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The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation.

Boulet S, Daudelin JF, Odagiu L, Pelletier AN, Yun TJ, Lesage S, Cheong C, Labrecque N.

Proc Natl Acad Sci U S A. 2019 Jul 8. pii: 201821296. doi: 10.1073/pnas.1821296116. [Epub ahead of print]


Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease.

Chung J, Radojcic V, Perkey E, Parnell TJ, Niknafs Y, Jin X, Friedman A, Labrecque N, Blazar BR, Brennan TV, Siebel CW, Maillard I.

J Immunol. 2019 Jul 15;203(2):557-568. doi: 10.4049/jimmunol.1900192. Epub 2019 Jun 10.


The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.

De Sousa DM, Duval F, Daudelin JF, Boulet S, Labrecque N.

PLoS One. 2019 Apr 5;14(4):e0215012. doi: 10.1371/journal.pone.0215012. eCollection 2019.


Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape.

Chorro L, Suzuki M, Chin SS, Williams TM, Snapp EL, Odagiu L, Labrecque N, Lauvau G.

Nat Commun. 2018 Dec 18;9(1):5368. doi: 10.1038/s41467-018-07806-6.


In Situ Analysis of T Cell Receptor Signals during Positive Selection.

Labrecque N, Dong M, Sood A, Melichar HJ.

In: Soboloff J, Kappes DJ, editors. Signaling Mechanisms Regulating T Cell Diversity and Function. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 2.


Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome.

Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P.

Sci Immunol. 2018 Mar 16;3(21). pii: eaan4626. doi: 10.1126/sciimmunol.aan4626.


The circadian clock in immune cells controls the magnitude of Leishmania parasite infection.

Kiessling S, Dubeau-Laramée G, Ohm H, Labrecque N, Olivier M, Cermakian N.

Sci Rep. 2017 Sep 7;7(1):10892. doi: 10.1038/s41598-017-11297-8.


Enhancing circadian clock function in cancer cells inhibits tumor growth.

Kiessling S, Beaulieu-Laroche L, Blum ID, Landgraf D, Welsh DK, Storch KF, Labrecque N, Cermakian N.

BMC Biol. 2017 Feb 14;15(1):13. doi: 10.1186/s12915-017-0349-7.


Inflammation enhances the vaccination potential of CD40-activated B cells in mice.

Mathieu M, Odagiu L, Gaudot L, Daudelin JF, Melichar HJ, Lapointe R, Labrecque N.

Eur J Immunol. 2017 Feb;47(2):269-279. doi: 10.1002/eji.201646568. Epub 2016 Dec 27.


VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation.

Oussa NA, Dahmani A, Gomis M, Richaud M, Andreev E, Navab-Daneshmand AR, Taillefer J, Carli C, Boulet S, Sabbagh L, Labrecque N, Sapieha P, Delisle JS.

J Immunol. 2016 Nov 15;197(10):3927-3935. Epub 2016 Oct 10.


Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.

Laroche-Lefebvre C, Yousefi M, Daudelin JF, Charpentier T, Tarrab E, Klinck R, Lamarre A, Labrecque N, Stäger S, Duplay P.

J Immunol. 2016 Nov 1;197(9):3618-3627. Epub 2016 Sep 23.


Neuropilin-1-Expressing Microglia Are Associated With Nascent Retinal Vasculature Yet Dispensable for Developmental Angiogenesis.

Dejda A, Mawambo G, Daudelin JF, Miloudi K, Akla N, Patel C, Andriessen EM, Labrecque N, Sennlaub F, Sapieha P.

Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1530-6. doi: 10.1167/iovs.15-18598.


Notch controls effector CD8+ T cell differentiation.

Duval F, Mathieu M, Labrecque N.

Oncotarget. 2015 Sep 8;6(26):21787-8. No abstract available.


The Notch signaling pathway controls short-lived effector CD8+ T cell differentiation but is dispensable for memory generation.

Mathieu M, Duval F, Daudelin JF, Labrecque N.

J Immunol. 2015 Jun 15;194(12):5654-62. doi: 10.4049/jimmunol.1402837. Epub 2015 May 13.


Circadian Clocks in the Immune System.

Labrecque N, Cermakian N.

J Biol Rhythms. 2015 Aug;30(4):277-90. doi: 10.1177/0748730415577723. Epub 2015 Apr 20. Review.


The atypical MAPK ERK3 controls positive selection of thymocytes.

Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N.

Immunology. 2015 May;145(1):161-9. doi: 10.1111/imm.12433.


Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk.

Dejda A, Mawambo G, Cerani A, Miloudi K, Shao Z, Daudelin JF, Boulet S, Oubaha M, Beaudoin F, Akla N, Henriques S, Menard C, Stahl A, Delisle JS, Rezende FA, Labrecque N, Sapieha P.

J Clin Invest. 2014 Nov;124(11):4807-22. doi: 10.1172/JCI76492. Epub 2014 Oct 1.


IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiation.

Boulet S, Daudelin JF, Labrecque N.

J Immunol. 2014 Aug 15;193(4):1847-54. doi: 10.4049/jimmunol.1302365. Epub 2014 Jul 11.


The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.

Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque N.

Mol Cell Biol. 2014 Sep 15;34(18):3374-87. doi: 10.1128/MCB.01701-13. Epub 2014 Jul 7.


The non-classical MAP kinase ERK3 controls T cell activation.

Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque N.

PLoS One. 2014 Jan 27;9(1):e86681. doi: 10.1371/journal.pone.0086681. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e104727.


Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.

Lebel MÈ, Daudelin JF, Chartrand K, Tarrab E, Kalinke U, Savard P, Labrecque N, Leclerc D, Lamarre A.

J Immunol. 2014 Feb 1;192(3):1071-8. doi: 10.4049/jimmunol.1302030. Epub 2013 Dec 27.


Hoxb4 overexpression in CD4 memory phenotype T cells increases the central memory population upon homeostatic proliferation.

Frison H, Giono G, Thébault P, Fournier M, Labrecque N, Bijl JJ.

PLoS One. 2013 Dec 6;8(12):e81573. doi: 10.1371/journal.pone.0081573. eCollection 2013.


IL-6 production by dendritic cells is dispensable for CD8+ memory T-cell generation.

Daudelin JF, Mathieu M, Boulet S, Labrecque N.

Biomed Res Int. 2013;2013:126189. doi: 10.1155/2013/126189. Epub 2012 Dec 30.


Notch signaling regulates PD-1 expression during CD8(+) T-cell activation.

Mathieu M, Cotta-Grand N, Daudelin JF, Thébault P, Labrecque N.

Immunol Cell Biol. 2013 Jan;91(1):82-8. doi: 10.1038/icb.2012.53. Epub 2012 Oct 16.


The p35 human invariant chain in transgenic mice restores mature B cells in the absence of endogenous CD74.

Genève L, Ménard C, Labrecque N, Thibodeau J.

Int Immunol. 2012 Oct;24(10):645-60. Epub 2012 Sep 10.


Human invariant chain isoform p35 restores thymic selection and antigen presentation in CD74-deficient mice.

Genève L, Chemali M, Desjardins M, Labrecque N, Thibodeau J.

Immunol Cell Biol. 2012 Oct;90(9):896-902. doi: 10.1038/icb.2012.27. Epub 2012 Jun 12.


Murine superficial lymph node surgery.

Mathieu M, Labrecque N.

J Vis Exp. 2012 May 21;(63):e3444. doi: 10.3791/3444.


CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells.

Mathieu M, Cotta-Grand N, Daudelin JF, Boulet S, Lapointe R, Labrecque N.

PLoS One. 2012;7(1):e30139. doi: 10.1371/journal.pone.0030139. Epub 2012 Jan 23.


Circadian variation of the response of T cells to antigen.

Fortier EE, Rooney J, Dardente H, Hardy MP, Labrecque N, Cermakian N.

J Immunol. 2011 Dec 15;187(12):6291-300. doi: 10.4049/jimmunol.1004030. Epub 2011 Nov 9.


Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.

Rafei M, Hardy MP, Williams P, Vanegas JR, Forner KA, Dulude G, Labrecque N, Galipeau J, Perreault C.

J Immunol. 2011 Sep 15;187(6):3133-44. doi: 10.4049/jimmunol.1101097. Epub 2011 Aug 15.


Epitope density influences CD8+ memory T cell differentiation.

Leignadier J, Labrecque N.

PLoS One. 2010 Oct 29;5(10):e13740. doi: 10.1371/journal.pone.0013740.


Molecular and genetic parameters defining T-cell clonal selection.

Labrecque N, Baldwin T, Lesage S.

Immunol Cell Biol. 2011 Jan;89(1):16-26. doi: 10.1038/icb.2010.119. Epub 2010 Oct 19. Review.


Lowering TCR expression on naive CD8+ T cells does not affect memory T-cell differentiation.

Leignadier J, Rooney J, Daudelin JF, Labrecque N.

Immunol Cell Biol. 2011 Feb;89(2):322-5. doi: 10.1038/icb.2010.80. Epub 2010 Jun 29.


Memory T-lymphocyte survival does not require T-cell receptor expression.

Leignadier J, Hardy MP, Cloutier M, Rooney J, Labrecque N.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20440-5. doi: 10.1073/pnas.0806289106. Epub 2008 Dec 12.


Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.

Allard EL, Hardy MP, Leignadier J, Marquis M, Rooney J, Lehoux D, Labrecque N.

Eur J Immunol. 2007 Nov;37(11):3069-77.


IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade.

Ostiguy V, Allard EL, Marquis M, Leignadier J, Labrecque N.

J Leukoc Biol. 2007 Sep;82(3):645-56. Epub 2007 Jun 6.


IL-7 receptor expression levels do not identify CD8+ memory T lymphocyte precursors following peptide immunization.

Lacombe MH, Hardy MP, Rooney J, Labrecque N.

J Immunol. 2005 Oct 1;175(7):4400-7.


Inflammatory response to peritoneal implantation of alginate-poly-L-lysine microcapsules.

Robitaille R, Dusseault J, Henley N, Desbiens K, Labrecque N, Hallé JP.

Biomaterials. 2005 Jul;26(19):4119-27.


The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis.

Sabbagh L, Kaech SM, Bourbonnière M, Woo M, Cohen LY, Haddad EK, Labrecque N, Ahmed R, Sékaly RP.

J Immunol. 2004 Nov 1;173(9):5425-33.


An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.

Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S.

EMBO Rep. 2003 Oct;4(10):964-8. Epub 2003 Sep 19.


Changes in the lymph node microenvironment induced by oncostatin M.

Louis I, Dulude G, Corneau S, Brochu S, Boileau C, Meunier C, Côté C, Labrecque N, Perreault C.

Blood. 2003 Aug 15;102(4):1397-404. Epub 2003 Apr 17.


Tissue distribution of target antigen has a decisive influence on the outcome of adoptive cancer immunotherapy.

Meunier MC, Roy-Proulx G, Labrecque N, Perreault C.

Blood. 2003 Jan 15;101(2):766-70. Epub 2002 Aug 22.


Murine spermatogonial stem cells: targeted transgene expression and purification in an active state.

Giuili G, Tomljenovic A, Labrecque N, Oulad-Abdelghani M, Rassoulzadegan M, Cuzin F.

EMBO Rep. 2002 Aug;3(8):753-9. Epub 2002 Jul 15.


Thymic and extrathymic T cell development pathways follow different rules.

Terra R, Labrecque N, Perreault C.

J Immunol. 2002 Jul 15;169(2):684-92.


How much TCR does a T cell need?

Labrecque N, Whitfield LS, Obst R, Waltzinger C, Benoist C, Mathis D.

Immunity. 2001 Jul;15(1):71-82.


Alternative proteolytic processing of mouse mammary tumor virus superantigens.

Denis F, Shoukry NH, Delcourt M, Thibodeau J, Labrecque N, McGrath H, Munzer JS, Seidah NG, Sékaly RP.

J Virol. 2000 Apr;74(7):3067-73.


Toxic MHC class II beta chains.

Labrecque N, Madsen L, Fugger L, Benoist C, Mathis D.

Immunity. 1999 Nov;11(5):515-6. No abstract available.


Mice lacking all conventional MHC class II genes.

Madsen L, Labrecque N, Engberg J, Dierich A, Svejgaard A, Benoist C, Mathis D, Fugger L.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10338-43.


HLA-DR polymorphism affects the interaction with CD4.

Fleury S, Thibodeau J, Croteau G, Labrecque N, Aronson HE, Cantin C, Long EO, Sékaly RP.

J Exp Med. 1995 Sep 1;182(3):733-41.


Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding.

Thibodeau J, Cloutier I, Lavoie PM, Labrecque N, Mourad W, Jardetzky T, Sékaly RP.

Science. 1994 Dec 16;266(5192):1874-8.


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