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Items: 1 to 50 of 172

1.

Phosphodiesterase PdeD, dynacortin, and a Kelch repeat-containing protein are direct GSK3 substrates in Dictyostelium that contribute to chemotaxis towards cAMP.

Baumgardner K, Lin C, Firtel RA, Lacal J.

Environ Microbiol. 2018 May;20(5):1888-1903. doi: 10.1111/1462-2920.14126.

PMID:
29626371
2.

Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.

Valdés-Mora F, Locke WJ, Bandrés E, Gallego-Ortega D, Cejas P, García-Cabezas MA, Colino-Sanguino Y, Feliú J, Del Pulgar TG, Lacal JC.

Oncotarget. 2017 Apr 18;8(16):26755-26770. doi: 10.18632/oncotarget.15815.

3.

Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization.

Liu Y, Lacal J, Firtel RA, Kortholt A.

Small GTPases. 2018 Jul 4;9(4):360-364. doi: 10.1080/21541248.2016.1235390. Epub 2016 Oct 14.

4.

A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis.

Liu Y, Lacal J, Veltman DM, Fusetti F, van Haastert PJ, Firtel RA, Kortholt A.

Dev Cell. 2016 Jun 6;37(5):458-72. doi: 10.1016/j.devcel.2016.05.001. Epub 2016 May 26.

5.

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.

Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV.

Oncotarget. 2016 Mar 15;7(11):12582-97. doi: 10.18632/oncotarget.7179.

6.

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

Mazarico JM, Sánchez-Arévalo Lobo VJ, Favicchio R, Greenhalf W, Costello E, Carrillo-de Santa Pau E, Marqués M, Lacal JC, Aboagye E, Real FX.

Mol Cancer Ther. 2016 Feb;15(2):323-33. doi: 10.1158/1535-7163.MCT-15-0214. Epub 2016 Jan 14.

7.
8.

A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products.

Estévez-Braun A, Ravelo AG, Pérez-Sacau E, Lacal JC.

Clin Transl Oncol. 2015 Jan;17(1):74-84. doi: 10.1007/s12094-014-1260-0. Epub 2014 Dec 4.

PMID:
25472447
9.

Internal sense of direction: sensing and signaling from cytoplasmic chemoreceptors.

Collins KD, Lacal J, Ottemann KM.

Microbiol Mol Biol Rev. 2014 Dec;78(4):672-84. doi: 10.1128/MMBR.00033-14. Review.

10.

Choline kinase inhibition in rheumatoid arthritis.

Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS.

Ann Rheum Dis. 2015 Jul;74(7):1399-407. doi: 10.1136/annrheumdis-2014-205696. Epub 2014 Oct 1.

11.
12.

Characterization of molecular interactions using isothermal titration calorimetry.

Krell T, Lacal J, García-Fontana C, Silva-Jiménez H, Rico-Jiménez M, Lugo AC, Darias JA, Ramos JL.

Methods Mol Biol. 2014;1149:193-203. doi: 10.1007/978-1-4939-0473-0_16.

PMID:
24818906
13.

Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase.

Zimmerman T, Moneriz C, Diez A, Bautista JM, Gómez Del Pulgar T, Cebrián A, Lacal JC.

Antimicrob Agents Chemother. 2013 Dec;57(12):5878-88. doi: 10.1128/AAC.00920-13. Epub 2013 Sep 16.

14.

Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.

Cebrián A, Taron M, Sala N, Ardanaz E, Chirlaque MD, Larrañaga N, Redondo ML, Sánchez MJ, Gómez del Pulgar T, Camps C, Rosell R, González CA, Lacal JC.

Clin Transl Oncol. 2014 Jan;16(1):107-12. doi: 10.1007/s12094-013-1080-7. Epub 2013 Jul 30.

PMID:
23896864
15.

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

de la Cueva A, Ramírez de Molina A, Alvarez-Ayerza N, Ramos MA, Cebrián A, Del Pulgar TG, Lacal JC.

PLoS One. 2013 Jun 10;8(6):e64961. doi: 10.1371/journal.pone.0064961. Print 2013.

16.

Tactic responses to pollutants and their potential to increase biodegradation efficiency.

Lacal J, Reyes-Darias JA, García-Fontana C, Ramos JL, Krell T.

J Appl Microbiol. 2013 Apr;114(4):923-33. doi: 10.1111/jam.12076. Epub 2012 Dec 18. Review.

17.

Protein chimerism: novel source of protein diversity in humans adds complexity to bottom-up proteomics.

Casado-Vela J, Lacal JC, Elortza F.

Proteomics. 2013 Jan;13(1):5-11. doi: 10.1002/pmic.201200371. Epub 2012 Dec 12.

PMID:
23161619
18.

Evidence for chemoreceptors with bimodular ligand-binding regions harboring two signal-binding sites.

Pineda-Molina E, Reyes-Darias JA, Lacal J, Ramos JL, García-Ruiz JM, Gavira JA, Krell T.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18926-31. doi: 10.1073/pnas.1201400109. Epub 2012 Oct 29.

19.

Bioavailability of pollutants and chemotaxis.

Krell T, Lacal J, Reyes-Darias JA, Jimenez-Sanchez C, Sungthong R, Ortega-Calvo JJ.

Curr Opin Biotechnol. 2013 Jun;24(3):451-6. doi: 10.1016/j.copbio.2012.08.011. Epub 2012 Sep 13. Review.

PMID:
22981870
20.

Analysis of solvent tolerance in Pseudomonas putida DOT-T1E based on its genome sequence and a collection of mutants.

Udaondo Z, Duque E, Fernández M, Molina L, de la Torre J, Bernal P, Niqui JL, Pini C, Roca A, Matilla MA, Molina-Henares MA, Silva-Jiménez H, Navarro-Avilés G, Busch A, Lacal J, Krell T, Segura A, Ramos JL.

FEBS Lett. 2012 Aug 31;586(18):2932-8. doi: 10.1016/j.febslet.2012.07.031. Epub 2012 Jul 20. Review.

21.

Upregulation of trefoil factor 3 (TFF3) after rectal cancer chemoradiotherapy is an adverse prognostic factor and a potential therapeutic target.

Casado E, Garcia VM, Sánchez JJ, Gómez Del Pulgar MT, Feliu J, Maurel J, Castelo B, Moreno Rubio J, López RA, García-Cabezas MÁ, Burgos E, de Castro J, Belda-Iniesta C, López-Gómez M, Gómez-Raposo C, Zambrana F, Sereno M, Fernández-Martos C, Vázquez P, Lacal JC, González-Barón M, Cejas P.

Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):1151-8. doi: 10.1016/j.ijrobp.2012.01.083. Epub 2012 Apr 18.

PMID:
22516806
22.

Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.

Ramírez de Molina A, de la Cueva A, Machado-Pinilla R, Rodriguez-Fanjul V, Gomez del Pulgar T, Cebrian A, Perona R, Lacal JC.

Curr Cancer Drug Targets. 2012 Jul;12(6):617-24.

PMID:
22515519
23.

Crystallization and crystallographic analysis of the ligand-binding domain of the Pseudomonas putida chemoreceptor McpS in complex with malate and succinate.

Gavira JA, Lacal J, Ramos JL, García-Ruiz JM, Krell T, Pineda-Molina E.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):428-31. doi: 10.1107/S1744309112004940. Epub 2012 Mar 27.

24.

Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium.

Pintzas A, Zhivotovsky B, Workman P, Clarke PA, Linardopoulos S, Martinou JC, Lacal JC, Robine S, Nasioulas G, Andera L.

Cancer Biol Ther. 2012 May;13(7):458-66. doi: 10.4161/cbt.19600. Epub 2012 May 1. Review.

PMID:
22406997
25.

Responses of Pseudomonas putida to toxic aromatic carbon sources.

Krell T, Lacal J, Guazzaroni ME, Busch A, Silva-Jiménez H, Fillet S, Reyes-Darías JA, Muñoz-Martínez F, Rico-Jiménez M, García-Fontana C, Duque E, Segura A, Ramos JL.

J Biotechnol. 2012 Jul 31;160(1-2):25-32. doi: 10.1016/j.jbiotec.2012.01.026. Epub 2012 Feb 1.

PMID:
22321573
26.

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics.

Casado-Vela J, Cebrián A, Gómez del Pulgar MT, Lacal JC.

Clin Transl Oncol. 2011 Sep;13(9):617-28. doi: 10.1007/s12094-011-0707-9. Review.

PMID:
21865133
27.

Human urine proteomics: building a list of human urine cancer biomarkers.

Casado-Vela J, Gómez del Pulgar T, Cebrián A, Alvarez-Ayerza N, Lacal JC.

Expert Rev Proteomics. 2011 Jun;8(3):347-60. doi: 10.1586/epr.11.26. Review.

PMID:
21679116
28.

Bacterial chemotaxis towards aromatic hydrocarbons in Pseudomonas.

Lacal J, Muñoz-Martínez F, Reyes-Darías JA, Duque E, Matilla M, Segura A, Calvo JJ, Jímenez-Sánchez C, Krell T, Ramos JL.

Environ Microbiol. 2011 Jul;13(7):1733-44. doi: 10.1111/j.1462-2920.2011.02493.x. Epub 2011 May 23.

PMID:
21605304
29.

The pGRT1 plasmid of Pseudomonas putida DOT-T1E encodes functions relevant for survival under harsh conditions in the environment.

Molina L, Duque E, Gómez MJ, Krell T, Lacal J, García-Puente A, García V, Matilla MA, Ramos JL, Segura A.

Environ Microbiol. 2011 Aug;13(8):2315-27. doi: 10.1111/j.1462-2920.2011.02492.x. Epub 2011 May 23.

PMID:
21605303
30.

Physiologically relevant divalent cations modulate citrate recognition by the McpS chemoreceptor.

Lacal J, García-Fontana C, Callejo-García C, Ramos JL, Krell T.

J Mol Recognit. 2011 Mar-Apr;24(2):378-85. doi: 10.1002/jmr.1101.

PMID:
21360620
31.

Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications.

Casado-Vela J, Cebrián A, Gómez del Pulgar MT, Sánchez-López E, Vilaseca M, Menchén L, Diema C, Sellés-Marchart S, Martínez-Esteso MJ, Yubero N, Bru-Martínez R, Lacal JC.

Proteomics. 2011 Feb;11(4):590-603. doi: 10.1002/pmic.201000287. Epub 2011 Jan 13. Review. Erratum in: Proteomics. 2011 Apr;11(7):1370. Lacal, Juan Caelos [corrected to Lacal, Juan Carlos].

PMID:
21229583
32.

Diversity at its best: bacterial taxis.

Krell T, Lacal J, Muñoz-Martínez F, Reyes-Darias JA, Cadirci BH, García-Fontana C, Ramos JL.

Environ Microbiol. 2011 May;13(5):1115-24. doi: 10.1111/j.1462-2920.2010.02383.x. Epub 2010 Nov 18. Review.

PMID:
21087385
33.

Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions.

Gallego-Ortega D, Gómez del Pulgar T, Valdés-Mora F, Cebrián A, Lacal JC.

Adv Enzyme Regul. 2011;51(1):183-94. doi: 10.1016/j.advenzreg.2010.09.010. Epub 2010 Oct 28. Review.

PMID:
21035492
34.

Bacterial sensor kinases: diversity in the recognition of environmental signals.

Krell T, Lacal J, Busch A, Silva-Jiménez H, Guazzaroni ME, Ramos JL.

Annu Rev Microbiol. 2010;64:539-59. doi: 10.1146/annurev.micro.112408.134054. Review.

PMID:
20825354
35.

Sensing of environmental signals: classification of chemoreceptors according to the size of their ligand binding regions.

Lacal J, García-Fontana C, Muñoz-Martínez F, Ramos JL, Krell T.

Environ Microbiol. 2010 Nov;12(11):2873-84. doi: 10.1111/j.1462-2920.2010.02325.x. Epub 2010 Aug 25. Review.

PMID:
20738376
36.

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramírez de Molina A, Lacal JC, Workman P, Leach MO.

Cancer Res. 2010 Jul 1;70(13):5507-17. doi: 10.1158/0008-5472.CAN-09-4476. Epub 2010 Jun 15.

37.

Catabolite repression of the TodS/TodT two-component system and effector-dependent transphosphorylation of TodT as the basis for toluene dioxygenase catabolic pathway control.

Busch A, Lacal J, Silva-Jímenez H, Krell T, Ramos JL.

J Bacteriol. 2010 Aug;192(16):4246-50. doi: 10.1128/JB.00379-10. Epub 2010 Jun 11.

38.

Identification of a chemoreceptor for tricarboxylic acid cycle intermediates: differential chemotactic response towards receptor ligands.

Lacal J, Alfonso C, Liu X, Parales RE, Morel B, Conejero-Lara F, Rivas G, Duque E, Ramos JL, Krell T.

J Biol Chem. 2010 Jul 23;285(30):23126-36. doi: 10.1074/jbc.M110.110403. Epub 2010 May 24.

39.

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.

Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J.

Mol Cancer. 2009 Dec 31;8:131. doi: 10.1186/1476-4598-8-131.

40.

Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.

Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC.

PLoS One. 2009 Nov 12;4(11):e7819. doi: 10.1371/journal.pone.0007819.

41.

The enigma of cytosolic two-component systems: a hypothesis.

Krell T, Busch A, Lacal J, Silva-Jiménez H, Ramos JL.

Environ Microbiol Rep. 2009 Jun;1(3):171-6. doi: 10.1111/j.1758-2229.2009.00020.x. Epub 2009 Feb 24.

PMID:
23765790
42.

A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas.

Hernando E, Sarmentero-Estrada J, Koppie T, Belda-Iniesta C, Ramírez de Molina V, Cejas P, Ozu C, Le C, Sánchez JJ, González-Barón M, Koutcher J, Cordón-Cardó C, Bochner BH, Lacal JC, Ramírez de Molina A.

Oncogene. 2009 Jul 2;28(26):2425-35. doi: 10.1038/onc.2009.91. Epub 2009 May 18.

43.

The sensor kinase TodS operates by a multiple step phosphorelay mechanism involving two autokinase domains.

Busch A, Guazzaroni ME, Lacal J, Ramos JL, Krell T.

J Biol Chem. 2009 Apr 17;284(16):10353-60. doi: 10.1074/jbc.M900521200. Epub 2009 Feb 24.

44.

Choline kinase alpha depletion selectively kills tumoral cells.

Bañez-Coronel M, Ramírez de Molina A, Rodríguez-González A, Sarmentero J, Ramos MA, García-Cabezas MA, García-Oroz L, Lacal JC.

Curr Cancer Drug Targets. 2008 Dec;8(8):709-19.

PMID:
19075594
45.

Clinical and Translational Oncology accepted in SciSearch and journal citation reports.

Lacal JC.

Clin Transl Oncol. 2008 Dec;10(12):773. No abstract available.

PMID:
19068446
46.

FESEO and Clinical & Translational Oncology: a brief historical perspective.

Lacal JC.

Clin Transl Oncol. 2008 Nov;10(11):683-4. No abstract available.

PMID:
19015063
47.

TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer.

Valdés-Mora F, Gómez del Pulgar T, Bandrés E, Cejas P, Ramírez de Molina A, Pérez-Palacios R, Gallego-Ortega D, García-Cabezas MA, Casado E, Larrauri J, Nistal M, González-Barón M, García-Foncillas J, Lacal JC.

Ann Surg Oncol. 2009 Jan;16(1):78-87. doi: 10.1245/s10434-008-0166-x. Epub 2008 Nov 11.

PMID:
19002529
48.

Analysis of promazines in bovine livers by high performance liquid chromatography with ultraviolet and fluorimetric detection.

Quintana MC, Blanco MH, Lacal J, Hernández L.

Talanta. 2003 Feb 6;59(2):417-22.

PMID:
18968925
49.

Two levels of cooperativeness in the binding of TodT to the tod operon promoter.

Lacal J, Guazzaroni ME, Gutiérrez-del-Arroyo P, Busch A, Vélez M, Krell T, Ramos JL.

J Mol Biol. 2008 Dec 31;384(5):1037-47. doi: 10.1016/j.jmb.2008.10.011. Epub 2008 Oct 11.

PMID:
18950641
50.

Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.

Gómez Del Pulgar T, Valdés-Mora F, Bandrés E, Pérez-Palacios R, Espina C, Cejas P, García-Cabezas MA, Nistal M, Casado E, González-Barón M, García-Foncillas J, Lacal JC.

Int J Oncol. 2008 Jul;33(1):185-93.

PMID:
18575765

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