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The DEAH-box RNA helicase Dhr1 contains a remarkable carboxyl terminal domain essential for small ribosomal subunit biogenesis.

Roychowdhury A, Joret C, Bourgeois G, Heurgué-Hamard V, Lafontaine DLJ, Graille M.

Nucleic Acids Res. 2019 Jun 12. pii: gkz529. doi: 10.1093/nar/gkz529. [Epub ahead of print]


Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics.

Catez F, Dalla Venezia N, Marcel V, Zorbas C, Lafontaine DLJ, Diaz JJ.

Biochem Pharmacol. 2019 Jan;159:74-81. doi: 10.1016/j.bcp.2018.11.014. Epub 2018 Nov 20. Review.


SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.

Vendramin R, Verheyden Y, Ishikawa H, Goedert L, Nicolas E, Saraf K, Armaos A, Delli Ponti R, Izumikawa K, Mestdagh P, Lafontaine DLJ, Tartaglia GG, Takahashi N, Marine JC, Leucci E.

Nat Struct Mol Biol. 2018 Nov;25(11):1035-1046. doi: 10.1038/s41594-018-0143-4. Epub 2018 Oct 29.


AlkAniline-Seq: Profiling of m7 G and m3 C RNA Modifications at Single Nucleotide Resolution.

Marchand V, Ayadi L, Ernst FGM, Hertler J, Bourguignon-Igel V, Galvanin A, Kotter A, Helm M, Lafontaine DLJ, Motorin Y.

Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16785-16790. doi: 10.1002/anie.201810946. Epub 2018 Nov 16.


Use of the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics.

Stamatopoulou V, Parisot P, De Vleeschouwer C, Lafontaine DLJ.

Nat Protoc. 2018 Oct;13(10):2387-2406. doi: 10.1038/s41596-018-0044-3.


A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes.

Sharma S, Hartmann JD, Watzinger P, Klepper A, Peifer C, Kötter P, Lafontaine DLJ, Entian KD.

Sci Rep. 2018 Aug 9;8(1):11904. doi: 10.1038/s41598-018-30383-z.


The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.

Pellegrino S, Meyer M, Zorbas C, Bouchta SA, Saraf K, Pelly SC, Yusupova G, Evidente A, Mathieu V, Kornienko A, Lafontaine DLJ, Yusupov M.

Structure. 2018 Mar 6;26(3):416-425.e4. doi: 10.1016/j.str.2018.01.009. Epub 2018 Feb 8.


Identification of sites of 2'-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.

Sharma S, Marchand V, Motorin Y, Lafontaine DLJ.

Sci Rep. 2017 Sep 13;7(1):11490. doi: 10.1038/s41598-017-09734-9.


Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.

Sharma S, Yang J, van Nues R, Watzinger P, Kötter P, Lafontaine DLJ, Granneman S, Entian KD.

PLoS Genet. 2017 May 24;13(5):e1006804. doi: 10.1371/journal.pgen.1006804. eCollection 2017 May.


Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function.

Sloan KE, Warda AS, Sharma S, Entian KD, Lafontaine DLJ, Bohnsack MT.

RNA Biol. 2017 Sep 2;14(9):1138-1152. doi: 10.1080/15476286.2016.1259781. Epub 2016 Dec 2. Review.


The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.

Langhendries JL, Nicolas E, Doumont G, Goldman S, Lafontaine DL.

Oncotarget. 2016 Sep 13;7(37):59519-59534. doi: 10.18632/oncotarget.11148.


Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.

Bar DZ, Charar C, Dorfman J, Yadid T, Tafforeau L, Lafontaine DL, Gruenbaum Y.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4620-9. doi: 10.1073/pnas.1512156113. Epub 2016 Jul 25.


Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress.

Nicolas E, Parisot P, Pinto-Monteiro C, de Walque R, De Vleeschouwer C, Lafontaine DL.

Nat Commun. 2016 Jun 6;7:11390. doi: 10.1038/ncomms11390.


Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans.

Meyer B, Wurm JP, Sharma S, Immer C, Pogoryelov D, Kötter P, Lafontaine DL, Wöhnert J, Entian KD.

Nucleic Acids Res. 2016 May 19;44(9):4304-16. doi: 10.1093/nar/gkw244. Epub 2016 Apr 15.


Melanoma addiction to the long non-coding RNA SAMMSON.

Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC.

Nature. 2016 Mar 24;531(7595):518-22. doi: 10.1038/nature17161.


The cell proliferation antigen Ki-67 organises heterochromatin.

Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, Eguren M, Birling MC, Urbach S, Hem S, Déjardin J, Malumbres M, Jay P, Dulic V, Lafontaine DLj, Feil R, Fisher D.

Elife. 2016 Mar 7;5:e13722. doi: 10.7554/eLife.13722.


'View From A Bridge': A New Perspective on Eukaryotic rRNA Base Modification.

Sharma S, Lafontaine DLJ.

Trends Biochem Sci. 2015 Oct;40(10):560-575. doi: 10.1016/j.tibs.2015.07.008. Review.


The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.

Hauenschild R, Tserovski L, Schmid K, Thüring K, Winz ML, Sharma S, Entian KD, Wacheul L, Lafontaine DL, Anderson J, Alfonzo J, Hildebrandt A, Jäschke A, Motorin Y, Helm M.

Nucleic Acids Res. 2015 Nov 16;43(20):9950-64. doi: 10.1093/nar/gkv895. Epub 2015 Sep 13.


The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.

Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgué-Hamard V, Lafontaine DL.

Mol Biol Cell. 2015 Jun 1;26(11):2080-95. doi: 10.1091/mbc.E15-02-0073. Epub 2015 Apr 7.


Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.

Sharma S, Langhendries JL, Watzinger P, Kötter P, Entian KD, Lafontaine DL.

Nucleic Acids Res. 2015 Feb 27;43(4):2242-58. doi: 10.1093/nar/gkv075. Epub 2015 Feb 4.


Noncoding RNAs in eukaryotic ribosome biogenesis and function.

Lafontaine DL.

Nat Struct Mol Biol. 2015 Jan;22(1):11-9. doi: 10.1038/nsmb.2939. Review.


Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.

Létoquart J, Huvelle E, Wacheul L, Bourgeois G, Zorbas C, Graille M, Heurgué-Hamard V, Lafontaine DL.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5518-26. doi: 10.1073/pnas.1413089111. Epub 2014 Dec 8.


A new system for naming ribosomal proteins.

Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M.

Curr Opin Struct Biol. 2014 Feb;24:165-9. doi: 10.1016/ Epub 2014 Feb 10. Review.


The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors.

Tafforeau L, Zorbas C, Langhendries JL, Mullineux ST, Stamatopoulou V, Mullier R, Wacheul L, Lafontaine DL.

Mol Cell. 2013 Aug 22;51(4):539-51. doi: 10.1016/j.molcel.2013.08.011.


Screening the budding yeast genome reveals unique factors affecting K2 toxin susceptibility.

Servienė E, Lukša J, Orentaitė I, Lafontaine DL, Urbonavičius J.

PLoS One. 2012;7(12):e50779. doi: 10.1371/journal.pone.0050779. Epub 2012 Dec 5.


Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.

Figaro S, Wacheul L, Schillewaert S, Graille M, Huvelle E, Mongeard R, Zorbas C, Lafontaine DL, Heurgué-Hamard V.

Mol Cell Biol. 2012 Jun;32(12):2254-67. doi: 10.1128/MCB.06623-11. Epub 2012 Apr 9.


Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?

Mullineux ST, Lafontaine DL.

Biochimie. 2012 Jul;94(7):1521-32. doi: 10.1016/j.biochi.2012.02.001. Epub 2012 Feb 8. Review.


Diverse interactions mediate asymmetric incompatibility by the het-6 supergene complex in Neurospora crassa.

Lafontaine DL, Smith ML.

Fungal Genet Biol. 2012 Jan;49(1):65-73. doi: 10.1016/j.fgb.2011.11.001. Epub 2011 Nov 9.


The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.

Schillewaert S, Wacheul L, Lhomme F, Lafontaine DL.

Mol Cell Biol. 2012 Jan;32(2):430-44. doi: 10.1128/MCB.06019-11. Epub 2011 Nov 14.


The nucleolus: structure/function relationship in RNA metabolism.

Hernandez-Verdun D, Roussel P, Thiry M, Sirri V, Lafontaine DL.

Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):415-31. doi: 10.1002/wrna.39. Epub 2010 Sep 22. Review.


A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.

Leporé N, Lafontaine DL.

PLoS One. 2011;6(9):e24962. doi: 10.1371/journal.pone.0024962. Epub 2011 Sep 19.


The nucleolus: when 2 became 3.

Thiry M, Lamaye F, Lafontaine DL.

Nucleus. 2011 Jul-Aug;2(4):289-93. doi: 10.4161/nucl.2.4.16806. Epub 2011 Jul 1.


Nucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.

Lamaye F, Galliot S, Alibardi L, Lafontaine DL, Thiry M.

J Struct Biol. 2011 May;174(2):352-9. doi: 10.1016/j.jsb.2011.02.003. Epub 2011 Feb 16.


[<< Catch me if you can >>: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms].

Leporé N, Lafontaine DL.

Med Sci (Paris). 2010 Mar;26(3):259-66. doi: 10.1051/medsci/2010263259. Review. French.


A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes.

Lafontaine DL.

Trends Biochem Sci. 2010 May;35(5):267-77. doi: 10.1016/j.tibs.2009.12.006. Epub 2010 Jan 22. Review.


The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance.

Wery M, Ruidant S, Schillewaert S, Leporé N, Lafontaine DL.

RNA. 2009 Mar;15(3):406-19. doi: 10.1261/rna.1402709. Epub 2009 Jan 13.


TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.

Vanrobays E, Leplus A, Osheim YN, Beyer AL, Wacheul L, Lafontaine DL.

RNA. 2008 Oct;14(10):2061-73. doi: 10.1261/rna.1176708. Epub 2008 Aug 28.


Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.

Qiu H, Eifert J, Wacheul L, Thiry M, Berger AC, Jakovljevic J, Woolford JL Jr, Corbett AH, Lafontaine DL, Terns RM, Terns MP.

Mol Cell Biol. 2008 Jun;28(11):3686-99. doi: 10.1128/MCB.01115-07. Epub 2008 Mar 31.


Is ribosome synthesis controlled by pol I transcription?

Chédin S, Laferté A, Hoang T, Lafontaine DL, Riva M, Carles C.

Cell Cycle. 2007 Jan 1;6(1):11-5. Epub 2007 Jan 9. Review.


Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.

Hoang T, Peng WT, Vanrobays E, Krogan N, Hiley S, Beyer AL, Osheim YN, Greenblatt J, Hughes TR, Lafontaine DL.

Mol Cell Biol. 2005 Jul;25(13):5523-34.


Birth of a nucleolus: the evolution of nucleolar compartments.

Thiry M, Lafontaine DL.

Trends Cell Biol. 2005 Apr;15(4):194-9. Review.


The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology.

Colau G, Thiry M, Leduc V, Bordonné R, Lafontaine DL.

Mol Cell Biol. 2004 Sep;24(18):7976-86.


Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.

Vanrobays E, Gélugne JP, Caizergues-Ferrer M, Lafontaine DL.

RNA. 2004 Apr;10(4):645-56.


Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.

Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E.

EMBO J. 2002 Jun 3;21(11):2736-45.


The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.

Senger B, Lafontaine DL, Graindorge JS, Gadal O, Camasses A, Sanni A, Garnier JM, Breitenbach M, Hurt E, Fasiolo F.

Mol Cell. 2001 Dec;8(6):1363-73.


Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.

Verheggen C, Mouaikel J, Thiry M, Blanchard JM, Tollervey D, Bordonné R, Lafontaine DL, Bertrand E.

EMBO J. 2001 Oct 1;20(19):5480-90.


The function and synthesis of ribosomes.

Lafontaine DL, Tollervey D.

Nat Rev Mol Cell Biol. 2001 Jul;2(7):514-20. Review.


Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3.

Colley A, Beggs JD, Tollervey D, Lafontaine DL.

Mol Cell Biol. 2000 Oct;20(19):7238-46.


Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.

Kufel J, Allmang C, Chanfreau G, Petfalski E, Lafontaine DL, Tollervey D.

Mol Cell Biol. 2000 Aug;20(15):5415-24.


Synthesis and assembly of the box C+D small nucleolar RNPs.

Lafontaine DL, Tollervey D.

Mol Cell Biol. 2000 Apr;20(8):2650-9.

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