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Items: 1 to 50 of 82

1.

BAR scaffolds drive membrane fission by crowding disordered domains.

Snead WT, Zeno WF, Kago G, Perkins RW, Richter JB, Zhao C, Lafer EM, Stachowiak JC.

J Cell Biol. 2018 Nov 30. pii: jcb.201807119. doi: 10.1083/jcb.201807119. [Epub ahead of print]

PMID:
30504247
2.

Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing.

Zeno WF, Baul U, Snead WT, DeGroot ACM, Wang L, Lafer EM, Thirumalai D, Stachowiak JC.

Nat Commun. 2018 Oct 8;9(1):4152. doi: 10.1038/s41467-018-06532-3.

3.

Anti-HIV IgM protects against mucosal SHIV transmission.

Gong S, Tomusange K, Kulkarni V, Adeniji OS, Lakhashe SK, Hariraju D, Strickland A, Plake E, Frost PA, Ratcliffe SJ, Wang L, Lafer EM, Ruprecht RM.

AIDS. 2018 Jul 17;32(11):F5-F13. doi: 10.1097/QAD.0000000000001857.

PMID:
29762161
4.

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.

Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer EM, Mim C, Jahn R, Milosevic I.

Elife. 2018 Apr 13;7. pii: e32569. doi: 10.7554/eLife.32569.

5.

Correction to Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling.

Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP.

Biochemistry. 2017 Jul 18;56(28):3689. doi: 10.1021/acs.biochem.7b00566. Epub 2017 Jul 5. No abstract available.

PMID:
28677957
6.

Membrane fission by protein crowding.

Snead WT, Hayden CC, Gadok AK, Zhao C, Lafer EM, Rangamani P, Stachowiak JC.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3258-E3267. doi: 10.1073/pnas.1616199114. Epub 2017 Apr 3.

7.

Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling.

Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP.

Biochemistry. 2016 Dec 13;55(49):6880-6896. Epub 2016 Dec 2. Erratum in: Biochemistry. 2017 Jul 18;56(28):3689.

8.

Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.

McCammon KM, Panda SP, Xia C, Kim JJ, Moutinho D, Kranendonk M, Auchus RJ, Lafer EM, Ghosh D, Martasek P, Kar R, Masters BS, Roman LJ.

J Biol Chem. 2016 Sep 23;291(39):20487-502. doi: 10.1074/jbc.M116.716019. Epub 2016 Aug 5.

9.

Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation.

Sousa R, Liao HS, Cuéllar J, Jin S, Valpuesta JM, Jin AJ, Lafer EM.

Nat Struct Mol Biol. 2016 Sep;23(9):821-9. doi: 10.1038/nsmb.3272. Epub 2016 Aug 1.

10.

Intrinsically disordered proteins drive membrane curvature.

Busch DJ, Houser JR, Hayden CC, Sherman MB, Lafer EM, Stachowiak JC.

Nat Commun. 2015 Jul 24;6:7875. doi: 10.1038/ncomms8875.

11.

The role of molecular chaperones in clathrin mediated vesicular trafficking.

Sousa R, Lafer EM.

Front Mol Biosci. 2015 May 19;2:26. doi: 10.3389/fmolb.2015.00026. eCollection 2015. Review.

12.

Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain.

Zhuo Y, Cano KE, Wang L, Ilangovan U, Hinck AP, Sousa R, Lafer EM.

Biochemistry. 2015 Apr 28;54(16):2571-80. doi: 10.1021/acs.biochem.5b00065. Epub 2015 Apr 16.

13.

A parametrically constrained optimization method for fitting sedimentation velocity experiments.

Gorbet G, Devlin T, Hernandez Uribe BI, Demeler AK, Lindsey ZL, Ganji S, Breton S, Weise-Cross L, Lafer EM, Brookes EH, Demeler B.

Biophys J. 2014 Apr 15;106(8):1741-50. doi: 10.1016/j.bpj.2014.02.022.

14.

A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis.

Morgan JR, Jiang J, Oliphint PA, Jin S, Gimenez LE, Busch DJ, Foldes AE, Zhuo Y, Sousa R, Lafer EM.

J Neurosci. 2013 May 1;33(18):8009-21. doi: 10.1523/JNEUROSCI.4505-12.2013.

15.

Unraveling protein-protein interactions in clathrin assemblies via atomic force spectroscopy.

Jin AJ, Lafer EM, Peng JQ, Smith PD, Nossal R.

Methods. 2013 Mar;59(3):316-27. doi: 10.1016/j.ymeth.2012.12.006. Epub 2012 Dec 25.

16.

Evaluation of competing J domain:Hsp70 complex models in light of existing mutational and NMR data.

Sousa R, Jiang J, Lafer EM, Hinck AP, Wang L, Taylor AB, Maes EG.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):E734; author reply E735. doi: 10.1073/pnas.1120597109. Epub 2012 Mar 7. No abstract available.

17.

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.

Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3359-64. doi: 10.1073/pnas.1115967109. Epub 2012 Feb 13.

18.

Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).

Xu X, Mikhailova M, Chen Z, Pal S, Robichaud TK, Lafer EM, Baber S, Steffensen B.

Matrix Biol. 2011 Sep;30(7-8):404-12. doi: 10.1016/j.matbio.2011.07.001. Epub 2011 Aug 4.

19.

Dynamic interactions between clathrin and locally structured elements in a disordered protein mediate clathrin lattice assembly.

Zhuo Y, Ilangovan U, Schirf V, Demeler B, Sousa R, Hinck AP, Lafer EM.

J Mol Biol. 2010 Nov 26;404(2):274-90. doi: 10.1016/j.jmb.2010.09.044. Epub 2010 Sep 25.

20.

Polycomb group targeting through different binding partners of RING1B C-terminal domain.

Wang R, Taylor AB, Leal BZ, Chadwell LV, Ilangovan U, Robinson AK, Schirf V, Hart PJ, Lafer EM, Demeler B, Hinck AP, McEwen DG, Kim CA.

Structure. 2010 Aug 11;18(8):966-75. doi: 10.1016/j.str.2010.04.013.

21.

Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.

Radaev S, Zou Z, Huang T, Lafer EM, Hinck AP, Sun PD.

J Biol Chem. 2010 May 7;285(19):14806-14. doi: 10.1074/jbc.M109.079921. Epub 2010 Mar 5.

22.

AFM visualization of clathrin triskelia under fluid and in air.

Kotova S, Prasad K, Smith PD, Lafer EM, Nossal R, Jin AJ.

FEBS Lett. 2010 Jan 4;584(1):44-8. doi: 10.1016/j.febslet.2009.11.039.

23.

ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.

Woo HJ, Jiang J, Lafer EM, Sousa R.

Biochemistry. 2009 Dec 8;48(48):11470-7. doi: 10.1021/bi901256y.

24.

Structural transitions of the RING1B C-terminal region upon binding the polycomb cbox domain.

Wang R, Ilangovan U, Robinson AK, Schirf V, Schwarz PM, Lafer EM, Demeler B, Hinck AP, Kim CA.

Biochemistry. 2008 Aug 5;47(31):8007-15. doi: 10.1021/bi800857f. Epub 2008 Jul 11.

25.

Structure of the Hsp110:Hsc70 nucleotide exchange machine.

Schuermann JP, Jiang J, Cuellar J, Llorca O, Wang L, Gimenez LE, Jin S, Taylor AB, Demeler B, Morano KA, Hart PJ, Valpuesta JM, Lafer EM, Sousa R.

Mol Cell. 2008 Jul 25;31(2):232-43. doi: 10.1016/j.molcel.2008.05.006. Epub 2008 Jun 12.

26.

Clathrin triskelia show evidence of molecular flexibility.

Ferguson ML, Prasad K, Boukari H, Sackett DL, Krueger S, Lafer EM, Nossal R.

Biophys J. 2008 Aug;95(4):1945-55. doi: 10.1529/biophysj.107.126342. Epub 2008 May 23.

27.

Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP.

Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM, Rowe PS.

Endocrinology. 2008 Apr;149(4):1757-72. Epub 2007 Dec 27.

28.

Structural basis of J cochaperone binding and regulation of Hsp70.

Jiang J, Maes EG, Taylor AB, Wang L, Hinck AP, Lafer EM, Sousa R.

Mol Cell. 2007 Nov 9;28(3):422-33.

29.

Keep the traffic moving: mechanism of the Hsp70 motor.

Sousa R, Lafer EM.

Traffic. 2006 Dec;7(12):1596-603. Epub 2006 Oct 6. Review.

30.

Conformation of a clathrin triskelion in solution.

Ferguson ML, Prasad K, Sackett DL, Boukari H, Lafer EM, Nossal R.

Biochemistry. 2006 May 9;45(18):5916-22.

31.

Crystallization of a functionally intact Hsc70 chaperone.

Jiang J, Lafer EM, Sousa R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jan 1;62(Pt 1):39-43. Epub 2005 Dec 16.

32.

Measuring the elasticity of clathrin-coated vesicles via atomic force microscopy.

Jin AJ, Prasad K, Smith PD, Lafer EM, Nossal R.

Biophys J. 2006 May 1;90(9):3333-44. Epub 2006 Feb 10.

33.

Clathrin and synaptic vesicle endocytosis: studies at the squid giant synapse.

Augustine GJ, Morgan JR, Villalba-Galea CA, Jin S, Prasad K, Lafer EM.

Biochem Soc Trans. 2006 Feb;34(Pt 1):68-72. Review.

34.

Structural basis of interdomain communication in the Hsc70 chaperone.

Jiang J, Prasad K, Lafer EM, Sousa R.

Mol Cell. 2005 Nov 23;20(4):513-24.

35.
36.

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP).

Rowe PS, Garrett IR, Schwarz PM, Carnes DL, Lafer EM, Mundy GR, Gutierrez GE.

Bone. 2005 Jan;36(1):33-46. Epub 2004 Nov 24.

37.

Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity.

Morón JA, Zakharova I, Ferrer JV, Merrill GA, Hope B, Lafer EM, Lin ZC, Wang JB, Javitch JA, Galli A, Shippenberg TS.

J Neurosci. 2003 Sep 17;23(24):8480-8.

38.

Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling.

Morgan JR, Prasad K, Jin S, Augustine GJ, Lafer EM.

J Biol Chem. 2003 Aug 29;278(35):33583-92. Epub 2003 Jun 14.

39.

Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface.

Jiang J, Taylor AB, Prasad K, Ishikawa-Brush Y, Hart PJ, Lafer EM, Sousa R.

Biochemistry. 2003 May 20;42(19):5748-53.

PMID:
12741832
40.

Friedrich Loeffler's way to tbe Isle of Riems near Greifswald.

Wittmann W, Lafer EM.

Hist Med Vet. 2002;27(1-4):217-30. No abstract available.

PMID:
12506922
41.

Synaptic vesicle endocytosis: the races, places, and molecular faces.

Morgan JR, Augustine GJ, Lafer EM.

Neuromolecular Med. 2002;2(2):101-14. Review.

PMID:
12428806
42.

Clathrin-protein interactions.

Lafer EM.

Traffic. 2002 Aug;3(8):513-20. Review.

43.

PI 3-kinase regulation of dopamine uptake.

Carvelli L, Morón JA, Kahlig KM, Ferrer JV, Sen N, Lechleiter JD, Leeb-Lundberg LM, Merrill G, Lafer EM, Ballou LM, Shippenberg TS, Javitch JA, Lin RZ, Galli A.

J Neurochem. 2002 May;81(4):859-69.

44.

Uncoating of clathrin-coated vesicles in presynaptic terminals: roles for Hsc70 and auxilin.

Morgan JR, Prasad K, Jin S, Augustine GJ, Lafer EM.

Neuron. 2001 Oct 25;32(2):289-300.

45.

Rapid-fire synaptic vesicle exocytosis.

Morgan JR, Lafer EM, Augustine GJ.

Neuron. 2001 Apr;30(1):5-7. Review. No abstract available.

46.

A conserved clathrin assembly motif essential for synaptic vesicle endocytosis.

Morgan JR, Prasad K, Hao W, Augustine GJ, Lafer EM.

J Neurosci. 2000 Dec 1;20(23):8667-76.

47.

A role for the clathrin assembly domain of AP180 in synaptic vesicle endocytosis.

Morgan JR, Zhao X, Womack M, Prasad K, Augustine GJ, Lafer EM.

J Neurosci. 1999 Dec 1;19(23):10201-12.

48.

AP180 and AP-2 interact directly in a complex that cooperatively assembles clathrin.

Hao W, Luo Z, Zheng L, Prasad K, Lafer EM.

J Biol Chem. 1999 Aug 6;274(32):22785-94.

49.

Probing the phosphoinositide binding site of the clathrin assembly protein AP-2 with photoaffinity labels.

Profit AA, Chen J, Gu QM, Chaudhary A, Prasad K, Lafer EM, Prestwich GD.

Arch Biochem Biophys. 1998 Sep 1;357(1):85-94.

PMID:
9721186
50.

Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand.

Hao W, Tan Z, Prasad K, Reddy KK, Chen J, Prestwich GD, Falck JR, Shears SB, Lafer EM.

J Biol Chem. 1997 Mar 7;272(10):6393-8.

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