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Items: 31

1.

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C.

Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y.

2.

Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis.

Vancamelbeke M, Laeremans T, Vanhove W, Arnauts K, Ramalho AS, Farré R, Cleynen I, Ferrante M, Vermeire S.

J Crohns Colitis. 2019 Sep 27;13(10):1351-1361. doi: 10.1093/ecco-jcc/jjz064.

3.

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.

PMID:
30814739
4.

Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.

5.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

6.

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function.

Peyrassol X, Laeremans T, Lahura V, Debulpaep M, El Hassan H, Steyaert J, Parmentier M, Langer I.

Front Endocrinol (Lausanne). 2018 Apr 5;9:153. doi: 10.3389/fendo.2018.00153. eCollection 2018.

7.

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.

Pardon E, Betti C, Laeremans T, Chevillard F, Guillemyn K, Kolb P, Ballet S, Steyaert J.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5292-5295. doi: 10.1002/anie.201712581. Epub 2018 Mar 30.

PMID:
29469969
8.

Signal transduction analysis of the NLRP3-inflammasome pathway after cellular damage and its paracrine regulation.

Veltman D, Laeremans T, Passante E, Huber HJ.

J Theor Biol. 2017 Feb 21;415:125-136. doi: 10.1016/j.jtbi.2016.12.016. Epub 2016 Dec 22.

PMID:
28017802
9.

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.

Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F.

Sci Transl Med. 2016 Nov 23;8(366):366ra162.

PMID:
27881823
10.

Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.

Claes K, Vandewalle K, Laukens B, Laeremans T, Vosters O, Langer I, Parmentier M, Steyaert J, Callewaert N.

ACS Synth Biol. 2016 Oct 21;5(10):1070-1075. Epub 2016 May 20.

PMID:
27176489
11.

Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.

Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A.

J Biol Chem. 2016 Jul 29;291(31):16292-306. doi: 10.1074/jbc.M116.726547. Epub 2016 May 10.

12.

DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops.

van der Woning B, De Boeck G, Blanchetot C, Bobkov V, Klarenbeek A, Saunders M, Waelbroeck M, Laeremans T, Steyaert J, Hultberg A, De Haard H.

MAbs. 2016 Aug-Sep;8(6):1126-35. doi: 10.1080/19420862.2016.1189050. Epub 2016 May 21.

13.

Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.

Peyrassol X, Laeremans T, Gouwy M, Lahura V, Debulpaep M, Van Damme J, Steyaert J, Parmentier M, Langer I.

J Immunol. 2016 Mar 15;196(6):2893-901. doi: 10.4049/jimmunol.1500888. Epub 2016 Feb 10.

14.

Structural insights into µ-opioid receptor activation.

Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK.

Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5.

15.

Propagation of conformational changes during μ-opioid receptor activation.

Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S.

Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680. Epub 2015 Aug 5.

16.

Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action.

Bradley ME, Dombrecht B, Manini J, Willis J, Vlerick D, De Taeye S, Van den Heede K, Roobrouck A, Grot E, Kent TC, Laeremans T, Steffensen S, Van Heeke G, Brown Z, Charlton SJ, Cromie KD.

Mol Pharmacol. 2015 Feb;87(2):251-62. doi: 10.1124/mol.114.094821. Epub 2014 Dec 2.

PMID:
25468882
17.

A general protocol for the generation of Nanobodies for structural biology.

Pardon E, Laeremans T, Triest S, Rasmussen SG, Wohlkönig A, Ruf A, Muyldermans S, Hol WG, Kobilka BK, Steyaert J.

Nat Protoc. 2014 Mar;9(3):674-93. doi: 10.1038/nprot.2014.039. Epub 2014 Feb 27.

18.

Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.

Banner DW, Gsell B, Benz J, Bertschinger J, Burger D, Brack S, Cuppuleri S, Debulpaep M, Gast A, Grabulovski D, Hennig M, Hilpert H, Huber W, Kuglstatter A, Kusznir E, Laeremans T, Matile H, Miscenic C, Rufer AC, Schlatter D, Steyaert J, Stihle M, Thoma R, Weber M, Ruf A.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1124-37. doi: 10.1107/S0907444913006574. Epub 2013 May 15.

PMID:
23695257
19.

Structure of a bacterial type IV secretion core complex at subnanometre resolution.

Rivera-Calzada A, Fronzes R, Savva CG, Chandran V, Lian PW, Laeremans T, Pardon E, Steyaert J, Remaut H, Waksman G, Orlova EV.

EMBO J. 2013 Apr 17;32(8):1195-204. doi: 10.1038/emboj.2013.58. Epub 2013 Mar 19.

20.

Selection by phage display of single domain antibodies specific to antigens in their native conformation.

Verheesen P, Laeremans T.

Methods Mol Biol. 2012;911:81-104. doi: 10.1007/978-1-61779-968-6_6.

PMID:
22886247
21.

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.

Roovers RC, Vosjan MJ, Laeremans T, el Khoulati R, de Bruin RC, Ferguson KM, Verkleij AJ, van Dongen GA, van Bergen en Henegouwen PM.

Int J Cancer. 2011 Oct 15;129(8):2013-24. doi: 10.1002/ijc.26145. Epub 2011 Aug 8.

22.

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology.

Tijink BM, Laeremans T, Budde M, Stigter-van Walsum M, Dreier T, de Haard HJ, Leemans CR, van Dongen GA.

Mol Cancer Ther. 2008 Aug;7(8):2288-97. doi: 10.1158/1535-7163.MCT-07-2384.

23.

Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies.

Roovers RC, Laeremans T, Huang L, De Taeye S, Verkleij AJ, Revets H, de Haard HJ, van Bergen en Henegouwen PM.

Cancer Immunol Immunother. 2007 Mar;56(3):303-317.

PMID:
16738850
24.

Crystal structure of the intrinsically flexible addiction antidote MazE.

Loris R, Marianovsky I, Lah J, Laeremans T, Engelberg-Kulka H, Glaser G, Muyldermans S, Wyns L.

J Biol Chem. 2003 Jul 25;278(30):28252-7. Epub 2003 May 12.

25.
26.

Phaseolus vulgaris recognizes Azorhizobium caulinodans Nod factors with a variety of chemical substituents.

Laeremans T, Snoeck C, Mariën J, Verreth C, Martínez-Romero E, Promé JC, Vanderleyden J.

Mol Plant Microbe Interact. 1999 Sep;12(9):820-4.

27.
28.

Genes essential for nod factor production and nodulation are located on a symbiotic amplicon (AMPRtrCFN299pc60) in Rhizobium tropici.

Mavingui P, Laeremans T, Flores M, Romero D, Martínez-Romero E, Palacios R.

J Bacteriol. 1998 Jun;180(11):2866-74.

29.

Functional redundancy of genes for sulphate activation enzymes in Rhizobium sp. BR816.

Laeremans T, Coolsaet N, Verreth C, Snoeck C, Hellings N, Vanderleyden J, Martínez-Romero E.

Microbiology. 1997 Dec;143 ( Pt 12):3933-42.

PMID:
9421916
30.

Isolation and characterization of Rhizobium tropici Nod factor sulfation genes.

Laeremans T, Caluwaerts I, Verreth C, Rogel MA, Vanderleyden J, Martínez-Romero E.

Mol Plant Microbe Interact. 1996 Aug;9(6):492-500.

PMID:
8755625
31.

Characterization of the recA gene from Pseudomonas fluorescens OE 28.3 and construction of a recA mutant.

De Mot R, Laeremans T, Schoofs G, Vanderleyden J.

J Gen Microbiol. 1993 Jan;139(1):49-57.

PMID:
8450308

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