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Items: 20


Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination.

Rothschild G, Zhang W, Lim J, Giri PK, Laffleur B, Chen Y, Fang M, Chen Y, Nair L, Liu ZP, Deng H, Hammarström L, Wang J, Basu U.

Sci Immunol. 2020 Feb 7;5(44). pii: eaay5864. doi: 10.1126/sciimmunol.aay5864.


Biology of RNA Surveillance in Development and Disease.

Laffleur B, Basu U.

Trends Cell Biol. 2019 May;29(5):428-445. doi: 10.1016/j.tcb.2019.01.004. Epub 2019 Feb 10. Review.


G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation.

Dalloul Z, Chenuet P, Dalloul I, Boyer F, Aldigier JC, Laffleur B, El Makhour Y, Ryffel B, Quesniaux VFJ, Togbé D, Mergny JL, Cook-Moreau J, Cogné M.

J Allergy Clin Immunol. 2018 Oct;142(4):1352-1355. doi: 10.1016/j.jaci.2018.06.011. Epub 2018 Jun 20. No abstract available.


B Cell Intrinsic Mechanisms Constraining IgE Memory.

Laffleur B, Debeaupuis O, Dalloul Z, Cogné M.

Front Immunol. 2017 Nov 13;8:1277. doi: 10.3389/fimmu.2017.01277. eCollection 2017. Review.


The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.

Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang ZZ, Laffleur B, Kaake RM, McGregor MJ, Haas K, Pefanis E, Albrecht RA, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I.

Cell. 2017 May 4;169(4):679-692.e14. doi: 10.1016/j.cell.2017.04.021.


Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.

Lim J, Giri PK, Kazadi D, Laffleur B, Zhang W, Grinstein V, Pefanis E, Brown LM, Ladewig E, Martin O, Chen Y, Rabadan R, Boyer F, Rothschild G, Cogné M, Pinaud E, Deng H, Basu U.

Cell. 2017 Apr 20;169(3):523-537.e15. doi: 10.1016/j.cell.2017.03.043.


The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.

Le Noir S, Laffleur B, Carrion C, Garot A, Lecardeur S, Pinaud E, Denizot Y, Skok J, Cogné M.

Oncotarget. 2017 Feb 21;8(8):12929-12940. doi: 10.18632/oncotarget.14585.


RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.

Laffleur B, Basu U, Lim J.

J Mol Biol. 2017 Oct 27;429(21):3230-3241. doi: 10.1016/j.jmb.2016.12.021. Epub 2017 Jan 7. Review.


[When immunoglobulin genes assemble with bricks from other chromosomes].

Laffleur B, Dalloul Z, Dalloul I, Le Noir S, Cogné M.

Med Sci (Paris). 2016 8-9;32(8-9):677-80. doi: 10.1051/medsci/20163208006. Epub 2016 Sep 12. French. No abstract available.


Self-control for IgE production.

Laffleur B, Cogné M.

Oncotarget. 2015 Aug 21;6(24):19966-7. No abstract available.


Self-Restrained B Cells Arise following Membrane IgE Expression.

Laffleur B, Duchez S, Tarte K, Denis-Lagache N, Péron S, Carrion C, Denizot Y, Cogné M.

Cell Rep. 2015 Feb 17;10(6):900-909. doi: 10.1016/j.celrep.2015.01.023. Epub 2015 Feb 13.


AID-induced remodeling of immunoglobulin genes and B cell fate.

Laffleur B, Denis-Lagache N, Péron S, Sirac C, Moreau J, Cogné M.

Oncotarget. 2014 Mar 15;5(5):1118-31. Review.


Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination.

Laffleur B, Bardet SM, Garot A, Brousse M, Baylet A, Cogné M.

Genes Immun. 2014 Jul-Aug;15(5):341-6. doi: 10.1038/gene.2014.25. Epub 2014 May 22.


Specific impairment of proximal tubular cell proliferation by a monoclonal κ light chain responsible for Fanconi syndrome.

El Hamel C, Aldigier JC, Oblet C, Laffleur B, Bridoux F, Cogné M.

Nephrol Dial Transplant. 2012 Dec;27(12):4368-77. doi: 10.1093/ndt/gfs261. Epub 2012 Sep 28.


Class-specific effector functions of therapeutic antibodies.

Pascal V, Laffleur B, Cogné M.

Methods Mol Biol. 2012;901:295-317. doi: 10.1007/978-1-61779-931-0_19.


Production of human or humanized antibodies in mice.

Laffleur B, Pascal V, Sirac C, Cogné M.

Methods Mol Biol. 2012;901:149-59. doi: 10.1007/978-1-61779-931-0_9.


Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.

Pascal V, Laffleur B, Debin A, Cuvillier A, van Egmond M, Drocourt D, Imbertie L, Pangault C, Tarte K, Tiraby G, Cogné M.

Haematologica. 2012 Nov;97(11):1686-94. doi: 10.3324/haematol.2011.061408. Epub 2012 Jun 11.


[IgH locus suicide recombination, or when B cells surrender!].

Péron S, Laffleur B, Denis-Lagache N, Cook-Moreau J, Filloux M, Cogné M.

Med Sci (Paris). 2012 May;28(5):551-4. doi: 10.1051/medsci/2012285023. Epub 2012 May 30. French. No abstract available.


AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells.

Péron S, Laffleur B, Denis-Lagache N, Cook-Moreau J, Tinguely A, Delpy L, Denizot Y, Pinaud E, Cogné M.

Science. 2012 May 18;336(6083):931-4. doi: 10.1126/science.1218692. Epub 2012 Apr 26.


A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.

Fiancette R, Rouaud P, Vincent-Fabert C, Laffleur B, Magnone V, Cogné M, Denizot Y.

J Immunol. 2011 Dec 1;187(11):5772-82. doi: 10.4049/jimmunol.1102059. Epub 2011 Oct 28.

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