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Items: 20

1.

Modeling Human Cancer-induced Cachexia.

Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC.

Cell Rep. 2019 Aug 6;28(6):1612-1622.e4. doi: 10.1016/j.celrep.2019.07.016.

2.

Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2.

Londhe P, Yu PY, Ijiri Y, Ladner KJ, Fenger JM, London C, Houghton PJ, Guttridge DC.

Front Oncol. 2018 Apr 11;8:104. doi: 10.3389/fonc.2018.00104. eCollection 2018.

3.

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.

Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3798-E3807. doi: 10.1073/pnas.1801213115. Epub 2018 Apr 2.

4.

NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development.

Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC.

J Clin Invest. 2017 Oct 2;127(10):3796-3809. doi: 10.1172/JCI91561. Epub 2017 Sep 11.

5.

NFκB signaling in alveolar rhabdomyosarcoma.

Cleary MM, Mansoor A, Settelmeyer T, Ijiri Y, Ladner KJ, Svalina MN, Rubin BP, Guttridge DC, Keller C.

Dis Model Mech. 2017 Sep 1;10(9):1109-1115. doi: 10.1242/dmm.030882.

6.

MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB.

Shintaku J, Peterson JM, Talbert EE, Gu JM, Ladner KJ, Williams DR, Mousavi K, Wang R, Sartorelli V, Guttridge DC.

Cell Rep. 2016 Oct 4;17(2):514-526. doi: 10.1016/j.celrep.2016.09.010.

7.

A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas.

Yu PY, Balkhi MY, Ladner KJ, Alder H, Yu L, Mo X, Kraybill WG, Guttridge DC, Iwenofu OH.

Lab Invest. 2016 Apr;96(4):481-91. doi: 10.1038/labinvest.2015.168. Epub 2016 Feb 15.

8.

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.

Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BK.

Neuron. 2014 Mar 5;81(5):1009-1023. doi: 10.1016/j.neuron.2014.01.013.

9.

miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.

Balkhi MY, Iwenofu OH, Bakkar N, Ladner KJ, Chandler DS, Houghton PJ, London CA, Kraybill W, Perrotti D, Croce CM, Keller C, Guttridge DC.

Sci Signal. 2013 Jul 30;6(286):ra63. doi: 10.1126/scisignal.2004177. Erratum in: Sci Signal. 2013 Sep 10;6(292):er6. Balkhi, Mumtaz Y [corrected to Balkhi, M Y].

10.

DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo.

Wallace LM, Garwick SE, Mei W, Belayew A, Coppee F, Ladner KJ, Guttridge D, Yang J, Harper SQ.

Ann Neurol. 2011 Mar;69(3):540-52. doi: 10.1002/ana.22275. Epub 2010 Dec 8.

11.

TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.

Acharyya S, Sharma SM, Cheng AS, Ladner KJ, He W, Kline W, Wang H, Ostrowski MC, Huang TH, Guttridge DC.

PLoS One. 2010 Aug 30;5(8):e12479. doi: 10.1371/journal.pone.0012479.

12.

RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair.

Wang J, Jacob NK, Ladner KJ, Beg A, Perko JD, Tanner SM, Liyanarachchi S, Fishel R, Guttridge DC.

EMBO Rep. 2009 Nov;10(11):1272-8. doi: 10.1038/embor.2009.197. Epub 2009 Sep 25.

13.

NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.

Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC.

Cancer Cell. 2008 Nov 4;14(5):369-81. doi: 10.1016/j.ccr.2008.10.006.

14.

IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis.

Lesinski GB, Raig ET, Guenterberg K, Brown L, Go MR, Shah NN, Lewis A, Quimper M, Hade E, Young G, Chaudhury AR, Ladner KJ, Guttridge DC, Bouchard P, Carson WE 3rd.

Cancer Res. 2008 Oct 15;68(20):8351-60. doi: 10.1158/0008-5472.CAN-08-0426.

15.

IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis.

Bakkar N, Wang J, Ladner KJ, Wang H, Dahlman JM, Carathers M, Acharyya S, Rudnicki MA, Hollenbach AD, Guttridge DC.

J Cell Biol. 2008 Feb 25;180(4):787-802. doi: 10.1083/jcb.200707179.

16.

Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk.

Waldman WJ, Williams MV Jr, Lemeshow S, Binkley P, Guttridge D, Kiecolt-Glaser JK, Knight DA, Ladner KJ, Glaser R.

Brain Behav Immun. 2008 Feb;22(2):215-23. Epub 2007 Sep 12.

17.

RelA/p65 regulation of IkappaBbeta.

Hertlein E, Wang J, Ladner KJ, Bakkar N, Guttridge DC.

Mol Cell Biol. 2005 Jun;25(12):4956-68.

18.

Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.

Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S, Guttridge DC.

J Clin Invest. 2004 Aug;114(3):370-8.

19.

Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products.

Ladner KJ, Caligiuri MA, Guttridge DC.

J Biol Chem. 2003 Jan 24;278(4):2294-303. Epub 2002 Nov 12.

20.

Evidence that Mos protein may not act directly on cyclin.

Xu W, Ladner KJ, Smith LD.

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4573-7.

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