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Items: 1 to 50 of 158

1.

The modified vaccination technique designed to prevent and cure acute and chronic disorders.

Barabas AZ, Cole CD, Kovacs ZB, Kovacs EI, Lafreniere R, Weir DM.

Hum Antibodies. 2019 Sep 27. doi: 10.3233/HAB-190396. [Epub ahead of print]

PMID:
31594214
2.

The Modified Vaccination Technique.

Barabas A, Cole C, Kovacs Z, Kovacs E, Lafreniere R.

Vaccines (Basel). 2018 Dec 21;7(1). pii: E1. doi: 10.3390/vaccines7010001.

3.

Antibody-initiated beneficial and harmful immune responses.

Barabas AZ, Cole CD, Lafreniere R.

Immunol Res. 2018 Dec;66(6):783-789. doi: 10.1007/s12026-018-9037-0. Review.

PMID:
30456543
4.

Global characterization of copy number variants in epilepsy patients from whole genome sequencing.

Monlong J, Girard SL, Meloche C, Cadieux-Dion M, Andrade DM, Lafreniere RG, Gravel M, Spiegelman D, Dionne-Laporte A, Boelman C, Hamdan FF, Michaud JL, Rouleau G, Minassian BA, Bourque G, Cossette P.

PLoS Genet. 2018 Apr 12;14(4):e1007285. doi: 10.1371/journal.pgen.1007285. eCollection 2018 Apr.

5.

Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors.

Cruceanu C, Schmouth JF, Torres-Platas SG, Lopez JP, Ambalavanan A, Darcq E, Gross F, Breton B, Spiegelman D, Rochefort D, Hince P, Petite JM, Gauthier J, Lafrenière RG, Dion PA, Greenwood CM, Kieffer BL, Alda M, Turecki G, Rouleau GA.

Mol Psychiatry. 2018 Oct;23(10):2050-2056. doi: 10.1038/mp.2017.223. Epub 2017 Nov 21.

PMID:
29158579
6.

High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies.

Hamdan FF, Myers CT, Cossette P, Lemay P, Spiegelman D, Laporte AD, Nassif C, Diallo O, Monlong J, Cadieux-Dion M, Dobrzeniecka S, Meloche C, Retterer K, Cho MT, Rosenfeld JA, Bi W, Massicotte C, Miguet M, Brunga L, Regan BM, Mo K, Tam C, Schneider A, Hollingsworth G; Deciphering Developmental Disorders Study, FitzPatrick DR, Donaldson A, Canham N, Blair E, Kerr B, Fry AE, Thomas RH, Shelagh J, Hurst JA, Brittain H, Blyth M, Lebel RR, Gerkes EH, Davis-Keppen L, Stein Q, Chung WK, Dorison SJ, Benke PJ, Fassi E, Corsten-Janssen N, Kamsteeg EJ, Mau-Them FT, Bruel AL, Verloes A, Õunap K, Wojcik MH, Albert DVF, Venkateswaran S, Ware T, Jones D, Liu YC, Mohammad SS, Bizargity P, Bacino CA, Leuzzi V, Martinelli S, Dallapiccola B, Tartaglia M, Blumkin L, Wierenga KJ, Purcarin G, O'Byrne JJ, Stockler S, Lehman A, Keren B, Nougues MC, Mignot C, Auvin S, Nava C, Hiatt SM, Bebin M, Shao Y, Scaglia F, Lalani SR, Frye RE, Jarjour IT, Jacques S, Boucher RM, Riou E, Srour M, Carmant L, Lortie A, Major P, Diadori P, Dubeau F, D'Anjou G, Bourque G, Berkovic SF, Sadleir LG, Campeau PM, Kibar Z, Lafrenière RG, Girard SL, Mercimek-Mahmutoglu S, Boelman C, Rouleau GA, Scheffer IE, Mefford HC, Andrade DM, Rossignol E, Minassian BA, Michaud JL.

Am J Hum Genet. 2017 Nov 2;101(5):664-685. doi: 10.1016/j.ajhg.2017.09.008.

7.

Quantitative assessment of haemolysis secondary to modern infusion pumps.

Poder TG, Boileau JC, Lafrenière R, Thibault L, Carrier N, de Grandmont MJ, Beauregard P.

Vox Sang. 2017 Apr;112(3):201-209. doi: 10.1111/vox.12486. Epub 2017 Feb 15.

PMID:
28198026
8.

Suppression of tumor growth by a heterologous antibody directed against multiple myeloma dominant CD38 antigen in SCID mice injected with multiple myeloma cells.

Barabas AZ, Cole CD, Graeff RM, Kovacs ZB, Lafreniere R.

Hum Antibodies. 2016;24(3-4):53-57. doi: 10.3233/HAB-160295.

PMID:
28128765
9.

A novel modified vaccination technique produces IgG antibodies that cause complement-mediated lysis of multiple myeloma cells carrying CD38 antigen.

Barabas AZ, Cole CD, Graeff RM, Morcol T, Lafreniere R.

Hum Antibodies. 2016;24(3-4):45-51. doi: 10.3233/HAB-160294.

PMID:
28128764
10.

Tolerance, loss of tolerance and regaining tolerance to self by immune-mediated events.

Barabas AZ, Cole CD, Graeff RM, Lafreniere R, Weir DM.

Immunol Res. 2017 Feb;65(1):402-409. doi: 10.1007/s12026-016-8842-6.

PMID:
27456203
11.

Introduction of new technologies and decision making processes: a framework to adapt a Local Health Technology Decision Support Program for other local settings.

Poulin P, Austen L, Scott CM, Poulin M, Gall N, Seidel J, Lafrenière R.

Med Devices (Auckl). 2013 Nov 18;6:185-93. doi: 10.2147/MDER.S51384. eCollection 2013.

12.

Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder.

Cruceanu C, Ambalavanan A, Spiegelman D, Gauthier J, Lafrenière RG, Dion PA, Alda M, Turecki G, Rouleau GA.

Genome. 2013 Oct;56(10):634-40. doi: 10.1139/gen-2013-0081. Epub 2013 Sep 17.

13.

Multi-criteria development and incorporation into decision tools for health technology adoption.

Poulin P, Austen L, Scott CM, Waddell CD, Dixon E, Poulin M, Lafrenière R.

J Health Organ Manag. 2013;27(2):246-65.

PMID:
23802401
14.

Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues.

Shekarabi M, Lafrenière RG, Gaudet R, Laganière J, Marcinkiewicz MM, Dion PA, Rouleau GA.

PLoS One. 2013;8(2):e57807. doi: 10.1371/journal.pone.0057807. Epub 2013 Feb 25.

15.

WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio).

Bercier V, Brustein E, Liao M, Dion PA, Lafrenière RG, Rouleau GA, Drapeau P.

PLoS Genet. 2013;9(1):e1003124. doi: 10.1371/journal.pgen.1003124. Epub 2013 Jan 3.

16.

Regaining tolerance to a self-antigen by the modified vaccination technique.

Barabas AZ, Cole CD, Lafreniere R, Weir DM.

Clin Rev Allergy Immunol. 2013 Oct;45(2):193-201. doi: 10.1007/s12016-012-8350-y. Review.

PMID:
23296949
17.

Identification of novel genes involved in migraine.

Lafrenière RG, Rouleau GA.

Headache. 2012 Oct;52 Suppl 2:107-10. doi: 10.1111/j.1526-4610.2012.02237.x.

PMID:
23030542
18.

Immunopathological events initiated and maintained by pathogenic IgG autoantibodies in an experimental autoimmune kidney disease.

Barabas AZ, Cole CD, Lafreniere R, Weir DM.

Autoimmunity. 2012 Nov;45(7):495-509. doi: 10.3109/08916934.2012.702812. Epub 2012 Aug 17. Review.

PMID:
22816962
19.

Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice.

Wiltshire SA, Diez E, Miao Q, Dubé MP, Gagné M, Paquette O, Lafrenière RG, Ndao M, Castellani LW, Skamene E, Vidal SM, Fortin A.

Physiol Genomics. 2012 Sep 1;44(17):843-52. doi: 10.1152/physiolgenomics.00025.2012. Epub 2012 Jul 17.

20.

Functional analysis of missense variants in the TRESK (KCNK18) K channel.

Andres-Enguix I, Shang L, Stansfeld PJ, Morahan JM, Sansom MS, Lafrenière RG, Roy B, Griffiths LR, Rouleau GA, Ebers GC, Cader ZM, Tucker SJ.

Sci Rep. 2012;2:237. doi: 10.1038/srep00237. Epub 2012 Jan 27.

21.

Production of heterologous IgG antibody against Heymann nephritis antigen by injections of immune complexes.

Barabas AZ, Cole CD, Sensen M, Lafreniere R.

Int J Exp Pathol. 2012 Feb;93(1):11-7. doi: 10.1111/j.1365-2613.2011.00792.x. Epub 2011 Nov 22.

22.

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy.

Patino GA, Brackenbury WJ, Bao Y, Lopez-Santiago LF, O'Malley HA, Chen C, Calhoun JD, Lafrenière RG, Cossette P, Rouleau GA, Isom LL.

J Neurosci. 2011 Oct 12;31(41):14577-91. doi: 10.1523/JNEUROSCI.0361-11.2011.

23.

New technologies and surgical innovation: five years of a local health technology assessment program in a surgical department.

Poulin P, Austen L, Kortbeek JB, Lafrenière R.

Surg Innov. 2012 Jun;19(2):187-99. doi: 10.1177/1553350611421916. Epub 2011 Sep 26.

PMID:
21949011
24.

Migraine: Role of the TRESK two-pore potassium channel.

Lafrenière RG, Rouleau GA.

Int J Biochem Cell Biol. 2011 Nov;43(11):1533-6. doi: 10.1016/j.biocel.2011.08.002. Epub 2011 Aug 9. Review.

PMID:
21855646
25.

Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.

Gauthier J, Siddiqui TJ, Huashan P, Yokomaku D, Hamdan FF, Champagne N, Lapointe M, Spiegelman D, Noreau A, Lafrenière RG, Fathalli F, Joober R, Krebs MO, DeLisi LE, Mottron L, Fombonne E, Michaud JL, Drapeau P, Carbonetto S, Craig AM, Rouleau GA.

Hum Genet. 2011 Oct;130(4):563-73. doi: 10.1007/s00439-011-0975-z. Epub 2011 Mar 22.

26.

A population genetic approach to mapping neurological disorder genes using deep resequencing.

Myers RA, Casals F, Gauthier J, Hamdan FF, Keebler J, Boyko AR, Bustamante CD, Piton AM, Spiegelman D, Henrion E, Zilversmit M, Hussin J, Quinlan J, Yang Y, Lafrenière RG, Griffing AR, Stone EA, Rouleau GA, Awadalla P.

PLoS Genet. 2011 Feb;7(2):e1001318. doi: 10.1371/journal.pgen.1001318. Epub 2011 Feb 24.

27.

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.

Hamdan FF, Gauthier J, Araki Y, Lin DT, Yoshizawa Y, Higashi K, Park AR, Spiegelman D, Dobrzeniecka S, Piton A, Tomitori H, Daoud H, Massicotte C, Henrion E, Diallo O; S2D Group, Shekarabi M, Marineau C, Shevell M, Maranda B, Mitchell G, Nadeau A, D'Anjou G, Vanasse M, Srour M, Lafrenière RG, Drapeau P, Lacaille JC, Kim E, Lee JR, Igarashi K, Huganir RL, Rouleau GA, Michaud JL.

Am J Hum Genet. 2011 Mar 11;88(3):306-16. doi: 10.1016/j.ajhg.2011.02.001. Epub 2011 Mar 3. Erratum in: Am J Hum Genet. 2011 Apr 8;88(4):516.

28.

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

Tarabeux J, Kebir O, Gauthier J, Hamdan FF, Xiong L, Piton A, Spiegelman D, Henrion É, Millet B; S2D team, Fathalli F, Joober R, Rapoport JL, DeLisi LE, Fombonne É, Mottron L, Forget-Dubois N, Boivin M, Michaud JL, Drapeau P, Lafrenière RG, Rouleau GA, Krebs MO.

Transl Psychiatry. 2011 Nov 15;1:e55. doi: 10.1038/tp.2011.52.

29.

De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment.

Hamdan FF, Daoud H, Rochefort D, Piton A, Gauthier J, Langlois M, Foomani G, Dobrzeniecka S, Krebs MO, Joober R, Lafrenière RG, Lacaille JC, Mottron L, Drapeau P, Beauchamp MH, Phillips MS, Fombonne E, Rouleau GA, Michaud JL.

Am J Hum Genet. 2010 Nov 12;87(5):671-8. doi: 10.1016/j.ajhg.2010.09.017. Epub 2010 Oct 14.

30.

The role of autoimmunologists in investigating and treating autoimmune disorders.

Barabas AZ, Cole CD, Graeff RM, Lafreniere R, Weir DM.

Autoimmun Rev. 2011 Jan;10(3):166-70. doi: 10.1016/j.autrev.2010.09.020. Epub 2010 Sep 29. Review.

PMID:
20887816
31.

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA.

Nat Med. 2010 Oct;16(10):1157-60. doi: 10.1038/nm.2216. Epub 2010 Sep 26.

PMID:
20871611
32.

Direct measure of the de novo mutation rate in autism and schizophrenia cohorts.

Awadalla P, Gauthier J, Myers RA, Casals F, Hamdan FF, Griffing AR, Côté M, Henrion E, Spiegelman D, Tarabeux J, Piton A, Yang Y, Boyko A, Bustamante C, Xiong L, Rapoport JL, Addington AM, DeLisi JL, Krebs MO, Joober R, Millet B, Fombonne E, Mottron L, Zilversmit M, Keebler J, Daoud H, Marineau C, Roy-Gagnon MH, Dubé MP, Eyre-Walker A, Drapeau P, Stone EA, Lafrenière RG, Rouleau GA.

Am J Hum Genet. 2010 Sep 10;87(3):316-24. doi: 10.1016/j.ajhg.2010.07.019.

33.

Ethics, economics and the regulation and adoption of new medical devices: case studies in pelvic floor surgery.

Ross S, Weijer C, Gafni A, Ducey A, Thompson C, Lafreniere R.

BMC Med Ethics. 2010 Aug 26;11:14. doi: 10.1186/1472-6939-11-14.

34.

De novo truncating mutation in Kinesin 17 associated with schizophrenia.

Tarabeux J, Champagne N, Brustein E, Hamdan FF, Gauthier J, Lapointe M, Maios C, Piton A, Spiegelman D, Henrion E; Synapse to Disease Team, Millet B, Rapoport JL, Delisi LE, Joober R, Fathalli F, Fombonne E, Mottron L, Forget-Dubois N, Boivin M, Michaud JL, Lafrenière RG, Drapeau P, Krebs MO, Rouleau GA.

Biol Psychiatry. 2010 Oct 1;68(7):649-56. doi: 10.1016/j.biopsych.2010.04.018. Epub 2010 Jun 19.

PMID:
20646681
35.

Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.

Piton A, Gauthier J, Hamdan FF, Lafrenière RG, Yang Y, Henrion E, Laurent S, Noreau A, Thibodeau P, Karemera L, Spiegelman D, Kuku F, Duguay J, Destroismaisons L, Jolivet P, Côté M, Lachapelle K, Diallo O, Raymond A, Marineau C, Champagne N, Xiong L, Gaspar C, Rivière JB, Tarabeux J, Cossette P, Krebs MO, Rapoport JL, Addington A, Delisi LE, Mottron L, Joober R, Fombonne E, Drapeau P, Rouleau GA.

Mol Psychiatry. 2011 Aug;16(8):867-80. doi: 10.1038/mp.2010.54. Epub 2010 May 18.

36.

Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders.

Barabas AZ, Cole CD, Barabas AD, Graeff RM, Lafreniere R, Weir DM.

Scand J Immunol. 2010 Mar;71(3):125-33. doi: 10.1111/j.1365-3083.2009.02360.x. Review.

37.

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.

Gauthier J, Champagne N, Lafrenière RG, Xiong L, Spiegelman D, Brustein E, Lapointe M, Peng H, Côté M, Noreau A, Hamdan FF, Addington AM, Rapoport JL, Delisi LE, Krebs MO, Joober R, Fathalli F, Mouaffak F, Haghighi AP, Néri C, Dubé MP, Samuels ME, Marineau C, Stone EA, Awadalla P, Barker PA, Carbonetto S, Drapeau P, Rouleau GA; S2D Team.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7863-8. doi: 10.1073/pnas.0906232107. Epub 2010 Apr 12.

38.

[Reflections on ethics. ].

Lafrenière RJ, Beaulieu M.

Perspect Infirm. 2009 Sep-Oct;6(5):52-8. French. No abstract available.

PMID:
20120308
39.

De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy.

Hamdan FF, Piton A, Gauthier J, Lortie A, Dubeau F, Dobrzeniecka S, Spiegelman D, Noreau A, Pellerin S, Côté M, Henrion E, Fombonne E, Mottron L, Marineau C, Drapeau P, Lafrenière RG, Lacaille JC, Rouleau GA, Michaud JL.

Ann Neurol. 2009 Jun;65(6):748-53. doi: 10.1002/ana.21625.

PMID:
19557857
40.

No association between SRGAP3/MEGAP haploinsufficiency and mental retardation.

Hamdan FF, Gauthier J, Pellerin S, Dobrzeniecka S, Marineau C, Fombonne E, Mottron L, Lafrenière RG, Drapeau P, Lacaille JC, Rouleau GA, Michaud JL.

Arch Neurol. 2009 May;66(5):675-6. doi: 10.1001/archneurol.2009.65. No abstract available.

PMID:
19433673
41.

Correcting autoimmune anomalies in autoimmune disorders by immunological means, employing the modified vaccination technique.

Barabas AZ, Cole CD, Barabas AD, Graeff RM, Lafreniere R, Weir DM.

Autoimmun Rev. 2009 Jun;8(7):552-7. doi: 10.1016/j.autrev.2009.01.014. Epub 2009 Feb 3. Review.

PMID:
19393215
42.

[Mutations in the HSN2 exon of WNK1 cause hereditary sensory neuropathy type II].

Rivière JB, Dion P, Shekarabi M, Girard N, Faivre L, Lafrenière RG, Samuels M, Rouleau GA.

Med Sci (Paris). 2009 Mar;25(3):235-8. doi: 10.1051/medsci/2009253235. French. No abstract available.

43.

Preventing and treating chronic disorders using the modified vaccination technique.

Barabas AZ, Weir DM, Cole CD, Barabas AD, Bahlis NJ, Graeff RM, Lafreniere R.

Front Biosci (Landmark Ed). 2009 Jan 1;14:3892-8. Review.

PMID:
19273320
44.

Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.

Hamdan FF, Gauthier J, Spiegelman D, Noreau A, Yang Y, Pellerin S, Dobrzeniecka S, Côté M, Perreau-Linck E, Carmant L, D'Anjou G, Fombonne E, Addington AM, Rapoport JL, Delisi LE, Krebs MO, Mouaffak F, Joober R, Mottron L, Drapeau P, Marineau C, Lafrenière RG, Lacaille JC, Rouleau GA, Michaud JL; Synapse to Disease Group.

N Engl J Med. 2009 Feb 5;360(6):599-605. doi: 10.1056/NEJMoa0805392. Erratum in: N Engl J Med. 2009 Oct 29;361(18):1814. Perreault-Linck, Elizabeth [corrected to Perreau-Linck, Elizabeth].

45.

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.

Xiong L, Catoire H, Dion P, Gaspar C, Lafrenière RG, Girard SL, Levchenko A, Rivière JB, Fiori L, St-Onge J, Bachand I, Thibodeau P, Allen R, Earley C, Turecki G, Montplaisir J, Rouleau GA.

Hum Mol Genet. 2009 Mar 15;18(6):1065-74. doi: 10.1093/hmg/ddn443. Epub 2009 Jan 6.

46.

Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team, Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA.

Hum Mol Genet. 2008 Dec 15;17(24):3965-74. doi: 10.1093/hmg/ddn300. Epub 2008 Sep 18.

PMID:
18801879
47.

Novel de novo SHANK3 mutation in autistic patients.

Gauthier J, Spiegelman D, Piton A, Lafrenière RG, Laurent S, St-Onge J, Lapointe L, Hamdan FF, Cossette P, Mottron L, Fombonne E, Joober R, Marineau C, Drapeau P, Rouleau GA.

Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):421-4. doi: 10.1002/ajmg.b.30822.

PMID:
18615476
48.

Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.

Shekarabi M, Girard N, Rivière JB, Dion P, Houle M, Toulouse A, Lafrenière RG, Vercauteren F, Hince P, Laganiere J, Rochefort D, Faivre L, Samuels M, Rouleau GA.

J Clin Invest. 2008 Jul;118(7):2496-505. doi: 10.1172/JCI34088.

49.

Impact of surgeon training on outcomes after resective hepatic surgery.

McKay A, You I, Bigam D, Lafreniere R, Sutherland F, Ghali W, Dixon E.

Ann Surg Oncol. 2008 May;15(5):1348-55. doi: 10.1245/s10434-008-9838-9. Epub 2008 Feb 29.

PMID:
18306973
50.

New vaccination technology for endogenous antigen-derived ailments.

Barabas AZ, Cole CD, Barabas AD, Bahlis NJ, Lafreniere R.

IDrugs. 2008 Feb;11(2):111-5. Review.

PMID:
18240096

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