMID:
8553699
34.
35.

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