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Items: 1 to 50 of 165

1.

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.

Lin CC, Suen KM, Stainthorp A, Wieteska L, Biggs GS, Leitão A, Montanari CA, Ladbury JE.

Cancer Lett. 2019 Aug 10;457:86-97. doi: 10.1016/j.canlet.2019.05.008. Epub 2019 May 14.

2.

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

Fearnley GW, Abdul-Zani I, Latham AM, Hollstein MC, Ladbury JE, Wheatcroft SB, Odell AF, Ponnambalam S.

Biol Open. 2019 May 17;8(5). pii: bio034215. doi: 10.1242/bio.034215.

3.

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.

Maori E, Navarro IC, Boncristiani H, Seilly DJ, Rudolph KLM, Sapetschnig A, Lin CC, Ladbury JE, Evans JD, Heeney JL, Miska EA.

Mol Cell. 2019 May 2;74(3):598-608.e6. doi: 10.1016/j.molcel.2019.03.010. Epub 2019 Apr 18.

4.

Intrinsic Thermodynamics of Protein-Ligand Binding by Isothermal Titration Calorimetry as Aid to Drug Design.

Paketurytė V, Zubrienė A, Ladbury JE, Matulis D.

Methods Mol Biol. 2019;1964:61-74. doi: 10.1007/978-1-4939-9179-2_5.

PMID:
30929235
5.

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.

Shahul Hameed UF, Liao C, Radhakrishnan AK, Huser F, Aljedani SS, Zhao X, Momin AA, Melo FA, Guo X, Brooks C, Li Y, Cui X, Gao X, Ladbury JE, Jaremko Ł, Jaremko M, Li J, Arold ST.

Nucleic Acids Res. 2019 Mar 18;47(5):2666-2680. doi: 10.1093/nar/gky1299.

6.

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.

Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8388-8393. doi: 10.1073/pnas.1719861115. Epub 2018 Jul 30.

7.

Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.

Kinoshita M, Lin Y, Dai I, Okumura M, Markova N, Ladbury JE, Sterpone F, Lee YH.

Chem Commun (Camb). 2018 Jul 12;54(57):7995-7998. doi: 10.1039/c8cc02718h.

PMID:
29967909
8.

How the Distribution of Member Expectations Influences Cooperation and Competition in Groups: A Social Relations Model Analysis of Social Dilemmas.

Ladbury JL, Hinsz VB.

Pers Soc Psychol Bull. 2018 Oct;44(10):1502-1518. doi: 10.1177/0146167218771322. Epub 2018 May 9.

PMID:
29742995
9.

Effect of cell phone radiofrequency radiation on body temperature in rodents: Pilot studies of the National Toxicology Program's reverberation chamber exposure system.

Wyde ME, Horn TL, Capstick MH, Ladbury JM, Koepke G, Wilson PF, Kissling GE, Stout MD, Kuster N, Melnick RL, Gauger J, Bucher JR, McCormick DL.

Bioelectromagnetics. 2018 Apr;39(3):190-199. doi: 10.1002/bem.22116. Epub 2018 Mar 14.

PMID:
29537695
10.

Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design.

Linkuvienė V, Zubrienė A, Manakova E, Petrauskas V, Baranauskienė L, Zakšauskas A, Smirnov A, Gražulis S, Ladbury JE, Matulis D.

Q Rev Biophys. 2018 Jan;51:e10. doi: 10.1017/S0033583518000082. Review.

PMID:
30912486
11.

Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers of the 2-Year NTP Cancer Bioassay Study on Cell Phone Radiation.

Gong Y, Capstick M, Kuehn S, Wilson P, Ladbury J, Koepke G, McCormick DL, Melnick RL, Kuster N.

IEEE Trans Electromagn Compat. 2017 Dec;59(6):1798-1808. doi: 10.1109/TEMC.2017.2665039. Epub 2017 Mar 17.

12.

A Radio Frequency Radiation Exposure System for Rodents based on Reverberation Chambers.

Capstick M, Kuster N, Kuehn S, Berdinas-Torres V, Gong Y, Wilson P, Ladbury J, Koepke G, McCormick DL, Gauger J, Melnick RL.

IEEE Trans Electromagn Compat. 2017 Aug;59(4):1041-1052. doi: 10.1109/TEMC.2017.2649885. Epub 2017 Mar 17.

13.

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

Suen KM, Lin CC, Seiler C, George R, Poncet-Montange G, Biter AB, Ahmed Z, Arold ST, Ladbury JE.

Int J Biochem Cell Biol. 2018 Jan;94:89-97. doi: 10.1016/j.biocel.2017.11.014. Epub 2017 Dec 5.

14.

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity.

Kim JY, Kinoshita M, Kume S, Gt H, Sugiki T, Ladbury JE, Kojima C, Ikegami T, Kurisu G, Goto Y, Hase T, Lee YH.

Biochem J. 2016 Nov 1;473(21):3837-3854. Epub 2016 Aug 22.

15.

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43.

Belousova N, Mikheeva G, Xiong C, Stagg LJ, Gagea M, Fox PS, Bassett RL, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V.

Oncotarget. 2016 Aug 16;7(33):53414-53429. doi: 10.18632/oncotarget.10800.

16.

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network.

Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M.

Oncotarget. 2016 Apr 12;7(15):20054-67. doi: 10.18632/oncotarget.7911.

17.

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.

Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C.

J Biol Chem. 2016 Mar 11;291(11):5623-33. doi: 10.1074/jbc.M115.691303. Epub 2016 Jan 14.

18.

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.

Timsah Z, Berrout J, Suraokar M, Behrens C, Song J, Lee JJ, Ivan C, Gagea M, Shires M, Hu X, Vallien C, Kingsley CV, Wistuba I, Ladbury JE.

Am J Cancer Res. 2015 Sep 15;5(10):3135-48. eCollection 2015.

19.

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC.

J Clin Invest. 2015 Dec;125(12):4529-43. doi: 10.1172/JCI82826. Epub 2015 Nov 16.

20.

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.

Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR 4th, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS.

J Med Chem. 2015 Nov 25;58(22):8970-84. doi: 10.1021/acs.jmedchem.5b01321. Epub 2015 Nov 9.

21.

Erythropoietin Stimulates Tumor Growth via EphB4.

Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GN, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK.

Cancer Cell. 2015 Nov 9;28(5):610-622. doi: 10.1016/j.ccell.2015.09.008. Epub 2015 Oct 17.

22.

Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE.

Nat Commun. 2015 Aug 3;6:8007. doi: 10.1038/ncomms9007. No abstract available.

23.

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors.

Vohidov F, Knudsen SE, Leonard PG, Ohata J, Wheadon MJ, Popp BV, Ladbury JE, Ball ZT.

Chem Sci. 2015 Aug 1;6(8):4778-4783. doi: 10.1039/c5sc01602a. Epub 2015 Jun 3.

24.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE.

Oncogene. 2016 Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279. Epub 2015 Jul 27.

25.

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M.

Nat Immunol. 2015 Sep;16(9):970-9. doi: 10.1038/ni.3211. Epub 2015 Jul 13.

26.

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR 4th, Lin CC, Gagea M, Marti AA, Ladbury JE.

Nat Commun. 2015 Jun 24;6:7354. doi: 10.1038/ncomms8354. Erratum in: Nat Commun. 2015;6:8007.

27.

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

Davlieva M, Shi Y, Leonard PG, Johnson TA, Zianni MR, Arias CA, Ladbury JE, Shamoo Y.

Nucleic Acids Res. 2015 May 19;43(9):4758-73. doi: 10.1093/nar/gkv321. Epub 2015 Apr 19.

28.

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.

Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF.

J Biol Chem. 2015 May 1;290(18):11749-61. doi: 10.1074/jbc.M114.619833. Epub 2015 Mar 20.

29.

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.

Drake M, Furuta T, Suen KM, Gonzalez G, Liu B, Kalia A, Ladbury JE, Fire AZ, Skeath JB, Arur S.

Dev Cell. 2014 Dec 8;31(5):614-28. doi: 10.1016/j.devcel.2014.11.004.

30.

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

Poncet-Montange G, Zhan Y, Bardenhagen JP, Petrocchi A, Leo E, Shi X, Lee GR 4th, Leonard PG, Geck Do MK, Cardozo MG, Andersen JN, Palmer WS, Jones P, Ladbury JE.

Biochem J. 2015 Mar 1;466(2):337-46. doi: 10.1042/BJ20140933.

31.

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.

Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ.

Mol Oncol. 2015 Mar;9(3):586-600. doi: 10.1016/j.molonc.2014.10.011. Epub 2014 Nov 11.

32.

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.

Dudutienė V, Matulienė J, Smirnov A, Timm DD, Zubrienė A, Baranauskienė L, Morkūnaite V, Smirnovienė J, Michailovienė V, Juozapaitienė V, Mickevičiūtė A, Kazokaitė J, Bakšytė S, Kasiliauskaitė A, Jachno J, Revuckienė J, Kišonaitė M, Pilipuitytė V, Ivanauskaitė E, Milinavičiūtė G, Smirnovas V, Petrikaitė V, Kairys V, Petrauskas V, Norvaišas P, Lingė D, Gibieža P, Capkauskaitė E, Zakšauskas A, Kazlauskas E, Manakova E, Gražulis S, Ladbury JE, Matulis D.

J Med Chem. 2014 Nov 26;57(22):9435-46. doi: 10.1021/jm501003k. Epub 2014 Nov 10.

PMID:
25358084
33.

The toolbox is open, but who should pay for the job?

Ladbury JE, Hall A, Skidmore J.

Nat Rev Drug Discov. 2014 Jul;13(7):479-80. doi: 10.1038/nrd4367. No abstract available.

PMID:
24981345
34.

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

Aramini JM, Hamilton K, Ma LC, Swapna GVT, Leonard PG, Ladbury JE, Krug RM, Montelione GT.

Structure. 2014 Apr 8;22(4):515-525. doi: 10.1016/j.str.2014.01.010. Epub 2014 Feb 27.

35.

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity.

Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD.

PLoS One. 2014 Jan 27;9(1):e86784. doi: 10.1371/journal.pone.0086784. eCollection 2014.

36.

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.

Timsah Z, Ahmed Z, Lin CC, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE.

Nat Struct Mol Biol. 2014 Feb;21(2):180-8. doi: 10.1038/nsmb.2752. Epub 2014 Jan 19.

PMID:
24440983
37.

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.

Liu H, Thaker YR, Stagg L, Schneider H, Ladbury JE, Rudd CE.

J Biol Chem. 2013 Oct 11;288(41):29539-49. doi: 10.1074/jbc.M112.424846. Epub 2013 Aug 9.

38.

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.

Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK.

Cell. 2013 Aug 1;154(3):556-68. doi: 10.1016/j.cell.2013.06.048.

39.

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.

Cimo AM, Ahmed Z, McIntyre BW, Lewis DE, Ladbury JE.

Biochem J. 2013 Aug 15;454(1):109-21. doi: 10.1042/BJ20130485.

40.

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.

Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE.

Nat Struct Mol Biol. 2013 May;20(5):620-7. doi: 10.1038/nsmb.2557. Epub 2013 Apr 14.

41.

Biophysical characterization of VEGF-aHt DNA aptamer interactions.

Kanakaraj I, Chen WH, Poongavanam M, Dhamane S, Stagg LJ, Ladbury JE, Kourentzi K, Strych U, Willson RC.

Int J Biol Macromol. 2013 Jun;57:69-75. doi: 10.1016/j.ijbiomac.2013.02.016. Epub 2013 Mar 5.

PMID:
23470436
42.

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.

Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE.

J Cell Biol. 2013 Feb 18;200(4):493-504. doi: 10.1083/jcb.201204106.

43.

Structure and interactions of the human programmed cell death 1 receptor.

Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan SH, Huo J, Yu C, Evans EJ, Leslie AJ, Griffiths M, Stubberfield C, Griffin R, Henry AJ, Jansson A, Ladbury JE, Ikemizu S, Carr MD, Davis SJ.

J Biol Chem. 2013 Apr 26;288(17):11771-85. doi: 10.1074/jbc.M112.448126. Epub 2013 Feb 15.

44.

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions.

Seidel SA, Dijkman PM, Lea WA, van den Bogaart G, Jerabek-Willemsen M, Lazic A, Joseph JS, Srinivasan P, Baaske P, Simeonov A, Katritch I, Melo FA, Ladbury JE, Schreiber G, Watts A, Braun D, Duhr S.

Methods. 2013 Mar;59(3):301-15. doi: 10.1016/j.ymeth.2012.12.005. Epub 2012 Dec 24. Review.

45.

Probing cocaine-antibody interactions in buffer and human serum.

Ramakrishnan M, Alves De Melo F, Kinsey BM, Ladbury JE, Kosten TR, Orson FM.

PLoS One. 2012;7(7):e40518. doi: 10.1371/journal.pone.0040518. Epub 2012 Jul 10.

46.

A landscape of driver mutations in melanoma.

Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L.

Cell. 2012 Jul 20;150(2):251-63. doi: 10.1016/j.cell.2012.06.024.

47.

Inhibition of basal FGF receptor signaling by dimeric Grb2.

Lin CC, Melo FA, Ghosh R, Suen KM, Stagg LJ, Kirkpatrick J, Arold ST, Ahmed Z, Ladbury JE.

Cell. 2012 Jun 22;149(7):1514-24. doi: 10.1016/j.cell.2012.04.033.

48.

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems.

Chen Z, Vohidov F, Coughlin JM, Stagg LJ, Arold ST, Ladbury JE, Ball ZT.

J Am Chem Soc. 2012 Jun 20;134(24):10138-45. doi: 10.1021/ja302284p. Epub 2012 Jun 7.

PMID:
22621321
49.

Noise in cellular signaling pathways: causes and effects.

Ladbury JE, Arold ST.

Trends Biochem Sci. 2012 May;37(5):173-8. doi: 10.1016/j.tibs.2012.01.001. Epub 2012 Feb 15. Review.

50.

Catalysis and regulation.

Noble M, Ladbury JE.

Curr Opin Struct Biol. 2011 Dec;21(6):775-6. doi: 10.1016/j.sbi.2011.10.007. No abstract available.

PMID:
22142589

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