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Items: 4

1.

Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single Species Surrogate.

Barr JT, Lade JM, Tran TB, Dahal UP.

Drug Metab Dispos. 2019 Feb 7. pii: dmd.118.085936. doi: 10.1124/dmd.118.085936. [Epub ahead of print]

2.

Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.

Narayanan B, Lade JM, Heck CJS, Dietz KD, Wade H, Bumpus NN.

ChemMedChem. 2018 Apr 6;13(7):736-747. doi: 10.1002/cmdc.201700730. Epub 2018 Mar 2.

PMID:
29430850
3.

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.

Lade JM, To EE, Hendrix CW, Bumpus NN.

EBioMedicine. 2015 Jul 9;2(9):1145-52. doi: 10.1016/j.ebiom.2015.07.008. eCollection 2015 Sep.

4.

Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison.

Lade JM, Avery LB, Bumpus NN.

Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79. doi: 10.1128/AAC.01401-13. Epub 2013 Aug 5.

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