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Items: 6

1.

Plasma and Liver Protein Binding of N-Acetylgalactosamine-Conjugated Small Interfering RNA.

Humphreys SC, Thayer MB, Lade JM, Wu B, Sham K, Basiri B, Hao Y, Huang X, Smith R, Rock BM.

Drug Metab Dispos. 2019 Oct;47(10):1174-1182. doi: 10.1124/dmd.119.086967. Epub 2019 May 16.

PMID:
31097425
2.

Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics.

Thayer MB, Lade JM, Doherty D, Xie F, Basiri B, Barnaby OS, Bala NS, Rock BM.

Sci Rep. 2019 Mar 5;9(1):3566. doi: 10.1038/s41598-019-40187-4.

3.

Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate.

Barr JT, Lade JM, Tran TB, Dahal UP.

Drug Metab Dispos. 2019 Apr;47(4):419-423. doi: 10.1124/dmd.118.085936. Epub 2019 Feb 7.

PMID:
30733251
4.

Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.

Narayanan B, Lade JM, Heck CJS, Dietz KD, Wade H, Bumpus NN.

ChemMedChem. 2018 Apr 6;13(7):736-747. doi: 10.1002/cmdc.201700730. Epub 2018 Mar 2.

5.

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.

Lade JM, To EE, Hendrix CW, Bumpus NN.

EBioMedicine. 2015 Jul 9;2(9):1145-52. doi: 10.1016/j.ebiom.2015.07.008. eCollection 2015 Sep.

6.

Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison.

Lade JM, Avery LB, Bumpus NN.

Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79. doi: 10.1128/AAC.01401-13. Epub 2013 Aug 5.

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