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Items: 1 to 50 of 176

1.

Pharmacological Profile of JNJ-64179375: A Novel, Long Acting Exosite-1 Thrombin Inhibitor.

Huang Devine Z, Du F, Li Q, Bunce M, Lacy ER, Chintala M.

J Pharmacol Exp Ther. 2019 Aug 26. pii: jpet.119.261032. doi: 10.1124/jpet.119.261032. [Epub ahead of print]

2.

Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617-1620.

Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR.

J Immunol. 2018 Dec 1;201(11):3149-3152. No abstract available.

PMID:
30455370
3.

Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells.

Souquet B, Freed E, Berto A, Andric V, Audugé N, Reina-San-Martin B, Lacy E, Doye V.

Cell Rep. 2018 Nov 13;25(7):1994. doi: 10.1016/j.celrep.2018.11.012. No abstract available.

4.

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo.

Vandermeeren M, Borgers M, Van Kolen K, Theunis C, Vasconcelos B, Bottelbergs A, Wintmolders C, Daneels G, Willems R, Dockx K, Delbroek L, Marreiro A, Ver Donck L, Sousa C, Nanjunda R, Lacy E, Van De Casteele T, Van Dam D, De Deyn PP, Kemp JA, Malia TJ, Mercken MH.

J Alzheimers Dis. 2018;65(1):265-281. doi: 10.3233/JAD-180404.

PMID:
30040731
5.

Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells.

Souquet B, Freed E, Berto A, Andric V, Audugé N, Reina-San-Martin B, Lacy E, Doye V.

Cell Rep. 2018 May 22;23(8):2443-2454. doi: 10.1016/j.celrep.2018.04.070. Erratum in: Cell Rep. 2018 Nov 13;25(7):1994.

6.

Human IgG subclass cross-species reactivity to mouse and cynomolgus monkey Fcγ receptors.

Derebe MG, Nanjunda RK, Gilliland GL, Lacy ER, Chiu ML.

Immunol Lett. 2018 May;197:1-8. doi: 10.1016/j.imlet.2018.02.006. Epub 2018 Feb 21.

PMID:
29476755
7.

Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody.

Hinke SA, Cieniewicz AM, Kirchner T, D'Aquino K, Nanjunda R, Aligo J, Perkinson R, Cooper P, Boayke K, Chiu ML, Jarantow S, Lacy ER, Liang Y, Johnson DL, Whaley JM, Lingham RB, Kihm AJ.

Mol Metab. 2018 Apr;10:87-99. doi: 10.1016/j.molmet.2018.01.014. Epub 2018 Feb 3.

8.

Cross-sectional study examining the prevalence, correlates and sequencing of electronic cigarette and tobacco use among 11-16-year olds in schools in Wales.

de Lacy E, Fletcher A, Hewitt G, Murphy S, Moore G.

BMJ Open. 2017 Feb 3;7(2):e012784. doi: 10.1136/bmjopen-2016-012784.

9.

Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance.

Cieniewicz AM, Kirchner T, Hinke SA, Nanjunda R, D'Aquino K, Boayke K, Cooper PR, Perkinson R, Chiu ML, Jarantow S, Johnson DL, Whaley JM, Lacy ER, Lingham RB, Liang Y, Kihm AJ.

Diabetes. 2017 Jan;66(1):206-217. doi: 10.2337/db16-0633. Epub 2016 Oct 26.

10.

Symmetric BMPs on the Developmental Road.

Gavrilov S, Lacy E.

Dev Cell. 2016 Jun 20;37(6):488-90. doi: 10.1016/j.devcel.2016.06.007.

11.

Monoclonal antibodies targeting ST2L Domain 1 or Domain 3 differentially modulate IL-33-induced cytokine release by human mast cell and basophilic cell lines.

Fursov N, Lu J, Healy C, Wu SJ, Lacy E, Filer A, Li Y, Liu C, Lamb R, Jones B, Reddy R, Petley T, Duffy K.

Mol Immunol. 2016 Jul;75:178-87. doi: 10.1016/j.molimm.2016.05.019. Epub 2016 Jun 22.

PMID:
27294560
12.

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8.

Malia TJ, Teplyakov A, Ernst R, Wu SJ, Lacy ER, Liu X, Vandermeeren M, Mercken M, Luo J, Sweet RW, Gilliland GL.

Proteins. 2016 Apr;84(4):427-34. doi: 10.1002/prot.24988. Epub 2016 Feb 5.

13.

Immunohistochemical localization of renin-containing cells in two elasmobranch species.

Lacy ER, Reale E, Luciano L.

Fish Physiol Biochem. 2016 Jun;42(3):995-1004. doi: 10.1007/s10695-015-0191-1. Epub 2016 Jan 8.

PMID:
26746846
14.

CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function.

Santulli-Marotto S, Wheeler J, Lacy ER, Boakye K, Luongo J, Wu SJ, Ryan M.

Monoclon Antib Immunodiagn Immunother. 2015 Dec;34(6):373-80. doi: 10.1089/mab.2015.0039.

PMID:
26683175
15.

Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody.

Jarantow SW, Bushey BS, Pardinas JR, Boakye K, Lacy ER, Sanders R, Sepulveda MA, Moores SL, Chiu ML.

J Biol Chem. 2015 Oct 9;290(41):24689-704. doi: 10.1074/jbc.M115.651653. Epub 2015 Aug 10.

16.

ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.

Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, Anderson KV, Lacy E, Selleri L.

Cell Rep. 2014 Oct 23;9(2):674-87. doi: 10.1016/j.celrep.2014.09.019. Epub 2014 Oct 16.

17.

Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene.

Kehoe JW, Whitaker B, Bethea D, Lacy ER, Boakye K, Santulli-Marotto S, Ryan MH, Feng Y, Wheeler JC.

Protein Eng Des Sel. 2014 Jun;27(6):199-206. doi: 10.1093/protein/gzu012. Epub 2014 Apr 16.

PMID:
24742503
19.

Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung.

Santulli-Marotto S, Boakye K, Lacy E, Wu SJ, Luongo J, Kavalkovich K, Coelho A, Hogaboam CM, Ryan M.

PLoS One. 2013 Dec 5;8(12):e81465. doi: 10.1371/journal.pone.0081465. eCollection 2013.

20.

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations.

Vafa O, Gilliland GL, Brezski RJ, Strake B, Wilkinson T, Lacy ER, Scallon B, Teplyakov A, Malia TJ, Strohl WR.

Methods. 2014 Jan 1;65(1):114-26. doi: 10.1016/j.ymeth.2013.06.035. Epub 2013 Jul 17.

PMID:
23872058
21.

Can midlevel dental providers be a benefit to the American public?

Rodriguez TE, Galka AL, Lacy ES, Pellegrini AD, Sweier DG, Romito LM.

J Health Care Poor Underserved. 2013 May;24(2):892-906. doi: 10.1353/hpu.2013.0084.

PMID:
23728055
22.

Genetic dissection of ventral folding morphogenesis in mouse: embryonic visceral endoderm-supplied BMP2 positions head and heart.

Gavrilov S, Lacy E.

Curr Opin Genet Dev. 2013 Aug;23(4):461-9. doi: 10.1016/j.gde.2013.04.001. Epub 2013 May 21. Review.

23.
24.

Mechanisms of self-association of a human monoclonal antibody CNTO607.

Bethea D, Wu SJ, Luo J, Hyun L, Lacy ER, Teplyakov A, Jacobs SA, O'Neil KT, Gilliland GL, Feng Y.

Protein Eng Des Sel. 2012 Oct;25(10):531-7. Epub 2012 Aug 22.

PMID:
22915597
25.

Achieving student diversity in dental schools: a model that works.

Lacy ES, McCann AL, Miller BH, Solomon E, Reuben JS.

J Dent Educ. 2012 May;76(5):523-33.

26.

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, Zhou P.

Cell Res. 2012 Aug;22(8):1258-69. doi: 10.1038/cr.2012.48. Epub 2012 Mar 27.

27.

Equilibrium and kinetic analysis of human interleukin-13 and IL-13 receptor alpha-2 complex formation.

Lacy ER.

J Mol Recognit. 2012 Mar;25(3):184-91. doi: 10.1002/jmr.2150.

PMID:
22407982
28.

Characterization of neutralizing affinity-matured human respiratory syncytial virus F binding antibodies in the sub-picomolar affinity range.

Canziani GA, Melero JA, Lacy ER.

J Mol Recognit. 2012 Mar;25(3):136-46. doi: 10.1002/jmr.2149.

PMID:
22407977
29.

Guide for the mentoring dentist: the admissions office perspective.

Miller BH, Lacy ES, Pierpont HP, Segura A.

Tex Dent J. 2011 Nov;128(11):1191-3.

PMID:
22216564
30.

Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression.

Madabhushi M, Lacy E.

Dev Cell. 2011 Nov 15;21(5):907-19. doi: 10.1016/j.devcel.2011.08.027.

31.

Latino social network dynamics and the Hurricane Katrina disaster.

Hilfinger Messias DK, Barrington C, Lacy E.

Disasters. 2012 Jan;36(1):101-21. doi: 10.1111/j.1467-7717.2011.01243.x. Epub 2011 May 31.

PMID:
21623889
32.

Retention of underrepresented minority students in dental school: one dental schools story.

Lacy ES, Miller BH, Hornback SA, McCann AL, Reuben JS.

J Am Coll Dent. 2011 Winter;78(4):40-7.

PMID:
22416618
33.

Application of basic science to clinical problems: traditional vs. hybrid problem-based learning.

Callis AN, McCann AL, Schneiderman ED, Babler WJ, Lacy ES, Hale DS.

J Dent Educ. 2010 Oct;74(10):1113-24.

34.

Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.

Luo J, Wu SJ, Lacy ER, Orlovsky Y, Baker A, Teplyakov A, Obmolova G, Heavner GA, Richter HT, Benson J.

J Mol Biol. 2010 Oct 8;402(5):797-812. doi: 10.1016/j.jmb.2010.07.046. Epub 2010 Aug 4.

PMID:
20691190
35.

An acute stressor alters steroid hormone levels and activity but not sexual behavior in male and female Ocoee salamanders (Desmognathus ocoee).

Woodley SK, Lacy EL.

Horm Behav. 2010 Aug;58(3):427-32. doi: 10.1016/j.yhbeh.2010.05.011. Epub 2010 May 24.

PMID:
20580723
36.

Structure-based engineering of a monoclonal antibody for improved solubility.

Wu SJ, Luo J, O'Neil KT, Kang J, Lacy ER, Canziani G, Baker A, Huang M, Tang QM, Raju TS, Jacobs SA, Teplyakov A, Gilliland GL, Feng Y.

Protein Eng Des Sel. 2010 Aug;23(8):643-51. doi: 10.1093/protein/gzq037. Epub 2010 Jun 11.

PMID:
20543007
37.

Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α.

Shealy DJ, Cai A, Staquet K, Baker A, Lacy ER, Johns L, Vafa O, Gunn G 3rd, Tam S, Sague S, Wang D, Brigham-Burke M, Dalmonte P, Emmell E, Pikounis B, Bugelski PJ, Zhou H, Scallon BJ, Giles-Komar J.

MAbs. 2010 Jul-Aug;2(4):428-39. Epub 2010 Jul 1.

38.

The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.

Jerome-Majewska LA, Achkar T, Luo L, Lupu F, Lacy E.

Dev Biol. 2010 May 1;341(1):154-66. doi: 10.1016/j.ydbio.2010.02.019. Epub 2010 Feb 21.

39.

Free sulfhydryl measurement as an indicator of antibody stability.

Lacy ER, Baker M, Brigham-Burke M.

Anal Biochem. 2008 Nov 1;382(1):66-8. doi: 10.1016/j.ab.2008.07.016. Epub 2008 Jul 26.

PMID:
18675772
40.

Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions.

Cejas MA, Kinney WA, Chen C, Vinter JG, Almond HR Jr, Balss KM, Maryanoff CA, Schmidt U, Breslav M, Mahan A, Lacy E, Maryanoff BE.

Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8513-8. doi: 10.1073/pnas.0800291105. Epub 2008 Jun 16.

41.

Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.

Lupu F, Alves A, Anderson K, Doye V, Lacy E.

Dev Cell. 2008 Jun;14(6):831-42. doi: 10.1016/j.devcel.2008.03.011.

42.

Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies.

Tsui P, Das A, Whitaker B, Tornetta M, Stowell N, Kesavan P, Kaiser E, Lacy ER, Yan L, Snyder LA, Sweet R.

Hum Antibodies. 2007;16(3-4):117-25.

PMID:
18334747
43.
44.

A rapid method for generating and characterizing anti-variable region monoclonal antibodies.

Staquet K, Kwok D, Rycyzyn MA, Petley T, Lacy ER, Powers G, Giles-Komar J.

Hum Antibodies. 2006;15(4):155-62.

PMID:
17522437
45.

Katrina-related health concerns of Latino survivors and evacuees.

Messias DK, Lacy E.

J Health Care Poor Underserved. 2007 May;18(2):443-64.

PMID:
17483571
46.

Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.

Zhan J, Easton JB, Huang S, Mishra A, Xiao L, Lacy ER, Kriwacki RW, Houghton PJ.

Mol Cell Biol. 2007 May;27(9):3530-41. Epub 2007 Feb 26.

47.

The new transgenic mouse core: no longer a facility just for making mice.

Mark WH, Romanienko P, Lipman N, Lacy E.

Lab Anim (NY). 2006 Nov;35(10):27-34.

PMID:
17077832
48.

Characterization of digital waveforms using thermodynamic analogs: detection of contrast-targeted tissue in vivo.

Hughes MS, Marsh JN, Zhang H, Woodson AK, Allen JS, Lacy EK, Carradine C, Lanza GM, Wickline SA.

IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Sep;53(9):1609-16.

PMID:
16964911
49.

Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis.

Winter PM, Neubauer AM, Caruthers SD, Harris TD, Robertson JD, Williams TA, Schmieder AH, Hu G, Allen JS, Lacy EK, Zhang H, Wickline SA, Lanza GM.

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2103-9. Epub 2006 Jul 6.

PMID:
16825592
50.

Effect of low environmental salinity on plasma composition and renal function of the Atlantic stingray, a euryhaline elasmobranch.

Janech MG, Fitzgibbon WR, Ploth DW, Lacy ER, Miller DH.

Am J Physiol Renal Physiol. 2006 Oct;291(4):F770-80. Epub 2006 Apr 11.

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