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Osteoprotegerin is an effective countermeasure for spaceflight-induced bone loss in mice.

Lloyd SA, Morony SE, Ferguson VL, Simske SJ, Stodieck LS, Warmington KS, Livingston EW, Lacey DL, Kostenuik PJ, Bateman TA.

Bone. 2015 Dec;81:562-572. doi: 10.1016/j.bone.2015.08.021. Epub 2015 Aug 28.


Depression and borderline personality disorder.

Lacey DL.

Med J Aust. 2012 Dec 10;197(11):620; author reply 620-1. No abstract available.


Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.

Lacey DL, Boyle WJ, Simonet WS, Kostenuik PJ, Dougall WC, Sullivan JK, San Martin J, Dansey R.

Nat Rev Drug Discov. 2012 May;11(5):401-19. doi: 10.1038/nrd3705. Review.


Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury.

Li X, Grisanti M, Fan W, Asuncion FJ, Tan HL, Dwyer D, Han CY, Yu L, Lee J, Lee E, Barrero M, Kurimoto P, Niu QT, Geng Z, Winters A, Horan T, Steavenson S, Jacobsen F, Chen Q, Haldankar R, Lavallee J, Tipton B, Daris M, Sheng J, Lu HS, Daris K, Deshpande R, Valente EG, Salimi-Moosavi H, Kostenuik PJ, Li J, Liu M, Li C, Lacey DL, Simonet WS, Ke HZ, Babij P, Stolina M, Ominsky MS, Richards WG.

J Bone Miner Res. 2011 Nov;26(11):2610-21. doi: 10.1002/jbmr.472.


Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones.

Ominsky MS, Li C, Li X, Tan HL, Lee E, Barrero M, Asuncion FJ, Dwyer D, Han CY, Vlasseros F, Samadfam R, Jolette J, Smith SY, Stolina M, Lacey DL, Simonet WS, Paszty C, Li G, Ke HZ.

J Bone Miner Res. 2011 May;26(5):1012-21. doi: 10.1002/jbmr.307.


Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.

Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, Rosenfeld R, Chen Q, Boone T, Simonet WS, Lacey DL, Goldberg AL, Han HQ.

Cell. 2010 Aug 20;142(4):531-43. doi: 10.1016/j.cell.2010.07.011.


Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength.

Ominsky MS, Vlasseros F, Jolette J, Smith SY, Stouch B, Doellgast G, Gong J, Gao Y, Cao J, Graham K, Tipton B, Cai J, Deshpande R, Zhou L, Hale MD, Lightwood DJ, Henry AJ, Popplewell AG, Moore AR, Robinson MK, Lacey DL, Simonet WS, Paszty C.

J Bone Miner Res. 2010 May;25(5):948-59. doi: 10.1002/jbmr.14.


Effects of spaceflight on murine skeletal muscle gene expression.

Allen DL, Bandstra ER, Harrison BC, Thorng S, Stodieck LS, Kostenuik PJ, Morony S, Lacey DL, Hammond TG, Leinwand LL, Argraves WS, Bateman TA, Barth JL.

J Appl Physiol (1985). 2009 Feb;106(2):582-95. doi: 10.1152/japplphysiol.90780.2008. Epub 2008 Dec 12. Erratum in: J Appl Physiol. 2011 Jan;110(1):298.


Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis.

Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, Gao Y, Shalhoub V, Tipton B, Haldankar R, Chen Q, Winters A, Boone T, Geng Z, Niu QT, Ke HZ, Kostenuik PJ, Simonet WS, Lacey DL, Paszty C.

J Bone Miner Res. 2009 Apr;24(4):578-88. doi: 10.1359/jbmr.081206.


Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.

Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, Kurahara C, Gao Y, Cao J, Gong J, Asuncion F, Barrero M, Warmington K, Dwyer D, Stolina M, Morony S, Sarosi I, Kostenuik PJ, Lacey DL, Simonet WS, Ke HZ, Paszty C.

J Bone Miner Res. 2008 Jun;23(6):860-9. doi: 10.1359/jbmr.080216.


Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols.

Shalhoub V, Shatzen E, Henley C, Boedigheimer M, McNinch J, Manoukian R, Damore M, Fitzpatrick D, Haas K, Twomey B, Kiaei P, Ward S, Lacey DL, Martin D.

Calcif Tissue Int. 2006 Dec;79(6):431-42. Epub 2006 Dec 8.


Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.

Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, Morony S, Adamu S, Geng Z, Qiu W, Kostenuik P, Lacey DL, Simonet WS, Bolon B, Qian X, Shalhoub V, Ominsky MS, Zhu Ke H, Li X, Richards WG.

Bone. 2006 Oct;39(4):754-66. Epub 2006 May 26.


CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin.

Byrne FR, Morony S, Warmington K, Geng Z, Brown HL, Flores SA, Fiorino M, Yin SL, Hill D, Porkess V, Duryea D, Pretorius JK, Adamu S, Manoukian R, Danilenko DM, Sarosi I, Lacey DL, Kostenuik PJ, Senaldi G.

Gut. 2005 Jan;54(1):78-86. Erratum in: Gut. 2005 Feb;54(2):316. Manuokian, R [corrected to Manoukian, R].


Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.

Kwak KS, Zhou X, Solomon V, Baracos VE, Davis J, Bannon AW, Boyle WJ, Lacey DL, Han HQ.

Cancer Res. 2004 Nov 15;64(22):8193-8.


The effects of osteoprotegerin on the mechanical properties of rat bone.

Ross AB, Bateman TA, Kostenuik PJ, Ferguson VL, Lacey DL, Dunstan CR, Simske SJ.

J Mater Sci Mater Med. 2001 Jul;12(7):583-8.


Osteoclast differentiation and activation.

Boyle WJ, Simonet WS, Lacey DL.

Nature. 2003 May 15;423(6937):337-42. Review.


Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation.

Haddad IY, Milla C, Yang S, Panoskaltsis-Mortari A, Hawgood S, Lacey DL, Blazar BR.

Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L602-10. Epub 2003 May 9.


Role of RANK ligand in mediating increased bone resorption in early postmenopausal women.

Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL.

J Clin Invest. 2003 Apr;111(8):1221-30.


Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions.

Pecaut MJ, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ, Gridley DS.

J Appl Physiol (1985). 2003 May;94(5):2085-94. Epub 2003 Jan 3.


Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets.

Gridley DS, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ, Pecaut MJ.

J Appl Physiol (1985). 2003 May;94(5):2095-103. Epub 2002 Dec 27.


The effects of keratinocyte growth factor in preclinical models of mucositis.

Farrell CL, Rex KL, Chen JN, Bready JV, DiPalma CR, Kaufman SA, Rattan A, Scully S, Lacey DL.

Cell Prolif. 2002 Aug;35 Suppl 1:78-85. Review.


Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.

Rossi S, Blazar BR, Farrell CL, Danilenko DM, Lacey DL, Weinberg KI, Krenger W, Holländer GA.

Blood. 2002 Jul 15;100(2):682-91.


Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation.

Min D, Taylor PA, Panoskaltsis-Mortari A, Chung B, Danilenko DM, Farrell C, Lacey DL, Blazar BR, Weinberg KI.

Blood. 2002 Jun 15;99(12):4592-600.


rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease.

Byrne FR, Farrell CL, Aranda R, Rex KL, Scully S, Brown HL, Flores SA, Gu LH, Danilenko DM, Lacey DL, Ziegler TR, Senaldi G.

Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G690-701.


Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development.

Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A, Copeland NG, Gilbert DJ, Jenkins NA, Scully S, Lacey DL, Katsuki M, Asashima M, Yokota T.

Development. 2001 Aug;128(16):3105-15.


Regulation of glutathione redox status in lung and liver by conditioning regimens and keratinocyte growth factor in murine allogeneic bone marrow transplantation.

Ziegler TR, Panoskaltsus-Mortari A, Gu LH, Jonas CR, Farrell CL, Lacey DL, Jones DP, Blazar BR.

Transplantation. 2001 Oct 27;72(8):1354-62.


OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats.

Kostenuik PJ, Capparelli C, Morony S, Adamu S, Shimamoto G, Shen V, Lacey DL, Dunstan CR.

Endocrinology. 2001 Oct;142(10):4295-304.


Osteoprotegerin ameliorates sciatic nerve crush induced bone loss.

Bateman TA, Dunstan CR, Lacey DL, Ferguson VL, Ayers RA, Simske SJ.

J Orthop Res. 2001 Jul;19(4):518-23.


Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis.

Morony S, Capparelli C, Sarosi I, Lacey DL, Dunstan CR, Kostenuik PJ.

Cancer Res. 2001 Jun 1;61(11):4432-6.


Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis.

Bolon B, Carter C, Daris M, Morony S, Capparelli C, Hsieh A, Mao M, Kostenuik P, Dunstan CR, Lacey DL, Sheng JZ.

Mol Ther. 2001 Feb;3(2):197-205.


Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice.

Clohisy DR, Ramnaraine ML, Scully S, Qi M, Van G, Tan HL, Lacey DL.

J Orthop Res. 2000 Nov;18(6):967-76.


Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice.

Farrell CL, Rex KL, Kaufman SA, Dipalma CR, Chen JN, Scully S, Lacey DL.

Int J Radiat Biol. 1999 May;75(5):609-20.


Characterization of osteoclast precursors in human blood.

Shalhoub V, Elliott G, Chiu L, Manoukian R, Kelley M, Hawkins N, Davy E, Shimamoto G, Beck J, Kaufman SA, Van G, Scully S, Qi M, Grisanti M, Dunstan C, Boyle WJ, Lacey DL.

Br J Haematol. 2000 Nov;111(2):501-12.


Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury.

Panoskaltsis-Mortari A, Taylor PA, Rubin JS, Uren A, Welniak LA, Murphy WJ, Farrell CL, Lacey DL, Blazar BR.

Blood. 2000 Dec 15;96(13):4350-6.


Cyclophosphamide prevents systemic keratinocyte growth factor-induced up-regulation of surfactant protein A after allogeneic transplant in mice.

Yang S, Panoskaltsis-Mortari A, Ingbar DH, Matalon S, Zhu S, Resnik ER, Farrell CL, Lacey DL, Blazar BR, Haddad IY.

Am J Respir Crit Care Med. 2000 Nov;162(5):1884-90.


The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.

Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM.

Cell. 2000 Sep 29;103(1):41-50.


Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis.

Min H, Morony S, Sarosi I, Dunstan CR, Capparelli C, Scully S, Van G, Kaufman S, Kostenuik PJ, Lacey DL, Boyle WJ, Simonet WS.

J Exp Med. 2000 Aug 21;192(4):463-74.


Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo.

Lacey DL, Tan HL, Lu J, Kaufman S, Van G, Qiu W, Rattan A, Scully S, Fletcher F, Juan T, Kelley M, Burgess TL, Boyle WJ, Polverino AJ.

Am J Pathol. 2000 Aug;157(2):435-48.


Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation.

Panoskaltsis-Mortari A, Strieter RM, Hermanson JR, Fegeding KV, Murphy WJ, Farrell CL, Lacey DL, Blazar BR.

Blood. 2000 Aug 1;96(3):834-9.


Carbon dioxide angiography: effect of injection parameters on bolus configuration.

Lang EV, Gossler AA, Fick LJ, Barnhart W, Lacey DL.

J Vasc Interv Radiol. 1999 Jan;10(1):41-9.


KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT.

Panoskaltsis-Mortari A, Ingbar DH, Jung P, Haddad IY, Bitterman PB, Wangensteen OD, Farrell CL, Lacey DL, Blazar BR.

Am J Physiol Lung Cell Mol Physiol. 2000 May;278(5):L988-99.


Osteoprotegerin mitigates tail suspension-induced osteopenia.

Bateman TA, Dunstan CR, Ferguson VL, Lacey DL, Ayers RA, Simske SJ.

Bone. 2000 May;26(5):443-9.


Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy.

Capparelli C, Kostenuik PJ, Morony S, Starnes C, Weimann B, Van G, Scully S, Qi M, Lacey DL, Dunstan CR.

Cancer Res. 2000 Feb 15;60(4):783-7.


RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.

Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Van G, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1566-71.


The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.

Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL.

J Bone Miner Res. 2000 Jan;15(1):2-12. Review.


Effects of keratinocyte growth factor in the endometrium of rhesus macaques during the luteal-follicular transition.

Slayden OD, Rubin JS, Lacey DL, Brenner RM.

J Clin Endocrinol Metab. 2000 Jan;85(1):275-85.


Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM.

Nature. 1999 Nov 18;402(6759):304-9.


Ectopic overexpression of c-mpl by retroviral-mediated gene transfer suppressed megakaryopoiesis but enhanced erythropoiesis in mice.

Yan XQ, Lacey DL, Saris C, Mu S, Hill D, Hawley RG, Fletcher FA.

Exp Hematol. 1999 Sep;27(9):1409-17.


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