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Diagnostics and Therapeutics: The Yin and Yang of Diseases Such as Alzheimer.

Ladenson JH.

J Appl Lab Med. 2019 Oct 29. pii: jalm.2019.029603. doi: 10.1373/jalm.2019.029603. [Epub ahead of print] No abstract available.


Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.

Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM; Dominantly Inherited Alzheimer Network.

Alzheimers Dement. 2019 May;15(5):655-665. doi: 10.1016/j.jalz.2018.12.019. Epub 2019 Mar 4.


Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease.

Sutphen CL, McCue L, Herries EM, Xiong C, Ladenson JH, Holtzman DM, Fagan AM; ADNI.

Alzheimers Dement. 2018 Jul;14(7):869-879. doi: 10.1016/j.jalz.2018.01.012. Epub 2018 Mar 23.


Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study.

Willemse EAJ, De Vos A, Herries EM, Andreasson U, Engelborghs S, van der Flier WM, Scheltens P, Crimmins D, Ladenson JH, Vanmechelen E, Zetterberg H, Fagan AM, Blennow K, Bjerke M, Teunissen CE.

Clin Chem. 2018 Jun;64(6):927-937. doi: 10.1373/clinchem.2017.283028. Epub 2018 Mar 9.


Double Monoclonal Immunoassay for Quantifying Human Visinin-Like Protein-1 in CSF.

Crimmins DL, Herries EM, Ohlendorf MF, Brada NA, Garbett NC, Zipfel GJ, Schindler SE, Ladenson JH.

Clin Chem. 2017 Feb;63(2):603-604. doi: 10.1373/clinchem.2016.263236. Epub 2016 Dec 16. No abstract available.


Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.

Ju YE, Finn MB, Sutphen CL, Herries EM, Jerome GM, Ladenson JH, Crimmins DL, Fagan AM, Holtzman DM.

Ann Neurol. 2016 Jul;80(1):154-9. doi: 10.1002/ana.24672. Epub 2016 Jun 1.


Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease.

Tarawneh R, D'Angelo G, Crimmins D, Herries E, Griest T, Fagan AM, Zipfel GJ, Ladenson JH, Morris JC, Holtzman DM.

JAMA Neurol. 2016 May 1;73(5):561-71. doi: 10.1001/jamaneurol.2016.0086.


Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort.

Kester MI, Teunissen CE, Sutphen C, Herries EM, Ladenson JH, Xiong C, Scheltens P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM.

Alzheimers Res Ther. 2015 Sep 17;7(1):59. doi: 10.1186/s13195-015-0142-1.


Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease.

Kester MI, Teunissen CE, Crimmins DL, Herries EM, Ladenson JH, Scheltens P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM.

JAMA Neurol. 2015 Nov;72(11):1275-80. doi: 10.1001/jamaneurol.2015.1867.


Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.

Sutphen CL, Jasielec MS, Shah AR, Macy EM, Xiong C, Vlassenko AG, Benzinger TL, Stoops EE, Vanderstichele HM, Brix B, Darby HD, Vandijck ML, Ladenson JH, Morris JC, Holtzman DM, Fagan AM.

JAMA Neurol. 2015 Sep;72(9):1029-42. doi: 10.1001/jamaneurol.2015.1285.


Serum visinin-like protein-1 in concussed professional ice hockey players.

Shahim P, Mattsson N, Macy EM, Crimmins DL, Ladenson JH, Zetterberg H, Blennow K, Tegner Y.

Brain Inj. 2015;29(7-8):872-6. doi: 10.3109/02699052.2015.1018324. Epub 2015 May 8.


Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease.

Tarawneh R, Head D, Allison S, Buckles V, Fagan AM, Ladenson JH, Morris JC, Holtzman DM.

JAMA Neurol. 2015 Jun;72(6):656-65. doi: 10.1001/jamaneurol.2015.0202.


Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis.

Song H, Wohltmann M, Tan M, Ladenson JH, Turk J.

J Biol Chem. 2014 May 16;289(20):14194-210. doi: 10.1074/jbc.M114.561910. Epub 2014 Mar 19.


Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease.

Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM; Dominantly Inherited Alzheimer Network.

Sci Transl Med. 2014 Mar 5;6(226):226ra30. doi: 10.1126/scitranslmed.3007901.


Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury.

Gaut JP, Crimmins DL, Ohlendorf MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, Ladenson JH.

Clin Chem. 2014 May;60(5):747-57. doi: 10.1373/clinchem.2013.212993. Epub 2014 Jan 31.


Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.

Chowdhury S, Reeds DN, Crimmins DL, Patterson BW, Laciny E, Wang S, Tran HD, Griest TA, Rometo DA, Dunai J, Wallendorf MJ, Ladenson JH, Polonsky KS, Wice BM.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G301-9. doi: 10.1152/ajpgi.00383.2013. Epub 2013 Dec 19.


Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents.

Bao S, Song H, Tan M, Wohltmann M, Ladenson JH, Turk J.

Oxid Med Cell Longev. 2012;2012:989372. doi: 10.1155/2012/989372. Epub 2012 Nov 11.


Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors.

Gaut JP, Crimmins DL, Lockwood CM, McQuillan JJ, Ladenson JH.

Mod Pathol. 2013 May;26(5):716-24. doi: 10.1038/modpathol.2012.202. Epub 2012 Nov 30.


Use of a United States-based laboratory as a hematopathology reference center for a developing country: logistics and results.

Deetz CO, Scott MG, Ladenson JH, Seyoum M, Hassan A, Kreisel FH, Nguyen TT, Frater JL.

Int J Lab Hematol. 2013 Feb;35(1):77-81. doi: 10.1111/ijlh.12001. Epub 2012 Sep 3.


Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.

Wice BM, Reeds DN, Tran HD, Crimmins DL, Patterson BW, Dunai J, Wallendorf MJ, Ladenson JH, Villareal DT, Polonsky KS.

Diabetes. 2012 Jul;61(7):1793-800. doi: 10.2337/db11-1451. Epub 2012 Apr 20.


Reversal of EDTA Interference in the Measurement of Visinin-Like Protein 1.

Macy EM, Crimmins DL, McQuillan JJ, Griest TA, Brada NA, Tarawneh R, Lee JM, Ladenson JH.

Clin Chem. 2012 Apr 5. [Epub ahead of print] No abstract available.


CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease.

Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM.

Neurology. 2012 Mar 6;78(10):709-19. doi: 10.1212/WNL.0b013e318248e568. Epub 2012 Feb 22.


Advancing laboratory medicine through innovation: a tale of six inventors.

Rifai N, Diamandis EP, Lo YM, Kricka LJ, Wilding P, Ladenson JH, Wittwer CT.

Clin Chem. 2012 Mar;58(3):502-10. doi: 10.1373/clinchem.2011.178582. Epub 2012 Jan 11. No abstract available.


Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.

Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, Turk J.

J Biol Chem. 2012 Feb 17;287(8):5528-41. doi: 10.1074/jbc.M111.285114. Epub 2011 Dec 22.


Reflections on the evolution of cardiac biomarkers.

Ladenson JH.

Clin Chem. 2012 Jan;58(1):21-4. doi: 10.1373/clinchem.2011.165852. Epub 2011 Aug 24. No abstract available.


Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease.

Tarawneh R, D'Angelo G, Macy E, Xiong C, Carter D, Cairns NJ, Fagan AM, Head D, Mintun MA, Ladenson JH, Lee JM, Morris JC, Holtzman DM.

Ann Neurol. 2011 Aug;70(2):274-85. doi: 10.1002/ana.22448.


ETRAP (efficient trapping and purification) of target protein polyclonal antibodies from GST-protein immune sera.

Crimmins DL, Brada NA, Lockwood CM, Griest TA, Waldemer RJ, Cervinski MA, Ohlendorf MF, McQuillan JJ, Ladenson JH.

Biotechnol Appl Biochem. 2010 Dec;57(4):127-38. doi: 10.1042/BA20100279.


Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.

Song H, Rohrs H, Tan M, Wohltmann M, Ladenson JH, Turk J.

J Biol Chem. 2010 Oct 29;285(44):33843-57. doi: 10.1074/jbc.M110.153197. Epub 2010 Aug 23.


Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.

Wice BM, Wang S, Crimmins DL, Diggs-Andrews KA, Althage MC, Ford EL, Tran H, Ohlendorf M, Griest TA, Wang Q, Fisher SJ, Ladenson JH, Polonsky KS.

J Biol Chem. 2010 Jun 25;285(26):19842-53. doi: 10.1074/jbc.M110.129304. Epub 2010 Apr 26.


Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.

Song H, Wohltmann M, Bao S, Ladenson JH, Semenkovich CF, Turk J.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1097-114. doi: 10.1152/ajpendo.00780.2009. Epub 2010 Feb 23.


Troponin I, the story.

Ladenson JH.

Clin Chem. 2010 Mar;56(3):482-3. doi: 10.1373/clinchem.2009.138255. Epub 2010 Jan 7. No abstract available.


Dyskerin ablation in mouse liver inhibits rRNA processing and cell division.

Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, Mason PJ.

Mol Cell Biol. 2010 Jan;30(2):413-22. doi: 10.1128/MCB.01128-09. Epub 2009 Nov 16.


A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening.

Rader JS, Malone JP, Gross J, Gilmore P, Brooks RA, Nguyen L, Crimmins DL, Feng S, Wright JD, Taylor N, Zighelboim I, Funk MC, Huettner PC, Ladenson JH, Gius D, Townsend RR.

Proteomics Clin Appl. 2008 Dec;2(12):1658-69. doi: 10.1002/prca.200780146. Epub 2008 Oct 22.


The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients.

Lee JM, Blennow K, Andreasen N, Laterza O, Modur V, Olander J, Gao F, Ohlendorf M, Ladenson JH.

Clin Chem. 2008 Oct;54(10):1617-23. doi: 10.1373/clinchem.2008.104497. Epub 2008 Aug 14.


The role of human ribosomal proteins in the maturation of rRNA and ribosome production.

Robledo S, Idol RA, Crimmins DL, Ladenson JH, Mason PJ, Bessler M.

RNA. 2008 Sep;14(9):1918-29. doi: 10.1261/rna.1132008. Epub 2008 Aug 12.


Biomarkers of tissue injury.

Laterza OF, Modur VR, Ladenson JH.

Biomark Med. 2008 Feb;2(1):81-92. doi: 10.2217/17520363.2.1.81.


Impact of a multidisciplinary intervention for diabetes in Eritrea.

Windus DW, Ladenson JH, Merrins CK, Seyoum M, Windus D, Morin S, Tewelde B, Parvin CA, Scott MG, Goldfeder J.

Clin Chem. 2007 Nov;53(11):1954-9.


Establishing a simple and sustainable quality assurance program and clinical chemistry services in Eritrea.

Scott MG, Morin S, Hock KG, Seyoum M, Ladenson JH.

Clin Chem. 2007 Nov;53(11):1945-53.


A personal history of markers of myocyte injury [myocardial infarction].

Ladenson JH.

Clin Chim Acta. 2007 May;381(1):3-8. Epub 2007 Feb 28. Review.


Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production.

Idol RA, Robledo S, Du HY, Crimmins DL, Wilson DB, Ladenson JH, Bessler M, Mason PJ.

Blood Cells Mol Dis. 2007 Jul-Aug;39(1):35-43. Epub 2007 Mar 21.


Identification of novel brain biomarkers.

Laterza OF, Modur VR, Crimmins DL, Olander JV, Landt Y, Lee JM, Ladenson JH.

Clin Chem. 2006 Sep;52(9):1713-21. Epub 2006 Jul 20.


Between a rock and a hard place: disclosing medical errors.

Crone KG, Muraski MB, Skeel JD, Love-Gregory L, Ladenson JH, Gronowski AM.

Clin Chem. 2006 Sep;52(9):1809-14. Epub 2006 Jul 20.


Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment.

Ladenson RC, Crimmins DL, Landt Y, Ladenson JH.

Anal Chem. 2006 Jul 1;78(13):4501-8.


Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermis.

Konger RL, Billings SD, Thompson AB, Morimiya A, Ladenson JH, Landt Y, Pentland AP, Badve S.

J Invest Dermatol. 2005 May;124(5):965-70.


A monoclonal antibody with potential for aiding non-invasive prenatal diagnosis: utility in screening of pregnant women at risk of preeclampsia.

Fernández A, Prieto B, Escudero A, Ladenson JH, Alvarez FV.

J Histochem Cytochem. 2005 Mar;53(3):345-50.


Cardiac biomarkers for detection of myocardial infarction: perspectives from past to present.

Rosalki SB, Roberts R, Katus HA, Giannitsis E, Ladenson JH, Apple FS.

Clin Chem. 2004 Nov;50(11):2205-13. Epub 2004 Oct 1.


Expression of a novel regenerating gene product, Reg IV, by high density fermentation in Pichia pastoris: production, purification, and characterization.

Li A, Crimmins DL, Luo Q, Hartupee J, Landt Y, Ladenson JH, Wilson D, Anant S, Dieckgraefe BK.

Protein Expr Purif. 2003 Oct;31(2):197-206.


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