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Items: 1 to 50 of 135

1.

A geroscience mouse model for Alzheimer's disease.

Darvas M, Keene D, Ladiges W.

Pathobiol Aging Age Relat Dis. 2019 May 14;9(1):1616994. doi: 10.1080/20010001.2019.1616994. eCollection 2019. No abstract available.

2.

Glycine supplementation extends lifespan of male and female mice.

Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R.

Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27.

3.

Pathobiology of aging and age-related diseases is the official journal of the Geropathology Research Network.

Ladiges W.

Pathobiol Aging Age Relat Dis. 2019 Mar 18;9(1):1593786. doi: 10.1080/20010001.2019.1593786. eCollection 2019. No abstract available.

4.

Measuring biological age in mice using differential mass spectrometry.

Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA.

Aging (Albany NY). 2019 Feb 11;11(3):1045-1061. doi: 10.18632/aging.101810.

5.

Modeling Alzheimer's disease in progeria mice. An age-related concept.

Sharma K, Darvas M, Keene CD, Niedernhofer LJ, Ladiges W.

Pathobiol Aging Age Relat Dis. 2018 Oct 4;8(1):1524815. doi: 10.1080/20010001.2018.1524815. eCollection 2018.

6.

Fisetin is a senotherapeutic that extends health and lifespan.

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

7.

Chronic oral rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat.

den Hartigh LJ, Goodspeed L, Wang SA, Kenerson HL, Omer M, O'Brien KD, Ladiges W, Yeung R, Subramanian S.

Exp Physiol. 2018 Nov;103(11):1469-1480. doi: 10.1113/EP087207. Epub 2018 Sep 13.

8.

Testing drug combinations to slow aging.

Ladiges W, Liggitt D.

Pathobiol Aging Age Relat Dis. 2017 Nov 23;8(1):1407203. doi: 10.1080/20010001.2017.1407203. eCollection 2018. No abstract available.

9.

The potential use of physical resilience to predict healthy aging.

Schorr A, Carter C, Ladiges W.

Pathobiol Aging Age Relat Dis. 2017 Nov 21;8(1):1403844. doi: 10.1080/20010001.2017.1403844. eCollection 2018. Review.

10.

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.

Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12706. Epub 2017 Dec 31.

11.

Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Dec 22;8:221. doi: 10.3389/fgene.2017.00221. eCollection 2017.

12.

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Front Genet. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113. eCollection 2017. Erratum in: Front Genet. 2017 Dec 22;8:221.

13.

The emerging role of geropathology in preclinical aging studies.

Ladiges W.

Pathobiol Aging Age Relat Dis. 2017 Mar 21;7(1):1304005. doi: 10.1080/20010001.2017.1304005. eCollection 2017. No abstract available.

14.

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.

Diabetes. 2017 Aug;66(8):2072-2081. doi: 10.2337/db16-1334. Epub 2017 May 5.

15.

Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice.

Lefebvre KA, Kendrick PS, Ladiges W, Hiolski EM, Ferriss BE, Smith DR, Marcinek DJ.

Harmful Algae. 2017 Apr;64:20-29. doi: 10.1016/j.hal.2017.03.003. Epub 2017 Mar 27.

16.

A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.

Ladiges W, Snyder JM, Wilkinson E, Imai DM, Snider T, Ge X, Ciol M, Pettan-Brewer C, Pillai SPS, Morton J, Quarles E, Rabinovitch P, Niedernhofer L, Liggitt D.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):760-762. doi: 10.1093/gerona/glx019.

17.

Self-motivated and stress-response performance assays in mice are age-dependent.

Ge X, Ciol MA, Pettan-Brewer C, Goh J, Rabinovitch P, Ladiges W.

Exp Gerontol. 2017 May;91:1-4. doi: 10.1016/j.exger.2017.02.001. Epub 2017 Feb 8.

18.

Novel application of a Radial Water Tread maze can distinguish cognitive deficits in mice with traumatic brain injury.

Cline MM, Yumul JC, Hysa L, Murra D, Garwin GG, Cook DG, Ladiges WC, Minoshima S, Cross DJ.

Brain Res. 2017 Feb 15;1657:140-147. doi: 10.1016/j.brainres.2016.11.027. Epub 2016 Dec 5.

19.

Molecular pathology endpoints useful for aging studies.

Niedernhofer LJ, Kirkland JL, Ladiges W.

Ageing Res Rev. 2017 May;35:241-249. doi: 10.1016/j.arr.2016.09.012. Epub 2016 Oct 6. Review.

20.

Grip strength is potentially an early indicator of age-related decline in mice.

Ge X, Cho A, Ciol MA, Pettan-Brewer C, Snyder J, Rabinovitch P, Ladiges W.

Pathobiol Aging Age Relat Dis. 2016 Sep 8;6:32981. doi: 10.3402/pba.v6.32981. eCollection 2016. Erratum in: Pathobiol Aging Age Relat Dis. 2016 Oct 24;6:33718.

21.

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines.

Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W.

Pathobiol Aging Age Relat Dis. 2016 Jun 16;6:32397. doi: 10.3402/pba.v6.32397. eCollection 2016.

22.

Application of the microfluidic-assisted replication track analysis to measure DNA repair in human and mouse cells.

Welcsh P, Kehrli K, Lazarchuk P, Ladiges W, Sidorova J.

Methods. 2016 Oct 1;108:99-110. doi: 10.1016/j.ymeth.2016.04.029. Epub 2016 Apr 26.

23.

Pathology assessment is necessary to validate translational endpoints in preclinical aging studies.

Ladiges W.

Pathobiol Aging Age Relat Dis. 2016 Mar 23;6:31478. doi: 10.3402/pba.v6.31478. eCollection 2016.

24.

C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.

McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M.

Cell Rep. 2016 Mar 8;14(9):2059-2067. doi: 10.1016/j.celrep.2016.02.012. Epub 2016 Feb 25.

25.

Voluntary Wheel Running in Mice.

Goh J, Ladiges W.

Curr Protoc Mouse Biol. 2015 Dec 2;5(4):283-290. doi: 10.1002/9780470942390.mo140295.

26.

Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.

Ge X, Pettan-Brewer C, Morton J, Carter K, Fatemi S, Rabinovitch P, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2015 Sep 22;5:28776. doi: 10.3402/pba.v5.28776. eCollection 2015.

27.

Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. doi: 10.1093/gerona/glv080. Epub 2015 Aug 22.

28.

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

Ladiges W, Ikeno Y, Niedernhofer L, McIndoe RA, Ciol MA, Ritchey J, Liggitt D.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):431-4. doi: 10.1093/gerona/glv079. Epub 2015 Aug 4.

29.

Geropathology Research Network Symposium 2015.

Ladiges W.

Pathobiol Aging Age Relat Dis. 2015 Jul 1;5:28866. doi: 10.3402/pba.v5.28866. eCollection 2015. No abstract available.

30.

A model of chronic hepatitis in mice expressing a truncated XRCC1 protein.

Ge X, Pettan-Brewer C, Morton J, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2015 Mar 17;5:27703. doi: 10.3402/pba.v5.27703. eCollection 2015. No abstract available.

31.

Animal models play a vital role in translational aging research.

Ladiges WC.

Pathobiol Aging Age Relat Dis. 2015 Mar 17;5:27702. doi: 10.3402/pba.v5.27702. eCollection 2015. No abstract available.

32.

Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice.

Gilbert SJ, Meakin LB, Bonnet CS, Nowell MA, Ladiges WC, Morton J, Duance VC, Mason DJ.

Front Endocrinol (Lausanne). 2014 Oct 17;5:174. doi: 10.3389/fendo.2014.00174. eCollection 2014.

33.

An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice.

Pettan-Brewer C, Goh J, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2014 Aug 11;4. doi: 10.3402/pba.v4.24824. eCollection 2014.

34.

Pre-tumor exercise decreases breast cancer in old mice in a distance-dependent manner.

Goh J, Endicott E, Ladiges WC.

Am J Cancer Res. 2014 Jul 16;4(4):378-84. eCollection 2014.

35.

Exercise enhances wound healing and prevents cancer progression during aging by targeting macrophage polarity.

Goh J, Ladiges WC.

Mech Ageing Dev. 2014 Jul;139:41-8. doi: 10.1016/j.mad.2014.06.004. Epub 2014 Jun 13. Review.

PMID:
24932991
36.

The quality control theory of aging.

Ladiges W.

Pathobiol Aging Age Relat Dis. 2014 May 23;4. doi: 10.3402/pba.v4.24835. eCollection 2014.

37.

Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner.

Goh J, Tsai J, Bammler TK, Farin FM, Endicott E, Ladiges WC.

PLoS One. 2013 Nov 27;8(11):e80123. doi: 10.1371/journal.pone.0080123. eCollection 2013.

38.

A novel radial water tread maze tracks age-related cognitive decline in mice.

Pettan-Brewer C, Touch DV, Wiley JC, Hopkins HC, Rabinovitch PS, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2013 Oct 4;3. doi: 10.3402/pba.v3i0.20679. eCollection 2013.

39.

Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice.

Phelps M, Pettan-Brewer C, Ladiges W, Yablonka-Reuveni Z.

Biogerontology. 2013 Dec;14(6):729-39. doi: 10.1007/s10522-013-9447-2. Epub 2013 Sep 13.

40.

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK.

PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22.

41.

Pathology is a critical aspect of preclinical aging studies.

Ladiges W, Ikeno Y, Liggitt D, Treuting PM.

Pathobiol Aging Age Relat Dis. 2013 Aug 20;3. doi: 10.3402/pba.v3i0.22451. eCollection 2013.

42.

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

Garelick MG, Mackay VL, Yanagida A, Academia EC, Schreiber KH, Ladiges WC, Kennedy BK.

Cell Cycle. 2013 Aug 1;12(15):2493-504. doi: 10.4161/cc.25512. Epub 2013 Jul 1.

43.

Breast tumor cells primed by endoplasmic reticulum stress remodel macrophage phenotype.

Cullen SJ, Fatemie S, Ladiges W.

Am J Cancer Res. 2013 Apr 3;3(2):196-210. Print 2013.

44.

Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations.

Zheng R, Yang L, Sikorski MA, Enns LC, Czyzyk TA, Ladiges WC, McKnight GS.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1631-40. doi: 10.1073/pnas.1219542110. Epub 2013 Apr 8.

45.

A novel long term short interval physical activity regime improves body composition in mice.

Goh J, Ladiges WC.

BMC Res Notes. 2013 Feb 19;6:66. doi: 10.1186/1756-0500-6-66.

46.

B16 melanoma tumor growth is delayed in mice in an age-dependent manner.

Pettan-Brewer C, Morton J, Coil R, Hopkins H, Fatemie S, Ladiges W.

Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.19182. Epub 2012 Aug 20.

47.

Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells.

Fatemie S, Goh J, Pettan-Brewer C, Ladiges W.

Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.17391. Epub 2012 May 11.

48.

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.

Frock RL, Chen SC, Da DF, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK.

PLoS One. 2012;7(8):e42918. doi: 10.1371/journal.pone.0042918. Epub 2012 Aug 15.

49.

Mitochondrial redox signaling and cancer invasiveness.

Enns L, Ladiges W.

J Bioenerg Biomembr. 2012 Dec;44(6):635-8. doi: 10.1007/s10863-012-9467-7. Review.

50.

Exercise, physical activity and breast cancer: the role of tumor-associated macrophages.

Goh J, Kirk EA, Lee SX, Ladiges WC.

Exerc Immunol Rev. 2012;18:158-76. Review.

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