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Structure of the Helicobacter pylori Cag type IV secretion system.

Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD.

Elife. 2019 Jun 18;8. pii: e47644. doi: 10.7554/eLife.47644.


Control of antiviral innate immune response by protein geranylgeranylation.

Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D.

Sci Adv. 2019 May 29;5(5):eaav7999. doi: 10.1126/sciadv.aav7999. eCollection 2019 May.


Zinc intoxication induces ferroptosis in A549 human lung cells.

Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, McLean JA, Caprioli RM, Skaar EP.

Metallomics. 2019 May 22;11(5):982-993. doi: 10.1039/c8mt00360b.


Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.

Su M, Erwin AL, Campbell AM, Pyburn TM, Salay LE, Hanks JL, Lacy DB, Akey DL, Cover TL, Ohi MD.

J Mol Biol. 2019 May 3;431(10):1956-1965. doi: 10.1016/j.jmb.2019.03.029. Epub 2019 Apr 5.


A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB.

J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.


The role of toxins in Clostridium difficile infection.

Chandrasekaran R, Lacy DB.

FEMS Microbiol Rev. 2017 Nov 1;41(6):723-750. doi: 10.1093/femsre/fux048. Review.


Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.

Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA.

J Biol Chem. 2017 Oct 20;292(42):17290-17301. doi: 10.1074/jbc.M117.806687. Epub 2017 Aug 23.


Antibacterial photosensitization through activation of coproporphyrinogen oxidase.

Surdel MC, Horvath DJ Jr, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6652-E6659. doi: 10.1073/pnas.1700469114. Epub 2017 Jul 24.


Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.

J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.


Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.

Alvin JW, Lacy DB.

J Struct Biol. 2017 Jun;198(3):203-209. doi: 10.1016/j.jsb.2017.04.006. Epub 2017 Apr 19.


Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, Fischer P, Sher X, Gupta P, Lacy DB, Therien AG.

J Mol Biol. 2017 Apr 7;429(7):1030-1044. doi: 10.1016/j.jmb.2017.02.010. Epub 2017 Feb 21.


Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.

Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM.

J Proteome Res. 2017 Mar 3;16(3):1364-1375. doi: 10.1021/acs.jproteome.6b01004. Epub 2017 Feb 9.


Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis.

Chandrasekaran R, Kenworthy AK, Lacy DB.

PLoS Pathog. 2016 Dec 12;12(12):e1006070. doi: 10.1371/journal.ppat.1006070. eCollection 2016 Dec.


Crystal structure of Clostridium difficile toxin A.

Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB.

Nat Microbiol. 2016 Jan 11;1:15002. doi: 10.1038/nmicrobiol.2015.2.


Crystal structure of Clostridium difficile toxin A.

Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB.

Nat Microbiol. 2016;1. pii: 15002. Epub 2016 Jan 11.


Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms.

Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Lacy DB.

Infect Immun. 2016 Sep 19;84(10):2871-7. doi: 10.1128/IAI.00583-16. Print 2016 Oct.


A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain.

González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL.

Infect Immun. 2016 Aug 19;84(9):2662-70. doi: 10.1128/IAI.00254-16. Print 2016 Sep.


Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells.

Craven R, Lacy DB.

mSphere. 2015 Nov 18;1(1). pii: e00012-15. doi: 10.1128/mSphere.00012-15. eCollection 2016 Jan-Feb.


Clostridium difficile infection.

Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ.

Nat Rev Dis Primers. 2016 Apr 7;2:16020. doi: 10.1038/nrdp.2016.20. Review.


Exploiting dominant-negative toxins to combat Staphylococcus aureus pathogenesis.

Reyes-Robles T, Lubkin A, Alonzo F 3rd, Lacy DB, Torres VJ.

EMBO Rep. 2016 May;17(5):780. doi: 10.15252/embr.201670010. No abstract available.


Exploiting dominant-negative toxins to combat Staphylococcus aureus pathogenesis.

Reyes-Robles T, Lubkin A, Alonzo F 3rd, Lacy DB, Torres VJ.

EMBO Rep. 2016 Mar;17(3):428-40. doi: 10.15252/embr.201540994. Epub 2016 Feb 8. Erratum in: EMBO Rep. 2016 May;17(5):780.


Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.

Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E.

Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15.


Cloning and variation of ground state intestinal stem cells.

Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W.

Nature. 2015 Jun 11;522(7555):173-8. doi: 10.1038/nature14484. Epub 2015 Jun 3.


Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.

LaFrance ME, Farrow MA, Chandrasekaran R, Sheng J, Rubin DH, Lacy DB.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7073-8. doi: 10.1073/pnas.1500791112. Epub 2015 May 18.


The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid.

Varela Chavez C, Hoos S, Haustant GM, Chenal A, England P, Blondel A, Pauillac S, Lacy DB, Popoff MR.

Cell Microbiol. 2015 Oct;17(10):1477-93. doi: 10.1111/cmi.12449. Epub 2015 May 13.


Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.

Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3721-6. doi: 10.1073/pnas.1400680111. Epub 2014 Feb 24.


Identification of a crucial residue required for Staphylococcus aureus LukAB cytotoxicity and receptor recognition.

DuMont AL, Yoong P, Liu X, Day CJ, Chumbler NM, James DB, Alonzo F 3rd, Bode NJ, Lacy DB, Jennings MP, Torres VJ.

Infect Immun. 2014 Mar;82(3):1268-76. doi: 10.1128/IAI.01444-13. Epub 2013 Dec 30.


Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.

Farrow MA, Chumbler NM, Lapierre LA, Franklin JL, Rutherford SA, Goldenring JR, Lacy DB.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18674-9. doi: 10.1073/pnas.1313658110. Epub 2013 Oct 28.


Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection.

Reyes-Robles T, Alonzo F 3rd, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ.

Cell Host Microbe. 2013 Oct 16;14(4):453-9. doi: 10.1016/j.chom.2013.09.005.


Molecular assembly of botulinum neurotoxin progenitor complexes.

Benefield DA, Dessain SK, Shine N, Ohi MD, Lacy DB.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5630-5. doi: 10.1073/pnas.1222139110. Epub 2013 Mar 18.


Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.

Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT.

ACS Chem Biol. 2013 Apr 19;8(4):812-22. doi: 10.1021/cb300555n. Epub 2013 Feb 4.


Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism.

Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam DB, Goldenring JR, Lacy DB.

PLoS Pathog. 2012;8(12):e1003072. doi: 10.1371/journal.ppat.1003072. Epub 2012 Dec 6. Erratum in: PLoS Pathog. 2012 Dec;8(12). doi: 10.1371/annotation/f9017013-88c8-44db-818b-08b9322f3814. Haslam, David [corrected to Haslam, David B].


Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin.

Chambers MG, Pyburn TM, González-Rivera C, Collier SE, Eli I, Yip CK, Takizawa Y, Lacy DB, Cover TL, Ohi MD.

J Mol Biol. 2013 Feb 8;425(3):524-35. doi: 10.1016/j.jmb.2012.11.020. Epub 2012 Nov 20.


Toward a structural understanding of Clostridium difficile toxins A and B.

Pruitt RN, Lacy DB.

Front Cell Infect Microbiol. 2012 Mar 16;2:28. doi: 10.3389/fcimb.2012.00028. eCollection 2012. Review.


Structural determinants of Clostridium difficile toxin A glucosyltransferase activity.

Pruitt RN, Chumbler NM, Rutherford SA, Farrow MA, Friedman DB, Spiller B, Lacy DB.

J Biol Chem. 2012 Mar 9;287(11):8013-20. doi: 10.1074/jbc.M111.298414. Epub 2012 Jan 20.


Studies of the mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes.

Mushrush DJ, Koteiche HA, Sammons MA, Link AJ, McHaourab HS, Lacy DB.

J Biol Chem. 2011 Jul 29;286(30):27011-8. doi: 10.1074/jbc.M111.256982. Epub 2011 Jun 7.


Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization.

Johnson PM, Chen SS, Santomango TS, Williams PE, Lacy DB, McGuinness OP.

Metabolism. 2011 Jun;60(6):867-73. doi: 10.1016/j.metabol.2010.08.006. Epub 2010 Oct 12.


Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA.

Gangwer KA, Shaffer CL, Suerbaum S, Lacy DB, Cover TL, Bordenstein SR.

J Bacteriol. 2010 Dec;192(23):6126-35. doi: 10.1128/JB.01081-10. Epub 2010 Sep 24.


Structural organization of the functional domains of Clostridium difficile toxins A and B.

Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13467-72. doi: 10.1073/pnas.1002199107. Epub 2010 Jul 12.


Reconstitution of Helicobacter pylori VacA toxin from purified components.

González-Rivera C, Gangwer KA, McClain MS, Eli IM, Chambers MG, Ohi MD, Lacy DB, Cover TL.

Biochemistry. 2010 Jul 13;49(27):5743-52. doi: 10.1021/bi100618g.


Structural analysis of botulinum neurotoxin type G receptor binding .

Schmitt J, Karalewitz A, Benefield DA, Mushrush DJ, Pruitt RN, Spiller BW, Barbieri JT, Lacy DB.

Biochemistry. 2010 Jun 29;49(25):5200-5. doi: 10.1021/bi100412v.


Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin.

Ivie SE, McClain MS, Algood HM, Lacy DB, Cover TL.

BMC Microbiol. 2010 Feb 23;10:60. doi: 10.1186/1471-2180-10-60.


Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A.

Pruitt RN, Chagot B, Cover M, Chazin WJ, Spiller B, Lacy DB.

J Biol Chem. 2009 Aug 14;284(33):21934-40. doi: 10.1074/jbc.M109.018929. Epub 2009 Jun 24.


Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability.

Chen SS, Santomango TS, Williams PE, Lacy DB, McGuinness OP.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1172-8. doi: 10.1152/ajpendo.90821.2008. Epub 2009 Feb 10.


Botulinum neurotoxin devoid of receptor binding domain translocates active protease.

Fischer A, Mushrush DJ, Lacy DB, Montal M.

PLoS Pathog. 2008 Dec;4(12):e1000245. doi: 10.1371/journal.ppat.1000245. Epub 2008 Dec 19.


Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes.

Ivie SE, McClain MS, Torres VJ, Algood HM, Lacy DB, Yang R, Blanke SR, Cover TL.

Infect Immun. 2008 Jul;76(7):2843-51. doi: 10.1128/IAI.01664-07. Epub 2008 Apr 28.


Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.

Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16293-8. Epub 2007 Oct 2.


Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation.

Scobie HM, Marlett JM, Rainey GJ, Lacy DB, Collier RJ, Young JA.

PLoS One. 2007 Mar 28;2(3):e329.


Glucagon chronically impairs hepatic and muscle glucose disposal.

Chen SS, Zhang Y, Santomango TS, Williams PE, Lacy DB, McGuinness OP.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E928-35. Epub 2006 Nov 28.


Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.

Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA.

PLoS Pathog. 2006 Oct;2(10):e111. Erratum in: PLoS Pathog. 2008 Oct;4(10).doi:10.1371/annotation/08c1bcf0-da65-4abd-97c7-5df86b1120b5.

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