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Items: 1 to 50 of 147

1.

Cytotoxicity, Oxidative Stress, and Autophagy in Human Alveolar Epithelial Cell Line (A549 Cells) Exposed to Standardized Urban Dust.

Lukaszewicz A, Cwiklinska M, Zarzecki M, Szoka P, Lachowicz J, Holownia A.

Adv Exp Med Biol. 2019;1176:101-108. doi: 10.1007/5584_2019_387.

PMID:
31175637
2.

Towards the functional high-resolution coordination chemistry of blood plasma human serum albumin.

Al-Harthi S, Lachowicz JI, Nowakowski ME, Jaremko M, Jaremko Ł.

J Inorg Biochem. 2019 Sep;198:110716. doi: 10.1016/j.jinorgbio.2019.110716. Epub 2019 May 20.

3.

Cigarette Smoke-Induced Oxidative Stress and Autophagy in Human Alveolar Epithelial Cell Line (A549 Cells).

Szoka P, Lachowicz J, Cwiklińska M, Lukaszewicz A, Rybak A, Baranowska U, Holownia A.

Adv Exp Med Biol. 2019;1176:63-69. doi: 10.1007/5584_2019_373.

PMID:
31016633
4.

Iron Chelation for Iron Overload in Thalassemia.

Crisponi G, Nurchi VM, Lachowicz JI.

Met Ions Life Sci. 2019 Jan 14;19. pii: /books/9783110527872/9783110527872-009/9783110527872-009.xml. doi: 10.1515/9783110527872-009. Review.

PMID:
30855104
5.

A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays.

Nurchi VM, de Guadalupe Jaraquemada-Pelaez M, Crisponi G, Lachowicz JI, Cappai R, Gano L, Santos MA, Melchior A, Tolazzi M, Peana M, Medici S, Zoroddu MA.

J Inorg Biochem. 2019 Apr;193:152-165. doi: 10.1016/j.jinorgbio.2019.01.012. Epub 2019 Feb 6.

PMID:
30769225
6.

Phagocytosis and Autophagy in THP-1 Cells Exposed to Urban Dust: Possible Role of LC3-Associated Phagocytosis and Canonical Autophagy.

Holownia A, Niechoda A, Lachowicz J, Golabiewska E, Baranowska U.

Adv Exp Med Biol. 2019;1133:55-63. doi: 10.1007/5584_2018_323.

PMID:
30689175
7.

The interaction of aluminum with catecholamine-based neurotransmitters: can the formation of these species be considered a potential risk factor for neurodegenerative diseases?

Dalla Torre G, Mujika JI, Lachowicz JI, Ramos MJ, Lopez X.

Dalton Trans. 2019 May 7;48(18):6003-6018. doi: 10.1039/c8dt04216k.

PMID:
30688329
8.

Equilibrium studies of new bis-hydroxypyrone derivatives with Fe3+, Al3+, Cu2+ and Zn2.

Nurchi VM, Crisponi G, Lachowicz JI, Jaraquemada-Pelaez MG, Bretti C, Peana M, Medici S, Zoroddu MA.

J Inorg Biochem. 2018 Dec;189:103-114. doi: 10.1016/j.jinorgbio.2018.09.013. Epub 2018 Sep 17.

PMID:
30243118
9.

Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma.

Sadowski AR, Gardner HL, Borgatti A, Wilson H, Vail DM, Lachowicz J, Manley C, Turner A, Klein MK, Waite A, Sahora A, London CA.

BMC Vet Res. 2018 Aug 24;14(1):250. doi: 10.1186/s12917-018-1587-9.

10.

Design of Amperometric Biosensors for the Detection of Glucose Prepared by Immobilization of Glucose Oxidase on Conducting (Poly)Thiophene Films.

Pilo M, Farre R, Lachowicz JI, Masolo E, Panzanelli A, Sanna G, Senes N, Sobral A, Spano N.

J Anal Methods Chem. 2018 Mar 1;2018:1849439. doi: 10.1155/2018/1849439. eCollection 2018.

11.

Salicylamide derivatives for iron and aluminium sequestration. From synthesis to complexation studies.

Lachowicz JI, Crespo-Alonso M, Caltagirone C, Alberti G, Biesuz R, Orton JO, Nurchi VM.

J Trace Elem Med Biol. 2018 Dec;50:580-588. doi: 10.1016/j.jtemb.2018.04.010. Epub 2018 Apr 16.

PMID:
29685783
12.

Tungsten or Wolfram: Friend or Foe?

Zoroddu MA, Medici S, Peana M, Nurchi VM, Lachowicz JI, Laulicht-Glickc F, Costa M.

Curr Med Chem. 2018;25(1):65-74. doi: 10.2174/0929867324666170428105603. Review.

PMID:
28464784
13.

Depleted Uranium and Human Health.

Faa A, Gerosa C, Fanni D, Floris G, Eyken PV, Lachowicz JI, Nurchi VM.

Curr Med Chem. 2018;25(1):49-64. doi: 10.2174/0929867324666170426102343. Review.

PMID:
28462701
14.

Gold - Old Drug with New Potentials.

Faa G, Gerosa C, Fanni D, Lachowicz JI, Nurchi VM.

Curr Med Chem. 2018;25(1):75-84. doi: 10.2174/0929867324666170330091438. Review.

PMID:
28359231
15.

Interaction of a chelating agent, 5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one, with Al(III), Cu(II) and Zn(II) ions.

Peana M, Medici S, Nurchi VM, Lachowicz JI, Crisponi G, Garribba E, Sanna D, Zoroddu MA.

J Inorg Biochem. 2017 Jun;171:18-28. doi: 10.1016/j.jinorgbio.2017.03.001. Epub 2017 Mar 16.

PMID:
28343065
16.

Multi analytical technique study of human bones from an archaeological discovery.

Lachowicz JI, Palomba S, Meloni P, Carboni M, Sanna G, Floris R, Pusceddu V, Sarigu M.

J Trace Elem Med Biol. 2017 Mar;40:54-60. doi: 10.1016/j.jtemb.2016.12.006. Epub 2016 Dec 23.

PMID:
28159222
17.

Complex formation equilibria of Cu2+ and Zn2+ with Irbesartan and Losartan.

Lachowicz JI, Nurchi VM, Crisponi G, Jaraquemada-Pelaez MG, Caltagirone C, Peana M, Zoroddu MA, Szewczuk Z, Cooper GJ.

Eur J Pharm Sci. 2017 Jan 15;97:158-169. doi: 10.1016/j.ejps.2016.11.010. Epub 2016 Nov 10.

PMID:
27838251
18.

Influence of management and biological factors on the parasitic invasions in the wild-spread of blood-sucking nematode Ashworthius sidemi in European bison (Bison bonasus).

Kołodziej-Sobocińska M, Demiaszkiewicz AW, Lachowicz J, Borowik T, Kowalczyk R.

Int J Parasitol Parasites Wildl. 2016 Sep 29;5(3):286-294. eCollection 2016 Dec.

19.

Fluoroquinolones: A micro-species equilibrium in the protonation of amphoteric compounds.

Nurchi VM, Crisponi G, Lachowicz JI, Zoroddu MA, Peana M, Medici S, Veclani D, Tolazzi M, Melchior A.

Eur J Pharm Sci. 2016 Oct 10;93:380-91. doi: 10.1016/j.ejps.2016.08.053. Epub 2016 Aug 30.

PMID:
27586021
20.

Chemical features of in use and in progress chelators for iron overload.

Nurchi VM, Crisponi G, Lachowicz JI, Medici S, Peana M, Zoroddu MA.

J Trace Elem Med Biol. 2016 Dec;38:10-18. doi: 10.1016/j.jtemb.2016.05.010. Epub 2016 Jun 9. Review.

PMID:
27365273
21.

Hydroxypyridinones with enhanced iron chelating properties. Synthesis, characterization and in vivo tests of 5-hydroxy-2-(hydroxymethyl)pyridine-4(1H)-one.

Lachowicz JI, Nurchi VM, Crisponi G, Jaraquemada-Pelaez MG, Arca M, Pintus A, Santos MA, Quintanova C, Gano L, Szewczuk Z, Zoroddu MA, Peana M, Domínguez-Martín A, Choquesillo-Lazarte D.

Dalton Trans. 2016 Apr 21;45(15):6517-28. doi: 10.1039/c6dt00129g.

PMID:
26956442
22.

CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC.

Neuro Oncol. 2015 Nov;17 Suppl 6:vi1-26. doi: 10.1093/neuonc/nov169.

23.

Extension of occurrence area of the American fluke Fascioloides magna in south-western Poland.

Demiaszkiewicz AW, Kuligowska I, Pyziel AM, Lachowicz J, Kowalczyk R.

Ann Parasitol. 2015;61(2):93-6.

24.

Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators.

Lachowicz JI, Nurchi VM, Crisponi G, Jaraquemada-Pelaez Mde G, Ostrowska M, Jezierska J, Gumienna-Kontecka E, Peana M, Zoroddu MA, Choquesillo-Lazarte D, Niclós-Gutiérrez J, González-Pérez JM.

J Inorg Biochem. 2015 Oct;151:94-106. doi: 10.1016/j.jinorgbio.2015.08.011. Epub 2015 Aug 11.

PMID:
26281974
25.

Metal coordination and tyrosinase inhibition studies with Kojic-βAla-Kojic.

Lachowicz JI, Nurchi VM, Crisponi G, Pelaez Mde G, Rescigno A, Stefanowicz P, Cal M, Szewczuk Z.

J Inorg Biochem. 2015 Oct;151:36-43. doi: 10.1016/j.jinorgbio.2015.07.001. Epub 2015 Jul 26.

PMID:
26239546
26.

An NMR study on the 6,6'-(2-(diethylamino)ethylazanediyl)bis(methylene)bis(5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) interaction with Al(III) and Zn(II) ions.

Peana M, Medici S, Nurchi VM, Lachowicz JI, Crisponi G, Crespo-Alonso M, Santos MA, Zoroddu MA.

J Inorg Biochem. 2015 Jul;148:69-77. doi: 10.1016/j.jinorgbio.2015.01.016. Epub 2015 Feb 2.

PMID:
25687185
27.

The prevalence and distribution of Dirofilaria repens in dogs in the Mazovian Province of central-eastern Poland.

Demiaszkiewicz AW, Polańczyk G, Osińska B, Pyziel AM, Kuligowska I, Lachowicz J, Sikorski A.

Ann Agric Environ Med. 2014;21(4):701-4. doi: 10.5604/12321966.1129918.

28.

Doxorubicin chemotherapy for presumptive cardiac hemangiosarcoma in dogs.

Mullin CM, Arkans MA, Sammarco CD, Vail DM, Britton BM, Vickery KR, Risbon RE, Lachowicz J, Burgess KE, Manley CA, Clifford CA.

Vet Comp Oncol. 2016 Dec;14(4):e171-e183. doi: 10.1111/vco.12131. Epub 2014 Dec 18.

PMID:
25524594
29.

ANG4043, a novel brain-penetrant peptide-mAb conjugate, is efficacious against HER2-positive intracranial tumors in mice.

Regina A, Demeule M, Tripathy S, Lord-Dufour S, Currie JC, Iddir M, Annabi B, Castaigne JP, Lachowicz JE.

Mol Cancer Ther. 2015 Jan;14(1):129-40. doi: 10.1158/1535-7163.MCT-14-0399. Epub 2014 Dec 9.

30.

Toxicity of nanoparticles.

Zoroddu MA, Medici S, Ledda A, Nurchi VM, Lachowicz JI, Peana M.

Curr Med Chem. 2014;21(33):3837-53. Review.

PMID:
25306903
31.

Prevalence and distribution of Dirofilaria repens Railliet et Henry, 1911 in dogs in Poland.

Demiaszkiewicz AW, Polańczyk G, Osińska B, Pyziel AM, Kuligowska I, Lachowicz J, Sikorski A.

Pol J Vet Sci. 2014;17(3):515-7.

PMID:
25286663
32.

A new bis-3-hydroxy-4-pyrone as a potential therapeutic iron chelating agent. Effect of connecting and side chains on the complex structures and metal ion selectivity.

Nurchi VM, Crisponi G, Arca M, Crespo-Alonso M, Lachowicz JI, Mansoori D, Toso L, Pichiri G, Amelia Santos M, Marques SM, Niclós-Gutiérrez J, González-Pérez JM, Domínguez-Martín A, Choquesillo-Lazarte D, Szewczuk Z, Antonietta Zoroddu M, Peana M.

J Inorg Biochem. 2014 Dec;141:132-143. doi: 10.1016/j.jinorgbio.2014.09.002. Epub 2014 Sep 16.

PMID:
25260149
33.

The first report of Angiostrongylus vasorum (Nematoda; Metastrongyloidea) in Poland, in red foxes (Vulpes vulpes).

Demiaszkiewicz AW, Pyziel AM, Kuligowska I, Lachowicz J.

Acta Parasitol. 2014 Oct;59(4):758-62. doi: 10.2478/s11686-014-0290-7. Epub 2014 Sep 20.

PMID:
25236289
34.

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses.

Roberts NJ, Zhang L, Janku F, Collins A, Bai RY, Staedtke V, Rusk AW, Tung D, Miller M, Roix J, Khanna KV, Murthy R, Benjamin RS, Helgason T, Szvalb AD, Bird JE, Roy-Chowdhuri S, Zhang HH, Qiao Y, Karim B, McDaniel J, Elpiner A, Sahora A, Lachowicz J, Phillips B, Turner A, Klein MK, Post G, Diaz LA Jr, Riggins GJ, Papadopoulos N, Kinzler KW, Vogelstein B, Bettegowda C, Huso DL, Varterasian M, Saha S, Zhou S.

Sci Transl Med. 2014 Aug 13;6(249):249ra111. doi: 10.1126/scitranslmed.3008982.

35.

The parasitic fauna of the European bison (Bison bonasus) (Linnaeus, 1758) and their impact on the conservation. Part 2. The structure and changes over time.

Karbowiak G, Demiaszkiewicz AW, Pyziel AM, Wita I, Moskwa B, Werszko J, Bień J, Goździk K, Lachowicz J, Cabaj W.

Acta Parasitol. 2014 Sep;59(3):372-9. doi: 10.2478/s11686-014-0253-z. Epub 2014 Aug 15.

PMID:
25119349
36.

The parasitic fauna of the European bison (Bison bonasus) (Linnaeus, 1758) and their impact on the conservation. Part 1. The summarising list of parasites noted.

Karbowiak G, Demiaszkiewicz AW, Pyziel AM, Wita I, Moskwa B, Werszko J, Bień J, Goździk K, Lachowicz J, Cabaj W.

Acta Parasitol. 2014 Sep;59(3):363-71. doi: 10.2478/s11686-014-0252-0. Epub 2014 Aug 15. Review.

PMID:
25119348
37.

Nutritional iron deficiency: the role of oral iron supplementation.

Lachowicz JI, Nurchi VM, Fanni D, Gerosa C, Peana M, Zoroddu MA.

Curr Med Chem. 2014;21(33):3775-84. Review.

PMID:
25005180
38.

Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.

Zhou G, Zorn N, Ting P, Aslanian R, Lin M, Cook J, Lachowicz J, Lin A, Smith M, Hwa J, van Heek M, Walker S.

ACS Med Chem Lett. 2014 Mar 1;5(5):544-9. doi: 10.1021/ml400527n. eCollection 2014 May 8.

39.

Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.

Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1790-4. doi: 10.1016/j.bmcl.2014.02.028. Epub 2014 Feb 19.

PMID:
24618302
40.

Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.

Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P.

J Clin Invest. 2014 Mar;124(3):1199-213. doi: 10.1172/JCI70647. Epub 2014 Feb 17.

41.

The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.

DeMong D, Dai X, Hwa J, Miller M, Lin SI, Kang L, Stamford A, Greenlee W, Yu W, Wong M, Lavey B, Kozlowski J, Zhou G, Yang DY, Patel B, Soriano A, Zhai Y, Sondey C, Zhang H, Lachowicz J, Grotz D, Cox K, Morrison R, Andreani T, Cao Y, Liang M, Meng T, McNamara P, Wong J, Bradley P, Feng KI, Belani J, Chen P, Dai P, Gauuan J, Lin P, Zhao H.

J Med Chem. 2014 Mar 27;57(6):2601-10. doi: 10.1021/jm401858f. Epub 2014 Feb 26.

PMID:
24527772
42.

The first detection of nematodes Ashworthius sidemi in elk Alces alces (L.) in Poland and remarks of ashworthiosis foci limitations.

Demiaszkiewicz AW, Kuligowska I, Lachowicz J, Pyziel AM, Moskwa B.

Acta Parasitol. 2013 Dec;58(4):515-8. doi: 10.2478/s11686-013-0164-4. Epub 2013 Dec 13.

PMID:
24338312
43.

Searching for new aluminium chelating agents: a family of hydroxypyrone ligands.

Toso L, Crisponi G, Nurchi VM, Crespo-Alonso M, Lachowicz JI, Mansoori D, Arca M, Santos MA, Marques SM, Gano L, Niclós-Gutíerrez J, González-Pérez JM, Domínguez-Martín A, Choquesillo-Lazarte D, Szewczuk Z.

J Inorg Biochem. 2014 Jan;130:112-21. doi: 10.1016/j.jinorgbio.2013.09.022. Epub 2013 Oct 18.

PMID:
24200878
44.

Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy.

Kim HM, Smith MD, Kim JH, Caplen MA, Chan TY, McKittrick BA, Cook JA, van Heek M, Lachowicz J.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6410-4. doi: 10.1016/j.bmcl.2013.09.048. Epub 2013 Sep 25.

PMID:
24120540
45.

Manganese and cobalt binding in a multi-histidinic fragment.

Peana M, Medici S, Nurchi VM, Crisponi G, Lachowicz JI, Zoroddu MA.

Dalton Trans. 2013 Dec 14;42(46):16293-301. doi: 10.1039/c3dt51091c.

PMID:
24065052
46.

Bicyclic and tricyclic heterocycle derivatives as histamine H3 receptor antagonists for the treatment of obesity.

de Lera Ruiz M, Zheng J, Berlin MY, McCormick KD, Aslanian RG, West R, Hwa J, Lachowicz J, van Heek M.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):6004-9. doi: 10.1016/j.bmcl.2013.08.013. Epub 2013 Aug 19.

PMID:
24035485
47.

Iron(III) and aluminium(III) complexes with substituted salicyl-aldehydes and salicylic acids.

Nurchi VM, Crespo-Alonso M, Toso L, Lachowicz JI, Crisponi G, Alberti G, Biesuz R, Domínguez-Martín A, Niclós-Gutíerrez J, González-Pérez JM, Zoroddu MA.

J Inorg Biochem. 2013 Nov;128:174-82. doi: 10.1016/j.jinorgbio.2013.07.016. Epub 2013 Jul 18.

PMID:
23932552
48.

Chelation therapy for metal intoxication: comments from a thermodynamic viewpoint.

Nurchi VM, Alonso MC, Toso L, Lachowicz JI, Crisponi G.

Mini Rev Med Chem. 2013 Oct;13(11):1541-9.

PMID:
23895193
49.

A family of hydroxypyrone ligands designed and synthesized as iron chelators.

Toso L, Crisponi G, Nurchi VM, Crespo-Alonso M, Lachowicz JI, Santos MA, Marques SM, Niclós-Gutiérrez J, González-Pérez JM, Domínguez-Martín A, Choquesillo-Lazarte D, Szewczuk Z.

J Inorg Biochem. 2013 Oct;127:220-31. doi: 10.1016/j.jinorgbio.2013.06.009. Epub 2013 Jun 26.

PMID:
23859830
50.

The meaning of aluminium exposure on human health and aluminium-related diseases.

Crisponi G, Fanni D, Gerosa C, Nemolato S, Nurchi VM, Crespo-Alonso M, Lachowicz JI, Faa G.

Biomol Concepts. 2013 Feb;4(1):77-87. doi: 10.1515/bmc-2012-0045. Review.

PMID:
25436567

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