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Items: 22

1.

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.

Xie Z, Shapiro LP, Cahill ME, Russell TA, Lacor PN, Klein WL, Penzes P.

Eur J Neurosci. 2019 May;49(9):1091-1101. doi: 10.1111/ejn.14311. Epub 2019 Jan 20.

PMID:
30565792
2.

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.

Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL.

J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2.

3.

Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo.

Epelbaum S, Youssef I, Lacor PN, Chaurand P, Duplus E, Brugg B, Duyckaerts C, Delatour B.

Neurobiol Aging. 2015 Jun;36(6):2043-52. doi: 10.1016/j.neurobiolaging.2015.03.005. Epub 2015 Mar 16.

PMID:
25862419
4.

Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).

Perez SE, Raghanti MA, Hof PR, Kramer L, Ikonomovic MD, Lacor PN, Erwin JM, Sherwood CC, Mufson EJ.

J Comp Neurol. 2013 Dec 15;521(18):4318-38. doi: 10.1002/cne.23428.

5.

Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease.

Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM.

Neurobiol Aging. 2013 Sep;34(9):2081-90. doi: 10.1016/j.neurobiolaging.2012.12.028. Epub 2013 Apr 9.

PMID:
23582659
6.

Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice.

Xiao C, Davis FJ, Chauhan BC, Viola KL, Lacor PN, Velasco PT, Klein WL, Chauhan NB.

J Alzheimers Dis. 2013;35(4):777-88. doi: 10.3233/JAD-122419.

7.

Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies.

Velasco PT, Heffern MC, Sebollela A, Popova IA, Lacor PN, Lee KB, Sun X, Tiano BN, Viola KL, Eckermann AL, Meade TJ, Klein WL.

ACS Chem Neurosci. 2012 Nov 21;3(11):972-81. doi: 10.1021/cn300122k. Epub 2012 Oct 23.

8.

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers.

Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, Rego AC, Pereira CM.

Aging Cell. 2012 Oct;11(5):823-33. doi: 10.1111/j.1474-9726.2012.00848.x. Epub 2012 Jul 16.

9.

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo.

Fonte V, Dostal V, Roberts CM, Gonzales P, Lacor PN, Velasco PT, Magrane J, Dingwell N, Fan EY, Silverman MA, Stein GH, Link CD.

Mol Neurodegener. 2011 Aug 23;6(1):61. doi: 10.1186/1750-1326-6-61. Erratum in: Mol Neurodegener. 2014;9:12. Lacor, Pascale [corrected to Lacor, Pascale N]; Velasco, Pauline T [added].

10.

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity.

Bao F, Wicklund L, Lacor PN, Klein WL, Nordberg A, Marutle A.

Neurobiol Aging. 2012 Apr;33(4):825.e1-13. doi: 10.1016/j.neurobiolaging.2011.05.003. Epub 2011 Jun 17.

PMID:
21683475
11.

Aβ oligomer-induced synapse degeneration in Alzheimer's disease.

Wilcox KC, Lacor PN, Pitt J, Klein WL.

Cell Mol Neurobiol. 2011 Aug;31(6):939-48. doi: 10.1007/s10571-011-9691-4. Epub 2011 May 3. Review.

12.

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.

Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, Triller A.

Neuron. 2010 Jun 10;66(5):739-54. doi: 10.1016/j.neuron.2010.04.029.

13.

Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y.

J Alzheimers Dis. 2009;18(4):787-98. doi: 10.3233/JAD-2009-1189.

PMID:
19661619
14.

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}.

Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL.

J Biol Chem. 2009 Jul 10;284(28):18742-53. doi: 10.1074/jbc.M109.011015. Epub 2009 Apr 30.

15.

Advances on the understanding of the origins of synaptic pathology in AD.

Lacor PN.

Curr Genomics. 2007 Dec;8(8):486-508. doi: 10.2174/138920207783769530.

16.

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers.

De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL.

Neurobiol Aging. 2008 Sep;29(9):1334-47. Epub 2007 Apr 2.

17.

Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.

Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL.

J Neurosci. 2007 Jan 24;27(4):796-807.

18.

Monoclonal antibodies that target pathological assemblies of Abeta.

Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL.

J Neurochem. 2007 Jan;100(1):23-35. Epub 2006 Nov 20.

19.

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL.

J Neurosci. 2004 Nov 10;24(45):10191-200.

20.

Self-assembly of Abeta(1-42) into globular neurotoxins.

Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL.

Biochemistry. 2003 Nov 11;42(44):12749-60.

PMID:
14596589
21.

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss.

Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10417-22. Epub 2003 Aug 18.

22.

Reelin secretion from glutamatergic neurons in culture is independent from neurotransmitter regulation.

Lacor PN, Grayson DR, Auta J, Sugaya I, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3556-61.

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