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Items: 21

1.

Liver X receptor modulators: a review of recently patented compounds (2009 - 2012).

Loren J, Huang Z, Laffitte BA, Molteni V.

Expert Opin Ther Pat. 2013 Oct;23(10):1317-35. doi: 10.1517/13543776.2013.814640. Epub 2013 Jul 5. Review.

PMID:
23826715
2.

Small-molecule inducer of ╬▓ cell proliferation identified by high-throughput screening.

Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG.

J Am Chem Soc. 2013 Feb 6;135(5):1669-72. doi: 10.1021/ja309304m. Epub 2013 Jan 25. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573.

PMID:
23330637
3.

Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids.

Gr├╝newald J, Hunt GS, Dong L, Niessen F, Wen BG, Tsao ML, Perera R, Kang M, Laffitte BA, Azarian S, Ruf W, Nasoff M, Lerner RA, Schultz PG, Smider VV.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4337-42. doi: 10.1073/pnas.0900507106. Epub 2009 Feb 25.

4.

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL.

J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u.

PMID:
18800767
5.

Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.

Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P.

J Lipid Res. 2004 Apr;45(4):616-25. Epub 2004 Jan 1.

6.

Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.

Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P.

J Biol Chem. 2004 Mar 12;279(11):9905-11. Epub 2003 Dec 29.

7.

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.

Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5419-24. Epub 2003 Apr 15.

8.

The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.

Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P.

Mol Cell Biol. 2003 Mar;23(6):2182-91.

9.

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.

Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P.

Nat Med. 2003 Feb;9(2):213-9. Epub 2003 Jan 13.

PMID:
12524534
10.

Identification of macrophage liver X receptors as inhibitors of atherosclerosis.

Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11896-901. Epub 2002 Aug 22.

11.

Synthetic LXR ligand inhibits the development of atherosclerosis in mice.

Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P.

Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9.

12.

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.

Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA.

J Biol Chem. 2002 Aug 30;277(35):31900-8. Epub 2002 May 24.

13.

Orphan nuclear receptors find a home in the arterial wall.

Laffitte BA, Tontonoz P.

Curr Atheroscler Rep. 2002 May;4(3):213-21. Review.

PMID:
11931719
14.

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.

Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P.

J Biol Chem. 2002 Mar 29;277(13):11019-25. Epub 2002 Jan 14.

15.

Autoregulation of the human liver X receptor alpha promoter.

Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P.

Mol Cell Biol. 2001 Nov;21(22):7558-68.

16.

Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, Gonzalez FJ, Willson TM, Edwards PA.

Mol Endocrinol. 2001 Oct;15(10):1720-8.

PMID:
11579204
17.

Biochemistry. An absorbing study of cholesterol.

Allayee H, Laffitte BA, Lusis AJ.

Science. 2000 Dec 1;290(5497):1709-11.

PMID:
11186392
18.

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.

Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P.

Mol Cell. 2001 Jan;7(1):161-71.

19.

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.

Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P.

Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12. Epub 2001 Jan 9.

20.

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12097-102.

21.

Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.

Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA.

J Biol Chem. 2000 Apr 7;275(14):10638-47.

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