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Items: 1 to 50 of 104

1.

Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra-/- Mice.

Arumugam P, Suzuki T, Shima K, McCarthy C, Sallese A, Wessendarp M, Ma Y, Meyer J, Black D, Chalk C, Carey B, Lachmann N, Moritz T, Trapnell BC.

Mol Ther. 2019 Jul 2. pii: S1525-0016(19)30305-3. doi: 10.1016/j.ymthe.2019.06.010. [Epub ahead of print]

PMID:
31326401
2.

Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis.

Hetzel M, Lopez-Rodriguez E, Mucci A, Nguyen AHH, Suzuki T, Shima K, Buchegger T, Dettmer S, Rodt T, Bankstahl JP, Malik P, Knudsen L, Schambach A, Hansen G, Trapnell BC, Lachmann N, Moritz T.

Haematologica. 2019 Jul 9. pii: haematol.2018.214866. doi: 10.3324/haematol.2018.214866. [Epub ahead of print]

3.

Preformed Donor-Specific HLA Antibodies in Living and Deceased Donor Transplantation: A Multicenter Study.

Ziemann M, Altermann W, Angert K, Arns W, Bachmann A, Bakchoul T, Banas B, von Borstel A, Budde K, Ditt V, Einecke G, Eisenberger U, Feldkamp T, Görg S, Guthoff M, Habicht A, Hallensleben M, Heinemann FM, Hessler N, Hugo C, Kaufmann M, Kauke T, Koch M, König IR, Kurschat C, Lehmann C, Marget M, Mühlfeld A, Nitschke M, Pego da Silva L, Quick C, Rahmel A, Rath T, Reinke P, Renders L, Sommer F, Spriewald B, Staeck O, Stippel D, Süsal C, Thiele B, Zecher D, Lachmann N.

Clin J Am Soc Nephrol. 2019 Jul 5;14(7):1056-1066. doi: 10.2215/CJN.13401118. Epub 2019 Jun 18.

PMID:
31213508
4.

A novel moisturizer with high sun protection factor improves cutaneous barrier function and the visible appearance of rosacea-prone skin.

Baldwin H, Santoro F, Lachmann N, Teissedre S.

J Cosmet Dermatol. 2019 Feb 25. doi: 10.1111/jocd.12889. [Epub ahead of print]

PMID:
30803131
5.

Clazakizumab in late antibody-mediated rejection: study protocol of a randomized controlled pilot trial.

Eskandary F, Dürr M, Budde K, Doberer K, Reindl-Schwaighofer R, Waiser J, Wahrmann M, Regele H, Spittler A, Lachmann N, Firbas C, Mühlbacher J, Bond G, Halloran PF, Chong E, Jilma B, Böhmig GA.

Trials. 2019 Jan 11;20(1):37. doi: 10.1186/s13063-018-3158-6.

6.

Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.

Dannenmann B, Zahabi A, Mir P, Oswald B, Bernhard R, Klimiankou M, Morishima T, Schulze-Osthoff K, Zeidler C, Kanz L, Lachmann N, Moritz T, Welte K, Skokowa J.

Exp Hematol. 2019 Mar;71:51-60. doi: 10.1016/j.exphem.2018.12.006. Epub 2019 Jan 4.

PMID:
30615903
7.

Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells-Ready for Take-Off.

Haake K, Ackermann M, Lachmann N.

Stem Cells Transl Med. 2019 Apr;8(4):332-339. doi: 10.1002/sctm.18-0134. Epub 2018 Dec 26. Review.

8.

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin AR, Brinkert K, Schott JW, Haake K, Kühnel MP, Glage S, Figueiredo C, Jonigk D, Sewald K, Schambach A, Wronski S, Moritz T, Martin U, Zweigerdt R, Munder A, Lachmann N.

Nat Commun. 2018 Nov 30;9(1):5088. doi: 10.1038/s41467-018-07570-7.

9.

An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.

Beneke V, Küster F, Neehus AL, Hesse C, Lopez-Rodriguez E, Haake K, Rafiei Hashtchin A, Schott JW, Walter D, Braun A, Wolkers WF, Ackermann M, Lachmann N.

Sci Rep. 2018 Nov 2;8(1):16281. doi: 10.1038/s41598-018-34524-2.

10.

The regulation of interferon type I pathway-related genes RSAD2 and ETV7 specifically indicates antibody-mediated rejection after kidney transplantation.

Matz M, Heinrich F, Zhang Q, Lorkowski C, Seelow E, Wu K, Lachmann N, Addo RK, Durek P, Mashreghi MF, Budde K.

Clin Transplant. 2018 Dec;32(12):e13429. doi: 10.1111/ctr.13429. Epub 2018 Nov 18.

PMID:
30341925
11.

Age-Dependent Transformation of Skin Biomechanical Properties and Micromorphology during Infancy and Childhood.

Fluhr JW, Bellemère G, Ferrari C, De Belilovsky C, Boyer G, Lachmann N, McGuckin CP, Forraz N, Darlenski R, Chadoutaud B, Msika P, Baudouin C, Pellacani G.

J Invest Dermatol. 2019 Feb;139(2):464-466. doi: 10.1016/j.jid.2018.07.034. Epub 2018 Sep 1. No abstract available.

12.

MicroRNA regulation in blood cells of renal transplanted patients with interstitial fibrosis/tubular atrophy and antibody-mediated rejection.

Matz M, Heinrich F, Lorkowski C, Wu K, Klotsche J, Zhang Q, Lachmann N, Durek P, Budde K, Mashreghi MF.

PLoS One. 2018 Aug 13;13(8):e0201925. doi: 10.1371/journal.pone.0201925. eCollection 2018.

13.

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.

Mucci A, Lopez-Rodriguez E, Hetzel M, Liu S, Suzuki T, Happle C, Ackermann M, Kempf H, Hillje R, Kunkiel J, Janosz E, Brennig S, Glage S, Bankstahl JP, Dettmer S, Rodt T, Gohring G, Trapnell B, Hansen G, Trapnell C, Knudsen L, Lachmann N, Moritz T.

Stem Cell Reports. 2018 Sep 11;11(3):696-710. doi: 10.1016/j.stemcr.2018.07.006. Epub 2018 Aug 9.

14.

Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies.

Mensch A, Beck T, Civello D, Kunigkeit C, Lachmann N, Stock S, Gandjour A, Müller D.

Pharmacoeconomics. 2018 Aug;36(8):987-994. doi: 10.1007/s40273-018-0651-4.

PMID:
29808254
15.

Pulmonary Transplantation of Human Induced Pluripotent Stem Cell-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis.

Happle C, Lachmann N, Ackermann M, Mirenska A, Göhring G, Thomay K, Mucci A, Hetzel M, Glomb T, Suzuki T, Chalk C, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):350-360. doi: 10.1164/rccm.201708-1562OC.

PMID:
29652170
16.

Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival.

Arnold ML, Bach C, Heinemann FM, Horn PA, Ziemann M, Lachmann N, Mühlbacher A, Dick A, Ender A, Thammanichanond D, Schaub S, Hönger G, Fischer GF, Mytilineos J, Hallensleben M, Hitzler WE, Seidl C, Spriewald BM.

Int J Immunogenet. 2018 Jun;45(3):95-101. doi: 10.1111/iji.12363. Epub 2018 Mar 25.

PMID:
29575597
17.

Effects of pregnancy on skin properties: A biomechanical approach.

Boyer G, Lachmann N, Bellemère G, De Belilovsky C, Baudouin C.

Skin Res Technol. 2018 Nov;24(4):551-556. doi: 10.1111/srt.12465. Epub 2018 Feb 26.

PMID:
29479745
18.

Late Steroid Withdrawal Following AB0-Incompatible Renal Transplantation.

Bachmann F, Lachmann N, Budde K, Liefeldt L, Halleck F, Naik M, Friedersdorff F, Rudolph B, Wu K, Meyer O, Slowinski T, Waiser J.

Transplant Proc. 2018 Jan - Feb;50(1):72-78. doi: 10.1016/j.transproceed.2017.12.008.

PMID:
29407335
19.

Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells.

Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH.

Blood Adv. 2017 Jun 2;1(14):903-914. doi: 10.1182/bloodadvances.2016003798. eCollection 2017 Jun 13.

20.

Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages.

Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, Kühnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N.

Stem Cell Reports. 2018 Jan 9;10(1):7-16. doi: 10.1016/j.stemcr.2017.11.011. Epub 2017 Dec 14.

21.

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N.

Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859. Epub 2017 Dec 12.

22.

TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis.

Kuhn A, Ackermann M, Mussolino C, Cathomen T, Lachmann N, Moritz T.

Sci Rep. 2017 Nov 9;7(1):15195. doi: 10.1038/s41598-017-14566-8.

23.

Invited letter in response to "Predicted indirectly recognizable HLA epitopes (PIRCHE): Only the tip of the iceberg?"

Lachmann N, Niemann M, Reinke P, Budde K, Schmidt D, Halleck F, Pruß A, Schönemann C, Spierings E, Staeck O.

Am J Transplant. 2018 Feb;18(2):523-524. doi: 10.1111/ajt.14535. Epub 2017 Nov 4. No abstract available.

24.

Late Conversion to Belatacept After Kidney Transplantation: Outcome and Prognostic Factors.

Dürr M, Lachmann N, Zukunft B, Schmidt D, Budde K, Brakemeier S.

Transplant Proc. 2017 Oct;49(8):1747-1756.e1. doi: 10.1016/j.transproceed.2017.05.013.

PMID:
28923620
25.

Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency.

Hetzel M, Suzuki T, Hashtchin AR, Arumugam P, Carey B, Schwabbauer M, Kuhn A, Meyer J, Schambach A, Van Der Loo J, Moritz T, Trapnell BC, Lachmann N.

Hum Gene Ther Methods. 2017 Dec;28(6):318-329. doi: 10.1089/hgtb.2017.092. Epub 2017 Aug 30.

26.

The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function.

Kunkiel J, Gödecke N, Ackermann M, Hoffmann D, Schambach A, Lachmann N, Wirth D, Moritz T.

Sci Rep. 2017 Aug 11;7(1):7919. doi: 10.1038/s41598-017-04212-8.

27.

Evaluation of a novel very high sun-protection-factor moisturizer in adults with rosacea-prone sensitive skin.

Grivet-Seyve M, Santoro F, Lachmann N.

Clin Cosmet Investig Dermatol. 2017 Jun 10;10:211-219. doi: 10.2147/CCID.S134857. eCollection 2017.

28.

Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells.

Ackermann M, Kuhn A, Kunkiel J, Merkert S, Martin U, Moritz T, Lachmann N.

Transfus Med Hemother. 2017 Jun;44(3):135-142. doi: 10.1159/000477129. Epub 2017 May 16.

29.

Donor-Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes Independently Predicts the Incidence of De Novo Donor-Specific HLA Antibodies Following Renal Transplantation.

Lachmann N, Niemann M, Reinke P, Budde K, Schmidt D, Halleck F, Pruß A, Schönemann C, Spierings E, Staeck O.

Am J Transplant. 2017 Dec;17(12):3076-3086. doi: 10.1111/ajt.14393. Epub 2017 Jul 28.

30.

Unacceptable human leucocyte antigens for organ offers in the era of organ shortage: influence on waiting time before kidney transplantation.

Ziemann M, Heßler N, König IR, Lachmann N, Dick A, Ditt V, Budde K, Reinke P, Eisenberger U, Suwelack B, Klein T, Westhoff TH, Arns W, Ivens K, Habicht A, Renders L, Stippel D, Bös D, Sommer F, Görg S, Nitschke M, Feldkamp T, Heinemann FM, Kelsch R.

Nephrol Dial Transplant. 2017 May 1;32(5):880-889. doi: 10.1093/ndt/gfw462.

PMID:
28340245
31.

Treatment of Antibody-Mediated Renal Allograft Rejection: Improving Step by Step.

Lachmann N, Duerr M, Schönemann C, Pruß A, Budde K, Waiser J.

J Immunol Res. 2017;2017:6872046. doi: 10.1155/2017/6872046. Epub 2017 Jan 31.

32.

Treatment of Acute Antibody-Mediated Renal Allograft Rejection With Cyclophosphamide.

Waiser J, Duerr M, Budde K, Rudolph B, Wu K, Bachmann F, Halleck F, Schönemann C, Lachmann N.

Transplantation. 2017 Oct;101(10):2545-2552. doi: 10.1097/TP.0000000000001617.

PMID:
28009783
33.

Donor Genotype and Intragraft Expression of CYP3A5 Reflect the Response to Steroid Treatment During Acute Renal Allograft Rejection.

Rekers NV, Flaig TM, Mallat MJK, Spruyt-Gerritse MJ, Zandbergen M, Anholts JDH, Bajema IM, Clahsen-van Groningen MC, Yang J, de Fijter JW, Claas FHJ, Brakemeier S, Lachmann N, Kreutz R, de Heer E, Budde K, Bolbrinker J, Eikmans M.

Transplantation. 2017 Sep;101(9):2017-2025. doi: 10.1097/TP.0000000000001584.

PMID:
27926596
34.

Effect of ABO incompatibility on T-cell flow cytometry cross-match results prior to living donor kidney transplantation.

Lindemann M, Lenz V, Nyadu B, Heinemann FM, Heinold A, Guberina H, Eisenberger U, Lachmann N, Schönemann C, Kribben A, Paul A, Horn PA, Witzke O.

Cytometry B Clin Cytom. 2018 Jul;94(4):623-630. doi: 10.1002/cyto.b.21496. Epub 2016 Dec 7.

35.

Rituximab in Combination With Bortezomib, Plasmapheresis, and High-Dose IVIG to Treat Antibody-Mediated Renal Allograft Rejection.

Waiser J, Duerr M, Schönemann C, Rudolph B, Wu K, Halleck F, Budde K, Lachmann N.

Transplant Direct. 2016 Jul 1;2(8):e91. eCollection 2016 Aug.

36.

Lung surfactant metabolism: early in life, early in disease and target in cell therapy.

Lopez-Rodriguez E, Gay-Jordi G, Mucci A, Lachmann N, Serrano-Mollar A.

Cell Tissue Res. 2017 Mar;367(3):721-735. doi: 10.1007/s00441-016-2520-9. Epub 2016 Oct 25. Review.

PMID:
27783217
37.

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.

Circulation. 2016 Dec 13;134(24):1973-1990. Epub 2016 Oct 25.

PMID:
27780851
38.

Clinical Outcome of Patients With De Novo C1q-Binding Donor-Specific HLA Antibodies After Renal Transplantation.

Bamoulid J, Roodenburg A, Staeck O, Wu K, Rudolph B, Brakemeier S, Halleck F, Lehner L, Schönemann C, Lachmann N, Budde K.

Transplantation. 2017 Sep;101(9):2165-2174. doi: 10.1097/TP.0000000000001487.

PMID:
27653301
39.

Non-HLA Antibodies May Accelerate Immune Responses After Intestinal and Multivisceral Transplantation.

Gerlach UA, Lachmann N, Ranucci G, Sawitzki B, Schoenemann C, Pratschke J, Dragun D, Pascher A.

Transplantation. 2017 Jan;101(1):141-149. doi: 10.1097/TP.0000000000001439.

PMID:
27495766
40.

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N.

Stem Cell Reports. 2016 Aug 9;7(2):292-305. doi: 10.1016/j.stemcr.2016.06.011. Epub 2016 Jul 21.

41.

Immunologic outcome in elderly kidney transplant recipients: is it time for HLA-DR matching?

Halleck F, Khadzhynov D, Liefeldt L, Schrezenmeier E, Lehner L, Duerr M, Schmidt D, Bamoulid J, Lachmann N, Waiser J, Budde K, Staeck O.

Nephrol Dial Transplant. 2016 Dec;31(12):2143-2149. Epub 2016 Jul 1.

PMID:
27369852
42.

Generation of HLA-Universal iPSC-Derived Megakaryocytes and Platelets for Survival Under Refractoriness Conditions.

Börger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C.

Mol Med. 2016 Sep;22:274-285. doi: 10.2119/molmed.2015.00235. Epub 2016 May 16.

43.

Dynamics and epitope specificity of anti-human leukocyte antibodies following renal allograft nephrectomy.

Lachmann N, Schönemann C, El-Awar N, Everly M, Budde K, Terasaki PI, Waiser J.

Nephrol Dial Transplant. 2016 Aug;31(8):1351-9. doi: 10.1093/ndt/gfw041. Epub 2016 Apr 19.

PMID:
27190369
45.

Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice.

Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Dalüge K, Hennig C, Moritz T, Happle C, Hansen G.

Eur J Immunol. 2016 Jul;46(7):1656-68. doi: 10.1002/eji.201546200. Epub 2016 May 27.

46.

Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1).

Brennig S, Lachmann N, Buchegger T, Hetzel M, Schambach A, Moritz T.

J Exp Clin Cancer Res. 2015 Dec 12;34:148. doi: 10.1186/s13046-015-0260-4.

47.

Complement-fixing antibodies against denatured HLA and MICA antigens are associated with antibody mediated rejection.

Cai J, Terasaki PI, Zhu D, Lachmann N, Schönemann C, Everly MJ, Qing X.

Exp Mol Pathol. 2016 Feb;100(1):45-50. doi: 10.1016/j.yexmp.2015.11.023. Epub 2015 Nov 23.

PMID:
26615783
48.

Identification of T Cell-Mediated Vascular Rejection After Kidney Transplantation by the Combined Measurement of 5 Specific MicroRNAs in Blood.

Matz M, Fabritius K, Lorkowski C, Dürr M, Gaedeke J, Durek P, Grün JR, Goestemeyer A, Bachmann F, Wu K, Rudolph B, Schmidt D, Weber U, Haftmann C, Unterwalder N, Lachmann N, Radbruch A, Neumayer HH, Mashreghi MF, Budde K.

Transplantation. 2016 Apr;100(4):898-907. doi: 10.1097/TP.0000000000000873.

PMID:
26444957
49.

TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T.

Biomaterials. 2015 Nov;69:191-200. doi: 10.1016/j.biomaterials.2015.07.057. Epub 2015 Aug 3.

PMID:
26295532
50.

Lost in translation: pluripotent stem cell-derived hematopoiesis.

Ackermann M, Liebhaber S, Klusmann JH, Lachmann N.

EMBO Mol Med. 2015 Nov;7(11):1388-402. doi: 10.15252/emmm.201505301. Review.

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