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Items: 1 to 50 of 224

1.

Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus.

Maness NJ, Schouest B, Singapuri A, Dennis M, Gilbert MH, Bohm RP, Schiro F, Aye PP, Baker K, Van Rompay KKA, Lackner AA, Bonaldo MC, Blair RV, Permar SR, Coffey LL, Panganiban AT, Magnani D.

Sci Rep. 2019 Sep 5;9(1):12802. doi: 10.1038/s41598-019-49209-7.

2.

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques.

Magnani DM, Rogers TF, Maness NJ, Grubaugh ND, Beutler N, Bailey VK, Gonzalez-Nieto L, Gutman MJ, Pedreño-Lopez N, Kwal JM, Ricciardi MJ, Myers TA, Julander JG, Bohm RP, Gilbert MH, Schiro F, Aye PP, Blair RV, Martins MA, Falkenstein KP, Kaur A, Curry CL, Kallas EG, Desrosiers RC, Goldschmidt-Clermont PJ, Whitehead SS, Andersen KG, Bonaldo MC, Lackner AA, Panganiban AT, Burton DR, Watkins DI.

Nat Commun. 2018 Apr 24;9(1):1624. doi: 10.1038/s41467-018-04056-4.

3.

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.

Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi: 10.1073/pnas.1711373114. Epub 2017 Dec 18.

4.

Nonhuman Primate Models and Understanding the Pathogenesis of HIV Infection and AIDS.

Veazey RS, Lackner AA.

ILAR J. 2017 Dec 1;58(2):160-171. doi: 10.1093/ilar/ilx032.

5.

The SIV Envelope Glycoprotein, Viral Tropism, and Pathogenesis: Novel Insights from Nonhuman Primate Models of AIDS.

Swanstrom AE, Del Prete GQ, Deleage C, Elser SE, Lackner AA, Hoxie JA.

Curr HIV Res. 2018;16(1):29-40. doi: 10.2174/1570162X15666171124123116. Review.

PMID:
29173176
6.

Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection.

Foreman TW, Veatch AV, LoBato DN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Lackner AA, Kousoulas KG, Khader SA, Kaushal D, Mehra S.

Am J Pathol. 2017 Dec;187(12):2811-2820. doi: 10.1016/j.ajpath.2017.08.014. Epub 2017 Sep 19.

7.

The Role of Defensins in HIV Pathogenesis.

Pace BT, Lackner AA, Porter E, Pahar B.

Mediators Inflamm. 2017;2017:5186904. doi: 10.1155/2017/5186904. Epub 2017 Aug 3. Review.

8.

Translational Research in the Nonhuman Primate Model of Tuberculosis.

Foreman TW, Mehra S, Lackner AA, Kaushal D.

ILAR J. 2017 Dec 1;58(2):151-159. doi: 10.1093/ilar/ilx015.

9.

TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.

Dowling DJ, van Haren SD, Scheid A, Bergelson I, Kim D, Mancuso CJ, Foppen W, Ozonoff A, Fresh L, Theriot TB, Lackner AA, Fichorova RN, Smirnov D, Vasilakos JP, Beaurline JM, Tomai MA, Midkiff CC, Alvarez X, Blanchard JL, Gilbert MH, Aye PP, Levy O.

JCI Insight. 2017 Mar 23;2(6):e91020. doi: 10.1172/jci.insight.91020.

10.

Hypoxia Sensing and Persistence Genes Are Expressed during the Intragranulomatous Survival of Mycobacterium tuberculosis.

Hudock TA, Foreman TW, Bandyopadhyay N, Gautam US, Veatch AV, LoBato DN, Gentry KM, Golden NA, Cavigli A, Mueller M, Hwang SA, Hunter RL, Alvarez X, Lackner AA, Bader JS, Mehra S, Kaushal D.

Am J Respir Cell Mol Biol. 2017 May;56(5):637-647. doi: 10.1165/rcmb.2016-0239OC.

11.

CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.

Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi: 10.1073/pnas.1611987113. Epub 2016 Sep 6.

12.

The flavivirus dengue induces hypertrophy of white matter astrocytes.

Lee KM, Chiu KB, Sansing HA, Didier PJ, Lackner AA, MacLean AG.

J Neurovirol. 2016 Dec;22(6):831-839. Epub 2016 Jun 6.

13.

Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.

Swanstrom AE, Haggarty B, Jordan APO, Romano J, Leslie GJ, Aye PP, Marx PA, Lackner AA, Del Prete GQ, Robinson JE, Betts MR, Montefiori DC, LaBranche CC, Hoxie JA.

J Virol. 2016 Apr 29;90(10):4966-4980. doi: 10.1128/JVI.02851-15. Print 2016 May 15.

14.

Contributions of Nonhuman Primates to Research on Aging.

Didier ES, MacLean AG, Mohan M, Didier PJ, Lackner AA, Kuroda MJ.

Vet Pathol. 2016 Mar;53(2):277-90. doi: 10.1177/0300985815622974. Epub 2016 Feb 11. Review.

15.

Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells.

Xu H, Wang X, Malam N, Aye PP, Alvarez X, Lackner AA, Veazey RS.

J Virol. 2015 Nov 25;90(3):1578-87. doi: 10.1128/JVI.02471-15. Print 2016 Feb 1.

16.

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.

Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S.

Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.

17.

Preferential Destruction of Interstitial Macrophages over Alveolar Macrophages as a Cause of Pulmonary Disease in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Cai Y, Sugimoto C, Arainga M, Midkiff CC, Liu DX, Alvarez X, Lackner AA, Kim WK, Didier ES, Kuroda MJ.

J Immunol. 2015 Nov 15;195(10):4884-91. doi: 10.4049/jimmunol.1501194. Epub 2015 Oct 2.

18.

Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS.

Xu H, Wang X, Malam N, Lackner AA, Veazey RS.

J Immunol. 2015 Nov 1;195(9):4351-7. doi: 10.4049/jimmunol.1501273. Epub 2015 Sep 25.

19.

Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus-infected macaques.

Xu H, Wang X, Lackner AA, Veazey RS.

FASEB J. 2015 Dec;29(12):5072-80. doi: 10.1096/fj.15-276477. Epub 2015 Aug 17.

20.

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif.

Breed MW, Elser SE, Torben W, Jordan AP, Aye PP, Midkiff C, Schiro F, Sugimoto C, Alvarez-Hernandez X, Blair RV, Somasunderam A, Utay NS, Kuroda MJ, Pahar B, Wiseman RW, O'Connor DH, LaBranche CC, Montefiori DC, Marsh M, Li Y, Piatak M Jr, Lifson JD, Keele BF, Fultz PN, Lackner AA, Hoxie JA.

J Virol. 2015 Oct;89(20):10156-75. doi: 10.1128/JVI.01134-15. Epub 2015 Jul 29.

21.

Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.

Sugimoto C, Hasegawa A, Saito Y, Fukuyo Y, Chiu KB, Cai Y, Breed MW, Mori K, Roy CJ, Lackner AA, Kim WK, Didier ES, Kuroda MJ.

J Immunol. 2015 Aug 15;195(4):1774-81. doi: 10.4049/jimmunol.1500522. Epub 2015 Jul 15.

22.

Increased monocyte turnover is associated with interstitial macrophage accumulation and pulmonary tissue damage in SIV-infected rhesus macaques.

Cai Y, Sugimoto C, Liu DX, Midkiff CC, Alvarez X, Lackner AA, Kim WK, Didier ES, Kuroda MJ.

J Leukoc Biol. 2015 Jun;97(6):1147-53. doi: 10.1189/jlb.4A0914-441R. Epub 2015 Mar 16.

23.

Reduced expression of CD27 by collagenase treatment: implications for interpreting b cell data in tissues.

Shen C, Xu H, Alvarez X, Lackner AA, Veazey RS, Wang X.

PLoS One. 2015 Mar 10;10(3):e0116667. doi: 10.1371/journal.pone.0116667. eCollection 2015.

24.

The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.

Mehra S, Foreman TW, Didier PJ, Ahsan MH, Hudock TA, Kissee R, Golden NA, Gautam US, Johnson AM, Alvarez X, Russell-Lodrigue KE, Doyle LA, Roy CJ, Niu T, Blanchard JL, Khader SA, Lackner AA, Sherman DR, Kaushal D.

Am J Respir Crit Care Med. 2015 May 15;191(10):1185-96. doi: 10.1164/rccm.201408-1502OC.

25.

Coats-like retinopathy in a Young Indian Rhesus Macaque (Macaca mulatta).

Liu DX, Gilbert MH, Wang X, Didier PJ, Shields CL, Lackner AA.

J Med Primatol. 2015 Apr;44(2):108-12. doi: 10.1111/jmp.12166. Epub 2015 Feb 6.

26.

Profound loss of intestinal Tregs in acutely SIV-infected neonatal macaques.

Wang X, Xu H, Shen C, Alvarez X, Liu D, Pahar B, Ratterree MS, Doyle-Meyers LA, Lackner AA, Veazey RS.

J Leukoc Biol. 2015 Feb;97(2):391-400. doi: 10.1189/jlb.4A0514-266RR. Epub 2014 Dec 9.

27.

Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques.

Mohan M, Kumar V, Lackner AA, Alvarez X.

J Immunol. 2015 Jan 1;194(1):291-306. doi: 10.4049/jimmunol.1401447. Epub 2014 Dec 1.

28.

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.

Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, Estes JD, Silvestri G, Lackner AA, Paiardini M.

PLoS Pathog. 2014 Oct 30;10(10):e1004467. doi: 10.1371/journal.ppat.1004467. eCollection 2014 Oct.

29.
30.

Microdissection approaches in tuberculosis research.

Hudock TA, Lackner AA, Kaushal D.

J Med Primatol. 2014 Oct;43(5):294-7. doi: 10.1111/jmp.12141. Epub 2014 Aug 28. Review.

31.

Localization of productively infected cells in the spleen and Peyer's patches of rhesus macaques during acute infection with SIVmac239Δnef-enhanced green fluorescent protein.

Yang GB, Alexander L, Aye P, Alvarez X, Desrosiers RC, Lackner AA.

AIDS Res Hum Retroviruses. 2014 Aug;30(8):738-9. doi: 10.1089/AID.2014.0160. No abstract available.

32.

Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.

Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA.

J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14.

33.

miR-190b is markedly upregulated in the intestine in response to simian immunodeficiency virus replication and partly regulates myotubularin-related protein-6 expression.

Mohan M, Chandra LC, Torben W, Aye PP, Alvarez X, Lackner AA.

J Immunol. 2014 Aug 1;193(3):1301-13. doi: 10.4049/jimmunol.1303479. Epub 2014 Jun 30.

34.
35.

PD-1(HIGH) Follicular CD4 T Helper Cell Subsets Residing in Lymph Node Germinal Centers Correlate with B Cell Maturation and IgG Production in Rhesus Macaques.

Xu H, Wang X, Lackner AA, Veazey RS.

Front Immunol. 2014 Mar 19;5:85. doi: 10.3389/fimmu.2014.00085. eCollection 2014.

36.

Detecting the simian immunodeficiency virus reservoir as viral DNA and RNA in situ simultaneously as a model to monitor viral latency.

Alvarez X, Midkiff C, Kuroda MJ, Mohan M, Lackner AA.

AIDS Res Hum Retroviruses. 2014 Mar;30(3):205-6. doi: 10.1089/aid.2014.0024. No abstract available.

37.

Comparison of the vaginal environment of Macaca mulatta and Macaca nemestrina throughout the menstrual cycle.

Hadzic SV, Wang X, Dufour J, Doyle L, Marx PA, Lackner AA, Paulsen DB, Veazey RS.

Am J Reprod Immunol. 2014 Apr;71(4):322-9. doi: 10.1111/aji.12201. Epub 2014 Feb 13. Review.

38.

Persistent babesiosis in a Rhesus macaque (Macaca mulatta) infected with a simian-human immunodeficiency virus.

Liu DX, Gill A, Holman PJ, Didier PJ, Blanchard JL, Veazey RS, Lackner AA.

J Med Primatol. 2014 Jun;43(3):206-8. doi: 10.1111/jmp.12105. Epub 2014 Feb 11.

39.

Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy.

Snook ER, Fisher-Perkins JM, Sansing HA, Lee KM, Alvarez X, MacLean AG, Peterson KE, Lackner AA, Bunnell BA.

Am J Pathol. 2014 Feb;184(2):382-96. doi: 10.1016/j.ajpath.2013.10.011. Epub 2013 Dec 4.

40.

Kinetics of liver macrophages (Kupffer cells) in SIV-infected macaques.

Ahsan MH, Gill AF, Alvarez X, Lackner AA, Veazey RS.

Virology. 2013 Nov;446(1-2):77-85. doi: 10.1016/j.virol.2013.07.026. Epub 2013 Aug 19.

41.

A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells.

Breed MW, Jordan AP, Aye PP, Sugimoto C, Alvarez X, Kuroda MJ, Pahar B, Keele BF, Hoxie JA, Lackner AA.

J Virol. 2013 Dec;87(23):13048-52. doi: 10.1128/JVI.02126-13. Epub 2013 Sep 11.

42.

Dynamics of cytokine/chemokine responses in intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection.

Kenway-Lynch CS, Das A, Pan D, Lackner AA, Pahar B.

J Virol. 2013 Nov;87(21):11916-23. doi: 10.1128/JVI.01750-13. Epub 2013 Aug 21.

43.

Divergent kinetics of proliferating T cell subsets in simian immunodeficiency virus (SIV) infection: SIV eliminates the "first responder" CD4+ T cells in primary infection.

Wang X, Xu H, Pahar B, Lackner AA, Veazey RS.

J Virol. 2013 Jun;87(12):7032-8. doi: 10.1128/JVI.00027-13. Epub 2013 Apr 17.

44.

Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection.

Mohan M, Kaushal D, Aye PP, Alvarez X, Veazey RS, Lackner AA.

PLoS One. 2013 Apr 9;8(4):e60122. doi: 10.1371/journal.pone.0060122. Print 2013.

45.

CD8 down-regulation and functional impairment of SIV-specific cytotoxic T lymphocytes in lymphoid and mucosal tissues during SIV infection.

Xu H, Wang X, Lackner AA, Veazey RS.

J Leukoc Biol. 2013 Jun;93(6):943-50. doi: 10.1189/jlb.1112580. Epub 2013 Mar 21.

46.

How well do you know your monkeys?

Kaushal D, Bohm RP Jr, Lackner AA.

J Med Primatol. 2013 Feb;42(1):48-9. doi: 10.1111/jmp.12032. No abstract available.

47.

Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis.

Mehra S, Alvarez X, Didier PJ, Doyle LA, Blanchard JL, Lackner AA, Kaushal D.

J Infect Dis. 2013 Apr;207(7):1115-27. doi: 10.1093/infdis/jis778. Epub 2012 Dec 18.

48.

Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes.

Renner NA, Sansing HA, Inglis FM, Mehra S, Kaushal D, Lackner AA, Maclean AG.

J Cell Physiol. 2013 Jun;228(6):1284-94. doi: 10.1002/jcp.24283.

49.

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.

Breed MW, Jordan AP, Aye PP, Lichtveld CF, Midkiff CC, Schiro FR, Haggarty BS, Sugimoto C, Alvarez X, Sandler NG, Douek DC, Kuroda MJ, Pahar B, Piatak M Jr, Lifson JD, Keele BF, Hoxie JA, Lackner AA.

J Virol. 2013 Feb;87(3):1528-43. doi: 10.1128/JVI.01928-12. Epub 2012 Nov 14.

50.

HIV pathogenesis: the host.

Lackner AA, Lederman MM, Rodriguez B.

Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a007005. doi: 10.1101/cshperspect.a007005. Review.

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