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Items: 1 to 50 of 66

1.

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR.

Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. doi: 10.1016/j.chembiol.2019.07.001. Epub 2019 Jul 25.

PMID:
31353319
2.

Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoGAA) in treatment-naïve and alglucosidase alfa-treated patients with late-onset Pompe disease: A phase 1, open-label, multicenter, multinational, ascending dose study.

Pena LDM, Barohn RJ, Byrne BJ, Desnuelle C, Goker-Alpan O, Ladha S, Laforêt P, Mengel KE, Pestronk A, Pouget J, Schoser B, Straub V, Trivedi J, Van Damme P, Vissing J, Young P, Kacena K, Shafi R, Thurberg BL, Culm-Merdek K, van der Ploeg AT; NEO1 Investigator Group.

Neuromuscul Disord. 2019 Mar;29(3):167-186. doi: 10.1016/j.nmd.2018.12.004. Epub 2018 Dec 17.

3.

Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres.

Neuwirth C, Braun N, Claeys KG, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Appelfeller M, Tümmler A, Finegan E, Glass JD, Babu S, Ladha SS, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, Weber M.

Clin Neurophysiol. 2018 Aug;129(8):1756-1762. doi: 10.1016/j.clinph.2018.04.614. Epub 2018 May 3.

PMID:
29803404
4.

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.

Ladha S, Qiu X, Casal L, Caron NS, Ehrnhoefer DE, Hayden MR.

Cell Death Discov. 2018 Mar 12;4:40. doi: 10.1038/s41420-018-0043-8. eCollection 2018.

5.

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.

Ehrnhoefer DE, Martin DDO, Schmidt ME, Qiu X, Ladha S, Caron NS, Skotte NH, Nguyen YTN, Vaid K, Southwell AL, Engemann S, Franciosi S, Hayden MR.

Acta Neuropathol Commun. 2018 Mar 6;6(1):16. doi: 10.1186/s40478-018-0518-0.

6.

Engineered agrin attenuates the severity of experimental autoimmune myasthenia gravis.

Li Z, Li M, Wood K, Hettwer S, Muley SA, Shi FD, Liu Q, Ladha SS.

Muscle Nerve. 2018 May;57(5):814-820. doi: 10.1002/mus.26025. Epub 2018 Jan 8.

7.

Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials.

Khalid SI, Ampie L, Kelly R, Ladha SS, Dardis C.

Front Neurol. 2017 Sep 25;8:486. doi: 10.3389/fneur.2017.00486. eCollection 2017. Review.

8.

Homozygous Familial Hypercholesterolemia: Anesthetic Challenges and Review of Literature.

Ladha S, Makhija N, Kiran U, Aarav SK.

World J Pediatr Congenit Heart Surg. 2017 Jan 1:2150135117702127. doi: 10.1177/2150135117702127. [Epub ahead of print]

PMID:
28952401
9.

Management of iatrogenic pulmonary artery injury during pulmonary artery banding.

Makhija N, Aggarwal S, Talwar S, Ladha S, Das D, Kiran U.

Ann Card Anaesth. 2017 Jul-Sep;20(3):379-380. doi: 10.4103/aca.ACA_47_17.

10.

Diagnostic dilemma: Low oxygen saturation during cardiac surgery.

Ladha S, Aggarwal S, Kiran U, Choudhary A, Kapoor PM, Choudhary UK.

Ann Card Anaesth. 2017 Apr-Jun;20(2):262-264. doi: 10.4103/aca.ACA_34_17.

11.

The role of Rajyoga meditation for modulation of anxiety and serum cortisol in patients undergoing coronary artery bypass surgery: A prospective randomized control study.

Kiran U, Ladha S, Makhija N, Kapoor PM, Choudhury M, Das S, Gharde P, Malik V, Airan B.

Ann Card Anaesth. 2017 Apr-Jun;20(2):158-162. doi: 10.4103/aca.ACA_32_17.

12.

Anger: An enemy of heart, raj yoga meditation is heart friendly.

Kiran U, Ladha S.

Ann Card Anaesth. 2017 Apr-Jun;20(2):127-128. doi: 10.4103/aca.ACA_29_17. No abstract available.

13.

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian LJ, Lee CW, Yue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW, Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A, Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN, McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A, Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitcheva D, Antognetti G, McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD, Floeter MK, Rothstein JD, Boylan KB, Petrucelli L.

Sci Transl Med. 2017 Mar 29;9(383). pii: eaai7866. doi: 10.1126/scitranslmed.aai7866.

14.

Basic arterial blood gas biomarkers as a predictor of mortality in tetralogy of Fallot patients.

Bhardwaj V, Kapoor PM, Irpachi K, Ladha S, Chowdhury UK.

Ann Card Anaesth. 2017 Jan-Mar;20(1):67-71. doi: 10.4103/0971-9784.197839.

15.

Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis.

Zhang CJ, Gong Y, Zhu W, Qi Y, Yang CS, Fu Y, Chang G, Li Y, Shi S, Wood K, Ladha S, Shi FD, Liu Q, Yan Y.

J Immunol. 2016 Oct 1;197(7):2610-7. doi: 10.4049/jimmunol.1500725. Epub 2016 Aug 19.

16.

Simulation in cardiac catheterization laboratory: Need of the hour to improve the clinical skills.

Aggarwal S, Choudhury E, Ladha S, Kapoor PM, Kiran U.

Ann Card Anaesth. 2016 Jul-Sep;19(3):521-6. doi: 10.4103/0971-9784.185548. Review.

17.

Simulation-based transthoracic echocardiography: "An anesthesiologist's perspective".

Magoon R, Sharma A, Ladha S, Kapoor PM, Hasija S.

Ann Card Anaesth. 2016 Jul-Sep;19(3):511-5. doi: 10.4103/0971-9784.185544. Review.

18.

The role of blood lactate clearance as a predictor of mortality in children undergoing surgery for tetralogy of Fallot.

Ladha S, Kapoor PM, Singh SP, Kiran U, Chowdhury UK.

Ann Card Anaesth. 2016 Apr-Jun;19(2):217-24. doi: 10.4103/0971-9784.179589.

19.

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.

Burns TM, Smith GA, Allen JA, Amato AA, Arnold WD, Barohn R, Benatar M, Bird SJ, Bromberg M, Chahin N, Ciafaloni E, Cohen JA, Corse A, Crum BA, David WS, Dimberg E, Sousa EA, Donofrio PD, Dyck PJ, Engel AG, Ensrud ER, Ferrante M, Freimer M, Gable KL, Gibson S, Gilchrist JM, Goldstein JM, Gooch CL, Goodman BP, Gorelov D, Gospe SM Jr, Goyal NA, Guidon AC, Guptill JT, Gutmann L, Gutmann L, Gwathmey K, Harati Y, Harper CM Jr, Hehir MK, Hobson-Webb LD, Howard JF Jr, Jackson CE, Johnson N, Jones SM, Juel VC, Kaminski HJ, Karam C, Kennelly KD, Khella S, Khoury J, Kincaid JC, Kissel JT, Kolb N, Lacomis D, Ladha S, Larriviere D, Lewis RA, Li Y, Litchy WJ, Logigian E, Lou JS, MacGowen DJ, Maselli R, Massey JM, Mauermann ML, Mathews KD, Meriggioli MN, Miller RG, Moon JS, Mozaffar T, Nations SP, Nowak RJ, Ostrow LW, Pascuzzi RM, Peltier A, Ruzhansky K, Richman DP, Ross MA, Rubin DI, Russell JA, Sachs GM, Salajegheh MK, Saperstein DS, Scelsa S, Selcen D, Shaibani A, Shieh PB, Silvestri NJ, Singleton JR, Smith BE, So YT, Solorzano G, Sorenson EJ, Srinivasen J, Tavee J, Tawil R, Thaisetthawatkul P, Thornton C, Trivedi J, Vernino S, Wang AK, Webb TA, Weiss MD, Windebank AJ, Wolfe GI.

Muscle Nerve. 2016 Feb;53(2):165-8. doi: 10.1002/mus.25009. Epub 2015 Dec 21. No abstract available.

PMID:
26662952
20.

Unruptured Sinus of Valsalva Aneurysm with Right Ventricular Outflow Tract Obstruction and Ventricular Septal Defect--A Rare Combination.

Das S, Ladha S, Airan B.

Echocardiography. 2015 Aug;32(8):1322-4. doi: 10.1111/echo.12920. Epub 2015 Mar 3.

PMID:
25736051
21.

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.

Wong BKY, Ehrnhoefer DE, Graham RK, Martin DDO, Ladha S, Uribe V, Stanek LM, Franciosi S, Qiu X, Deng Y, Kovalik V, Zhang W, Pouladi MA, Shihabuddin LS, Hayden MR.

Neurobiol Dis. 2015 Apr;76:24-36. doi: 10.1016/j.nbd.2014.12.030. Epub 2015 Jan 9.

PMID:
25583186
22.

Autophagy in Huntington disease and huntingtin in autophagy.

Martin DD, Ladha S, Ehrnhoefer DE, Hayden MR.

Trends Neurosci. 2015 Jan;38(1):26-35. doi: 10.1016/j.tins.2014.09.003. Epub 2014 Oct 2. Review.

PMID:
25282404
23.

Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial.

Wills AM, Hubbard J, Macklin EA, Glass J, Tandan R, Simpson EP, Brooks B, Gelinas D, Mitsumoto H, Mozaffar T, Hanes GP, Ladha SS, Heiman-Patterson T, Katz J, Lou JS, Mahoney K, Grasso D, Lawson R, Yu H, Cudkowicz M; MDA Clinical Research Network.

Lancet. 2014 Jun 14;383(9934):2065-2072. doi: 10.1016/S0140-6736(14)60222-1. Epub 2014 Feb 28.

24.

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.

Ehrnhoefer DE, Skotte NH, Ladha S, Nguyen YT, Qiu X, Deng Y, Huynh KT, Engemann S, Nielsen SM, Becanovic K, Leavitt BR, Hasholt L, Hayden MR.

Hum Mol Genet. 2014 Feb 1;23(3):717-29. doi: 10.1093/hmg/ddt458. Epub 2013 Sep 18.

PMID:
24070868
25.

Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis.

Sun F, Ladha SS, Yang L, Liu Q, Shi SX, Su N, Bomprezzi R, Shi FD.

Muscle Nerve. 2014 Apr;49(4):487-94. doi: 10.1002/mus.23951. Epub 2014 Feb 27.

26.

Post-lumbar puncture headache is reduced with use of atraumatic needles in ALS.

Quinn C, Macklin EA, Atassi N, Bowser R, Boylan K, Cudkowicz M, Fournier C, Ladha SS, Lacomis D, Berry J.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):632-4. doi: 10.3109/21678421.2013.808227. Epub 2013 Jul 8. No abstract available.

PMID:
23834161
27.

Lower extremity predominant stiff-person syndrome and limbic encephalitis with amphiphysin antibodies in breast cancer.

Krishna VR, Knievel K, Ladha S, Sivakumar K.

J Clin Neuromuscul Dis. 2012 Dec;14(2):72-4. doi: 10.1097/CND.0b013e31826f0d99.

PMID:
23172386
28.

It is ALL about the 6p22 histone gene cluster: characterizing the unique genetic features of Down's syndrome patients.

Ladha S.

Clin Genet. 2012 Apr;81(4):364-5. doi: 10.1111/j.1399-0004.2011.01837.x. Epub 2012 Jan 16. No abstract available.

PMID:
22171667
29.

Getting to the bottom of autism spectrum and related disorders: MBD5 as a key contributor.

Ladha S.

Clin Genet. 2012 Apr;81(4):363-4. doi: 10.1111/j.1399-0004.2011.01836.x. Epub 2012 Jan 16. No abstract available.

PMID:
22171639
30.

A new era of non-invasive prenatal genetic diagnosis: exploiting fetal epigenetic differences.

Ladha S.

Clin Genet. 2012 Apr;81(4):362-3. doi: 10.1111/j.1399-0004.2011.01835.x. Epub 2012 Jan 16. No abstract available.

PMID:
22171618
31.

A quantitative method for the specific assessment of caspase-6 activity in cell culture.

Ehrnhoefer DE, Skotte NH, Savill J, Nguyen YT, Ladha S, Cao LP, Dullaghan E, Hayden MR.

PLoS One. 2011;6(11):e27680. doi: 10.1371/journal.pone.0027680. Epub 2011 Nov 29.

32.

Of ORC and forks: the identification of mutations implicated in Meier-Gorlin syndrome.

Ladha S.

Clin Genet. 2011 Dec;80(6):506-7. doi: 10.1111/j.1399-0004.2011.01779.x. Epub 2011 Oct 12. No abstract available.

PMID:
21895639
33.

Step to CEP152: uncovering a new mutation implicated in Seckel syndrome.

Ladha S.

Clin Genet. 2011 May;79(5):428-30. doi: 10.1111/j.1399-0004.2011.01655.x. Epub 2011 Mar 13. No abstract available.

PMID:
21395565
34.

Mad for SMAD: unraveling the genetics of a new aneurysm syndrome.

Ladha S.

Clin Genet. 2011 Jun;79(6):510-1. doi: 10.1111/j.1399-0004.2011.01666.x. Epub 2011 Apr 4. No abstract available.

PMID:
21391992
35.

Insight into the genetic cause underlying Kabuki syndrome.

Ladha S.

Clin Genet. 2011 Feb;79(2):133-4. doi: 10.1111/j.1399-0004.2010.01586.x. Epub 2010 Nov 11. No abstract available.

PMID:
21070213
36.

Histopathologic progression and a novel mutation in a child with nemaline myopathy.

Ladha S, Coons S, Johnsen S, Sambuughin N, Bien-Wilner R, Sivakumar K.

J Child Neurol. 2008 Jul;23(7):813-7. doi: 10.1177/0883073808314363. Epub 2008 May 16.

PMID:
18487519
37.

Antibodies to myelin-associated glycoprotein (anti-Mag) in IgM amyloidosis may influence expression of neuropathy in rare patients.

Garces-Sanchez M, Dyck PJ, Kyle RA, Zeldenrust S, Wu Y, Ladha SS, Klein CJ.

Muscle Nerve. 2008 Apr;37(4):490-5. doi: 10.1002/mus.20955.

PMID:
18236455
38.

Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic review.

Ladha SS, Dyck PJ, Spinner RJ, Perez DG, Zeldenrust SR, Amrami KK, Solomon A, Klein CJ.

J Peripher Nerv Syst. 2006 Dec;11(4):346-52.

PMID:
17117943
39.

Oncogenic osteomalacia: muscular weakness and multiple fractures.

Ladha SS, Whitaker MD, Bosch EP.

Neurology. 2006 Jul 25;67(2):364-5. No abstract available.

PMID:
16864847
40.

Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread: an unusual entity.

Ladha SS, Spinner RJ, Suarez GA, Amrami KK, Dyck PJ.

Muscle Nerve. 2006 Nov;34(5):659-65.

PMID:
16810682
41.

Vasculitic neuropathy.

Ladha SS, Dyck PJ.

J Clin Neuromuscul Dis. 2005 Sep;7(1):50-3. doi: 10.1097/01.cnd.0000179810.47493.9a. No abstract available.

PMID:
19078782
42.

Case of neuroleptic malignant-like syndrome precipitated by abrupt fava bean discontinuance.

Ladha SS, Walker R, Shill HA.

Mov Disord. 2005 May;20(5):630-1.

PMID:
15719433
43.
44.

Measurement of the lateral diffusion of human MHC class I molecules on HeLa cells by fluorescence recovery after photobleaching using a phycoerythrin probe.

Georgiou G, Bahra SS, Mackie AR, Wolfe CA, O'Shea P, Ladha S, Fernandez N, Cherry RJ.

Biophys J. 2002 Apr;82(4):1828-34.

45.

Fluorescence recovery after photobleaching reveals that LPS rapidly transfers from CD14 to hsp70 and hsp90 on the cell membrane.

Triantafilou K, Triantafilou M, Ladha S, Mackie A, Dedrick RL, Fernandez N, Cherry R.

J Cell Sci. 2001 Jul;114(Pt 13):2535-45. Erratum in: J Cell Sci 2001 Sep;114(Pt 17):3072.

46.

Lipid dynamics in the plasma membrane of ram and bull spermatozoa after washing and exposure to macromolecules BSA and PVP.

Wolfe CA, James PS, Gunning AP, Ladha S, Christova Y, Jones R.

Mol Reprod Dev. 2001 Jul;59(3):306-13.

PMID:
11424216
47.
48.

Effects of dietary fish oil supplementation on the phospholipid composition and fluidity of cell membranes from human volunteers.

Lund EK, Harvey LJ, Ladha S, Clark DC, Johnson IT.

Ann Nutr Metab. 1999;43(5):290-300.

PMID:
10749029
49.

Membrane interactions of the putative fusion peptide (MF alpha P) from fertilin-alpha, the mouse sperm protein complex involved in fertilization.

Wolfe CA, Cladera J, Ladha S, Senior S, Jones R, O'Shea P.

Mol Membr Biol. 1999 Jul-Sep;16(3):257-63.

PMID:
10503247
50.

Lipid dynamics in the plasma membrane of fresh and cryopreserved human spermatozoa.

James PS, Wolfe CA, Mackie A, Ladha S, Prentice A, Jones R.

Hum Reprod. 1999 Jul;14(7):1827-32.

PMID:
10402398

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