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Items: 1 to 50 of 63

1.

Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.

Rothman DM, Gao X, George E, Rasmusson T, Bhatia D, Alimov I, Wang L, Kamel A, Hatsis P, Feng Y, Tutter A, Michaud G, McDonald E 3rd, Venkatesan K, Farley D, Digan ME, Ni Y, Harbinski F, Gunduz M, Wilson CJ, Buckler A, Labow M, Tallarico J, Myer VE, Porter JA, Wang S.

Chem Biol. 2015 Sep 17;22(9):1228-37. doi: 10.1016/j.chembiol.2015.06.025. Epub 2015 Sep 10.

2.

TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.

Shambharkar PB, Bittinger M, Latario B, Xiong Z, Bandyopadhyay S, Davis V, Lin V, Yang Y, Valdez R, Labow MA.

PLoS One. 2015 May 21;10(5):e0127480. doi: 10.1371/journal.pone.0127480. eCollection 2015.

3.

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO.

Nat Cell Biol. 2014 Nov;16(11):1069-79. doi: 10.1038/ncb3053. Epub 2014 Oct 19.

PMID:
25327288
4.

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.

Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcázar-Román A, Murphy L, Billich A, Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, Joberty G, Bouwmeester T, Labow MA, Finan PM, Porter JA, Ploegh HL, Baird D, De Camilli P, Tallarico JA, Huang Q.

Chem Biol. 2013 Jul 25;20(7):912-21. doi: 10.1016/j.chembiol.2013.05.010.

5.

A hypomorphic lsd1 allele results in heart development defects in mice.

Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T.

PLoS One. 2013 Apr 24;8(4):e60913. doi: 10.1371/journal.pone.0060913. Print 2013.

6.

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.

Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E1026-34. doi: 10.1073/pnas.1217072110. Epub 2013 Feb 19.

7.

Retraction: Defective heart development in hypomorphic LSD1 mice.

Nicholson TB, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T.

Cell Res. 2012 Apr 10. doi: 10.1038/cr.2012.60. [Epub ahead of print] No abstract available.

PMID:
22491473
8.

Defective heart development in hypomorphic LSD1 mice.

Nicholson TB, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T.

Cell Res. 2011 Dec 6. doi: 10.1038/cr.2011.194. [Epub ahead of print] Retraction in: Cell Res. 2012 Apr 10;:.

PMID:
22143567
9.

Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling.

Chen J, Shen Q, Labow M, Gaither LA.

Cancer Res. 2011 Jun 15;71(12):4280-91. doi: 10.1158/0008-5472.CAN-10-3761. Epub 2011 Apr 28.

10.

The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.

Gottar-Guillier M, Dodeller F, Huesken D, Iourgenko V, Mickanin C, Labow M, Gaveriaux S, Kinzel B, Mueller M, Alitalo K, Littlewood-Evans A, Cenni B.

J Immunol. 2011 May 15;186(10):6014-23. doi: 10.4049/jimmunol.1002813. Epub 2011 Apr 6.

11.

KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation.

Lohmann F, Loureiro J, Su H, Fang Q, Lei H, Lewis T, Yang Y, Labow M, Li E, Chen T, Kadam S.

Stem Cells. 2010 Feb;28(2):201-12. doi: 10.1002/stem.278.

12.

Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, Leighton-Davies J, Wilson CJ, Myer V, Cornellataracido I, Baryza J, Tallarico J, Joberty G, Bantscheff M, Schirle M, Bouwmeester T, Mathy JE, Lin K, Compton T, Labow M, Wiedmann B, Gaither LA.

J Virol. 2009 Oct;83(19):10058-74. doi: 10.1128/JVI.02418-08. Epub 2009 Jul 15.

13.

Cholesterol biosynthesis modulation regulates dengue viral replication.

Rothwell C, Lebreton A, Young Ng C, Lim JY, Liu W, Vasudevan S, Labow M, Gu F, Gaither LA.

Virology. 2009 Jun 20;389(1-2):8-19. doi: 10.1016/j.virol.2009.03.025. Epub 2009 May 5.

14.

Identification of novel genes and pathways regulating SREBP transcriptional activity.

Chatterjee S, Szustakowski JD, Nanguneri NR, Mickanin C, Labow MA, Nohturfft A, Dev KK, Sivasankaran R.

PLoS One. 2009;4(4):e5197. doi: 10.1371/journal.pone.0005197. Epub 2009 Apr 21.

15.

Role for Med12 in regulation of Nanog and Nanog target genes.

Tutter AV, Kowalski MP, Baltus GA, Iourgenko V, Labow M, Li E, Kadam S.

J Biol Chem. 2009 Feb 6;284(6):3709-18. doi: 10.1074/jbc.M805677200. Epub 2008 Nov 26.

16.

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells.

Rines DR, Gomez-Ferreria MA, Zhou Y, DeJesus P, Grob S, Batalov S, Labow M, Huesken D, Mickanin C, Hall J, Reinhardt M, Natt F, Lange J, Sharp DJ, Chanda SK, Caldwell JS.

Genome Biol. 2008;9(2):R44. doi: 10.1186/gb-2008-9-2-r44. Epub 2008 Feb 26.

17.

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.

Gaither A, Porter D, Yao Y, Borawski J, Yang G, Donovan J, Sage D, Slisz J, Tran M, Straub C, Ramsey T, Iourgenko V, Huang A, Chen Y, Schlegel R, Labow M, Fawell S, Sellers WR, Zawel L.

Cancer Res. 2007 Dec 15;67(24):11493-8.

18.

Integrating high-content screening and ligand-target prediction to identify mechanism of action.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y.

Nat Chem Biol. 2008 Jan;4(1):59-68. Epub 2007 Dec 9.

PMID:
18066055
19.

Optimization procedure for small interfering RNA transfection in a 384-well format.

Borawski J, Lindeman A, Buxton F, Labow M, Gaither LA.

J Biomol Screen. 2007 Jun;12(4):546-59. Epub 2007 Apr 13.

PMID:
17435168
20.

Genome-wide functional analysis of human cell-cycle regulators.

Mukherji M, Bell R, Supekova L, Wang Y, Orth AP, Batalov S, Miraglia L, Huesken D, Lange J, Martin C, Sahasrabudhe S, Reinhardt M, Natt F, Hall J, Mickanin C, Labow M, Chanda SK, Cho CY, Schultz PG.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14819-24. Epub 2006 Sep 25.

21.

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84. Epub 2006 Sep 15.

22.

The application of systems biology to drug discovery.

Cho CR, Labow M, Reinhardt M, van Oostrum J, Peitsch MC.

Curr Opin Chem Biol. 2006 Aug;10(4):294-302. Epub 2006 Jul 5. Review.

PMID:
16822703
23.

A quantitative high-throughput endothelial cell migration assay.

Mastyugin V, McWhinnie E, Labow M, Buxton F.

Drug Discov Today. 2005 Autumn;Suppl:43-9.

PMID:
23570165
24.

Design of a genome-wide siRNA library using an artificial neural network.

Huesken D, Lange J, Mickanin C, Weiler J, Asselbergs F, Warner J, Meloon B, Engel S, Rosenberg A, Cohen D, Labow M, Reinhardt M, Natt F, Hall J.

Nat Biotechnol. 2005 Aug;23(8):995-1001. Epub 2005 Jul 17. Erratum in: Nat Biotechnol. 2005 Oct;23(10):1315. Nat Biotechnol. 2006 Aug;24(8):1033.

PMID:
16025102
25.

Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.

Daouti S, Latario B, Nagulapalli S, Buxton F, Uziel-Fusi S, Chirn GW, Bodian D, Song C, Labow M, Lotz M, Quintavalla J, Kumar C.

Osteoarthritis Cartilage. 2005 Jun;13(6):508-18.

26.

A quantitative high-throughput endothelial cell migration assay.

Mastyugin V, McWhinnie E, Labow M, Buxton F.

J Biomol Screen. 2004 Dec;9(8):712-8.

PMID:
15634798
27.

Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.

Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M.

Curr Biol. 2004 Dec 14;14(23):2156-61.

28.

Genome-scale functional profiling of the mammalian AP-1 signaling pathway.

Chanda SK, White S, Orth AP, Reisdorph R, Miraglia L, Thomas RS, DeJesus P, Mason DE, Huang Q, Vega R, Yu DH, Nelson CG, Smith BM, Terry R, Linford AS, Yu Y, Chirn GW, Song C, Labow MA, Cohen D, King FJ, Peters EC, Schultz PG, Vogt PK, Hogenesch JB, Caldwell JS.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12153-8. Epub 2003 Sep 26.

29.

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.

Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12147-52. Epub 2003 Sep 23.

30.

Rapid expression cloning of receptors using epitope-tagged ligands and high-speed cell sorting.

Robeva AS, Yan-Neale Y, Burfeind P, Bodian DL, Chirn GW, Kolbinger F, Labow M, Vallon RD.

Cytometry A. 2003 Feb;51(2):59-67.

31.
32.

Identification of a novel beta-chemokine, MEC, down-regulated in primary breast tumors.

Mickanin CS, Bhatia U, Labow M.

Int J Oncol. 2001 May;18(5):939-44.

PMID:
11295038
34.

The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor.

Schiffenbauer J, Streit WJ, Butfiloski E, LaBow M, Edwards C 3rd, Moldawer LL.

Clin Immunol. 2000 May;95(2):117-23.

PMID:
10779405
35.

Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra.

Josephs MD, Solorzano CC, Taylor M, Rosenberg JJ, Topping D, Abouhamze A, Mackay SL, Hirsch E, Hirsh D, Labow M, Moldawer LL.

Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R824-30.

36.

IL-1 receptor accessory protein is an essential component of the IL-1 receptor.

Cullinan EB, Kwee L, Nunes P, Shuster DJ, Ju G, McIntyre KW, Chizzonite RA, Labow MA.

J Immunol. 1998 Nov 15;161(10):5614-20.

37.

Noninvasive, in utero imaging of mouse embryonic heart development with 40-MHz echocardiography.

Srinivasan S, Baldwin HS, Aristizabal O, Kwee L, Labow M, Artman M, Turnbull DH.

Circulation. 1998 Sep 1;98(9):912-8.

PMID:
9738647
38.

Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice.

Satoskar AR, Okano M, Connaughton S, Raisanen-Sokolwski A, David JR, Labow M.

Eur J Immunol. 1998 Jul;28(7):2066-74.

39.

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis.

Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, Zon LI.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6881-6.

40.

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.

Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW.

Immunity. 1998 May;8(5):625-34.

42.

Cre-mediated generation of a VCAM-1 null allele in transgenic mice.

Terry RW, Kwee L, Baldwin HS, Labow MA.

Transgenic Res. 1997 Sep;6(5):349-56.

PMID:
9322371
43.

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.

Labow M, Shuster D, Zetterstrom M, Nunes P, Terry R, Cullinan EB, Bartfai T, Solorzano C, Moldawer LL, Chizzonite R, McIntyre KW.

J Immunol. 1997 Sep 1;159(5):2452-61.

PMID:
9278338
44.

Interferon immunogenicity: preclinical evaluation of interferon-alpha 2a.

Palleroni AV, Aglione A, Labow M, Brunda MJ, Pestka S, Sinigaglia F, Garotta G, Alsenz J, Braun A.

J Interferon Cytokine Res. 1997 Jul;17 Suppl 1:S23-7.

PMID:
9241612
45.

Heterogeneity of expression of E- and P-selectins in vivo.

Eppihimer MJ, Wolitzky B, Anderson DC, Labow MA, Granger DN.

Circ Res. 1996 Sep;79(3):560-9.

PMID:
8781489
46.

Reproduction in mice lacking a functional type 1 IL-1 receptor.

Abbondanzo SJ, Cullinan EB, McIntyre K, Labow MA, Stewart CL.

Endocrinology. 1996 Aug;137(8):3598-601.

PMID:
8754793
47.
48.

Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex.

Greenfeder SA, Nunes P, Kwee L, Labow M, Chizzonite RA, Ju G.

J Biol Chem. 1995 Jun 9;270(23):13757-65.

49.

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice.

Kwee L, Baldwin HS, Shen HM, Stewart CL, Buck C, Buck CA, Labow MA.

Development. 1995 Feb;121(2):489-503.

50.

Use of lac activator proteins for regulated expression of oncogenes.

Labow MA.

Methods Enzymol. 1995;254:375-87. No abstract available.

PMID:
8531700

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