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Items: 1 to 50 of 64

1.

Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency.

Neganova I, Cotts L, Banks P, Gassner K, Shukurov A, Armstrong L, Ladds G, Lako M.

Stem Cells. 2018 Dec 4. doi: 10.1002/stem.2954. [Epub ahead of print]

PMID:
30512203
2.

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.

Lazarus KA, Hadi F, Zambon E, Bach K, Santolla MF, Watson JK, Correia LL, Das M, Ugur R, Pensa S, Becker L, Campos LS, Ladds G, Liu P, Evan GI, McCaughan FM, Le Quesne J, Lee JH, Calado D, Khaled WT.

Nat Commun. 2018 Aug 20;9(1):3327. doi: 10.1038/s41467-018-05790-5.

3.

Emerging patents in the therapeutic areas of glioma and glioblastoma.

Harris M, Svensson F, Kopanitsa L, Ladds G, Bailey D.

Expert Opin Ther Pat. 2018 Jul;28(7):573-590. doi: 10.1080/13543776.2018.1494155. Epub 2018 Jul 9. Review.

PMID:
29950117
4.

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.

Bridge LJ, Mead J, Frattini E, Winfield I, Ladds G.

J Theor Biol. 2018 Apr 7;442:44-65. doi: 10.1016/j.jtbi.2018.01.010. Epub 2018 Jan 12.

5.

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.

Kalash L, Val C, Azuaje J, Loza MI, Svensson F, Zoufir A, Mervin L, Ladds G, Brea J, Glen R, Sotelo E, Bender A.

J Cheminform. 2017 Dec 30;9(1):67. doi: 10.1186/s13321-017-0249-4.

6.

Hyperglycaemia does not affect antigen-specific activation and cytolytic killing by CD8+ T cells in vivo.

Recino A, Barkan K, Wong FS, Ladds G, Cooke A, Wallberg M.

Biosci Rep. 2017 Aug 30;37(4). pii: BSR20171079. doi: 10.1042/BSR20171079. Print 2017 Aug 31.

7.

The effects of RAMPs upon cell signalling.

Routledge SJ, Ladds G, Poyner DR.

Mol Cell Endocrinol. 2017 Jul 5;449:12-20. doi: 10.1016/j.mce.2017.03.033. Epub 2017 Apr 5. Review.

PMID:
28390954
8.

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.

Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodcock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G.

J Biol Chem. 2016 Dec 2;291(49):25763. No abstract available.

9.

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.

Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodlock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G.

J Biol Chem. 2016 Oct 14;291(42):21925-21944. Epub 2016 Aug 26. Erratum in: J Biol Chem. 2016 Dec 2;291(49):25763.

10.

Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.

Hay DL, Walker CS, Gingell JJ, Ladds G, Reynolds CA, Poyner DR.

Biochem Soc Trans. 2016 Apr 15;44(2):568-73. doi: 10.1042/BST20150237. Review.

PMID:
27068971
11.

Feedback activation of neurofibromin terminates growth factor-induced Ras activation.

Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I.

Cell Commun Signal. 2016 Feb 9;14:5. doi: 10.1186/s12964-016-0128-z.

12.

Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G.

J Med Chem. 2016 Feb 11;59(3):947-64. doi: 10.1021/acs.jmedchem.5b01402. Epub 2016 Feb 1.

PMID:
26756468
13.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

14.

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

Weston C, Lu J, Li N, Barkan K, Richards GO, Roberts DJ, Skerry TM, Poyner D, Pardamwar M, Reynolds CA, Dowell SJ, Willars GB, Ladds G.

J Biol Chem. 2015 Sep 18;290(38):23009-22. doi: 10.1074/jbc.M114.624601. Epub 2015 Jul 21.

15.

Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons.

Prokic EJ, Weston C, Yamawaki N, Hall SD, Jones RS, Stanford IM, Ladds G, Woodhall GL.

Neuropharmacology. 2015 Aug;95:192-205. doi: 10.1016/j.neuropharm.2015.03.006. Epub 2015 Mar 20.

16.

Ras activation revisited: role of GEF and GAP systems.

Hennig A, Markwart R, Esparza-Franco MA, Ladds G, Rubio I.

Biol Chem. 2015 Aug;396(8):831-48. doi: 10.1515/hsz-2014-0257. Review.

PMID:
25781681
17.

Image based validation of dynamical models for cell reorientation.

Lockley R, Ladds G, Bretschneider T.

Cytometry A. 2015 Jun;87(6):471-80. doi: 10.1002/cyto.a.22600. Epub 2014 Dec 9.

18.

Parameter identification problems in the modelling of cell motility.

Croft W, Elliott CM, Ladds G, Stinner B, Venkataraman C, Weston C.

J Math Biol. 2015 Aug;71(2):399-436. doi: 10.1007/s00285-014-0823-6. Epub 2014 Sep 2.

PMID:
25174444
19.

One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.

Lock A, Forfar R, Weston C, Bowsher L, Upton GJ, Reynolds CA, Ladds G, Dixon AM.

Biochim Biophys Acta. 2014 Dec;1838(12):3036-51. doi: 10.1016/j.bbamem.2014.08.019. Epub 2014 Aug 23.

20.

Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast.

Weston C, Poyner D, Patel V, Dowell S, Ladds G.

Br J Pharmacol. 2014 Aug;171(15):3651-65. doi: 10.1111/bph.12716.

21.

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

Weston C, Bond M, Croft W, Ladds G.

PLoS One. 2013 Oct 16;8(10):e77487. doi: 10.1371/journal.pone.0077487. eCollection 2013.

22.

A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.

Croft W, Hill C, McCann E, Bond M, Esparza-Franco M, Bennett J, Rand D, Davey J, Ladds G.

J Biol Chem. 2013 Sep 20;288(38):27327-42. doi: 10.1074/jbc.M113.497826. Epub 2013 Jul 30.

23.

The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast.

Mos M, Esparza-Franco MA, Godfrey EL, Richardson K, Davey J, Ladds G.

PLoS One. 2013 Jul 3;8(7):e65927. doi: 10.1371/journal.pone.0065927. Print 2013.

24.

Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

Bond M, Croft W, Tyson R, Bretschneider T, Davey J, Ladds G.

Yeast. 2013 Apr;30(4):145-56. doi: 10.1002/yea.2949. Epub 2013 Mar 20.

25.

Heterologous expression of GPCRs in fission yeast.

Davey J, Ladds G.

Methods Mol Biol. 2011;746:113-31. doi: 10.1007/978-1-61779-126-0_7.

PMID:
21607855
26.

Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.

Li S, Spooner RA, Allen SC, Guise CP, Ladds G, Schnöder T, Schmitt MJ, Lord JM, Roberts LM.

Mol Biol Cell. 2010 Aug 1;21(15):2543-54. doi: 10.1091/mbc.E09-08-0743. Epub 2010 Jun 2.

27.

Regulators of G protein signalling proteins in the human myometrium.

Ladds G, Zervou S, Vatish M, Thornton S, Davey J.

Eur J Pharmacol. 2009 May 21;610(1-3):23-8. doi: 10.1016/j.ejphar.2009.03.042. Epub 2009 Mar 24.

PMID:
19318093
28.

Dual positive and negative regulation of GPCR signaling by GTP hydrolysis.

Smith B, Hill C, Godfrey EL, Rand D, van den Berg H, Thornton S, Hodgkin M, Davey J, Ladds G.

Cell Signal. 2009 Jul;21(7):1151-60. doi: 10.1016/j.cellsig.2009.03.004. Epub 2009 Mar 12.

PMID:
19285552
29.

The cationic region of Rhes mediates its interactions with specific Gbeta subunits.

Hill C, Goddard A, Ladds G, Davey J.

Cell Physiol Biochem. 2009;23(1-3):1-8. doi: 10.1159/000204075. Epub 2009 Feb 18.

30.

Identification of caspase 3 motifs and critical aspartate residues in human phospholipase D1b and phospholipase D2a.

Wright MH, Farquhar MJ, Aletrari MO, Ladds G, Hodgkin MN.

Biochem Biophys Res Commun. 2008 May 2;369(2):478-84. doi: 10.1016/j.bbrc.2008.02.064. Epub 2008 Feb 25.

PMID:
18298948
31.

Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity.

Hill C, Brownlie Z, Davey J, Milligan G, Ladds G.

Cell Signal. 2008 Feb;20(2):323-36. Epub 2007 Oct 18.

PMID:
18031991
32.

The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae.

Allen SC, Moore KA, Marsden CJ, Fülöp V, Moffat KG, Lord JM, Ladds G, Roberts LM.

FEBS J. 2007 Nov;274(21):5586-99. Epub 2007 Oct 4.

33.
34.

Interaction of PLD1b with actin in antigen-stimulated mast cells.

Farquhar MJ, Powner DJ, Levine BA, Wright MH, Ladds G, Hodgkin MN.

Cell Signal. 2007 Feb;19(2):349-58. Epub 2006 Jul 28.

PMID:
16978840
35.

Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.

Goddard A, Ladds G, Forfar R, Davey J.

Fungal Genet Biol. 2006 Dec;43(12):840-51. Epub 2006 Aug 1.

PMID:
16884933
36.

Differential effects of RGS proteins on G alpha(q) and G alpha(11) activity.

Ladds G, Goddard A, Hill C, Thornton S, Davey J.

Cell Signal. 2007 Jan;19(1):103-13. Epub 2006 Jun 7.

PMID:
16843638
37.

Investigating RGS proteins in yeast.

Hill C, Goddard A, Davey J, Ladds G.

Semin Cell Dev Biol. 2006 Jun;17(3):352-62. Epub 2006 Apr 5. Review.

PMID:
16698293
38.

Utilisation of the budding yeast Saccharomyces cerevisiae for the generation and isolation of non-lethal ricin A chain variants.

Allen SC, Byron A, Lord JM, Davey J, Roberts LM, Ladds G.

Yeast. 2005 Dec;22(16):1287-97.

39.

Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit.

Hiskens R, Vatish M, Hill C, Davey J, Ladds G.

Biochem Biophys Res Commun. 2005 Dec 2;337(4):1038-46. Epub 2005 Oct 4.

PMID:
16225846
40.

Functional analysis of heterologous GPCR signalling pathways in yeast.

Ladds G, Goddard A, Davey J.

Trends Biotechnol. 2005 Jul;23(7):367-73. Review.

PMID:
15923053
41.

A constitutively active GPCR retains its G protein specificity and the ability to form dimers.

Ladds G, Davis K, Das A, Davey J.

Mol Microbiol. 2005 Jan;55(2):482-97.

43.

An efficient bipartite PCR technique to introduce specific changes in large plasmids.

Davis K, Ladds G, Das A, Goddard A, Davey J.

Mol Biotechnol. 2004 Nov;28(3):201-4.

PMID:
15542921
44.

Analysis of human GPCRs in fission yeast.

Ladds G, Davey J.

Curr Opin Drug Discov Devel. 2004 Sep;7(5):683-91. Review.

PMID:
15503870
45.

Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor.

Blanks AM, Vatish M, Allen MJ, Ladds G, de Wit NC, Slater DM, Thornton S.

J Clin Endocrinol Metab. 2003 Jul;88(7):3392-400.

PMID:
12843193
46.

Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins.

Ladds G, Davis K, Hillhouse EW, Davey J.

Mol Microbiol. 2003 Feb;47(3):781-92.

47.

Corticotropin-releasing hormone receptors.

Hillhouse EW, Randeva H, Ladds G, Grammatopoulos D.

Biochem Soc Trans. 2002 Aug;30(4):428-32. Review.

PMID:
12196108
48.

Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.

Didmon M, Davis K, Watson P, Ladds G, Broad P, Davey J.

Curr Genet. 2002 Jul;41(4):241-53. Epub 2002 Jun 25.

PMID:
12172965
50.

A temperature-sensitive Krp1 allows in vivo characterization of kexin activation.

Ladds G, Davis K, Powner D, Davey J.

Mol Microbiol. 2000 Aug;37(3):606-18.

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