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Items: 1 to 50 of 74

1.

MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.

Kozlowski M, Corujo D, Hothorn M, Guberovic I, Mandemaker IK, Blessing C, Sporn J, Gutierrez-Triana A, Smith R, Portmann T, Treier M, Scheffzek K, Huet S, Timinszky G, Buschbeck M, Ladurner AG.

EMBO Rep. 2018 Oct;19(10). pii: e44445. doi: 10.15252/embr.201744445. Epub 2018 Sep 3.

2.

A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene.

Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD, Ladurner AG.

Mol Cell. 2017 Dec 7;68(5):860-871.e7. doi: 10.1016/j.molcel.2017.11.019.

3.

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

Posavec Marjanović M, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M.

Nat Struct Mol Biol. 2017 Nov;24(11):902-910. doi: 10.1038/nsmb.3481. Epub 2017 Oct 9.

4.

Remodelers tap into nucleosome plasticity.

Singh HR, Murawska M, Ladurner AG.

Nat Struct Mol Biol. 2017 Apr 6;24(4):341-343. doi: 10.1038/nsmb.3394. No abstract available.

PMID:
28384136
5.

sNASP and ASF1A function through both competitive and compatible modes of histone binding.

Bowman A, Koide A, Goodman JS, Colling ME, Zinne D, Koide S, Ladurner AG.

Nucleic Acids Res. 2017 Jan 25;45(2):643-656. doi: 10.1093/nar/gkw892. Epub 2016 Oct 5.

6.

The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage.

Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G, Huet S.

Mol Biol Cell. 2016 Dec 1;27(24):3791-3799. Epub 2016 Oct 12.

7.

Nick Your DNA, Mark Your Chromatin.

Nardozza AP, Ladurner AG.

Mol Cell. 2016 Oct 6;64(1):7-9. doi: 10.1016/j.molcel.2016.09.023.

8.

CENPs and Sweet Nucleosomes Face the FACT.

Murawska M, Ladurner AG.

Trends Biochem Sci. 2016 Sep;41(9):736-738. doi: 10.1016/j.tibs.2016.07.010. Epub 2016 Aug 4.

PMID:
27499233
9.

Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides.

Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10634-8. doi: 10.1002/anie.201604058. Epub 2016 Jul 28.

PMID:
27464500
10.

The Metabolic Impact on Histone Acetylation and Transcription in Ageing.

Peleg S, Feller C, Ladurner AG, Imhof A.

Trends Biochem Sci. 2016 Aug;41(8):700-711. doi: 10.1016/j.tibs.2016.05.008. Epub 2016 Jun 7. Review.

11.

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.

Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H.

Cell Rep. 2016 Feb 9;14(5):1156-1168. doi: 10.1016/j.celrep.2015.12.103. Epub 2016 Jan 28.

12.

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila.

Peleg S, Feller C, Forne I, Schiller E, Sévin DC, Schauer T, Regnard C, Straub T, Prestel M, Klima C, Schmitt Nogueira M, Becker L, Klopstock T, Sauer U, Becker PB, Imhof A, Ladurner AG.

EMBO Rep. 2016 Mar;17(3):455-69. doi: 10.15252/embr.201541132. Epub 2016 Jan 18.

13.

The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats.

Bowman A, Lercher L, Singh HR, Zinne D, Timinszky G, Carlomagno T, Ladurner AG.

Nucleic Acids Res. 2016 Apr 20;44(7):3105-17. doi: 10.1093/nar/gkv1372. Epub 2015 Dec 15.

14.

ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence.

Kozlowski M, Ladurner AG.

Mol Cell. 2015 Sep 3;59(5):713-5. doi: 10.1016/j.molcel.2015.08.010.

15.

Corrigendum: The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.

Ali AA, Timinszky G, Arribas-Bosacoma R, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, Oliver AW.

Nat Struct Mol Biol. 2015 Aug;22(8):645. doi: 10.1038/nsmb0815-645a. No abstract available.

PMID:
26243658
16.

Designing Cell-Type-Specific Genome-wide Experiments.

Handley A, Schauer T, Ladurner AG, Margulies CE.

Mol Cell. 2015 May 21;58(4):621-31. doi: 10.1016/j.molcel.2015.04.024. Review.

17.

PARP1 and CBP lose their footing in cancer.

Timinszky G, Ladurner AG.

Nat Struct Mol Biol. 2014 Nov;21(11):947-8. doi: 10.1038/nsmb.2913. No abstract available.

PMID:
25372309
18.

ACF takes the driver's seat.

Singh HR, Ladurner AG.

Mol Cell. 2014 Aug 7;55(3):345-6. doi: 10.1016/j.molcel.2014.07.014.

19.

Catch me if you can: how the histone chaperone FACT capitalizes on nucleosome breathing.

Hondele M, Ladurner AG.

Nucleus. 2013 Nov-Dec;4(6):443-9. doi: 10.4161/nucl.27235. Epub 2013 Dec 5.

20.

CAST-ChIP maps cell-type-specific chromatin states in the Drosophila central nervous system.

Schauer T, Schwalie PC, Handley A, Margulies CE, Flicek P, Ladurner AG.

Cell Rep. 2013 Oct 17;5(1):271-82. doi: 10.1016/j.celrep.2013.09.001. Epub 2013 Oct 3.

21.

Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function.

Czarna A, Berndt A, Singh HR, Grudziecki A, Ladurner AG, Timinszky G, Kramer A, Wolf E.

Cell. 2013 Jun 6;153(6):1394-405. doi: 10.1016/j.cell.2013.05.011.

22.

The recognition and removal of cellular poly(ADP-ribose) signals.

Barkauskaite E, Jankevicius G, Ladurner AG, Ahel I, Timinszky G.

FEBS J. 2013 Aug;280(15):3491-507. doi: 10.1111/febs.12358. Epub 2013 Jun 18. Review.

23.

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT.

Hondele M, Stuwe T, Hassler M, Halbach F, Bowman A, Zhang ET, Nijmeijer B, Kotthoff C, Rybin V, Amlacher S, Hurt E, Ladurner AG.

Nature. 2013 Jul 4;499(7456):111-4. doi: 10.1038/nature12242. Epub 2013 May 22.

PMID:
23698368
24.

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.

Sharifi R, Morra R, Appel CD, Tallis M, Chioza B, Jankevicius G, Simpson MA, Matic I, Ozkan E, Golia B, Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, Krahn J, Wan A, Trembath RC, Crosby AH, Ahel D, Hay R, Ladurner AG, Timinszky G, Williams RS, Ahel I.

EMBO J. 2013 May 2;32(9):1225-37. doi: 10.1038/emboj.2013.51. Epub 2013 Mar 12.

25.

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.

Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG.

Nat Struct Mol Biol. 2013 Apr;20(4):508-14. doi: 10.1038/nsmb.2523. Epub 2013 Mar 10.

PMID:
23474712
26.

Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.

Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B.

Structure. 2013 Mar 5;21(3):462-75. doi: 10.1016/j.str.2012.12.019.

27.

Circadian acetylome reveals regulation of mitochondrial metabolic pathways.

Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. doi: 10.1073/pnas.1217632110. Epub 2013 Jan 22.

28.

Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation.

Oppikofer M, Kueng S, Keusch JJ, Hassler M, Ladurner AG, Gut H, Gasser SM.

EMBO J. 2013 Feb 6;32(3):437-49. doi: 10.1038/emboj.2012.343. Epub 2013 Jan 8.

29.

Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases.

Hassler M, Ladurner AG.

Curr Opin Struct Biol. 2012 Dec;22(6):721-9. doi: 10.1016/j.sbi.2012.08.005. Epub 2012 Sep 15. Review.

PMID:
22985748
30.

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.

Ali AAE, Timinszky G, Arribas-Bosacoma R, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, Oliver AW.

Nat Struct Mol Biol. 2012 Jun 10;19(7):685-692. doi: 10.1038/nsmb.2335. Erratum in: Nat Struct Mol Biol. 2015 Aug;22(8):645.

31.

A unified phylogeny-based nomenclature for histone variants.

Talbert PB, Ahmad K, Almouzni G, Ausió J, Berger F, Bhalla PL, Bonner WM, Cande WZ, Chadwick BP, Chan SW, Cross GA, Cui L, Dimitrov SI, Doenecke D, Eirin-López JM, Gorovsky MA, Hake SB, Hamkalo BA, Holec S, Jacobsen SE, Kamieniarz K, Khochbin S, Ladurner AG, Landsman D, Latham JA, Loppin B, Malik HS, Marzluff WF, Pehrson JR, Postberg J, Schneider R, Singh MB, Smith MM, Thompson E, Torres-Padilla ME, Tremethick DJ, Turner BM, Waterborg JH, Wollmann H, Yelagandula R, Zhu B, Henikoff S.

Epigenetics Chromatin. 2012 Jun 21;5:7. doi: 10.1186/1756-8935-5-7.

32.

The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity.

Hondele M, Ladurner AG.

Curr Opin Struct Biol. 2011 Dec;21(6):698-708. doi: 10.1016/j.sbi.2011.10.003. Epub 2011 Nov 3. Review.

PMID:
22054910
33.

PARG: a macrodomain in disguise.

Hassler M, Jankevicius G, Ladurner AG.

Structure. 2011 Oct 12;19(10):1351-3. doi: 10.1016/j.str.2011.09.007.

34.

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.

Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE.

Genes Dev. 2011 Sep 1;25(17):1835-46. doi: 10.1101/gad.17175111.

35.

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.

Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13.

PMID:
19680243
36.

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.

Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4. doi: 10.1073/pnas.0906920106. Epub 2009 Aug 6.

37.

Histone macroH2A isoforms predict the risk of lung cancer recurrence.

Sporn JC, Kustatscher G, Hothorn T, Collado M, Serrano M, Muley T, Schnabel P, Ladurner AG.

Oncogene. 2009 Sep 24;28(38):3423-8. doi: 10.1038/onc.2009.26. Epub 2009 Aug 3.

PMID:
19648962
38.

Chromatin places metabolism center stage.

Ladurner AG.

Cell. 2009 Jul 10;138(1):18-20. doi: 10.1016/j.cell.2009.06.025.

39.

Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.

Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A.

Science. 2009 Apr 24;324(5926):513-6. doi: 10.1126/science.1168120.

40.

Sensing NAD metabolites through macro domains.

Till S, Ladurner AG.

Front Biosci (Landmark Ed). 2009 Jan 1;14:3246-58. Review.

PMID:
19273270
41.

Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome.

Dani N, Stilla A, Marchegiani A, Tamburro A, Till S, Ladurner AG, Corda D, Di Girolamo M.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4243-8. doi: 10.1073/pnas.0900066106. Epub 2009 Feb 25.

42.

Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity.

Vinciguerra M, Santini MP, Claycomb WC, Ladurner AG, Rosenthal N.

Aging (Albany NY). 2009 Dec 10;2(1):43-62.

43.

PARP: a transferase by any other name.

Till S, Diamantara K, Ladurner AG.

Nat Struct Mol Biol. 2008 Dec;15(12):1243-4. doi: 10.1038/nsmb1208-1243. No abstract available.

PMID:
19050719
44.

The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.

Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9. doi: 10.1073/pnas.0712293105. Epub 2008 Jun 25.

45.

Repression of RNA polymerase II transcription by a Drosophila oligopeptide.

Timinszky G, Bortfeld M, Ladurner AG.

PLoS One. 2008 Jun 25;3(6):e2506. doi: 10.1371/journal.pone.0002506.

46.

A metabolic throttle regulates the epigenetic state of rDNA.

Grummt I, Ladurner AG.

Cell. 2008 May 16;133(4):577-80. doi: 10.1016/j.cell.2008.04.026. Review.

47.

RNA Pol IV plays catch with Argonaute 4.

Till S, Ladurner AG.

Cell. 2007 Nov 16;131(4):643-5.

48.

An acetylation switch in p53 mediates holo-TFIID recruitment.

Li AG, Piluso LG, Cai X, Gadd BJ, Ladurner AG, Liu X.

Mol Cell. 2007 Nov 9;28(3):408-21.

49.

Modular paths to 'decoding' and 'wiping' histone lysine methylation.

Kustatscher G, Ladurner AG.

Curr Opin Chem Biol. 2007 Dec;11(6):628-35. Epub 2007 Nov 7. Review.

PMID:
17988933
50.

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.

Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG.

Nat Struct Mol Biol. 2007 Oct;14(10):897-903. Epub 2007 Sep 23.

PMID:
17891150

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