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Items: 1 to 50 of 53

1.

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate.

Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR.

Science. 2019 Oct 11;366(6462). pii: eaav5728. doi: 10.1126/science.aav5728.

PMID:
31601741
2.

Pivotal role for αV integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation.

Schrock DC, Leddon SA, Hughson A, Miller J, Lacy-Hulbert A, Fowell DJ.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4462-4470. doi: 10.1073/pnas.1809329116. Epub 2019 Feb 15.

3.

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.

Akilesh HM, Buechler MB, Duggan JM, Hahn WO, Matta B, Sun X, Gessay G, Whalen E, Mason M, Presnell SR, Elkon KB, Lacy-Hulbert A, Barnes BJ, Pepper M, Hamerman JA.

Science. 2019 Jan 11;363(6423). pii: eaao5213. doi: 10.1126/science.aao5213.

PMID:
30630901
4.

αv Integrins regulate germinal center B cell responses through noncanonical autophagy.

Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, Stuart LM, Orr MT, Rawlings DJ, Jackson SW, Lacy-Hulbert A, Acharya M.

J Clin Invest. 2018 Aug 31;128(9):4163-4178. doi: 10.1172/JCI99597. Epub 2018 Aug 20.

5.

ConfocalVR: Immersive Visualization for Confocal Microscopy.

Stefani C, Lacy-Hulbert A, Skillman T.

J Mol Biol. 2018 Oct 19;430(21):4028-4035. doi: 10.1016/j.jmb.2018.06.035. Epub 2018 Jun 24.

6.

GOP-1: Helping phagosomes pass the acid test.

Stuart LM, Lacy-Hulbert A.

J Cell Biol. 2017 Jun 5;216(6):1517-1519. doi: 10.1083/jcb.201704047. Epub 2017 May 24.

7.

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis.

Khurana S, Schouteden S, Manesia JK, Santamaria-Martínez A, Huelsken J, Lacy-Hulbert A, Verfaillie CM.

Nat Commun. 2016 Dec 1;7:13500. doi: 10.1038/ncomms13500.

8.

β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.

Boucard-Jourdin M, Kugler D, Endale Ahanda ML, This S, De Calisto J, Zhang A, Mora JR, Stuart LM, Savill J, Lacy-Hulbert A, Paidassi H.

J Immunol. 2016 Sep 1;197(5):1968-78. doi: 10.4049/jimmunol.1600244. Epub 2016 Aug 1.

9.

Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function.

Du F, Garg AV, Kosar K, Majumder S, Kugler DG, Mir GH, Maggio M, Henkel M, Lacy-Hulbert A, McGeachy MJ.

Cell Rep. 2016 Aug 2;16(5):1339-1351. doi: 10.1016/j.celrep.2016.06.065. Epub 2016 Jul 21.

10.

The Role of Autophagy-Related Proteins in Candida albicans Infections.

Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM.

Pathogens. 2016 Mar 29;5(2). pii: E34. doi: 10.3390/pathogens5020034. Review.

11.

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.

Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A.

Nat Commun. 2016 Mar 11;7:10917. doi: 10.1038/ncomms10917.

12.

De-Mst-ifying microbicidal killing.

Stuart LM, Lacy-Hulbert A.

Nat Immunol. 2015 Nov;16(11):1107-8. doi: 10.1038/ni.3291. No abstract available.

PMID:
26482969
13.

Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.

Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH.

Mol Cell Biol. 2015 Apr;35(8):1401-13. doi: 10.1128/MCB.00112-15. Epub 2015 Feb 9.

14.

Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM.

J Infect Dis. 2014 Dec 1;210(11):1844-54. doi: 10.1093/infdis/jiu290. Epub 2014 May 19.

15.

Integrin αv in the mechanical response of osteoblast lineage cells.

Kaneko K, Ito M, Naoe Y, Lacy-Hulbert A, Ikeda K.

Biochem Biophys Res Commun. 2014 May 2;447(2):352-7. doi: 10.1016/j.bbrc.2014.04.006. Epub 2014 Apr 13.

16.

Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment.

Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C.

Oncogene. 2015 Jan 22;34(4):516-24. doi: 10.1038/onc.2013.585. Epub 2014 Jan 27.

17.

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D.

Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10.

18.

Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.

Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ.

Nat Immunol. 2013 Sep;14(9):949-58. doi: 10.1038/ni.2682. Epub 2013 Aug 11.

19.

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.

Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM.

Nat Immunol. 2013 Jun;14(6):543-53. doi: 10.1038/ni.2595. Epub 2013 May 5.

20.

Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics.

Chen L, Stuart L, Ohsumi TK, Burgess S, Varshney GK, Dastur A, Borowsky M, Benes C, Lacy-Hulbert A, Schmidt EV.

BMC Cancer. 2013 Feb 27;13:93. doi: 10.1186/1471-2407-13-93.

21.

Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.

van Gils JM, Ramkhelawon B, Fernandes L, Stewart MC, Guo L, Seibert T, Menezes GB, Cara DC, Chow C, Kinane TB, Fisher EA, Balcells M, Alvarez-Leite J, Lacy-Hulbert A, Moore KJ.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):911-9. doi: 10.1161/ATVBAHA.112.301155. Epub 2013 Feb 21.

22.

EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.

Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE.

PLoS Pathog. 2012;8(7):e1002798. doi: 10.1371/journal.ppat.1002798. Epub 2012 Jul 5.

23.

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.

Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB.

Gastroenterology. 2012 Sep;143(3):719-729.e2. doi: 10.1053/j.gastro.2012.06.008. Epub 2012 Jun 15.

24.

Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis.

Shanmugam NK, Ellenbogen S, Trebicka E, Wang L, Mukhopadhyay S, Lacy-Hulbert A, Gallini CA, Garrett WS, Cherayil BJ.

PLoS One. 2012;7(5):e38136. doi: 10.1371/journal.pone.0038136. Epub 2012 May 31.

25.

Penetration resistance: PKR's other talent.

Lacy-Hulbert A, Stuart LM.

Immunity. 2012 May 25;36(5):695-6. doi: 10.1016/j.immuni.2012.05.010.

26.

Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production.

Perez B, Paquette N, Païdassi H, Zhai B, White K, Skvirsky R, Lacy-Hulbert A, Stuart LM.

J Biol Chem. 2012 May 4;287(19):16029-36. doi: 10.1074/jbc.M112.340489. Epub 2012 Mar 20.

27.

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.

van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ.

Nat Immunol. 2012 Jan 8;13(2):136-43. doi: 10.1038/ni.2205.

28.

The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.

Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH.

Development. 2011 Dec;138(23):5157-66. doi: 10.1242/dev.069153.

29.

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM.

Immunity. 2011 Oct 28;35(4):536-49. doi: 10.1016/j.immuni.2011.08.015. Epub 2011 Oct 20.

30.

Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice.

Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR.

Gastroenterology. 2011 Dec;141(6):2109-18. doi: 10.1053/j.gastro.2011.09.015. Epub 2011 Sep 16.

31.

Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.

Païdassi H, Acharya M, Zhang A, Mukhopadhyay S, Kwon M, Chow C, Stuart LM, Savill J, Lacy-Hulbert A.

Gastroenterology. 2011 Nov;141(5):1813-20. doi: 10.1053/j.gastro.2011.06.076. Epub 2011 Jul 13.

32.

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.

Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A.

J Clin Invest. 2010 Dec;120(12):4445-52. doi: 10.1172/JCI43796. Epub 2010 Nov 22.

33.

Alpha (v) integrins license regulatory T cells to apoptotic cells and self-associated antigens.

Païdassi H, Acharya M, Lacy-Hulbert A.

Ann N Y Acad Sci. 2010 Oct;1209:68-76. doi: 10.1111/j.1749-6632.2010.05783.x.

PMID:
20958318
34.

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development.

van der Flier A, Badu-Nkansah K, Whittaker CA, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO.

Development. 2010 Jul;137(14):2439-49. doi: 10.1242/dev.049551.

35.

Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.

Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM.

J Immunol. 2010 Jun 15;184(12):7071-81. doi: 10.4049/jimmunol.1000110. Epub 2010 May 17.

36.

Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM.

J Biol Chem. 2010 Jun 25;285(26):20147-54. doi: 10.1074/jbc.M110.115584. Epub 2010 Apr 20.

37.

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ.

Nat Immunol. 2010 Feb;11(2):155-61. doi: 10.1038/ni.1836. Epub 2009 Dec 27.

38.

Natural killer cells require selectins for suppression of subcutaneous tumors.

Sobolev O, Stern P, Lacy-Hulbert A, Hynes RO.

Cancer Res. 2009 Mar 15;69(6):2531-9. doi: 10.1158/0008-5472.CAN-08-3126. Epub 2009 Mar 3.

39.

Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells.

Tóth B, Garabuczi E, Sarang Z, Vereb G, Vámosi G, Aeschlimann D, Blaskó B, Bécsi B, Erdõdi F, Lacy-Hulbert A, Zhang A, Falasca L, Birge RB, Balajthy Z, Melino G, Fésüs L, Szondy Z.

J Immunol. 2009 Feb 15;182(4):2084-92. doi: 10.4049/jimmunol.0803444.

40.

Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.

McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO.

Am J Pathol. 2008 Jun;172(6):1740-7. doi: 10.2353/ajpath.2008.070700. Epub 2008 May 8.

41.

Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins.

Lacy-Hulbert A, Smith AM, Tissire H, Barry M, Crowley D, Bronson RT, Roes JT, Savill JS, Hynes RO.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15823-8. Epub 2007 Sep 25.

42.

Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.

Lacy-Hulbert A, Ueno T, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H Jr, Sayegh MH, Hynes RO, Abdi R.

Am J Transplant. 2007 May;7(5):1080-90. Epub 2007 Mar 12.

43.

Requirements for apoptotic cell contact in regulation of macrophage responses.

Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J, Lacy-Hulbert A.

J Immunol. 2006 Sep 15;177(6):4047-54.

44.

Designer macrophages: oxidative metabolism fuels inflammation repair.

Lacy-Hulbert A, Moore KJ.

Cell Metab. 2006 Jul;4(1):7-8. Review.

45.

Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.

Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A, Hodivala-Dilke K.

Nat Med. 2005 Feb;11(2):167-74. Epub 2005 Jan 16.

PMID:
15654327
46.

Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice.

Devitt A, Parker KG, Ogden CA, Oldreive C, Clay MF, Melville LA, Bellamy CO, Lacy-Hulbert A, Gangloff SC, Goyert SM, Gregory CD.

J Cell Biol. 2004 Dec 20;167(6):1161-70.

47.

Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.

McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO.

Development. 2005 Jan;132(1):165-76. Epub 2004 Dec 2.

48.

Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion.

Lucas M, Stuart LM, Savill J, Lacy-Hulbert A.

J Immunol. 2003 Sep 1;171(5):2610-5.

49.

Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation.

Stuart LM, Lucas M, Simpson C, Lamb J, Savill J, Lacy-Hulbert A.

J Immunol. 2002 Feb 15;168(4):1627-35.

50.

Interruption of coding sequences by heterologous introns can enhance the functional expression of recombinant genes.

Lacy-Hulbert A, Thomas R, Li XP, Lilley CE, Coffin RS, Roes J.

Gene Ther. 2001 Apr;8(8):649-53.

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