Format

Send to

Choose Destination
Sci Adv. 2017 Oct 11;3(10):eaao1874. doi: 10.1126/sciadv.aao1874. eCollection 2017 Oct.

Increased weight gain by C-section: Functional significance of the primordial microbiome.

Author information

1
Division of Translational Medicine, Department of Medicine, New York University, School of Medicine, New York, NY 10016, USA.
2
Sackler Institute of Graduate Biomedical Sciences, Department of Microbiology, New York University, School of Medicine, New York, NY 10016, USA.

Abstract

Epidemiological evidence supports a direct association between early microbiota impact-including C-section-and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section-born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relationship between C-section and increased body weight, supporting the involvement of maternal vaginal bacteria in normal metabolic development.

PMID:
29026883
PMCID:
PMC5636202
DOI:
10.1126/sciadv.aao1874
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center