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Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.

Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12706. Epub 2017 Dec 31.


Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Dec 22;8:221. doi: 10.3389/fgene.2017.00221. eCollection 2017.


Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113. eCollection 2017. Erratum in: Front Genet. 2017 Dec 22;8:221.


Novel application of a Radial Water Tread maze can distinguish cognitive deficits in mice with traumatic brain injury.

Cline MM, Yumul JC, Hysa L, Murra D, Garwin GG, Cook DG, Ladiges WC, Minoshima S, Cross DJ.

Brain Res. 2017 Feb 15;1657:140-147. doi: 10.1016/j.brainres.2016.11.027. Epub 2016 Dec 5.


C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.

McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M.

Cell Rep. 2016 Mar 8;14(9):2059-2067. doi: 10.1016/j.celrep.2016.02.012. Epub 2016 Feb 25.


Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.

Ge X, Pettan-Brewer C, Morton J, Carter K, Fatemi S, Rabinovitch P, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2015 Sep 22;5:28776. doi: 10.3402/pba.v5.28776. eCollection 2015.


Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. doi: 10.1093/gerona/glv080. Epub 2015 Aug 22.


A model of chronic hepatitis in mice expressing a truncated XRCC1 protein.

Ge X, Pettan-Brewer C, Morton J, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2015 Mar 17;5:27703. doi: 10.3402/pba.v5.27703. eCollection 2015. No abstract available.


Animal models play a vital role in translational aging research.

Ladiges WC.

Pathobiol Aging Age Relat Dis. 2015 Mar 17;5:27702. doi: 10.3402/pba.v5.27702. eCollection 2015. No abstract available.


Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice.

Gilbert SJ, Meakin LB, Bonnet CS, Nowell MA, Ladiges WC, Morton J, Duance VC, Mason DJ.

Front Endocrinol (Lausanne). 2014 Oct 17;5:174. doi: 10.3389/fendo.2014.00174. eCollection 2014.


An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice.

Pettan-Brewer C, Goh J, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2014 Aug 11;4. doi: 10.3402/pba.v4.24824. eCollection 2014.


Pre-tumor exercise decreases breast cancer in old mice in a distance-dependent manner.

Goh J, Endicott E, Ladiges WC.

Am J Cancer Res. 2014 Jul 16;4(4):378-84. eCollection 2014.


Exercise enhances wound healing and prevents cancer progression during aging by targeting macrophage polarity.

Goh J, Ladiges WC.

Mech Ageing Dev. 2014 Jul;139:41-8. doi: 10.1016/j.mad.2014.06.004. Epub 2014 Jun 13. Review.


Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner.

Goh J, Tsai J, Bammler TK, Farin FM, Endicott E, Ladiges WC.

PLoS One. 2013 Nov 27;8(11):e80123. doi: 10.1371/journal.pone.0080123. eCollection 2013.


A novel radial water tread maze tracks age-related cognitive decline in mice.

Pettan-Brewer C, Touch DV, Wiley JC, Hopkins HC, Rabinovitch PS, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2013 Oct 4;3. doi: 10.3402/pba.v3i0.20679. eCollection 2013.


The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK.

PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22.


Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

Garelick MG, Mackay VL, Yanagida A, Academia EC, Schreiber KH, Ladiges WC, Kennedy BK.

Cell Cycle. 2013 Aug 1;12(15):2493-504. doi: 10.4161/cc.25512. Epub 2013 Jul 1.


Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations.

Zheng R, Yang L, Sikorski MA, Enns LC, Czyzyk TA, Ladiges WC, McKnight GS.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1631-40. doi: 10.1073/pnas.1219542110. Epub 2013 Apr 8.


A novel long term short interval physical activity regime improves body composition in mice.

Goh J, Ladiges WC.

BMC Res Notes. 2013 Feb 19;6:66. doi: 10.1186/1756-0500-6-66.


Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.

Frock RL, Chen SC, Da DF, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK.

PLoS One. 2012;7(8):e42918. doi: 10.1371/journal.pone.0042918. Epub 2012 Aug 15.


Exercise, physical activity and breast cancer: the role of tumor-associated macrophages.

Goh J, Kirk EA, Lee SX, Ladiges WC.

Exerc Immunol Rev. 2012;18:158-76. Review.


Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK.

Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802.


XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility.

McNeill DR, Lin PC, Miller MG, Pistell PJ, de Souza-Pinto NC, Fishbein KW, Spencer RG, Liu Y, Pettan-Brewer C, Ladiges WC, Wilson DM 3rd.

Nucleic Acids Res. 2011 Oct;39(18):7992-8004. doi: 10.1093/nar/gkr280. Epub 2011 Jul 6.


Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.

Wiley JC, Pettan-Brewer C, Ladiges WC.

Aging Cell. 2011 Jun;10(3):418-28. doi: 10.1111/j.1474-9726.2011.00680.x. Epub 2011 Mar 22.


Tumor growth is suppressed in mice expressing a truncated XRCC1 protein.

Pettan-Brewer C, Morton J, Cullen S, Enns L, Kehrli KR, Sidorova J, Goh J, Coil R, Ladiges WC.

Am J Cancer Res. 2012;2(2):168-77. Epub 2012 Feb 15.


Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction.

Enns LC, Bible KL, Emond MJ, Ladiges WC.

BMC Res Notes. 2010 Nov 16;3:307. doi: 10.1186/1756-0500-3-307.


Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.

Wiley JC, Meabon JS, Frankowski H, Smith EA, Schecterson LC, Bothwell M, Ladiges WC.

PLoS One. 2010 Feb 9;5(2):e9135. doi: 10.1371/journal.pone.0009135.


Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.

Dhillon KK, Sidorova JM, Albertson TM, Anderson JB, Ladiges WC, Rabinovitch PS, Preston BD, Monnat RJ Jr.

DNA Repair (Amst). 2010 Jan 2;9(1):11-22. doi: 10.1016/j.dnarep.2009.09.013. Epub 2009 Nov 5.


Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC.

J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1221-31. doi: 10.1093/gerona/glp133. Epub 2009 Sep 23.


Disruption of protein kinase A in mice enhances healthy aging.

Enns LC, Morton JF, Treuting PR, Emond MJ, Wolf NS, Dai DF, McKnight GS, Rabinovitch PS, Ladiges WC.

PLoS One. 2009 Jun 18;4(6):e5963. doi: 10.1371/journal.pone.0005963. Erratum in: PLoS One. 2010;5(2) doi: 10.1371/annotation/c7cad2dc-1eca-487e-89ae-151a22d8a0b4. Dai, Dao-Fu [added].


Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS.

Circulation. 2009 Jun 2;119(21):2789-97. doi: 10.1161/CIRCULATIONAHA.108.822403. Epub 2009 May 18.


Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria.

Treuting PM, Linford NJ, Knoblaugh SE, Emond MJ, Morton JF, Martin GM, Rabinovitch PS, Ladiges WC.

J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):813-22.


Clinical relevance of transgenic mouse models for aging research.

Enns LC, Wiley JC, Ladiges WC.

Crit Rev Eukaryot Gene Expr. 2008;18(1):81-91. Review.


Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.

Wiley JC, Smith EA, Hudson MP, Ladiges WC, Bothwell M.

J Biol Chem. 2007 Nov 16;282(46):33313-25. Epub 2007 Sep 11.


Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis.

Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA.

Mol Cell Biol. 2007 Nov;27(21):7669-82. Epub 2007 Sep 4.


Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

McConnachie LA, Mohar I, Hudson FN, Ware CB, Ladiges WC, Fernandez C, Chatterton-Kirchmeier S, White CC, Pierce RH, Kavanagh TJ.

Toxicol Sci. 2007 Oct;99(2):628-36. Epub 2007 Jun 21.


Mitochondrial point mutations do not limit the natural lifespan of mice.

Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2007 Apr;39(4):540-3. Epub 2007 Mar 4.


Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice.

Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ.

J Biol Chem. 2006 Sep 29;281(39):28865-75. Epub 2006 Jul 13.


Mouse models of XRCC1 DNA repair polymorphisms and cancer.

Ladiges WC.

Oncogene. 2006 Mar 13;25(11):1612-9. Review.


Approaches to determine clinical significance of genetic variants.

MacAuley A, Ladiges WC.

Mutat Res. 2005 Jun 3;573(1-2):205-20. Review.


Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.

Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, Baskin CR, MacAuley A, Goodman AG, LeBoeuf RC, Katze MG.

Diabetes. 2005 Apr;54(4):1074-81.


Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature.

Weiss JM, Goode EL, Ladiges WC, Ulrich CM.

Mol Carcinog. 2005 Mar;42(3):127-41. Review.


Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice.

Ware CB, Siverts LA, Nelson AM, Morton JF, Ladiges WC.

Transgenic Res. 2003 Dec;12(6):743-6.


Generation of genetically altered mouse models for aging studies.

Treuting PM, Hopkins HC, Ware CA, Rabinovitch PR, Ladiges WC.

Exp Mol Pathol. 2002 Feb;72(1):49-55.


Transgenic animals in toxicology.

Ladiges WC, Ware CB.

Curr Protoc Toxicol. 2001;Chapter 1:Unit1.3. doi: 10.1002/0471140856.tx0103s00. Review.


Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei.

Schriner SE, Ogburn CE, Smith AC, Newcomb TG, Ladiges WC, Dollé ME, Vijg J, Fukuchi K, Martin GM.

Free Radic Biol Med. 2000 Oct 1;29(7):664-73.


Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.

Wang L, Ogburn CE, Ware CB, Ladiges WC, Youssoufian H, Martin GM, Oshima J.

Genetics. 2000 Jan;154(1):357-62.


Evaluation of FVB/N mice as recipients for transgenic embryos.

Perret-Gentil MI, Murray L, Bird DJ, Ladiges WC.

Lab Anim Sci. 1999 Aug;49(4):427-8. No abstract available.


FVB/N (H2(q)) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments.

Osman GE, Hannibal MC, Anderson JP, Lasky SR, Ladiges WC, Hood L.

Immunogenetics. 1999 Sep;49(10):851-9.


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