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Items: 6

1.

FDA Approval Summary: Lenvatinib for Progressive, Radio-iodine-Refractory Differentiated Thyroid Cancer.

Nair A, Lemery SJ, Yang J, Marathe A, Zhao L, Zhao H, Jiang X, He K, Ladouceur G, Mitra AK, Zhou L, Fox E, Aungst S, Helms W, Keegan P, Pazdur R.

Clin Cancer Res. 2015 Dec 1;21(23):5205-8. doi: 10.1158/1078-0432.CCR-15-1377. Epub 2015 Aug 31.

2.

FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy.

Kim G, Ison G, McKee AE, Zhang H, Tang S, Gwise T, Sridhara R, Lee E, Tzou A, Philip R, Chiu HJ, Ricks TK, Palmby T, Russell AM, Ladouceur G, Pfuma E, Li H, Zhao L, Liu Q, Venugopal R, Ibrahim A, Pazdur R.

Clin Cancer Res. 2015 Oct 1;21(19):4257-61. doi: 10.1158/1078-0432.CCR-15-0887. Epub 2015 Jul 17. Review.

3.

Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists.

Ladouceur GH, Cook JH, Hertzog DL, Jones JH, Hundertmark T, Korpusik M, Lease TG, Livingston JN, MacDougall ML, Osterhout MH, Phelan K, Romero RH, Schoen WR, Shao C, Smith RA.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3421-4.

PMID:
12419375
4.

Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis.

Smith RA, Hertzog DL, Osterhout MH, Ladouceur GH, Korpusik M, Bobko MA, Jones JH, Phelan K, Romero RH, Hundertmark T, MacDougall ML, Livingston JN, Schoen WR.

Bioorg Med Chem Lett. 2002 May 6;12(9):1303-6.

PMID:
11965376
5.

Discovery of 5-hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists.

Ladouceur GH, Cook JH, Doherty EM, Schoen WR, MacDougall ML, Livingston JN.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):461-4.

PMID:
11814820
6.

Synthesis and evaluation of [125I]-(S)-iodozacopride, a high affinity radioligand for 5HT3 receptors.

Gehlert DR, Schober DA, Gackenheimer SL, Mais DE, Ladouceur G, Robertson DW.

Neurochem Int. 1993 Oct;23(4):373-83.

PMID:
8220179

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