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Items: 1 to 50 of 97

1.

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11.

2.

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

Lee SH, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F.

Biochem Pharmacol. 2017 Aug 15;138:140-149. doi: 10.1016/j.bcp.2017.05.007. Epub 2017 May 15.

PMID:
28522407
3.

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis.

Abdulkarim B, Hernangomez M, Igoillo-Esteve M, Cunha DA, Marselli L, Marchetti P, Ladriere L, Cnop M.

Endocrinology. 2017 Jun 1;158(6):1659-1670. doi: 10.1210/en.2016-1773.

PMID:
28323924
4.

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladrière L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL.

Diabetes. 2017 Jan;66(1):100-112. doi: 10.2337/db16-0592. Epub 2016 Oct 13.

5.

Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis.

Mathijs I, Da Cunha DA, Himpe E, Ladriere L, Chellan N, Roux CR, Joubert E, Muller C, Cnop M, Louw J, Bouwens L.

Mol Nutr Food Res. 2014 Oct;58(10):1980-90. doi: 10.1002/mnfr.201400211. Epub 2014 Aug 4.

PMID:
25044754
6.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

Cnop M, Abdulkarim B, Bottu G, Cunha DA, Igoillo-Esteve M, Masini M, Turatsinze JV, Griebel T, Villate O, Santin I, Bugliani M, Ladriere L, Marselli L, McCarthy MI, Marchetti P, Sammeth M, Eizirik DL.

Diabetes. 2014 Jun;63(6):1978-93. doi: 10.2337/db13-1383. Epub 2013 Dec 30.

7.

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

Oliveira AF, Cunha DA, Ladriere L, Igoillo-Esteve M, Bugliani M, Marchetti P, Cnop M.

Biotechniques. 2015 May 1;58(5):228-33. doi: 10.2144/000114285. eCollection 2015 May. No abstract available.

8.

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.

Cnop M, Igoillo-Esteve M, Rai M, Begu A, Serroukh Y, Depondt C, Musuaya AE, Marhfour I, Ladrière L, Moles Lopez X, Lefkaditis D, Moore F, Brion JP, Cooper JM, Schapira AH, Clark A, Koeppen AH, Marchetti P, Pandolfo M, Eizirik DL, Féry F.

Ann Neurol. 2012 Dec;72(6):971-82. doi: 10.1002/ana.23698.

9.

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction.

Bugliani M, Liechti R, Cheon H, Suleiman M, Marselli L, Kirkpatrick C, Filipponi F, Boggi U, Xenarios I, Syed F, Ladriere L, Wollheim C, Lee MS, Marchetti P.

Mol Cell Endocrinol. 2013 Mar 10;367(1-2):1-10. doi: 10.1016/j.mce.2012.12.001. Epub 2012 Dec 12.

PMID:
23246353
10.

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

Miani M, Colli ML, Ladrière L, Cnop M, Eizirik DL.

Endocrinology. 2012 Jul;153(7):3017-28. doi: 10.1210/en.2011-2090. Epub 2012 Apr 23.

PMID:
22529213
11.

Perturbation of glycerol metabolism in hepatocytes from n3-PUFA-depleted rats.

Portois L, Zhang Y, Ladrière L, Perret J, Louchami K, Gaspard N, Hupkens E, Bolaky N, Delforge V, Beauwens R, Malaisse WJ, Sener A, Carpentier YA, Delporte C.

Int J Mol Med. 2012 Jun;29(6):1121-6. doi: 10.3892/ijmm.2012.943. Epub 2012 Mar 16.

PMID:
22426780
12.

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction.

Cnop M, Ladrière L, Igoillo-Esteve M, Moura RF, Cunha DA.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:76-82. doi: 10.1111/j.1463-1326.2010.01279.x. Review.

PMID:
21029303
13.

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.

Igoillo-Esteve M, Marselli L, Cunha DA, Ladrière L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M.

Diabetologia. 2010 Jul;53(7):1395-405. doi: 10.1007/s00125-010-1707-y. Epub 2010 Apr 6. Erratum in: Diabetologia. 2012 Mar;55(3):863.

PMID:
20369226
14.

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

Ladrière L, Igoillo-Esteve M, Cunha DA, Brion JP, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

J Clin Endocrinol Metab. 2010 Mar;95(3):1442-9. doi: 10.1210/jc.2009-2322. Epub 2010 Jan 15.

PMID:
20080856
15.

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.

Diabetes. 2010 Feb;59(2):358-74. doi: 10.2337/db09-1159. Epub 2009 Nov 23.

16.

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-62. doi: 10.2337/db09-0685. Epub 2009 Aug 31.

17.

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.

Cnop M, Igoillo-Esteve M, Cunha DA, Ladrière L, Eizirik DL.

Biochem Soc Trans. 2008 Oct;36(Pt 5):909-15. doi: 10.1042/BST0360909. Review.

PMID:
18793160
18.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.

19.

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.

Cardozo AK, Buchillier V, Mathieu M, Chen J, Ortis F, Ladrière L, Allaman-Pillet N, Poirot O, Kellenberger S, Beckmann JS, Eizirik DL, Bonny C, Maurer F.

Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. Epub 2007 Jun 14.

20.

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.

Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.

Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.

21.

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.

22.

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.

Diabetes. 2005 Aug;54(8):2396-403.

23.

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.

Rasschaert J, Ladrière L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.

J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.

24.

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.

PMID:
15297438
25.

Metabolism of 13C-enriched D-fructose in hepatocytes from Goto-Kakizaki rats.

Malaisse WJ, Ladriere L, Verbruggen I, Willem R.

Int J Mol Med. 2004 May;13(5):697-703.

PMID:
15067373
26.

Effects of D-glucose upon D-fructose metabolism in rat hepatocytes: A 13C NMR study.

Malaisse WJ, Ladrière L, Verbruggen I, Willem R.

Mol Cell Biochem. 2002 Dec;241(1-2):103-6.

PMID:
12482031
27.

Pharmacodynamics, insulinotropic action and hypoglycemic effect of nateglinide and glibenclamide in normal and diabetic rats.

Courtois P, Jijakli H, Ladriere L, Oguzhan B, Sener A, Malaisse WJ.

Int J Mol Med. 2003 Jan;11(1):105-9.

PMID:
12469228
28.
29.

Oxidation of D-[U-(14)C] glucose and [1,12-(14)C] dodecanedioic acid by pancreatic islets from Goto-Kakizaki rats.

Malaisse WJ, Doherty M, Ladrière L, Greco AV, Mingrone G.

Horm Metab Res. 2001 Aug;33(8):463-6.

PMID:
11544559
30.

Pancreatic fate of D-[3H] mannoheptulose.

Malaisse WJ, Doherty M, Kadiata MM, Ladriere L, Malaisse-Lagae F.

Cell Biochem Funct. 2001 Sep;19(3):171-9.

PMID:
11494306
32.
33.

Labeling of pancreatic glycogen by D-[U-14c]glucose in hyperglycemic rats.

Ladrière L, Louchami K, Laghmich A, Malaisse-Lagae F, Malaisse WJ.

Endocrine. 2001 Apr;14(3):383-97.

PMID:
11444437
34.

Assessment of islet beta-cell mass in isolated rat pancreases perfused with D-[(3)H]mannoheptulose.

Ladrière L, Leclercq-Meyer V, Malaisse WJ.

Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E298-303.

35.

Uptake of D-mannoheptulose by rat erythrocytes, hepatocytes and parotid cells.

Ramirez R, Courtois P, Ladriere L, Kadiata MM, Sener A, Malaisse WJ.

Int J Mol Med. 2001 Jul;8(1):37-42.

PMID:
11408946
36.

Pancreatic and hepatic glycogen content in normoglycemic and hyperglycemic rats.

Malaisse WJ, Ladrière L, Cancelas J, Acitores A, Villanueva-Peñacarrillo ML, Valverde I.

Mol Cell Biochem. 2001 Mar;219(1-2):45-9.

PMID:
11354252
37.

Pancreatic fate of a (125)I-labelled mouse monoclonal antibody directed against pancreatic B-cell surface ganglioside(s) in control and diabetic rats.

Ladriĕre L, Malaisse-Lagae F, Alejandro R, Malaisse WJ.

Cell Biochem Funct. 2001 Jun;19(2):107-15.

PMID:
11335935
38.

Uptake of 1-deoxy-1-[125I]iodo-D-mannoheptulose by different cell types: in vitro and in vivo experiments.

Sener A, Bessieres B, Courtois P, Ladriere L, Louchami K, Jijakli H, Malaisse WJ.

Int J Mol Med. 2001 May;7(5):495-500.

PMID:
11295110
39.

Assessment of B-cell mass in isolated islets exposed to D-[3H]mannoheptulose.

Malaisse WJ, Ladrière L.

Int J Mol Med. 2001 Apr;7(4):405-6.

PMID:
11254882
40.

Pancreatic fate of 6-deoxy-6-[125I]iodo-D-glucose: in vitro experiments.

Malaisse WJ, Ladrière L, Sener A.

Endocrine. 2000 Dec;13(3):411-6.

PMID:
11216655
41.

Stimulus-secretion coupling of arginine-induced insulin release: comparison between the cationic amino acid and its methyl ester.

Sener A, Best LC, Yates AP, Kadiata MM, Olivares E, Louchami K, Jijakli H, Ladrière L, Malaisse WJ.

Endocrine. 2000 Dec;13(3):329-40.

PMID:
11216645
42.

Pancreatic fate of 14C-labelled hexoses.

Malaisse WJ, Ladriere L, Kadiata MM, Malaisse-Lagae F.

Cell Biochem Funct. 2000 Dec;18(4):281-91.

PMID:
11180291
43.

Pancreatic uptake of [2-(14)C]alloxan.

Malaisse WJ, Doherty M, Ladrière L, Malaisse-Lagae F.

Int J Mol Med. 2001 Mar;7(3):311-5.

PMID:
11179513
44.

Pancreatic glycogen content in Goto-Kakizaki rats.

Ladriere L, Malaisse WJ.

Int J Mol Med. 2001 Feb;7(2):173-5.

PMID:
11172621
45.

D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.

Sener A, Ladriere L, Benito C, Gomis R, Malaisse-Lagae F, Malaisse WJ.

Int J Mol Med. 2000 Dec;6(6):617-20.

PMID:
11078819
46.

Uptake of tritiated glibenclamide by endocrine and exocrine pancreas.

Ladrière L, Malaisse-Lagae F, Malaisse WJ.

Endocrine. 2000 Aug;13(1):133-6.

PMID:
11051057
47.

Pancreatic fate of 6-deoxy-6-[125I]iodo-D-glucose: in vivo experiments.

Malaisse WJ, Ladrière L, Malaisse-Lagae F.

Endocrine. 2000 Aug;13(1):95-101.

PMID:
11051052
48.

Pancreatic fate of 6-deoxy-6-[125I]iodo-D-glucose: in vitro experiments.

Malaisse WJ, Ladrière L, Sener A.

Endocrine. 2000 Aug;13(1):89-94. Corrected and republished in: Endocrine. 2000 Dec;13(3):411-6.

PMID:
11051051
49.

Fate of 2-deoxy-2-[18F]fluoro-D-glucose in hyperglycemic rats.

Malaisse WJ, Damhaut P, Ladriere L, Goldman S.

Int J Mol Med. 2000 Nov;6(5):549-52.

PMID:
11029522
50.

Metabolism of alpha-D-[1,2-13C]glucose pentaacetate and alpha-D-glucose penta[2-13C]acetate in rat hepatocytes.

Malaisse WJ, Ladrière L, Kadiata MM, Verbruggen I, Willem R.

Arch Biochem Biophys. 2000 Sep 1;381(1):61-6.

PMID:
11019820

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