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Items: 1 to 50 of 214

1.

Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis.

Jerkic M, Masterson C, Ormesher L, Gagnon S, Goyal S, Rabani R, Otulakowski G, Zhang H, Kavanagh BP, Laffey JG.

J Clin Med. 2019 Jun 13;8(6). pii: E847. doi: 10.3390/jcm8060847.

PMID:
31200579
2.

Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study.

McNicholas BA, Rezoagli E, Pham T, Madotto F, Guiard E, Fanelli V, Bellani G, Griffin MD, Ranieri M, Laffey JG; ESICM Trials Group and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators.

Crit Care Med. 2019 May 31. doi: 10.1097/CCM.0000000000003832. [Epub ahead of print]

PMID:
31162201
3.

The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration.

Heunks L, Bellani G, Pham T, Brochard L, Laffey JG.

Eur Respir J. 2019 Mar 18;53(3). pii: 1802228. doi: 10.1183/13993003.02228-2018. Print 2019 Mar. No abstract available.

PMID:
30886021
4.

Extracellular Vesicles from Interferon-γ-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats.

Varkouhi AK, Jerkic M, Ormesher L, Gagnon S, Goyal S, Rabani R, Masterson C, Spring C, Chen PZ, Gu FX, Dos Santos CC, Curley GF, Laffey JG.

Anesthesiology. 2019 May;130(5):778-790. doi: 10.1097/ALN.0000000000002655.

PMID:
30870158
5.

Declining Mortality in Patients With Acute Respiratory Distress Syndrome: An Analysis of the Acute Respiratory Distress Syndrome Network Trials.

Zhang Z, Spieth PM, Chiumello D, Goyal H, Torres A, Laffey JG, Hong Y.

Crit Care Med. 2019 Mar;47(3):315-323. doi: 10.1097/CCM.0000000000003499.

PMID:
30779718
6.

Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury.

Islam D, Huang Y, Fanelli V, Delsedime L, Wu S, Khang J, Han B, Grassi A, Li M, Xu Y, Luo A, Wu J, Liu X, McKillop M, Medin J, Qiu H, Zhong N, Liu M, Laffey J, Li Y, Zhang H.

Am J Respir Crit Care Med. 2019 May 15;199(10):1214-1224. doi: 10.1164/rccm.201802-0356OC.

PMID:
30521764
7.

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.

Pham T, Serpa Neto A, Pelosi P, Laffey JG, De Haro C, Lorente JA, Bellani G, Fan E, Brochard LJ, Pesenti A, Schultz MJ, Artigas A; LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group.

Anesthesiology. 2019 Feb;130(2):263-283. doi: 10.1097/ALN.0000000000002508.

PMID:
30499850
8.

Cell therapy in acute respiratory distress syndrome.

Horie S, Gonzalez HE, Laffey JG, Masterson CH.

J Thorac Dis. 2018 Sep;10(9):5607-5620. doi: 10.21037/jtd.2018.08.28. Review.

9.

Is Activity Tracker-Measured Ambulation an Accurate and Reliable Determinant of Postoperative Quality of Recovery? A Prospective Cohort Validation Study.

Massouh F, Martin R, Chan B, Ma J, Patel V, Geary MP, Laffey JG, Wijeysundera DN, Abdallah FW.

Anesth Analg. 2018 Oct 30. doi: 10.1213/ANE.0000000000003913. [Epub ahead of print]

PMID:
30379677
10.

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.

van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D; Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators.

Crit Care Med. 2019 Feb;47(2):229-238. doi: 10.1097/CCM.0000000000003519.

11.

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.

12.

Recommended Reading from the Galway University Hospitals, Department of Anaesthesia and Intensive Care Medicine Fellows.

Rezoagli E, McNicholas B, Moran P, Laffey JG.

Am J Respir Crit Care Med. 2018 Oct 2. doi: 10.1164/rccm.201804-0782RR. [Epub ahead of print] No abstract available.

PMID:
30277812
13.

Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury.

Shologu N, Scully M, Laffey JG, O'Toole D.

Int J Mol Sci. 2018 Sep 30;19(10). pii: E2996. doi: 10.3390/ijms19102996.

14.

Sepsis: Therapeutic Potential of Immunosuppression versus Immunostimulation.

Rezoagli E, Masterson CH, McCarthy SD, Laffey JG.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):128-130. doi: 10.1165/rcmb.2018-0284RO. No abstract available.

PMID:
30230345
15.

Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries.

Abe T, Madotto F, Pham T, Nagata I, Uchida M, Tamiya N, Kurahashi K, Bellani G, Laffey JG; LUNG-SAFE Investigators and the ESICM Trials Group.

Crit Care. 2018 Aug 17;22(1):195. doi: 10.1186/s13054-018-2126-6.

16.

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group.

Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2.

PMID:
30078618
17.

Negative trials in critical care: why most research is probably wrong.

Laffey JG, Kavanagh BP.

Lancet Respir Med. 2018 Sep;6(9):659-660. doi: 10.1016/S2213-2600(18)30279-0. Epub 2018 Jul 27. No abstract available.

PMID:
30061048
18.

A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk.

McDonnell MJ, O'Toole D, Ward C, Pearson JP, Lordan JL, De Soyza A, Loebinger M, Chalmers JD, Laffey JG, Rutherford RM.

Respir Med. 2018 Aug;141:132-143. doi: 10.1016/j.rmed.2018.06.031. Epub 2018 Jun 30. Review.

PMID:
30053958
19.

Syndecan-2-positive, Bone Marrow-derived Human Mesenchymal Stromal Cells Attenuate Bacterial-induced Acute Lung Injury and Enhance Resolution of Ventilator-induced Lung Injury in Rats.

Masterson C, Devaney J, Horie S, O'Flynn L, Deedigan L, Elliman S, Barry F, O'Brien T, O'Toole D, Laffey JG.

Anesthesiology. 2018 Sep;129(3):502-516. doi: 10.1097/ALN.0000000000002327.

PMID:
29979191
20.

Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.

Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group.

Crit Care. 2018 Jun 12;22(1):157. doi: 10.1186/s13054-018-2079-9.

21.

Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study.

Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group.

Intensive Care Med. 2018 May;44(5):564-577. doi: 10.1007/s00134-018-5152-6. Epub 2018 Apr 9.

PMID:
29632996
22.

Should continuous rather than single-injection interscalene block be routinely offered for major shoulder surgery? A meta-analysis of the analgesic and side-effects profiles.

Vorobeichik L, Brull R, Bowry R, Laffey JG, Abdallah FW.

Br J Anaesth. 2018 Apr;120(4):679-692. doi: 10.1016/j.bja.2017.11.104. Epub 2018 Feb 13.

23.

Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis.

Rabani R, Volchuk A, Jerkic M, Ormesher L, Garces-Ramirez L, Canton J, Masterson C, Gagnon S, Tatham KC, Marshall J, Grinstein S, Laffey JG, Szaszi K, Curley GF.

Eur Respir J. 2018 Apr 26;51(4). pii: 1702021. doi: 10.1183/13993003.02021-2017. Print 2018 Apr.

PMID:
29519920
24.

The Randomized Educational Acute Respiratory Distress Syndrome Diagnosis Study: A Trial to Improve the Radiographic Diagnosis of Acute Respiratory Distress Syndrome.

Goddard SL, Rubenfeld GD, Manoharan V, Dev SP, Laffey J, Bellani G, Pham T, Fan E.

Crit Care Med. 2018 May;46(5):743-748. doi: 10.1097/CCM.0000000000003000.

PMID:
29438110
25.

Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT.

McAuley DF, Laffey JG, O’Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, Murphy L, McNally C, Agus AM, McDowell C, Jackson C.

Southampton (UK): NIHR Journals Library; 2018 Jan.

26.

Research in Extracorporeal Life Support: A Call to Action.

Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet).

Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024. Epub 2018 Jan 31. No abstract available.

PMID:
29355550
27.

Acute respiratory distress syndrome.

Laffey JG, Misak C, Kavanagh BP.

BMJ. 2017 Nov 16;359:j5055. doi: 10.1136/bmj.j5055. No abstract available.

PMID:
29146585
28.

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Intensive Care Med. 2018 Jan;44(1):157-165. doi: 10.1007/s00134-017-4981-z.

PMID:
29138899
29.

Lessons to learn from epidemiologic studies in ARDS.

McNicholas BA, Rooney GM, Laffey JG.

Curr Opin Crit Care. 2018 Feb;24(1):41-48. doi: 10.1097/MCC.0000000000000473. Review.

PMID:
29135617
30.

Using Activity Trackers to Quantify Postpartum Ambulation: A Prospective Observational Study of Ambulation after Regional Anesthesia and Analgesia Interventions.

Ma J, Martin R, Chan B, Gofeld M, Geary MP, Laffey JG, Abdallah FW.

Anesthesiology. 2018 Mar;128(3):598-608. doi: 10.1097/ALN.0000000000001979.

PMID:
29135475
31.

Suprascapular and Interscalene Nerve Block for Shoulder Surgery: A Systematic Review and Meta-analysis.

Hussain N, Goldar G, Ragina N, Banfield L, Laffey JG, Abdallah FW.

Anesthesiology. 2017 Dec;127(6):998-1013. doi: 10.1097/ALN.0000000000001894. Review.

PMID:
28968280
32.

Stem Cell-based Therapies for Sepsis.

Keane C, Jerkic M, Laffey JG.

Anesthesiology. 2017 Dec;127(6):1017-1034. doi: 10.1097/ALN.0000000000001882. Review.

PMID:
28872482
33.

Noninvasive mechanical ventilation in early acute respiratory distress syndrome.

Grassi A, Foti G, Laffey JG, Bellani G.

Pol Arch Intern Med. 2017 Sep 29;127(9):614-620. doi: 10.20452/pamw.4088. Epub 2017 Aug 17. Review.

34.

The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation.

Jaber S, Bellani G, Blanch L, Demoule A, Esteban A, Gattinoni L, Guérin C, Hill N, Laffey JG, Maggiore SM, Mancebo J, Mayo PH, Mosier JM, Navalesi P, Quintel M, Vincent JL, Marini JJ.

Intensive Care Med. 2017 Sep;43(9):1352-1365. doi: 10.1007/s00134-017-4896-8. Epub 2017 Aug 7. Review.

PMID:
28785882
35.

Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study.

de Prost N, Pham T, Carteaux G, Mekontso Dessap A, Brun-Buisson C, Fan E, Bellani G, Laffey J, Mercat A, Brochard L, Maître B; LUNG SAFE investigators; ESICM trials group; REVA network.

Ann Intensive Care. 2017 Dec;7(1):69. doi: 10.1186/s13613-017-0281-6. Epub 2017 Jun 19.

36.

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F, Ranieri M, Rubenfeld G, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Lancet Respir Med. 2017 Aug;5(8):627-638. doi: 10.1016/S2213-2600(17)30213-8. Epub 2017 Jun 15.

PMID:
28624388
37.

The authors reply.

Curley GF, Jerkic M, Hogan G, Masterson C, O'Toole D, Devaney J, Laffey JG.

Crit Care Med. 2017 Jul;45(7):e737-e738. doi: 10.1097/CCM.0000000000002480. No abstract available.

PMID:
28622234
38.

Erratum to Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial.

Bluth T, Teichmann R, Kiss T, Bobek I, Canet J, Cinnella G, De Baerdemaeker L, Gregoretti C, Hedenstierna G, Hemmes SN, Hiesmayr M, Hollmann MW, Jaber S, Laffey JG, Licker MJ, Markstaller K, Matot I, Müller G, Mills GH, Mulier JP, Putensen C, Rossaint R, Schmitt J, Senturk M, Neto AS, Severgnini P, Sprung J, Vidal Melo MF, Wrigge H, Schultz MJ, Pelosi P, Gama de Abreu M; PROBESE investigators, and the PROtective VEntilation Network (PROVEnet) and on behalf of the Clinical Trial Network of the European Society of Anaesthesiology (ESA).

Trials. 2017 Jun 1;18(1):247. doi: 10.1186/s13063-017-1987-3. No abstract available.

39.

Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial.

Agus A, Hulme C, Verghis RM, McDowell C, Jackson C, O'Kane CM, Laffey JG, McAuley DF.

Crit Care. 2017 May 17;21(1):108. doi: 10.1186/s13054-017-1695-0.

40.

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial.

Bluth T, Teichmann R, Kiss T, Bobek I, Canet J, Cinnella G, De Baerdemaeker L, Gregoretti C, Hedenstierna G, Hemmes SN, Hiesmayr M, Hollmann MW, Jaber S, Laffey JG, Licker MJ, Markstaller K, Matot I, Müller G, Mills GH, Mulier JP, Putensen C, Rossaint R, Schmitt J, Senturk M, Serpa Neto A, Severgnini P, Sprung J, Vidal Melo MF, Wrigge H, Schultz MJ, Pelosi P, Gama de Abreu M; PROBESE investigators; PROtective VEntilation Network (PROVEnet); Clinical Trial Network of the European Society of Anaesthesiology (ESA).

Trials. 2017 Apr 28;18(1):202. doi: 10.1186/s13063-017-1929-0. Erratum in: Trials. 2017 Jun 1;18(1):247.

41.

Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value.

Laffey JG, Matthay MA.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):266-273. doi: 10.1164/rccm.201701-0107CP. Review.

42.
43.

A comparison of videolaryngoscopes for tracheal intubation in predicted difficult airway: a feasibility study.

Vargas M, Pastore A, Aloj F, Laffey JG, Servillo G.

BMC Anesthesiol. 2017 Feb 20;17(1):25. doi: 10.1186/s12871-017-0318-2.

44.

Some remaining important questions after LUNG SAFE : Discussion of "Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study".

Dreyfuss D, Gaudry S, Madotto F, Laffey JG.

Intensive Care Med. 2017 Apr;43(4):598-599. doi: 10.1007/s00134-017-4706-3. Epub 2017 Feb 17. No abstract available.

PMID:
28213623
45.

Fifty Years of Research in ARDS. Insight into Acute Respiratory Distress Syndrome. From Models to Patients.

Laffey JG, Kavanagh BP.

Am J Respir Crit Care Med. 2017 Jul 1;196(1):18-28. doi: 10.1164/rccm.201612-2415CI. Review.

PMID:
28146637
46.

Statin therapy for acute respiratory distress syndrome: an individual patient data meta-analysis of randomised clinical trials.

Nagendran M, McAuley DF, Kruger PS, Papazian L, Truwit JD, Laffey JG, Thompson BT, Clarke M, Gordon AC.

Intensive Care Med. 2017 May;43(5):663-671. doi: 10.1007/s00134-016-4649-0. Epub 2016 Dec 21. Review.

47.

Continued under-recognition of acute respiratory distress syndrome after the Berlin definition: what is the solution?

Laffey JG, Pham T, Bellani G.

Curr Opin Crit Care. 2017 Feb;23(1):10-17. doi: 10.1097/MCC.0000000000000381. Review.

PMID:
27922845
48.

Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study.

McDonnell MJ, Aliberti S, Goeminne PC, Restrepo MI, Finch S, Pesci A, Dupont LJ, Fardon TC, Wilson R, Loebinger MR, Skrbic D, Obradovic D, De Soyza A, Ward C, Laffey JG, Rutherford RM, Chalmers JD.

Lancet Respir Med. 2016 Dec;4(12):969-979. doi: 10.1016/S2213-2600(16)30320-4. Epub 2016 Nov 16.

49.

Cryopreserved, Xeno-Free Human Umbilical Cord Mesenchymal Stromal Cells Reduce Lung Injury Severity and Bacterial Burden in Rodent Escherichia coli-Induced Acute Respiratory Distress Syndrome.

Curley GF, Jerkic M, Dixon S, Hogan G, Masterson C, O'Toole D, Devaney J, Laffey JG.

Crit Care Med. 2017 Feb;45(2):e202-e212. doi: 10.1097/CCM.0000000000002073.

PMID:
27861182
50.

Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators and the ESICM Trials Group.

Intensive Care Med. 2016 Dec;42(12):1865-1876. doi: 10.1007/s00134-016-4571-5. Epub 2016 Oct 18. Erratum in: Intensive Care Med. 2017 Nov 14;:.

PMID:
27757516

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