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Smart Scheduling - optimising national immunisation programmes to achieve maximum impact.

Ladhani SN, Ramsay ME.

Clin Infect Dis. 2019 Jun 15. pii: ciz500. doi: 10.1093/cid/ciz500. [Epub ahead of print] No abstract available.


Invasive meningococcal disease in patients with complement deficiencies: a case series (2008-2017).

Ladhani SN, Campbell H, Lucidarme J, Gray S, Parikh S, Willerton L, Clark SA, Lekshmi A, Walker A, Patel S, Bai X, Ramsay M, Borrow R.

BMC Infect Dis. 2019 Jun 14;19(1):522. doi: 10.1186/s12879-019-4146-5.


Effectiveness of 23-Valent Polysaccharide Pneumococcal Vaccine and Changes in Invasive Pneumococcal Disease Incidence from 2000 to 2017 in Those Aged 65 and Over in England and Wales.

Djennad A, Ramsay ME, Pebody R, Fry NK, Sheppard C, Ladhani SN, Andrews NJ.

EClinicalMedicine. 2019 Jan 2;6:42-50. doi: 10.1016/j.eclinm.2018.12.007. eCollection 2018 Dec.


Risk of invasive bacterial infections by week of age in infants: prospective national surveillance, England, 2010-2017.

Ladhani SN, Henderson KL, Muller-Pebody B, Ramsay ME, Riordan A.

Arch Dis Child. 2019 May 30. pii: archdischild-2018-316191. doi: 10.1136/archdischild-2018-316191. [Epub ahead of print]


B Part of It School Leaver protocol: an observational repeat cross-sectional study to assess the impact of a meningococcal serogroup B (4CMenB) vaccine programme on carriage of Neisseria meningitidis.

Marshall HS, McMillan M, Koehler A, Lawrence A, MacLennan J, Maiden M, Ramsay M, Ladhani SN, Trotter C, Borrow R, Finn A, Sullivan T, Richmond P, Kahler C, Whelan J, Vadivelu K.

BMJ Open. 2019 May 6;9(5):e027233. doi: 10.1136/bmjopen-2018-027233.


Lower risk of invasive meningococcal disease during pregnancy: national prospective surveillance in England, 2011-2014.

Parikh SR, Borrow R, Ramsay ME, Ladhani SN.

BJOG. 2019 Jul;126(8):1052-1057. doi: 10.1111/1471-0528.15701. Epub 2019 May 8.


The Epidemiology and Biostatistics of Pneumococcus.

Oligbu G, Fry NK, Ladhani SN.

Methods Mol Biol. 2019;1968:215-224. doi: 10.1007/978-1-4939-9199-0_18.


The Pneumococcus and Its Critical Role in Public Health.

Oligbu G, Fry NK, Ladhani SN.

Methods Mol Biol. 2019;1968:205-213. doi: 10.1007/978-1-4939-9199-0_17.


Invasive meningococcal disease as a cause of sudden and unexpected death in a teenager: The public health importance of confirming the diagnosis.

Campbell H, Borrow R, Arumugam C, Ramsay M, Ladhani SN.

J Infect. 2019 Apr;78(4):323-337. doi: 10.1016/j.jinf.2018.11.004. Epub 2018 Nov 23. No abstract available.


Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination.

Hanquet G, Krizova P, Valentiner-Branth P, Ladhani SN, Nuorti JP, Lepoutre A, Mereckiene J, Knol M, Winje BA, Ciruela P, Ordobas M, Guevara M, McDonald E, Morfeldt E, Kozakova J, Slotved HC, Fry NK, Rinta-Kokko H, Varon E, Corcoran M, van der Ende A, Vestrheim DF, Munoz-Almagro C, Latasa P, Castilla J, Smith A, Henriques-Normark B, Whittaker R, Pastore Celentano L, Savulescu C; SpIDnet/I-MOVE+ Pneumo Group.

Thorax. 2019 May;74(5):473-482. doi: 10.1136/thoraxjnl-2018-211767. Epub 2018 Oct 24.


Invasive Pneumococcal Disease in UK Children <1 Year of Age in the Post-13-Valent Pneumococcal Conjugate Vaccine Era: What Are the Risks Now?

Kent A, Makwana A, Sheppard CL, Collins S, Fry NK, Heath PT, Ramsay M, Ladhani SN.

Clin Infect Dis. 2019 Jun 18;69(1):84-90. doi: 10.1093/cid/ciy842.


Rapid Spread of Pneumococcal Nonvaccine Serotype 7C Previously Associated with Vaccine Serotype 19F, England and Wales.

Makwana A, Ladhani SN, Kapatai G, Campion E, Fry NK, Sheppard C.

Emerg Infect Dis. 2018 Oct;24(10):1919-1922. doi: 10.3201/eid2410.180114.


B Part of It protocol: a cluster randomised controlled trial to assess the impact of 4CMenB vaccine on pharyngeal carriage of Neisseria meningitidis in adolescents.

Marshall HS, McMillan M, Koehler A, Lawrence A, MacLennan JM, Maiden MCJ, Ramsay M, Ladhani SN, Trotter C, Borrow R, Finn A, Sullivan T, Richmond P, Kahler CM, Whelan J, Vadivelu K.

BMJ Open. 2018 Jul 10;8(7):e020988. doi: 10.1136/bmjopen-2017-020988.


Characteristics of Children With Invasive Pneumococcal Disease After the Introduction of the 13-valent Pneumococcal Conjugate Vaccine in England and Wales, 2010-2016.

Makwana A, Sheppard C, Borrow R, Fry N, Andrews NJ, Ladhani SN.

Pediatr Infect Dis J. 2018 Jul;37(7):697-703. doi: 10.1097/INF.0000000000001845.


Increased detection of human parechovirus infection in infants in England during 2016: epidemiology and clinical characteristics.

Ferreras Antolín L, Kadambari S, Braccio S, Tang JW, Xerry J, Allen DJ, Ladhani SN; Parechovirus Surveillance Network.

Arch Dis Child. 2018 Nov;103(11):1061-1066. doi: 10.1136/archdischild-2017-314281. Epub 2018 Jun 5.


Epidemiology, clinical presentation, risk factors, intensive care admission and outcomes of invasive meningococcal disease in England, 2010-2015.

Parikh SR, Campbell H, Gray SJ, Beebeejaun K, Ribeiro S, Borrow R, Ramsay ME, Ladhani SN.

Vaccine. 2018 Jun 18;36(26):3876-3881. doi: 10.1016/j.vaccine.2018.02.038. Epub 2018 Apr 24.


Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000-17: a prospective national observational cohort study.

Ladhani SN, Collins S, Djennad A, Sheppard CL, Borrow R, Fry NK, Andrews NJ, Miller E, Ramsay ME.

Lancet Infect Dis. 2018 Apr;18(4):441-451. doi: 10.1016/S1473-3099(18)30052-5. Epub 2018 Jan 26. Erratum in: Lancet Infect Dis. 2018 Feb 6;:.


Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age With Bacterial Meningitis in the United Kingdom and Ireland.

Okike IO, Ladhani SN, Johnson AP, Henderson KL, Blackburn RM, Muller-Pebody B, Cafferkey M, Anthony M, Ninis N, Heath PT; neoMen Study Group.

Pediatr Infect Dis J. 2018 Sep;37(9):837-843. doi: 10.1097/INF.0000000000001917.


Growing evidence supports 4CMenB effectiveness.

Ladhani SN, Borrow R, Andrews NJ.

Lancet Infect Dis. 2018 Apr;18(4):370-371. doi: 10.1016/S1473-3099(18)30051-3. Epub 2018 Jan 19. No abstract available.


Characteristics and Serotype Distribution of Childhood Cases of Invasive Pneumococcal Disease Following Pneumococcal Conjugate Vaccination in England and Wales, 2006-2014.

Oligbu G, Collins S, Andrews N, Sheppard CL, Fry NK, Slack MPE, Borrow R, Ladhani SN.

Clin Infect Dis. 2017 Oct 1;65(7):1191-1198. doi: 10.1093/cid/cix418.


Temporal associations between national outbreaks of meningococcal serogroup W and C disease in the Netherlands and England: an observational cohort study.

Knol MJ, Hahné SJM, Lucidarme J, Campbell H, de Melker HE, Gray SJ, Borrow R, Ladhani SN, Ramsay ME, van der Ende A.

Lancet Public Health. 2017 Oct;2(10):e473-e482. doi: 10.1016/S2468-2667(17)30157-3. Epub 2017 Aug 24.


Estimating primary care attendance rates for fever in infants after meningococcal B vaccination in England using national syndromic surveillance data.

Harcourt S, Morbey RA, Bates C, Carter H, Ladhani SN, de Lusignan S, Smith GE, Elliot AJ.

Vaccine. 2018 Jan 25;36(4):565-571. doi: 10.1016/j.vaccine.2017.11.076. Epub 2017 Dec 13.


The yin and yang of fever after meningococcal B vaccination.

Ladhani SN, Riordan A.

Arch Dis Child. 2017 Oct;102(10):881-882. doi: 10.1136/archdischild-2017-313419. No abstract available.


Risk of invasive meningococcal disease in university students in England and optimal strategies for protection using MenACWY vaccine.

Mandal S, Campbell H, Ribeiro S, Gray S, Carr T, White J, Ladhani SN, Ramsay ME.

Vaccine. 2017 Oct 13;35(43):5814-5818. doi: 10.1016/j.vaccine.2017.09.024. Epub 2017 Sep 18.


Meningococcal B Vaccine Failure With a Penicillin-Resistant Strain in a Young Adult on Long-Term Eculizumab.

Parikh SR, Lucidarme J, Bingham C, Warwicker P, Goodship T, Borrow R, Ladhani SN.

Pediatrics. 2017 Sep;140(3). pii: e20162452. doi: 10.1542/peds.2016-2452. Epub 2017 Aug 11.


Assessment of healthcare delivery in the early management of bacterial meningitis in UK young infants: an observational study.

Okike IO, Ladhani SN, Anthony M, Ninis N, Heath PT.

BMJ Open. 2017 Aug 21;7(8):e015700. doi: 10.1136/bmjopen-2016-015700.


Childhood Deaths Attributable to Invasive Pneumococcal Disease in England and Wales, 2006-2014.

Oligbu G, Collins S, Sheppard CL, Fry NK, Slack M, Borrow R, Ladhani SN.

Clin Infect Dis. 2017 Jul 15;65(2):308-314. doi: 10.1093/cid/cix310.


Frequent capsule switching in 'ultra-virulent' meningococci - Are we ready for a serogroup B ST-11 complex outbreak?

Lucidarme J, Lekshmi A, Parikh SR, Bray JE, Hill DM, Bratcher HB, Gray SJ, Carr AD, Jolley KA, Findlow J, Campbell H, Ladhani SN, Ramsay ME, Maiden MCJ, Borrow R.

J Infect. 2017 Aug;75(2):95-103. doi: 10.1016/j.jinf.2017.05.015. Epub 2017 Jun 1.


Short-term changes in the health state of children with group B meningococcal disease: A prospective, national cohort study.

Kennedy ITR, van Hoek AJ, Ribeiro S, Christensen H, Edmunds WJ, Ramsay ME, Ladhani SN.

PLoS One. 2017 May 18;12(5):e0177082. doi: 10.1371/journal.pone.0177082. eCollection 2017.


Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study.

Braccio S, Irwin A, Riordan A, Shingadia D, Kelly DA, Bansal S, Ramsay M, Ladhani SN.

Arch Dis Child. 2017 Jul;102(7):624-628. doi: 10.1136/archdischild-2016-311916. Epub 2017 Apr 4.


Meningococcal serogroup B strain coverage of the multicomponent 4CMenB vaccine with corresponding regional distribution and clinical characteristics in England, Wales, and Northern Ireland, 2007-08 and 2014-15: a qualitative and quantitative assessment.

Parikh SR, Newbold L, Slater S, Stella M, Moschioni M, Lucidarme J, De Paola R, Giuliani M, Serino L, Gray SJ, Clark SA, Findlow J, Pizza M, Ramsay ME, Ladhani SN, Borrow R.

Lancet Infect Dis. 2017 Jul;17(7):754-762. doi: 10.1016/S1473-3099(17)30170-6. Epub 2017 Mar 30.


Effectiveness and impact of a reduced infant schedule of 4CMenB vaccine against group B meningococcal disease in England: a national observational cohort study.

Parikh SR, Andrews NJ, Beebeejaun K, Campbell H, Ribeiro S, Ward C, White JM, Borrow R, Ramsay ME, Ladhani SN.

Lancet. 2016 Dec 3;388(10061):2775-2782. doi: 10.1016/S0140-6736(16)31921-3. Epub 2016 Oct 27.


Intensive Care Admissions for Children With Enterovirus and Human Parechovirus Infections in the United Kingdom and The Republic of Ireland, 2010-2014.

Braccio S, Kapetanstrataki M, Sharland M, Ladhani SN.

Pediatr Infect Dis J. 2017 Mar;36(3):339-342. doi: 10.1097/INF.0000000000001430.


Schedules for Pneumococcal Vaccination of Preterm Infants: An RCT.

Kent A, Ladhani SN, Andrews NJ, Scorrer T, Pollard AJ, Clarke P, Hughes SM, Heal C, Menson E, Chang J, Satodia P, Collinson AC, Faust SN, Goldblatt D, Miller E, Heath PT; PUNS Study Group.

Pediatrics. 2016 Sep;138(3). pii: e20153945. doi: 10.1542/peds.2015-3945. Epub 2016 Aug 8.


Meningococcal Group W Disease in Infants and Potential Prevention by Vaccination.

Parikh SR, Campbell H, Beebeejaun K, Ribeiro S, Gray SJ, Borrow R, Ramsay ME, Ladhani SN.

Emerg Infect Dis. 2016 Aug;22(8):1505-7. doi: 10.3201/eid2208.160128. No abstract available.


Children with Haemophilus influenzae type b (Hib) vaccine failure have long-term bactericidal antibodies against virulent Hib strains with multiple capsular loci.

Townsend-Payne K, Ladhani SN, Findlow H, Slack M, Borrow R.

Vaccine. 2016 Jul 25;34(34):3931-4. doi: 10.1016/j.vaccine.2016.06.033. Epub 2016 Jun 20.


Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy.

Kent A, Ladhani SN, Andrews NJ, Matheson M, England A, Miller E, Heath PT; PUNS study group.

Pediatrics. 2016 Jul;138(1). pii: e20153854. doi: 10.1542/peds.2015-3854. Epub 2016 Jun 2.


Prevention and treatment of mother-to-child transmission of syphilis.

Braccio S, Sharland M, Ladhani SN.

Curr Opin Infect Dis. 2016 Jun;29(3):268-74. doi: 10.1097/QCO.0000000000000270. Review.


Lymphocyte subpopulations in premature infants: an observational study.

Kent A, Scorrer T, Pollard AJ, Snape MD, Clarke P, Few K, Menson E, Varghese AS, Hughes S, Ladhani SN, Heath PT.

Arch Dis Child Fetal Neonatal Ed. 2016 Nov;101(6):F546-F551. doi: 10.1136/archdischild-2015-309246. Epub 2016 Apr 13.


Presentation with gastrointestinal symptoms and high case fatality associated with group W meningococcal disease (MenW) in teenagers, England, July 2015 to January 2016.

Campbell H, Parikh SR, Borrow R, Kaczmarski E, Ramsay ME, Ladhani SN.

Euro Surveill. 2016;21(12). doi: 10.2807/1560-7917.ES.2016.21.12.30175.


Outbreak of Zika virus disease in the Americas and the association with microcephaly, congenital malformations and Guillain-Barré syndrome.

Ladhani SN, O'Connor C, Kirkbride H, Brooks T, Morgan D.

Arch Dis Child. 2016 Jul;101(7):600-2. doi: 10.1136/archdischild-2016-310590. Epub 2016 Mar 14. No abstract available.


Effectiveness of Meningococcal B Vaccine against Endemic Hypervirulent Neisseria meningitidis W Strain, England.

Ladhani SN, Giuliani MM, Biolchi A, Pizza M, Beebeejaun K, Lucidarme J, Findlow J, Ramsay ME, Borrow R.

Emerg Infect Dis. 2016 Feb;22(2):309-11. doi: 10.3201/eid2202.150369.


Enter B and W: two new meningococcal vaccine programmes launched.

Ladhani SN, Ramsay M, Borrow R, Riordan A, Watson JM, Pollard AJ.

Arch Dis Child. 2016 Jan;101(1):91-5. doi: 10.1136/archdischild-2015-308928. Review.


Invasive meningococcal disease in England: assessing disease burden through linkage of multiple national data sources.

Ladhani SN, Waight PA, Ribeiro S, Ramsay ME.

BMC Infect Dis. 2015 Dec 1;15:551. doi: 10.1186/s12879-015-1247-7.


Question 1: Does prophylactic paracetamol prevent fever after vaccination in infants?

Braccio S, Saliba V, Ramsay M, Ladhani SN.

Arch Dis Child. 2015 Dec;100(12):1178-81. doi: 10.1136/archdischild-2015-309366. Review. No abstract available.


Clinical and Molecular Epidemiology of Childhood Invasive Nontypeable Haemophilus influenzae Disease in England and Wales.

Collins S, Vickers A, Ladhani SN, Flynn S, Platt S, Ramsay ME, Litt DJ, Slack MP.

Pediatr Infect Dis J. 2016 Mar;35(3):e76-84. doi: 10.1097/INF.0000000000000996.


The introduction of the meningococcal B (MenB) vaccine (Bexsero®) into the national infant immunisation programme--New challenges for public health.

Ladhani SN, Campbell H, Parikh SR, Saliba V, Borrow R, Ramsay M.

J Infect. 2015 Dec;71(6):611-4. doi: 10.1016/j.jinf.2015.09.035. Epub 2015 Oct 2. Review.


Antibody responses after primary immunization in infants born to women receiving a pertussis-containing vaccine during pregnancy: single arm observational study with a historical comparator.

Ladhani SN, Andrews NJ, Southern J, Jones CE, Amirthalingam G, Waight PA, England A, Matheson M, Bai X, Findlow H, Burbidge P, Thalasselis V, Hallis B, Goldblatt D, Borrow R, Heath PT, Miller E.

Clin Infect Dis. 2015 Dec 1;61(11):1637-44. doi: 10.1093/cid/civ695. Epub 2015 Sep 15. Erratum in: Clin Infect Dis. 2016 Jun 15;62(12 ):1621.


Reply to Musher.

Brousseau N, Slack MP, Waight P, Borrow R, Ladhani SN.

Clin Infect Dis. 2016 Jan 1;62(1):133-4. doi: 10.1093/cid/civ811. Epub 2015 Sep 14. No abstract available.


Rapid Declines in Age Group-Specific Rotavirus Infection and Acute Gastroenteritis Among Vaccinated and Unvaccinated Individuals Within 1 Year of Rotavirus Vaccine Introduction in England and Wales.

Atchison CJ, Stowe J, Andrews N, Collins S, Allen DJ, Nawaz S, Brown D, Ramsay ME, Ladhani SN.

J Infect Dis. 2016 Jan 15;213(2):243-9. doi: 10.1093/infdis/jiv398. Epub 2015 Jul 30.


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