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Respir Care. 2018 Oct;63(10):1223-1230. doi: 10.4187/respcare.06136. Epub 2018 Jul 31.

Assessment of Respiratory Muscle Weakness in Subjects With Neuromuscular Disease.

Author information

1
Department of Pulmonology, Centro Hospitalar de Vila Nova de Gaia e Espinho, Entidade Pública Empresarial (EPE), Vila Nova de Gaia, Portugal. 6oliveiramariajoao@gmail.com.
2
Department of Pulmonology, Centro Hospitalar de Vila Nova de Gaia e Espinho, Entidade Pública Empresarial (EPE), Vila Nova de Gaia, Portugal.
3
Public Health Unit, Agrupamento de Centros de Saúde (ACeS) Porto Ocidental, Porto, Portugal.

Abstract

INTRODUCTION:

Neuromuscular diseases (NMD) are a group of rare heterogeneous disorders that may be accompanied by respiratory muscle weakness. The simplest measurements of respiratory muscle strength are maximum inspiratory pressure (PImax) and maximum expiratory pressure (PEmax) of the mouth. Inspiratory muscle weakness can also be evaluated by the sniff test (sniff nasal inspiratory pressure method). This study tested the agreements in PImax and PEmax (measured by using a plethysmograph and portable equipment) as well as the correlations of PImax and PEmax by using the sniff nasal inspiratory pressure method, lung function, and arterial blood gas parameters in subjects with NMD.

METHODS:

This prospective, noninterventional study measured respiratory parameters in all the subjects with NMD who underwent measurement of maximum respiratory pressures.

RESULTS:

A total of 55 subjects with NMD were included. There were no statistically significant differences in PImax and PEmax measured by using a plethysmograph and portable equipment. Moreover, PImax showed a good correlation with the sniff nasal inspiratory pressure method.

CONCLUSIONS:

Measurements of PImax and PEmax by using portable equipment were equivalent to those performed by using the accepted standard, plethysmography, in the subjects with NMD. Noninvasive evaluation of the sniff test with the portable equipment correlates with PImax, which makes this approach a good method for measuring the maximum strength of inspiratory muscles in patients with NMD.

KEYWORDS:

maximum expiratory pressure; maximum inspiratory pressure; neuromuscular diseases; respiratory muscle weakness; sniff; sniff nasal inspiratory pressure

PMID:
30065077
DOI:
10.4187/respcare.06136

Conflict of interest statement

The authors have disclosed no conflicts of interest.

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